| Budget Amount *help |
¥4,110,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2006: ¥1,900,000 (Direct Cost: ¥1,900,000)
|
|---|
| Research Abstract |
In the present study, various pharmacological effects of medicinal herbs which have been used as antidaiabetes, antiinflammation, tonic were examined. Among them, bioactive saponins were isolated and their chemical structures were elucidated on the basis of chemical and physicochemical evidence. Structural requirements of the active saponins for the bioactivities and mechanisms of action were clarified in part.
Five new cucurbitane-type triterpenes, karavilagenins and ten new cucurbitane-type triterpene saponins, karavilosides, were isolated from the dried fruit of Sri Lanka Momordica charantica with anti-diabetic effects and their chemical structures were determined. The major steroidal alkaloid saponins, solamargine and solasonine, from the fruit of Solanaum lycocarpum cultivated in Brazil showed gastroprotections in rats and were found to inhibit the increase in blood glucose levels in sucrose-loaded rats. The methanolic extract from flower of Borassus flabrllifera collected in Thail
… More
and and its principal constituent, dioscin, showed anti-hyperglycemic effects and chemical structures of six new spirostane-type steroidal saponins, borassosides, were determined. From the fruit of Citrullus colocynthis, cucurbitacin E and its glycosides were isolated as laxative and anti-allergic principles together with the chemical determination of two new cucurbitane-type triterpene saponins. The major saponis from the flower buds of Panax ginseng were found to show gastroprotective effects in rats and seventeen new dammarane-type triterpene saponins, floralginsenosides, were isolated and their chemical structures were determined. New biofunctional effects of flowers of Bellis perennis and Camellia sinensis were examined, and enhancement of gastrointestinal transit and inhibition of absorption of triglycerides, etc. New saponins perennisaponins, floratheasaponins and chakasaponins were isolated as the active constituents and their chemical structures were determined. With regard to mechanism of the inhibition of absorption of triglycerides, inhibitions of pancreatic lipase activity and gastric emptying are involved in their effects. Less
|
