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Development of Hg(II)-trapping technology based on the physicochemical properties of the T-Hg(II)-T base-pair

Research Project

Project/Area Number 18550146
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemistry related to living body
Research InstitutionTohoku University

Principal Investigator

TANAKA Yoshiyuki  Tohoku University, Tohoku University, Graduate School of Pharmaceutical Sciences, Associate Professor (70333797)

Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥4,120,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2006: ¥2,300,000 (Direct Cost: ¥2,300,000)
KeywordsHg(II) / DNA / NMR / Hg(II)-trapping / Structure determination / T-Hg(II)-T base-pairs / physicochemical properties / DNA-metal interactions / 水銀錯体 / チミン塩基 / スピン結合 / 安定同位体標識
Research Abstract

Recently, FAO and WHO warned that the amount of mercury accumulated in large fishes (especially in tune) became a toxic level against embryos. In order to reduce mercury accumulated in fishes, it is important to reduce the concentration (total amount) of environmental mercury. For this purpose, considerable numbers of techniques to capture Hg(II) from environment have been proposed, such as precipitation with iodide (r), chelation of Hg(II) by resins modified with EDTA-related compounds or cysteine, and bacterial trapping of mercury (bio-remediation). However, these techniques are not specific for Hg(II) ions. In this project, we propose a new technology for a Hg(II)trapping which is highly specific for Hg(II). This technique rely on a knowledge in our group that Hg(II) is captured by thymine (T) residues in T -T mismatches in DNA duplexes (J. Am Chem Soc., 2006, 128, 2172-2173.). Therefore, the awardee of this grant (Tanaka) postulated that by using resins modified with oligo-T would … More work as a Hg(II)trapping device. He then synthesized the oligo-T-modified poly-stylene resin, and examine its Hg(II)-trapping efficiency with ICP spectroscopy. It was found that this oligo-T modified poly-stylene resin (Hg(II) trapping device) efficiently trapped Hg(II) from solution in the presence or absence of other metal rations. More interestingly, this Hg(II)trapping device specifically captured Hg(II) without trapping any other metal cations significantly. In addition, the awardee performed structure determination and physicochemical characterizations of T-Hg(II) T base-pairs, in outer to facilitate developments of more efficient Hg(II) trapping devices and to clarify appropriate sequences for them. Especially, the determination of the chemical structure of T-Hg(II) T base-pairs with ^15N NMR (J. Am Chem Soc., 2007, 129, 244-245.) gave impact to the field of nucleic acids-metal interactions in world-wide manner, and the awardee was invited as. A writer for a book chapter (N. Hadjiliadis and E. Sletten Eds., "Metal Complexes - DNA Interactions", Blackwell Publishing, Oxford, UK.) and a personal account (Dalton Transactions). In conclusion, the awardee revealed the fundamental properties of the T-Hg(II) T base-pan and created a Hg(II)-trapping device based on basic sciences of the T-Hg(II) T base-pairs. Less

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (62 results)

All 2008 2007 2006 Other

All Journal Article (22 results) (of which Peer Reviewed: 6 results) Presentation (37 results) Book (1 results) Remarks (2 results)

  • [Journal Article] 新規ナノデバイス材料としてのメタロDNA分子の構造2008

    • Author(s)
      田中好幸, 鳥越秀峰, 小野晶
    • Journal Title

      生物物理 48

      Pages: 119-124

    • NAID

      110006640408

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 核酸分子の生理活性の化学的解剖-金属イオンとの相互作用研究から見えてきたもの-2008

    • Author(s)
      田中好幸
    • Journal Title

      生命化学研究レター 26

      Pages: 16-23

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] ^15N-^15N J-coupling across Hg^<II>: Direct observation of Hg^<II>-mediated T-T base pairs in a DNA duplex2007

    • Author(s)
      田中好幸, 他5名(第1著者)
    • Journal Title

      Journal of the American Chemical Society 129

      Pages: 244-245

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Synthesis of an enantiomeric DNA oligomer and its T-Hg^<II>-T base-pair formation2007

    • Author(s)
      春田佳一郎, 他7名(第2著者)
    • Journal Title

      Nucleic Acids Symp. Ser. 51

      Pages: 187-188

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Structural and physicochemical features on the metal-mediated base pairs2007

    • Author(s)
      田中好幸, 他ll名
    • Journal Title

      Nucleic Acids Symp. Ser. 51

      Pages: 75-76

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Spectroscopic studies on a novel intramolecular hydrogen bond within the (6-4) photoproduct2007

    • Author(s)
      山元淳平, 他4名(第2著者)
    • Journal Title

      Nucleic Acids Symp. Ser. 51

      Pages: 79-80

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 遺伝子治療薬としての酵素RNA分子(リボザイム)の構造2007

    • Author(s)
      田中好幸, 春田佳一郎
    • Journal Title

      医薬ジャーナル 43

      Pages: 5-14

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] Synthesis of an enantiomeric DNA oligomer and its T-Hg^<II>-Tbase-pair formation2007

    • Author(s)
      春田佳一郎, 他7名(第2著者)
    • Journal Title

      Nucleic Acids Symp. Ser. 51

      Pages: 187-188

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Structural and physicochemical features on the metal-mediated base pairs2007

    • Author(s)
      田中好幸, 他11名
    • Journal Title

      Nucleic Acids Symp. Ser. 51

      Pages: 75-76

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Spectroscopic studies on a novel intramolecular hydrogen bondwithin the (6-4) photoproduct2007

    • Author(s)
      山元淳平, 他4名(第2著者)
    • Journal Title

      Nucleic Acids Symp. Ser. 51

      Pages: 79-80

    • Related Report
      2007 Annual Research Report
  • [Journal Article] ^<15>N-^<15>N J-coupling across Hg^<II> : Direct observation of Hg^<II>-mediated T-T base pairs in a DNA duplex2007

    • Author(s)
      田中好幸, 織田修司, 山口浩, 根東義則, 児嶋長次郎, 小野晶
    • Journal Title

      Journal of the American Chemical Society 129.2

      Pages: 244-245

    • Related Report
      2006 Annual Research Report
  • [Journal Article] NMR spectroscopic study of a DNA duplex with mercury-mediated T-T base pairs2006

    • Author(s)
      田中好幸, 他6名(第1著者)
    • Journal Title

      Nucleosides Nucleotides & Nucleic Acids 25

      Pages: 613-624

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Complexation of 5,10,15,20-tetrakis (N-methylpyridinium-4-yl)-21H, 23H-porphyrin with G-quadruplex DNA2006

    • Author(s)
      三田肇, 他5名(第3著者)
    • Journal Title

      Biochemistry 45

      Pages: 6765-6772

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] NMR spectroscopic observation of a metal-free acetylide anion2006

    • Author(s)
      田中好幸, 他7名(第1著者)
    • Journal Title

      Chemistry-An Asian Journal 1

      Pages: 518-585

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Structural analyses on the mercury^<II>-mediated T-T base pair2006

    • Author(s)
      田中好幸, 他6名
    • Journal Title

      Nucleic Acids Symp. Ser. 50

      Pages: 47-48

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Spectroscopic analysis of Ag^I-DNA complex2006

    • Author(s)
      織田修司, 他4名(最終著者)
    • Journal Title

      Nucleic Acids Symp. Ser. 50

      Pages: 199-200

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] NMR spectroscopic study of a DNA duplex with mercury-mediated T-T base pairs2006

    • Author(s)
      田中好幸, 山口浩, 織田修司, 野村誠, 児嶋長次郎, 根東義則, 小野晶
    • Journal Title

      Nucleosides, Nucleotides & Nucleic Acids 25.4-25.6

      Pages: 613-624

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Complexation of 5,10,15,20-tetrakis(N-methylpyridinium-4-yl)-21H, 23H-porphyrin with G-quadruplex DNA2006

    • Author(s)
      三田肇, 大山貴子, 田中好幸, 山本泰彦
    • Journal Title

      Biochemistry 45.22

      Pages: 6765-6772

    • Related Report
      2006 Annual Research Report
  • [Journal Article] NMR spectroscopic observation of a metal-free acetylide anion2006

    • Author(s)
      田中好幸, 荒川真, 山口洋平, 堀千恵子, 上野正弘, 今堀龍志, 根東義則
    • Journal Title

      Chemistry-An Asian Journal 1.4

      Pages: 581-585

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Structural analyses on the mercury^<II>-mediated T-T base pair2006

    • Author(s)
      田中好幸, 織田修司, 山口浩, 工藤恵, 根東義則, 児嶋長次郎, 小野晶
    • Journal Title

      Nucleic Acids Symposium Series 50

      Pages: 47-48

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Spectroscopic analysis of Ag^<I->DNA complex2006

    • Author(s)
      織田修司, 小室朋之, 根東義則, 小野晶, 田中好幸
    • Journal Title

      Nucleic Acids Symposium Series 50

      Pages: 199-200

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 最も強いブレンステッド塩基性を示す有機化合物2006

    • Author(s)
      根東義則, 田中好幸
    • Journal Title

      化学,有機塩基のチャンピオン(化学同人)(京都) (紹介記事)

      Pages: 2-2

    • Related Report
      2006 Annual Research Report
  • [Presentation] T-Hg-T塩基対形成能を利用した水銀トラップデバイスの開発(口頭発表)2008

    • Author(s)
      春田佳一郎, 他5名
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Development of a Hg^<II> trapping device (Oral)2008

    • Author(s)
      Kaichiro Haruta, Takuya Kawamura, Yoshinori Kondo, Itaru Okamoto, Akira Ono, Yoshiyuki Tanaka
    • Organizer
      The annual meeting of the Chemical Society of Japan (The 88^<th> Spring Meeting)
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-03-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 核酸の構造形成に関わる金属イオン-NMR分光法で見る金属核酸相互作用(口頭)2007

    • Author(s)
      田中好幸
    • Organizer
      多元研講演会-核酸医薬への展開を目指した人工核酸の新しいサイエンス
    • Place of Presentation
      仙台
    • Year and Date
      2007-05-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structural metal ions of nucleic acids(Oral)2007

    • Author(s)
      Yoshiyuki Tanaka
    • Organizer
      Tagen-ken Symposium
    • Place of Presentation
      Sendai (Japan)
    • Year and Date
      2007-05-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 核酸の構造形成に関わる金属イオン-NMR分光法で見る金属核酸相互作用(口頭)2007

    • Author(s)
      田中好幸
    • Organizer
      多元研講演会-核酸医薬への展開を目指した人工核酸の新しいサイエンス-
    • Place of Presentation
      仙台
    • Year and Date
      2007-05-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] DNA二重らせん構造中における水銀(II)を介したチミンの塩基対形成(口頭)2007

    • Author(s)
      田中好幸, 他5名
    • Organizer
      日本化学会第87春季年会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 水銀(II)を介したT-T塩基対を含むDNA二重らせん分子の溶液構造決定(ポスター)2007

    • Author(s)
      田中好幸, 他7名
    • Organizer
      日本薬学会第127年会
    • Place of Presentation
      富山
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 多核NMRにより核酸と金属が形成する化学結合を検出する:J-カップリング・化学シフトの利用(口頭)2007

    • Author(s)
      田中好幸
    • Organizer
      第7回蛋白質科学会ワークショップ-見えないものを見る, 蛋白質機能解明に向けてNMRは何ができるか?-
    • Place of Presentation
      仙台
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 水銀を介したT-T塩基対における窒素-水銀共有結合形成の可逆性に関する研究(口頭)2007

    • Author(s)
      内山朋美, 他9名
    • Organizer
      第34回生体分子科学討論会
    • Place of Presentation
      仙台
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 水銀を介したT-T塩基対の分光学的・熱力学的研究(口頭)2007

    • Author(s)
      田中好幸, 他9名
    • Organizer
      第22回生体機能関連化学シンポジウム
    • Place of Presentation
      仙台
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Structural and physicochemical features on the metal-mediated base pairs(口頭)2007

    • Author(s)
      田中好幸, 他11名
    • Organizer
      5th International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Formation of Hg(II)-mediated T-T base-pairs in a DNA duplex (Oral)2007

    • Author(s)
      Yoshiyuki Tanaka. Shuji Oda, Tomoyuki Komuro, Yoshinori Kondo, Hidetaka Torigoe Akira Ono
    • Organizer
      The annual meeting of the Chemical Society of Japan (The 87^<th> Spring Meeting)
    • Place of Presentation
      Osaka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structure determination of a DNA duplex with Hg(II)-mediated T-T base-pairs (Poster)2007

    • Author(s)
      Yoshiyuki Tanaka*, Shuji Oda, Tomoyuki Komuro, Hiroshi Yamaguchi, Megumi Kudo, Yoshinori Kondo, Hidetaka Torigoe and Akira Ono
    • Organizer
      The 127th, Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Toyama (Japan)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Detection of coordination bonds on nucleic acids-J-couplings and chemical shifts-(Symposist)2007

    • Author(s)
      Yoshiyuki Tanaka
    • Organizer
      The 7^<th> Annual meeting of the Protein Science Society of Japan
    • Place of Presentation
      Sendai (Japan)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Research on the reversibility of T-Hg(II)-T base-pairing (Oral)2007

    • Author(s)
      Tomomi Uchiyama, Tomoyuki Komuro, Takashi Miura, Hideo Takeuchi, Kaichiro Haruta, Takuya Kawamura, Shuji Oda, Hiroshi Yamaguchi, Yoshinori Kondo, Hidetaka Torigoe, Akira Ono and Yoshiyuki Tanaka
    • Organizer
      34th Symposium on Biomolecular Sciences
    • Place of Presentation
      Sendai (Japan)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Spectroscopic and thermodynamic studies on Hg(II)-mediated T-T base-pairs (Oral)2007

    • Author(s)
      Yoshiyuki Tanaka, Tomomi Uchiyama, Tomoyuki Komuro, Takashi Miura, Hideo Takeuchi, Kaichiro Haruta, Takuya Kawamura, Yoshinori Kondo, Hidetaka Torigoe and Akira Ono
    • Organizer
      22nd Symposium on Biofunctional Chemistry
    • Place of Presentation
      Sendai (Japan)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structural and physicochemical features on the metal-mediated base pairs (Oral)2007

    • Author(s)
      Yoshiyuki Tanaka, Shuji Oda, Hiroshi Yamaguchi, Kaichiro Haruta, Takuya Kawamura, Yoshinori Kondo, Tomomi Uchiyama, Takashi Miura, Hideo, Takeuchi, Hidetaka Tori goe, Chojiro Kojima, Akira Ono
    • Organizer
      5th International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      Tokyo (Japan)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of an enantiomeric DNA oligomer and its T-Hg^<II>-T base-pair formation(Poster)2007

    • Author(s)
      Kaichiro Haruta, Yoshiyuki Tanaka*, Takuya Kawamura, Yoshinori Kondo, Akira Ono, Hiroyuki Yamakoshi, Naoki Kanoh, Yoshiharu Iwabuchi*
    • Organizer
      5th International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      Tokyo(Japan)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structural and physicochemical features on the metal-mediated base pairs(口頭)2007

    • Author(s)
      田中好幸, 他11名
    • Organizer
      5th International Symposium on Nucleic A cids Chemistry
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] Synthesis of an enantiomeric DNA oligomer and its T-Hg^<II>-T base-pair formation(ポスター)2007

    • Author(s)
      春田佳一郎, 他7名
    • Organizer
      5th International Symposium on Nucleic A cids Chemistry
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] 水銀イオンを介したT-T塩基対の溶液構造解析(口頭発表)2006

    • Author(s)
      織田修司, 他6名
    • Organizer
      平成18年度日本生物物理学会東北支部研究発表会
    • Place of Presentation
      仙台
    • Year and Date
      2006-06-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structural studies on a DNA duplex including T-Hg-T base pairs (Oral)2006

    • Author(s)
      Shuji Oda, Hiroshi Yamaguchi, Megumi Kudo, Yoshinori Kondo, Chojiro Kojima, Akira Ono and Yoshiyuki Tanaka
    • Organizer
      Heisei 18th Tohoku-Shibu Meeting of Biophysical Society of Japan
    • Place of Presentation
      Sendai (Japan)
    • Year and Date
      2006-06-10
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 水銀イオンを介したT-T塩基対の三次元構造解析(ポスター)2006

    • Author(s)
      織田修司, 他6名
    • Organizer
      第3回東北大学バイオサイエンスシンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2006-05-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DNA-Hg complexのラマンスペクトルを用いた構造解析(ポスター)2006

    • Author(s)
      内山朋美, 他4名
    • Organizer
      第3回東北大学バイオサイエンスシンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2006-05-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Three-dimensional structure of DNA duplex including T-Hg-T base pairs (Poster)2006

    • Author(s)
      Shuji Oda, Hiroshi Yamaguchi, Megumi Kudo, Yoshinori Kondo, Chojiro Kojima, Akira Ono and Yoshiyuki Tanaka
    • Organizer
      3rd Tohoku Bioscience Symposium
    • Place of Presentation
      Sendai (Japan)
    • Year and Date
      2006-05-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structural studies on T-Hg-T base-pairs with Raman spectroscopy (Poster)2006

    • Author(s)
      Tomomi Uchiyama, Takashi Miura, Yoshiyuki Tanaka, Yoshinori Kondo and Hideo Takeuchi
    • Organizer
      3rd Tohoku Bioscience Symposium
    • Place of Presentation
      Sendai (Japan)
    • Year and Date
      2006-05-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 二重らせんDNA分子のHg(II)を介した塩基対形成(口頭)2006

    • Author(s)
      田中好幸, 他5名
    • Organizer
      第33回生体分子科学討論会
    • Place of Presentation
      名古屋
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 核酸塩基の金属を介した塩基対形成と二重らせん中における構造解析(口頭)2006

    • Author(s)
      田中好幸, 他6名
    • Organizer
      第21回生体機能関連化学シンポジウム(生体機能関連化学部会・バイオテクノロジー部会・生命化学研究会合同シンポジウム)
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Spectroscopic analysis of DNA duplex including T-Hg-T base pairs(ポスター)2006

    • Author(s)
      織田修司, 他5名
    • Organizer
      5th East Asian Biophysics Symposium
    • Place of Presentation
      沖縄
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 水銀(II)を介したT-T塩基対の構造化学研究(口頭)2006

    • Author(s)
      田中好幸, 他6名
    • Organizer
      第33回核酸化学シンポジウム
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DNA-銀(I)相互作用の分光学的解析(ポスター)2006

    • Author(s)
      織田修司, 他6名
    • Organizer
      第33回核酸化学シンポジウム
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of an enantiomeric DNA oligomer and its T-Hg^<II> base-pair formation(ポスター)2006

    • Author(s)
      春田佳一郎, 他7名
    • Organizer
      5th International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Base-pairing of thymines with mercury^<II> (Oral)2006

    • Author(s)
      Yoshiyuki Tanaka, Shuji Oda, Hiroshi Yamaguchi, Yoshinori Kondo, Chojiro Kojima and Akira Ono
    • Organizer
      33rd Symposium on Biomolecular Sciences
    • Place of Presentation
      Nagoya (Japan)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structural analyses of metel-mediated base pairs in DNA duplexes (Oral)2006

    • Author(s)
      Yoshiyuki Tanaka, Shuji Oda, Hiroshi Yamaguchi, Megumi Kudo, Yoshinori Kondo, Chojiro Kojima and Akira Ono
    • Organizer
      21st Symposium on Biofunctional Chemistry
    • Place of Presentation
      Kyoto (Japan)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Spectroscopic analysis of DNA duplex including T-Hg-T base pairs (Poster)2006

    • Author(s)
      Shuji Oda, Hiroshi Yamaguchi, Akira Ono, Chojiro Kojima, Yoshinori Kondo and Yoshiyuki Tanaka
    • Organizer
      5th East Asia Biophysics Symposium
    • Place of Presentation
      Okinawa(Japan)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structural analyses on the mercury^<II>-mediated T-T base pair (Oral)2006

    • Author(s)
      Yoshiyuki Tanaka*, Shuji Oda, Hiroshi Yamaguchi, Megumi Kudo, Yoshinori Kondo, Chojiro Kojima, Akira Ono
    • Organizer
      33rd Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      Osaka(Japan)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Spectroscopic analysis of Ag^I-DNA(Poster)2006

    • Author(s)
      Shuji Oda, Tomoyuki Komuro, Yoshinori Kondo, Chojiro Kojima, Akira Ono and Yoshiyuki Tanaka*
    • Organizer
      33rd Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      Osaka (Japan)
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Recent Research Developments in Physical Chemistry2007

    • Author(s)
      田中好幸, 他4名
    • Publisher
      Transworld Research Network, India
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.pharm.tohoku.ac.jp/~henkan/lab/tanaka/tanaka.html

    • Related Report
      2007 Final Research Report Summary
  • [Remarks]

    • URL

      http://www.pharm.tohoku.ac.jp/~henkan/lab/tanaka/tanaka.html

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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