Mechanism and role of phagocytosis of dying cells and microbes

• Project/Area Number: 18570123
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Functional biochemistry
• Research Institution: Kanazawa University
• Principal Investigator: SHIRATSUCHI Akiko Kanazawa University, Graduate School of Medical Science, Associate Professor (90303297)
• Project Period (FY): 2006 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥3,960,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥360,000); Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2006: ¥2,400,000 (Direct Cost: ¥2,400,000)
• Keywords: phagocytosis / apoptosis / signal transduction / microbes / spermatogenesis / innate immunity / Toll-like receptor / influenza virus / Toll様受容体 / 貧食 / スカベンジャー受容体

Research Abstract

1) Mechanism and role of SR-BI-mediated apoptotic spermatogenic cells by Sertoli cells in the testis. After phagocytosis of apoptotic spermatogenic cells, testicular somatic Sertoli cells produced unknown factor(s) by which spermatogenic cells could differentiate into spermatozoa. To identify the factor, we selected one candidate protein by proteome analysis of Sertoli cells and identified its primary structure. We found that the expression of the factor was stimulated in transcriptional level during phagocytosis. We have been generating knockout mice of the factor, and we are going to examine the role of the factor on spermatogenesis in mice.
2) Role of TLR-JNK pathway on bacterial survival in macrophages Staphylococcus aureus induced JNK phosphorylation in mouse peritoneal macrophages depending on toll-like receptor TLR2. This activation of INK pathway caused inhibition of superoxide production in the macrophages, and this allowed engulfed S. aureus to survive in the macrophages.
3) Role of phagocytosis of influenza virus-infected cells by macrophages Influenza virus-infected cells produced macrophage-activating factor that enhance macrophage phagocytosis of virus-infected cells depending on both virus infection and apoptosis. This factor would be heat-labile material since it lost the activity after heat-treatment.

Research Products

• [Journal Article] Bridging effect of recombinant human mannose-binding lectin in macrophage phagocytosis of Eschericha coli. (2008)
  • Author(s): Shiratsuchi, A., Watanabe, I., Ju, J.-S., Lee, B.-L., and Nakanishi, Y.
  • Journal Title: Immunology (in press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Mechanisms and consequences of phagocytosis of influenza virus-infected cells. (2008)
  • Author(s): Nakanishi, Y., Hashimoto, Y., Takizawa, T., and Shiratsuchi, A.
  • Journal Title: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry (in press)
  • NAID: 120001130313
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Involvement of cannabinoid receptor CB2 in dectin-1-medicated macrophage phagocytosis. (2008)
  • Author(s): Shiratsuchi, A., Watanabe, I., Yoshida, H., and Nakanishi
  • Journal Title: Immunol. Cell Biol. 86 Pages: 179-184
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Mechanisms and roles of phagocytosis in invertebrates. (2008)
  • Author(s): Nakanishi, Y., and Shiratsuchi, A
  • Journal Title: Invertebrate Survival Journal (in press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Bridging effect of recombinant human mannose-binding lectin in macrophage phagocytosis of Eschericha coli (2008)
  • Author(s): Shiratsuchi, A., Watanabe, I., Ju, J.,-S., Lee, B.,-L., Nakanishi, Y
  • Journal Title: Immunology
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mechanisms and roles of phagocytosis in invertebrates (2008)
  • Author(s): Nakanishi, Y., Shiratsuchi, A
  • Journal Title: Invertebrate Survival Journal
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mechanisms and consequences of phagocytosis of influenza virus-infected cells (2008)
  • Author(s): Nakanishi, Y., Hashimoto, Y., Takizawa, T., Shiratsuchi, A
  • Journal Title: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
  • NAID: 120001130313
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] and Nakanishi Involvement of cannabinoi d receptor CB2 in dectin-l-mediated macrophage phagocytosis (2008)
  • Author(s): Shiratsuchi, A., Watanabe, I., Yoshida, H
  • Journal Title: Immunol. Cell Biol
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Bridging effect of recombinant human mannose-binding lectin in macrophage phagocytosis of Eschericha coli. (2008)
  • Author(s): Shiratsuchi, A., Watanabe, I., Ju, J.-S., Lee, B.-L., and Nakanishi, Y.
  • Journal Title: Immunology (掲載確定)(in press)
  • Peer Reviewed
• [Journal Article] Involvement of cannabinoid receptor CB2 in dectin-1-mediated macrophage phagocytosis (2008)
  • Author(s): Shiratsuchi, A., Watanabe, I., Yoshida, H., and Nakanishi
  • Journal Title: Immunol.Cell Biol. 86 Pages: 179-184
  • Peer Reviewed
• [Journal Article] Mechanisms and consequences of phagocytosis of influenza virus-infected cells (2008)
  • Author(s): Nakanishi, Y., Hashimoto, Y., Taldzawa, T., and Shiratsuchi, A.
  • Journal Title: Anti-lnflammatory & Anti-Allergy Agents in Medicinal Chemistry (掲載確定)(in press)
  • NAID: 120001130313
  • Peer Reviewed
• [Journal Article] TLR2-mediated survival of Staphylococcus aureus in macrophages: a novel bacterial strategy against host innate immunity. (2007)
  • Author(s): Watanabe, I., Ichiki, M., Shiratsuchi, A., and Nakanishi, Y.
  • Journal Title: J. Immunol. 178 Pages: 4917-4925
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Participation of nitric oxide reductase in survival of Pseudomonas aeruginosa in LPS-activated macrophages. (2007)
  • Author(s): Kakishima, K., Shiratsuchi, A., Taoka, A., Nakanishi, Y., and Fukumori, Y.
  • Journal Title: Biochem. Biophys. Res. Commun. 355 Pages: 587-591
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Evidence for phagocytosis of influenza virus-infected, apoptotic cells by neutrophils nad macrophages in mice. (2007)
  • Author(s): Hashimoto, Y., Moki, T., Takizawa, T., Shiratsuchi, A., and Nakanishi, Y.
  • Journal Title: J. Immunol. 178 Pages: 2448-2457
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Identification of calreticulin as a marker for phagocytosis of apoptotic cells in Drosophila. (2007)
  • Author(s): Kuraishi, T., Manaka, J., Shiratsuchi, A., Nakanishi, Y., 他5名
  • Journal Title: Exp. Cell Res. 313 Pages: 500-510
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Perturbation of spermatogenesis by androgen antagonists directly injected into seminiferous tubules of live mice. (2007)
  • Author(s): Nagaosa, K., Kishimoto, A., Kizu, R., Nakagawa, A. Shiratsuchi, A., and Nakanishi, Y.
  • Journal Title: Reproduction 133 Pages: 21-27
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] TLR2-mediated survival of Staphylococcus aureu s in macrophages : a novel bacterial strategy against he st innate immunity (2007)
  • Author(s): Watanabe, I., Ichiki, M., Shiratsuchi, A., Nakanishi, Y
  • Journal Title: J. Immunol 077 Pages: 4917-4925
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Participation of nitric oxide reductase in survival of Pseudomonas aeruginosa in LPS-activated macrophages (2007)
  • Author(s): Kakishima, K., Shiratsuchi, A., Taoka, A., Nakanishi, Y., Fulcumori, Y
  • Journal Title: Biochem. Biophys. Res. Commun 355 Pages: 587-591
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Evidence for phagocytosis of influe nza virus-infected, apoptotic cells by neutrophils and macrophages in mice (2007)
  • Author(s): Hashimoto, Y., Moki, T.,Takizawa,T., Shiratsuchi, A., Nakanishi, Y
  • Journal Title: J. Immunol 078 Pages: 2448-2457
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification of calreticulin as a marker for phagocytosis of apoptotic cells in Drosophila (2007)
  • Author(s): Kuraishi, T., Manaka, J., Shiratsuchi, A., Nakanishi, Y., et. al.
  • Journal Title: Exp. Cell Res 313 Pages: 500-510
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Perturbation of sper matogenesis by androgen antagonists directly injected i nto seminiferous tubules of live mice (2007)
  • Author(s): Nagaosa, K., Kishimoto, A., Kin, R., Nakagawa, A., Shiratsuchi, A., Nakanishi, Y
  • Journal Title: Reproduction 133 Pages: 21-27
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Evidence for class scavenger receptor type I-mediated engulf ment of apoptotic spermatogenic cells by testicular Ser toli cells (2007)
  • Author(s): Osada, Y., Shiratsuchi, A., Nakanishi, Y
  • Journal Title: Exp. Cell Res 312 Pages: 1820-1830
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] TLR2-mediated survival of Staphylococcus aureus in macrophages: a novel bacterial strategy against host innate immunity (2007)
  • Author(s): Watanabe, I., Ichiki, M., Shiratsuchi A., and Nakanishi, Y.
  • Journal Title: J.Immunol 178 Pages: 4917-4925
  • Peer Reviewed
• [Journal Article] Participation of nitric oxide reductase in survival of Pseudomonas aeruginosa in LPS-activated macrophages (2007)
  • Author(s): Kakishima, K., Shiratsuchi. A., Taoka, A., Nakanishi, Y., and Fukumori, Y.
  • Journal Title: Biochem.Biophys.Res.Commun. 355 Pages: 587-591
  • Peer Reviewed
• [Journal Article] Evidence for phagocytosis of influenza virus-infected,apoptotic cells by neutrophils and macrophages in mice (2007)
  • Author(s): Hashimoto, Y., Moki, T., Taldzawa, T., Shiratsuchi, A., and Nakanishi, Y.
  • Journal Title: J.Immunol 178 Pages: 2448-2457
  • Peer Reviewed
• [Journal Article] Identification of calreticulin as a marker for phagocytosis of apoptotic cells in Drosophila (2007)
  • Author(s): Kuraishi, T., Manaka, J., Shiratsuchi A., Nakanishi, Y 他5名
  • Journal Title: Exp.Cell Res. 313 Pages: 500-510
  • Peer Reviewed
• [Journal Article] Perturbation of spermatogenesis by androgen antagonists directly injected into seminiferous tubules of live mice (2007)
  • Author(s): Nagaosa, K., Kishimoto, A., Kizu, R., Nakagawa, A. Shiratsuchi, A., and Nakanishi, Y.
  • Journal Title: Reproducrion 133 Pages: 21-27
  • Peer Reviewed
• [Journal Article] Elimination of influenza virus-infected cells byapoptosis-dependent (2007)
  • Author(s): Hashimoto, Y., Moki, T., Shiratsuchi, A., Takizawa, T., Nakanishi,Y.
  • Journal Title: J.Immunol (in press)
• [Journal Article] Identification of calreticulin as a marker for phagocytosis of apoptotic cells in Drosophila. (2007)
  • Author(s): Kuraishi, T., Manaka, J., Kono, M., Ishii, H., Yamamoto, N., Koizumi, K., Shiratsuchi, A., Lee, B.-L., Higashida, H., Nakanishi,Y.
  • Journal Title: Exp. Cell Res. (in press)
• [Journal Article] Mechanisms and roles of phagocytosis in invertebrates. (2007)
  • Author(s): Nakanishi, Y., Shiratsuchi, A
  • Journal Title: Invertebrate Survival Journal (in press)
• [Journal Article] Evidence for class B scavenger receptor type I-mediated engulfment of apoptotic spermatogenic cells by testicular Sertoli cells. (2006)
  • Author(s): Osada, Y., Shiratsuchi, A. and Nakanishi, Y.
  • Journal Title: Exp. Cell Res. 312 Pages: 1820-1830
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Perturbation of spematogenesis by androgen antagonists directly injected into seminiferous tubules of live mice. (2006)
  • Author(s): Nagaosa, K., Kishimoto, A., Kizu, R., Nakagawa, A., Shiratsuchi, A., Nakanishi,Y.
  • Journal Title: Reproduction 133 Pages: 1-8
• [Journal Article] Evidence for class B scavenger receptor type I-mediated englfment of apoptotic spermatogenic cells by testicular Sertoli cells. (2006)
  • Author(s): Osada, Y., Shiratsuchi, A., Nakanishi, Y.
  • Journal Title: Exp. Cell Res 312 Pages: 1820-1830
• [Presentation] Dectin-1を介するマクロファージ貪食作用のカンナビノイド受容体CB2による調節 (2007)
  • Author(s): 白土明子, 渡邉郁子, 中西義信
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Nakanishi Regulation o : Dectin-l-mediated phagocytosis by cannabinoid receptor CB2 (2007)
  • Author(s): A. Shiratsuchi, I. Watanabe, Y
  • Organizer: 30th BMB annunal meeting
  • Place of Presentation: Yokohama
  • Year and Date: 2007-12-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Study of inflammation in seminiferous tubules in the testis (2007)
  • Author(s): K. Nagaosa, A. Shiratsuchi, Y. Nakanishi, et. al.
  • Organizer: 30th BMB annunal meeting
  • Place of Presentation: Yokohama
  • Year and Date: 2007-12-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Phagocytic elimination of influenza virus-infected cells by phagocytes in mice (2007)
  • Author(s): Y. Hashimoto, A. Shiratsuchi, Y. Nakanishi, et. al.
  • Organizer: 30th BMB annunal meeting
  • Place of Presentation: Yokohama
  • Year and Date: 2007-12-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] TLR2 ant JNK-mediated inhibition of killing of S. aureus in the macrophages (2007)
  • Author(s): I. Watanabe, A. Shiratsuchi, Y. Nakanishi, et. al.
  • Organizer: 30th BMB annunal meeting
  • Place of Presentation: Yokohama
  • Year and Date: 2007-12-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Identification of a ligand for Draper, a Drosophila phagocytic receptor (2007)
  • Author(s): T. Kuraishi, A. Shiratsuchi, Y. Nakanishi, et. al.
  • Organizer: 30th BMB annunal meeting
  • Place of Presentation: Yokohama
  • Year and Date: 2007-12-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Dectin-1を介するマクロファージ貧食作用のカンナビノイド受容体CB2による調節 (2007)
  • Author(s): 白土明子, 渡邉郁子, 中西義信
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-15
• [Presentation] マウスにおけるインフルzンザウイルス感染アポトーシス細胞の貧食除去 (2007)
  • Author(s): 橋本優実, 茂木武, 滝澤剛則, 白土明子, 中西義信
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-15
• [Presentation] ショウジョウバエ貧食受容体Draperが認識するアポトーシス細胞表層分子の同定 (2007)
  • Author(s): 倉石貴透, 山本奈央子, 上田晃一, 中山洋, 橋本優実, 白土明子, 中西義信
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-15
• [Presentation] 精細管内の細菌に対する免疫応答の解析 (2007)
  • Author(s): 永長一茂, 中嶋千恵, 長田洋一, 岸本淳司, 白土明子, 中西義信
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] マウスにおけるインフルエンザウイルス感染アポトーシス細胞の貪食除去 (2007)
  • Author(s): 橋本優実, 茂木武, 滝澤剛則, 白土明子, 中西義信
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] TLR2とJNKを介したマクロファージ内での黄色ブドウ球菌の殺菌阻害 (2007)
  • Author(s): 渡邉郁子, 一木万奈美, 白土明子, 中西義信
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ショウジョウバエ貪食受容体Draperが認識するアポトーシス細胞表層分子の同定 (2007)
  • Author(s): 倉石貴透, 山本奈央子, 上田晃一, 中山洋, 橋本優実, 白土明子, 中西義信
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 細菌による免疫機構の乗っ取り:TLR2を介した黄色ブドウ球菌のマクロファージ内での生存 (2007)
  • Author(s): 白土明子
  • Organizer: 第18回フォーラム・イン・ドージン
  • Place of Presentation: 熊本
  • Year and Date: 2007-11-29
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] TLR2-mediated survival of S. aureus in macrophages (2007)
  • Author(s): A. Shiratsuchi
  • Organizer: 18th Forum in Dojin
  • Place of Presentation: Kumamoto
  • Year and Date: 2007-11-29
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] マクロファージに貪食された黄色ブドウ球菌のToll様受容体TLR2経路を介する生存:細菌の宿主自然免疫に対する新たな戦略 (2007)
  • Author(s): 白土明子, 渡辺郁子, 一木万奈美, 中西義信
  • Organizer: 第19回微生物シンポジウム:発展する微生物科学
  • Place of Presentation: 東京
  • Year and Date: 2007-09-08
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] マクロファージに貧食された黄色ブドウ球菌のToll様受容体TLR2.経路を介する生存:細菌の宿主自然免疫に対する新たな戦略 (2007)
  • Author(s): 白土明子, 渡辺郁子, 一木万奈美, 中西義信
  • Organizer: 第19回微生物シンポジウム:発展する微生物科学
  • Place of Presentation: 東京
  • Year and Date: 2007-09-08
• [Presentation] A novel bacterial strategy against macrophage phagocytic killing (2007)
  • Author(s): A. Shiratsuchi, I. Watanabe, Y. Nakanishi
  • Organizer: 19th Symposium on Microbial Sciences
  • Place of Presentation: Tokyo
  • Year and Date: 2007-09-07
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 精細管への微量注入法を用いた化学物質の精巣毒性評価法の開発 (2007)
  • Author(s): 永長一茂, 岸本淳司, 木津良一, 中川彰久, 白土明子, 中西義信
  • Organizer: 日本アンドロロジー学会第25回学術大会
  • Place of Presentation: 加賀
  • Year and Date: 2007-07-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Purturbation of spermatogenesis by androgen antagonists directly injected into seminiferous tubules of mice (2007)
  • Author(s): K. Nagaosa, A. Shiratsuchi, Y. Nakanishi, et. al.
  • Organizer: 25th Annual Meeting of The Japan Society of Andorology
  • Place of Presentation: Kaga
  • Year and Date: 2007-07-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Isolation of an endoplasimic reticulum protein as a candidate ligand for Draper, a Drosophila phagocytosis receptor (2007)
  • Author(s): Kuraishi, T, Yamamoto, N., Shiratsuchi, A., Yoshinobu Nakanishi, 他4名
  • Organizer: 第8回日本ショウジョウバエ研究集会
  • Place of Presentation: 淡路
  • Year and Date: 2007-07-02
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Isolation of an endoplasminc reticulum protein as a candidate ligand for Draper, a Drosophila phagocytosis receptor (2007)
  • Author(s): Kuraishi,T., Yamamoto, N., Shiratsuchi, A., Yoshinobu, Nakanishi, et. al.
  • Organizer: 8th Japan Drosophila Meeting
  • Place of Presentation: Awaji, Japan
  • Year and Date: 2007-07-02
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Isolation of an endoplasimic reticulum protein as a candidate ligand for Draper,a Drosophila phagocytosis receptor (2007)
  • Author(s): Kuraishi, T, Yamatnoto, N., Shiratsuchi, A. Yoshinobu Nakanishi 他4名
  • Organizer: 第8回日本ショウジョウバエ研究集会
  • Place of Presentation: 淡路
  • Year and Date: 2007-07-02
• [Presentation] TLR2-mediated survival of Staphylococcus aureus in macrophatges (2007)
  • Author(s): Shiratsuchi, A., Watanabe, I., Ichiki, M., and Nakanishi, Y.
  • Organizer: Gordon Conference: Apoptotic Cell Recognition and Clearance
  • Place of Presentation: Maine, USA
  • Year and Date: 2007-06-20
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] TLR2-mediated survival of Staphylococcus aureus in macro phatges (2007)
  • Author(s): Shimtsuchi, A., Watanabe, I., Ichiki, M., Nakanishi, Y
  • Organizer: Gordon Conference : Apoptotic Cell Recognition and Clearance
  • Place of Presentation: Maine, USA
  • Year and Date: 2007-06-20
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] TLR2-mediated survival of Staphylococcus aureus in macrophatges (2007)
  • Author(s): Shiratsuchi, A., Watanabe, I., Ichiki, M., and Nakanishi, Y.
  • Organizer: Gordon Conference: Apoptotic Cell Recognition and Clearance
  • Place of Presentation: Maine,USA
  • Year and Date: 2007-06-19
• [Presentation] TLR2-mediated survival of Staphylococcus aureus in macrophages: a novel bacterial strategy against host innate immunity (2007)
  • Author(s): Shiratsuchi, A.
  • Organizer: 19th FAOBMB Seoul Conference: Symposium Innate Immunity
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2007-05-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] TLR2-mediated survival of Staphylococcus a ureus in macrophages : a novel bacterial strategy against hos t innate immunity (2007)
  • Author(s): Shiratsuchi, A
  • Organizer: 19th FAOBMB Seoul Conference : Symposium Innate Immunity
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2007-05-28
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] TLR2-mediated survival of Staphylococcus aureus in macrophages: a novel bacterial strategy against host innate immunity (2007)
  • Author(s): Shiratsuchi. A.
  • Organizer: 19th FAOBMB Seoul Conference: Symposium Innate Immunrty
  • Place of Presentation: Seoul,Korea
  • Year and Date: 2007-05-27
• [Presentation] アナンダミド前駆体N-アシルホスファチジルエタノールアミンのマクロファージ貪食抑制効果 (2007)
  • Author(s): 一木万奈美, 白土明子, 岡本安雄, 上田夏生, 中西義信
  • Organizer: 日本生化学会北陸支部第25回大会
  • Place of Presentation: 金沢
  • Year and Date: 2007-05-26
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Inhibitory effect of NPPE on macrophage phagocytosis (2007)
  • Author(s): M. Ichiki, A. Shimtsuchi, Y. Nakanishi, et. al.
  • Organizer: 25th Annual Meeting of BMB Hokuriku Branch
  • Place of Presentation: Kanazawa
  • Year and Date: 2007-05-26
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] アナンダミド前駆体革アシルボスファチジルエタノールアミンのマクロファージ食食抑制効果 (2007)
  • Author(s): 一木万奈美, 白土明子, 岡本安雄, 上田夏生, 中西義信
  • Organizer: 日本生化学会北陸支部第25回大会
  • Place of Presentation: 金沢
  • Year and Date: 2007-05-26
• [Presentation] クラスBスカベンジャー受容体タイプIを介したアポトーシス細胞の細胞内情報経路の解析 (2007)
  • Author(s): 砂谷俊郎, 長田洋一, 白土明子, 中西義信
  • Organizer: 日本薬学会第127年会
  • Place of Presentation: 富山
  • Year and Date: 2007-03-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] マクロファージ内での黄色ブドウ球菌のToll様受容体TLR2による抑制 (2006)
  • Author(s): 一木万奈美, 渡辺郁子, 白土明子, 中西義信
  • Organizer: 日本薬学会北陸支部会
  • Place of Presentation: 金沢
  • Year and Date: 2006-07-08
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] インフルエンザ発症マウス肺組織でのウイルス感染細胞の貪食とウイルス除去 (2006)
  • Author(s): 茂木武, 橋本優実, 滝澤剛則, 白土明子, 中西義信
  • Organizer: 日本薬学会北陸支部会
  • Place of Presentation: 金沢
  • Year and Date: 2006-07-08
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Inhibition o killing of S. aureus in macrophages (2006)
  • Author(s): M. Ichiki, A. Shiratsuchi, Y. Nakanishi, et. al.
  • Organizer: 2006 Meeting of The Pharmaceutical Society of Japan, Hokuriku Branch
  • Place of Presentation: Kanazawa
  • Year and Date: 2006-07-08
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Phagocytosis of influenza virus-infected cells in the lung of mice (2006)
  • Author(s): T. Moki, A. Shiratsuchi, Y. Nakanishi, et. al.
  • Organizer: 2006 Meeting of The Pharmaceutical Society of Japan, Hokuriku Branch
  • Place of Presentation: Kanazawa
  • Year and Date: 2006-07-08
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Toll-like receptor 2-mediated resistance of Staphylocuccus aureus against phagocytic killing in macrophages (2006)
  • Author(s): A. Shiratsuchi, I. Watanabe, I.Ichiki, and Y. Nakanishi
  • Organizer: 第20回国際生化学分子生物学会
  • Place of Presentation: 京都
  • Year and Date: 2006-06-19
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Nakanishi Toll-like receptor 2-mediated resistance of Staphylococcus aureus against phagocytic killing in macrophages (2006)
  • Author(s): A. Shiratsuchi, I. Watanabe, I. Ichiki, Y
  • Organizer: 20th IUBMB annunal meeting
  • Place of Presentation: Kyoto
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Intracellular signaling for SR-BI-mediated phagocytosis of apoptotic cells
  • Author(s): T. Sunatani, A. Shimtsuchi, Y. Nakanishi, et. al.
  • Organizer: 127th Annual Meeting of The Pharmaceutical Society of Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] Pattern recognition in phagocytic clearance of altered self. In: Target Pattern Recognition in Innate Immunity, chapter 11 (2006)
  • Author(s): Nakanishi, Y., Henson, P. M., and Shiratsuchi, A
  • Total Pages: 10
  • Publisher: Landes Bioscience, Austin
  • Description: 「研究成果報告書概要(和文)」より
• [Remarks] 「研究成果報告書概要(和文)」より
  • URL: http://www.p.kanazawa-u.ac.jp/lab/seitai.html