Chemistry of Sq group containing amino acid (ASQ): Incorporation of ASQ into peptides and their function
Project/Area Number |
18510191
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Living organism molecular science
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Research Institution | Osaka City University |
Principal Investigator |
SHINADA Tetsuro Osaka City University, 大学院・理学研究科, 准教授 (30271513)
|
Project Period (FY) |
2006 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥3,680,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2006: ¥1,600,000 (Direct Cost: ¥1,600,000)
|
Keywords | スクアリン酸 / アミノ酸 / ペプチド / 立体配座 / 生物活性 / アミノ酸アナログ / エンケファリン / 水素結合 |
Research Abstract |
アミノ酸, ペプチドは生命の維持機能をつかさどる重要な分子である. その機能を探る研究は生命科学研究における重要な課題である. 本研究では, 近年注目を集めている機能性酸性分子, スクアリン酸を組み込んだアミノ酸誘導体を世界で初めてペプチドへ導入することに成功した. これによって, 従来にない機能をそなえたペプチド類の合成が可能になるとともに, その基本的諸性質を初めて明らかにできた
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Total Synthesis of 5, 6, 11-Trideoxytetrodo- toxin. Umezawa2006
Author(s)
T. ; Hayashi, T, Sakai, H. ; Yoshikawa, T. ; Izumida, M. ; Teramoto, H. ; Tamatani, Y. Hirose, T. ; Ohfune, Y. ; Shinada, T.
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Journal Title
Org. Lett. 8
Pages: 4971-4974
Related Report
Peer Reviewed
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[Journal Article] Novel Biologically Active Peptides from the Venom of Polistes rothneyi iwatai.2006
Author(s)
Murata, K., Shinada, T., Ohfune, Y., Hisada, M., Yasuda, A., Naoki, H., Nakajima,T.
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Journal Title
Biol. Pharm. Bull. 29
Pages: 2493-2497
NAID
Related Report
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[Journal Article] On the Stereoselectivity of the Asymmetric Transferring Strecker Synthesis in a Cyclohexane System : Synthesis of Optically Active Cis-and Trans-1-amino-2-hydroxycyclohexane-1-carboxylic Acids2006
Author(s)
Shinada, T., Kawakami, T., Sakai, H., Matsuda, H., Umezawa, T., Kawasaki, M., Namba, K., Ohfune,Y.
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Journal Title
Bull. Chem. Soc. Jpn. 79
Pages: 768-774
Related Report
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[Journal Article] Total Synthesis of 5,6,11-Trideoxytetrodotoxin.2006
Author(s)
Umezawa, T., Hayashi, T, Sakai, H., Yoshikawa, T., Izumida, M., Teramoto, H., Tamatani, Y., Hirose, T., Ohfune, Y., Shinaka,T.
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Journal Title
Org. Lett. 8
Pages: 4971-4974
Related Report
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