A analysis of bone quality of growing rat mandible by a novel evaluation system
| Project/Area Number |
18560677
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Structural/Functional materials
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
FUJITANI Wataru Osaka University, Graduate School of Engineering, Technical Researcher (90379149)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NAKANO Takayoshi Osaka University, Graduate school of engineering, Associate Professor (30243182)
UMAKOSHI Yukichi Osaka University, Graduate School of Engineering, Professor (00029216)
|
|---|
| Project Period (FY) |
2006 – 2007
|
| Project Status |
Completed (Fiscal Year 2007)
|
| Budget Amount *help |
¥3,920,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2006: ¥2,100,000 (Direct Cost: ¥2,100,000)
|
|---|
| Keywords | bone quality / rat mandible / biological apatite(BAp) / preferred alignment of BAP / X-ray diffraction / in vivo stress distribution |
|---|
| Research Abstract |
We focused on the effect of growing and biting stress on the quality and quantity of rat and beagle mandible. The effect of the biting stress was analyzed just under the tooth root of biting and non-biting animal. The non-biting animal was achieved by tooth extraction. The preferred alignment of the c-axis in biological apatite (BAp) as a bone quality parameter was analyzed by means of the novel technique based on the X-ray diffraction.The volume and the density as conventional parameters for bone tissue were also evaluated. Following results were obtained from this research.
(1) The cross-sectional area of cortical bone monotonically increased with growing in both in rat and in beagle. However,the increase in bone density and the apatite alignment saturated earlier than that in cortical area.The distribution of the bone density and Bap alignment showed significantly varied depending on the position.
(2) In general in the mandible, the uni-directional BAp alignment along the mesiodistal axis could be found. However, just under the tooth root, Bap was aligned along the biting direction due to the applied biting stress. This result clearly represents Bap alignment is the parameter which can sensitively reflect the in vivo stress distribution.
(3) In the case of non-biting beagle mandible, quite different distribution of the bone density and BAp alignment was found. The lack of biting stress induced more homogenous distribution of bone density and Bap alignment.
We conclude that the change in the bone density and the BAp alignment is closely related to the degree of growing and in vivo stress distribution due to the biting. The BAp texture is sensitively controlled depending on the local stress distribution, as a result, bone tissue can exhibit effective mechanical function against the mechanical environment.
|
Report
(3 results)
Research Products
(27 results)
-
-
-
-
-
-
-
-
-
-
[Journal Article] 生体材料最適形状設計のための金属インプラント周囲ならびに一方向性孔内部に導入される新生骨の骨質評価2007
Author(s)
石本卓也, 中野貴由, 寒知子, 大橋芳夫, 藤谷渉, 馬越佑吉, 服部友一, 樋口裕一, 多根正和, 中嶋英雄
-
Journal Title
日本金属学会誌 Vol.71,No.4(in press)
NAID
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
