Delayed effects of prenatal exposure to methylmercury on nervous system and physiological aging

• Project/Area Number: 18510029
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental impact assessment/Environmental policy
• Research Institution: National Institute for Minamata Disease
• Principal Investigator: SAKAMOTO Mineshi National Institute for Minamata Disease, 疫学研究部, 部長 (60344420)
• Co-Investigator(Kenkyū-buntansha): MURATA Katsuyuki 秋田大学, 医学部, 教授 (80157776)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,280,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
• Keywords: メチル水銀 / 神経系 / 胎児曝露 / メチルフ水銀 / 胎児影響 / 胎児性水俣病 / 老化

Research Abstract

胎児期に受けたメチル水銀の加齢に伴って出現する後影響に関する研究は、重要な緊急課題である。そこで、我々は脳の発達時期にメチル水銀曝露を受けた患者における一定期間後において観察される影響について、疫学研究と動物実験により、神経生理学的、神経行動学的面から検討する。

Research Products

• [Journal Article] Changes in mercury concentrations of segmental maternal hair during gestation and their correlations with other biomarkers of fetal exposure to methylmercury in the Japanese population (2008)
  • Author(s): Sakamoto M, Kubota M, Murata K, Nakai K, Sonoda I, Satoh H
  • Journal Title: Enviro Res (106) Pages: 207-276
  • Peer Reviewed
• [Journal Article] Prenatal Methylmercury Exposure: Effects on Stress Response During Active Learning (2008)
  • Author(s): Maria Rosaria Carratu, Addolorata Coluccia, Antonella M. E. Modafferi, Pietro Borracci, Sergio Scaccianoce, Mineshi Sakamoto and Vincenzo Cuomo
  • Journal Title: Bulletin of Environmental Contamination and Toxicology (37) Pages: 3-8
  • Peer Reviewed
• [Journal Article] Changes in mercury concentrations of segmental maternal hair during gestation and their correlations with other biomarkers of fetal exposure to methylmercury in the Japanese population (2008)
  • Author(s): Sakamoto M, Kubota M, Murata K, Nakai K, Sonoda I, Satoh H.
  • Journal Title: Environmental Research 106 Pages: 270-276
  • Peer Reviewed
• [Journal Article] Prenatal Methylmercury Exposure : Effects on Stress Response During Active Learning (2008)
  • Author(s): Maria Rosaria Carratu, Addolorata Coluccia, Antonella M. E. Modafferi, Pietro Borracci, Sergio Scaccianoce, Mineshi Sakamoto, Vincenzo Cuomo
  • Journal Title: Bulletin of Environmental Contamination and Toxicology 81 Pages: 539-542
  • Peer Reviewed
• [Journal Article] メチル水銀と健康について (2008)
  • Author(s): 坂本峰至
  • Journal Title: 環境管理 37 Pages: 3-8
• [Journal Article] Changes in mercury concentrations of segmental maternal hair during gestation and their correlations with other biomarkers of fetal exposure to methylmercury in the Japanese population. (2008)
  • Author(s): Sakamoto M, Kubota M, Murata K, Nakai K, Sonoda I, Satoh H
  • Journal Title: Environ Res 106 Pages: 270-276
  • Peer Reviewed
• [Journal Article] Heavy metal contamination status of Japanese cranes (Grus japonensis) in east Hokkaido, Japan-extensive mercury pollution (2007)
  • Author(s): Teraoka H, Kumagai Y, Iwai H, Haraguchi K, Ohba T, Nakai K, Satoh H: Sakamoto M, Momose K, Masatomi H, Hiraga T
  • Journal Title: Environ Toxicl Chem (26) Pages: 307-312
  • Peer Reviewed
• [Journal Article] 有村公良胎児性水俣病患者の現在のActivity of Daily Living (ADL) 実態と15年前との比較およびコミュニケーション障害に関する研究 (2007)
  • Author(s): 劉 暁潔,坂本峰至,加藤たけ子,岡本美和
  • Journal Title: 日本衛生学会誌 (62) Pages: 905-910
  • Peer Reviewed
• [Journal Article] Heavy metal contamination status of Japanese cranes(Grus japonensis) in east Hokkaido, Japan-extensive mercury pollution. (2007)
  • Author(s): Teraoka H, Kumagai Y, Iwai H, Haraguchi K, Ohba T, Nakai K, Satoh H : Sakamoto M, Momose K, Masatomi H, Hiraga T
  • Journal Title: Environ Toxicol Chem 26 Pages: 307-312
  • Peer Reviewed
• [Journal Article] 胎児性水俣病患者の現在のActivity of Daily Living(ADL) 実態と15年前との比較およびコミュニケーション障害に関する研究 (2007)
  • Author(s): 劉 暁潔,坂辺峰至,加藤たけ子,岡本美和,有村公良
  • Journal Title: 日本衛生学会誌 62 Pages: 905-910
  • Peer Reviewed
• [Journal Article] Correlations between mercury concentrations in umbilical cord tissue and other biomarkers of fetal exposure to methylmercury in the Japanese population. (2007)
  • Author(s): Sakamoto M
  • Journal Title: Environmental Research 103(1) Pages: 106-111
• [Journal Article] High exposure of Chinese mercury mine workers to elemental mercury vapor and increased methylmercury levels in their hair. (2007)
  • Author(s): Sakamoto M
  • Journal Title: Environmental Health and Preventive Medicine 12(2) Pages: 66-70
  • NAID: 110006243384
• [Journal Article] Effects of low dose methylmercury administration during the postnatal brain growth spurt in rats. (2007)
  • Author(s): Coluccia A
  • Journal Title: Neurotoxicology and Teratology 29(2) Pages: 282-287
• [Journal Article] Methylmercury Exposure and Health Effects in Humans : A Worldwide Concern (2007)
  • Author(s): Mergler D
  • Journal Title: AMBIO 36(1) Pages: 3-11
• [Journal Article] Total mercury levels in hair, toenail, and urine among women free from occupational exposure and their relations to renal tubular function. (2007)
  • Author(s): Ohno T
  • Journal Title: Environmental Research 103(2) Pages: 191-197
• [Journal Article] 胎児性水俣病患者の現在のActivity of Daily Living(ADL)実態と15年前との比較およびコミュニケーション障害に関する研究
  • Author(s): 劉 暁潔
  • Journal Title: 日本衛星学雑誌 (印刷中)
• [Presentation] 母体からの重金属および脂肪酸の胎児移行について (2009)
  • Author(s): 坂本峰至
  • Organizer: 第8回横浜微量成分ワークショップ
  • Place of Presentation: 水俣
  • Year and Date: 2009-01-09
• [Presentation] Effects of environmental enrichment on neurobehavioral deficits caused by methylmercury treatment during postnatal development of rats (2008)
  • Author(s): Mineshi Sakamoto, Ricardo Oliveila et al.
  • Organizer: 25th International Neurotoxicology Conference
  • Place of Presentation: Rochester, USA
  • Year and Date: 2008-10-14
• [Presentation] “生殖次世代影響研究企画シンポジウム"「胎盤通過性・胎児移行と次世代影響」 (2008)
  • Author(s): 坂本峰至
  • Organizer: 第79回日本衛生学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-08-30
• [Presentation] 胎盤通過性・胎児移行と次世代影響 (2008)
  • Author(s): 坂本 峰至
  • Organizer: 生殖次世代影響研究企画シンポジウム
  • Place of Presentation: 東京
• [Presentation] 環境エンリッチがラットの脳発達期のメチル水銀投与で起こした神経行動学的障害に及ぼす効果に関する研究 (2008)
  • Author(s): 坂本峰至, Ricardo Oliveira
  • Organizer: 第78回日本衛生学会総会
  • Place of Presentation: 熊本
• [Presentation] 環境エンリッチがラットの脳発達期のメチル水銀投与で起こした神経行動学的障害に及ぼす効果に関する研究. (2008)
  • Author(s): 坂本峰至,Ricardo Oliveira
  • Organizer: 第78回日本衛生学会総会
  • Place of Presentation: 熊本
• [Presentation] メチル水銀の神経毒性を修飾する可能性のある重金属の胎児複合曝露についての研究. (2008)
  • Author(s): 坂本峰至,村田勝敬,仲井邦彦,佐藤洋
  • Organizer: 第78回日本衛生学会総会
  • Place of Presentation: 熊本
• [Presentation] 水俣病におけるメチル水銀の健康影響から,現在の低濃度メチル水銀を含む魚食の状況までの慨括 分析技術の進歩と多種物質の摂取の実態 (2008)
  • Author(s): 坂本峰至
  • Organizer: 第78回日本衛生学会総会,メインシンポジウム2 多種化学物質への低濃度日常曝露の時代の衛生学
  • Place of Presentation: 熊本
• [Presentation] 妊婦の魚介類を介したメチル水銀摂取が胎児に与える影響とその評価 (2007)
  • Author(s): 坂本峰至
  • Organizer: 衛生薬学・環境トキシコロジー フォーラム2007金属をめぐる最近の話題
  • Place of Presentation: 大坂
• [Presentation] Segmental hair mercury concentrations during gestation and correlations among baby hair, maternal blood and cord blood mercury levels at parturition (2007)
  • Author(s): Sakamoto M, Kubota M, Murata K, Nakai K, Satoh H
  • Organizer: International Conference on Fetal Programming and Development Toxicity
  • Place of Presentation: Torshavn, Faroe Islands
• [Presentation] 妊婦の魚介類を介したメチル水銀摂取が胎児に与える影響とその評価. (2007)
  • Author(s): 坂本 峰至
  • Organizer: 衛生薬学・環境トキシコロジー フォーラム2007金属をめぐる最近の話題
  • Place of Presentation: 大阪
• [Presentation] Segmental hair mercury concentrations during gestation and correlations among baby hair, maternal blood and cord blood mercury levels at parturition. (2007)
  • Author(s): Sakamoto M, Kubota M, Murata K, Nakai K, Satoh H
  • Organizer: International Conference on Fetal Programming and Development Toxicity.
  • Place of Presentation: Torshavn, Faroe Lslands.
• [Presentation] Difference in methylmercury exposure to fetus and breast-feeding offspring. (2007)
  • Author(s): Sakamoto M
  • Organizer: The 12th International Conference of the Pacific Basin Consort ion for Environment and Health Sciences.
  • Place of Presentation: Beijing, China.
• [Presentation] Exposure assessment of methylmercury in the Japanese pregnant women. (2007)
  • Author(s): Satoh H, Shimada M, Ohba T, Kameo S, Suzuki K, Sakurai K, Kurokawa N, Murata K, Sakamoto M, Nakai K
  • Organizer: VIIIth International Society for trace Element Research in Humans Conference.
  • Place of Presentation: Crete, Greece.
• [Remarks]
  • URL: http://www.nimd.go.jp/
• [Remarks]
  • URL: http://www.nimd.go.jp/kenkyu/report_list.html