| Project/Area Number |
18510231
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gender
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| Research Institution | Oita University |
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Principal Investigator |
NAKAGAWA Mikiko Oita University, School of Medicine, associate professor (50244182)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | menopause / women / microvascular angina / Kampo medicine / gender specific medicine / electrocardiogram / exercise tolerance test / oriental medicine |
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| Research Abstract |
Gender difference in the incidence of ventricular arrhythmias has been reported. Although an increased sympathetic tone during exercise play an important role on arrhythmia vulnerability, little is known about the gender difference of the dynamic electrophysiological response to exercise. We investigated whether there is a gender difference with respect to the dynamic response of ventricular repolarization during exercise. Methods : ECGs were continuously recorded in 20 healthy volunteers (10 men, 22±3years). Two protocols were designed to study the effect of exercise (Ex : ergometer for 3 min)under control conditions and B-adrenergic blockade(BB : propranolol, 0.1mg/kg iv). RR, QT and QTc intervals and T wave amplitude were measured at baseline and during Ex and recovery period. Results : (1) RR intervals were significantly longer in men than women throughout the procedure. (2) QTc were significantly longer in women than men during Ex in control and BB. (3) BB produced significant increases in RR and QT intervals and T wave amplitude during Ex compared to control period in both men and women. (4) BB produced a significant increase in QTc interval during Ex compared to control period in women, but not in men. Conclusion : Sympathetic modulation of the dynamics of ventricular repolarization during exercise was more pronounced in women than men, which may partially account for the gender difference of arrhythmias.
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