Research Project
Grant-in-Aid for Scientific Research (C)
Stem cells are responsible for replacing damaged or dying cells in various adult tissues throughout a lifetime. They possess great potential for further regenerative medicine. However, the molecular mechanisms governing stem cell regulation are still poorly understood. It is well thought that stem cell behavior is controlled by specialized microenvironments called niche. The Drosophila testis has provided one of the excellent stem cell systems to study how this niche regulates stem cell self-renewal, differentiation and proliferation.We and many other researchers demonstrated that both BMP-smad and JAK-STAT signaling are essential for maintaining germ-line stem cells in the Drosophila testis. In this study, we showed that localization of BMP using several different approaches. We also showed that and indirectly JAK-STAT signaling is required for the maintenance of germ-line stem cells.Furthermore, we have tried to introduce the niche concept in embryonic stem cells in culture.
All 2009 2008 2007 2006 Other
All Journal Article (10 results) (of which Peer Reviewed: 5 results) Presentation (11 results) Book (1 results)
Cell Stem Cell 2
Pages: 39-49
Biochem Biophys Res Commun. 375
Pages: 27-32
Am J Physiol. Gastrointest. Liver Physiol. 295
Am. J Physiol. Gastrointest. Liver Physi 295
Stem Cells 24
Pages: 2566-2572
Pages: 2566-2566
