Survey of candidate molecules relevant to diabetic angiopathy
Project/Area Number |
18500641
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Eating habits, studies on eating habits
|
Research Institution | National Institute of Advanced Industrial Science and Technology |
Principal Investigator |
FUKATSU Kayoko (SASAKI Kayoko) National Institute of Advanced Industrial Science and Technology, 農学部, 客員准教授 (70338903)
|
Co-Investigator(Kenkyū-buntansha) |
SATO Hideyo 山形大学, 農学部, 准教授 (60235380)
|
Project Period (FY) |
2006 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
|
Keywords | 血管障害 / 糖尿病 / 酸化ストレス / 培養細胞 / グルタチオン / 糖尿病血管障害 / 鉄 / 血管内皮細胞 / 糖化 / 生体分子 / 生理活性 / ストレス / 活性酸素 |
Research Abstract |
To investigate the novel candidate molecules involved in the cause of diabetic angiopathy, we used cultured human umbilical vein endothelial cells (HUVEC). In living HUVEC that was exposed to high glucose, antioxidant ability via the GSH cycle was remarkably reduced. The possibility was suggested that glycation of glutathione is responsible for this reduction. Two glycated glutathiones, whose N-position and S-position was respectively modified, were synthesized, and their coenzyme activities for antioxidative enzyme via GSH system were decreased. Further studies in this line would contribute to actual medical treatment in future.
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Report
(5 results)
Research Products
(25 results)