• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular and structural biostudies on streptococcalinyasion/infection mechanisms to host cells through degradation of extracellular matrices glyoceaminoglycans

Research Project

Project/Area Number 18580075
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied microbiology
Research InstitutionKyoto University

Principal Investigator

HASHIMOTO Wataru  Kyoto University, Grad. Schl.Agric, Associate Professor (30273519)

Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,880,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsStreptococcus / Glycosaminoalycan / Polysaccharide lyase / Unsaturated glucuronyl hydrolase / Invasion / infection mechanism / X-ray crystallography / Sulfated saccharide / Extracellular matrix / コンドロイチン / ヒアルロン酸リアーゼ / 遺伝子クラスター
Research Abstract

Some pathogenic microorganisms produce polysaccharide-degrading enzymes (lyases and hydrolases) to invade mammalian and/or plant cells. Mammalian glycosaminoglycans that form part of cell surface matrix are typical targets for microbial enzymes. Unsaturated glucuronyl hydrolase (UGL), which was genetically first identified in Bacillus sp. strain GL1, catalyzes the hydrolytic release of an unsaturated uronic acid from oligosaccharides produced through the reaction of the matrix-degrading polysaccharide lyases (e.g., hyaluronate and chondroitin lyases), suggesting that these enzymes function as a virulent factor in microbial infection. In this study, structure and function relationship of glycosaminoglycan-degrading enzymes, lyase and hydrolase, was analyzed.
Based on X-ray crystallography of enzyme-substrate complexes and site-directed mutagenesis, mechanisms for catalytic reaction and substrate recognition of hyaluronate lyase homologue (xanthan lyase) were clarified. A single tyrosine … More residue abstracts C5-proton of the uronate residue at subsite +1 and donates the proton to glycosidic bond to be cleaved.
In contrast with general glycoside hydrolases with the retention or inversion catalytic mechanism of an anomeric configuration, UGL uniquely triggers hydrolysis of vinyl ether groups in the unsaturated uronate residue but not of the glycosidic bond.
Recent complete genome sequence analyses indicate that a large number of microorganisms ranging from bacteria to fungi (over 70 species) have a UGL homologous gene in their genome. In the Carbohydrate-Active enZyme (CAZy) database, UGL and its homologues form a new family, GH-88. Microbial producers of UGL include pathogenic bacteria such as clostridia, streptococci, and vibrios. The enzyme homologous gene has been found especially in streptococci, Streptococcus agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes, and Streptococcus suis. Unlike the bacillus UGL, streptococcal UGL acts on unsaturated chondroitin disaccharide with a sulfate group at C4 of GalNAc. Less

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (55 results)

All 2008 2007 2006

All Journal Article (31 results) (of which Peer Reviewed: 17 results) Presentation (22 results) Book (2 results)

  • [Journal Article] Crystal structure of YihS in complex with D-mannose: Structural annotation of Escherichia coli and Salmonella enterica yihS-encoded proteins to an aldose-ketose isomerase2008

    • Author(s)
      Takafumi Itoh
    • Journal Title

      Journal of Molecular Biology 377

      Pages: 1443-1459

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Superchannel of bacteria: biological significance and new horizons2008

    • Author(s)
      Kousaku Murata
    • Journal Title

      Bioscience, Biotechnology and Biochemistry 72

      Pages: 265-277

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Crystal structure of YihS in complex with D-mannose : Structural annotation of Escherichia coli and Salmonella enterica yihS-encoded proteins to an aldose-ketose isomerase2008

    • Author(s)
      Takafumi, Itoh, Bunzo, Mikami, Wataru, Hashimoto, Kousaku, Murata
    • Journal Title

      Journal of Molecular Biology 377

      Pages: 1443-1459

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Superchannel of bacteria : biological significance and new horizons2008

    • Author(s)
      Kousaku, Murata, Shigeyuki, Kawai, Bunzo, Mikami, Wataru, Hashimoto
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry 72

      Pages: 265-277

    • NAID

      10027523626

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Crystal structure of YihS in complex with D-mannose:Structural annotation of Escherichia coli and Salmonella enterica yihS-encoded proteins to an aldose-ketose isomerase2008

    • Author(s)
      Takafumi Itoh
    • Journal Title

      Journal of Molecular Biology 377

      Pages: 1443-1459

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of a novel bacterial cell-surface flagellin binding to polysaccharide2008

    • Author(s)
      Yukie Maruyama
    • Journal Title

      Biochemistry 47

      Pages: 1393-1402

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydration of vinyl ether groups by unsaturated glycoside hydrolases and their role in bacterial pathogenesis2007

    • Author(s)
      Wataru Hashimoto
    • Journal Title

      International Microbiology 10

      Pages: 233-243

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A structural factor responsible for substrate recognition by Bacillus sp. GL1 xanthan lyase that acts specifically on pyruvated side chains of xanthan2007

    • Author(s)
      Yukie Maruyama
    • Journal Title

      Biochemistry 46

      Pages: 781-791

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Hydration of vinyl ether groups by unsaturated glycoside hydrolases and their role in bacterial pathogenesis2007

    • Author(s)
      Wataru, Hashimoto, Takafumi, Itoh, Yukie, Maruyama, Bunzo, Mikami, Kousaku, Murata
    • Journal Title

      International Microbiology 10

      Pages: 233-243

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A structural factor responsible for substrate recognition by Bacillus sp. GL1 xanthan lyase that acts specifically on pyruvated side chains of xanthan2007

    • Author(s)
      Yukie, Maruyama, Bunzo, Mikami, Wataru, Hashimoto, Kousaku, Murata
    • Journal Title

      Biochemistry 46

      Pages: 781-791

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Crystal structure of glycoside hydrolase family 78 α-L-rhamnosidase from Bacillus sp. GL 12007

    • Author(s)
      Zhongli Cui
    • Journal Title

      Journal of Molecular Biology 374

      Pages: 384-398

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel structural fold in polysaccharide lyases:Bacillus subtilis family 11rhamnogalacturonan lyase YesW with an eight-bladed β-propeller2007

    • Author(s)
      Akihito Ochiai
    • Journal Title

      Journal of Biological Chemistry 282

      Pages: 37134-37145

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plant cell wall degradation by saprophytic Bacillus subtilis:gene clusters responsible for rhamnogalacturonan depolymerization2007

    • Author(s)
      Akihito Ochiai
    • Journal Title

      Journal of Molecular Biology 374

      Pages: 384-398

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A structural factor responsible for substrate recognition by Bacillus sp. GLl xanthanlyase that acts specifically on pyruvated side chains of xanthan2007

    • Author(s)
      Yukie Maruyama
    • Journal Title

      Biochemistry 46

      Pages: 781-791

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 細菌器官の分子移植と環境浄化2007

    • Author(s)
      橋本 渉
    • Journal Title

      化学と生物 45

      Pages: 320-329

    • NAID

      10020174077

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bacterial proteins and CpG-rich exrtachromosomal DNA in potential cancer therapy2007

    • Author(s)
      Magdy Mahfouz
    • Journal Title

      Plasmid 57

      Pages: 4-17

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cupredoxin-cancer interrelationship:azurjn binding with EphB2, interference in EphB2 tyrosine phosphorylation, and inhibition of cancer growth2007

    • Author(s)
      Anita Chaudhari
    • Journal Title

      Biochemistry 46

      Pages: 781-791

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A structural factor responsible for substrate recognition by Bacillus sp. GL1 xanthan lyase that acts specifically on pyruvated side chains of xanthan2007

    • Author(s)
      Yukie Maruyama
    • Journal Title

      Biochemistry 46・3

      Pages: 781-791

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Structure of unsaturated rhamnogalacturonyl hydrolase complexed with substrate2006

    • Author(s)
      Takafumi Itoh
    • Journal Title

      Biochemical and Biophysical Research Communications 347

      Pages: 1021-1029

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Crystal structure of unsaturated glucuronyl hydrolase complexed with substrate: Molecular insights into its catalytic reaction mechanism2006

    • Author(s)
      Takafumi Itoh
    • Journal Title

      Journal of Biological Chemistry 281

      Pages: 29807-29816

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A novel glycoside hydrolase family 105: The structure of family 105 unsaturated rhamnogalacturonyl hydrolase complexed with a disaccharide in comparison with family 88 enzyme complexed with the disaccharide2006

    • Author(s)
      Takafumi Itoh
    • Journal Title

      Journal of Molecular Biology 360

      Pages: 573-585

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Substrate recognition by unsaturated glucuronyl hydrolase from Bacillus sp. GL12006

    • Author(s)
      Takafumi Itoh
    • Journal Title

      Biochemical and Biophysical Research Communications 344

      Pages: 253-262

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Structure of unsaturated rhamnogalacturonyl hydrolase complexed with substrate2006

    • Author(s)
      Takafumi, Itoh, Akihito, Ochiai, Bunzo, Mikami, Wataru, Hashimoto, Kousaku, Murata
    • Journal Title

      Biochemical and Biophysical Research Communications 347

      Pages: 1021-1029

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Crystal structure of unsaturated glucuronyl hydrolase complexed with substrate : Molecular insights into its catalytic reaction mechanism2006

    • Author(s)
      Takafumi, Itoh, Wataru, Hashimoto, Bunzo, Mikami, Kousaku, Murata
    • Journal Title

      Journal of Biological Chemistry 281

      Pages: 29807-29816

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A novel glycoside hydrolase family 105 : The structure of family 105 unsaturated rhamnogalacturonyl hydrolase complexed with a disaccharide in comparison with family 88 enzyme complexed with the disaccharide2006

    • Author(s)
      Takafumi, Itoh, Akihito, Ochiai, Bunzo, Mikami, Wataru, Hashimoto, Kousaku, Murata
    • Journal Title

      Journal of Molecular Biology 360

      Pages: 573-585

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Substrate recognition by unsaturated glucuronyl hydrolase from Bacillus sp. GL12006

    • Author(s)
      Takafumi, Itoh, Wataru, Hashimoto, Bunzo, Mikami, Kousaku, Murata
    • Journal Title

      Biochemical and Biophysical Research Communications 344

      Pages: 253-262

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Structure of unsaturated rhamnogalacturonyl hydrolase complexed with substrate2006

    • Author(s)
      Takafumi Itoh
    • Journal Title

      Biochemical and Biophysical Research Communication 347・4

      Pages: 1021-1029

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Crystal structure of unsaturated glucuronyl hydrolase complexed with substrate : Molecular insights into its catalytic reaction mechanism2006

    • Author(s)
      Takafumi Itoh
    • Journal Title

      Journal of Biological Chemistry 281・40

      Pages: 29807-29816

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A novel glycoside hydrolase family 105 : The structure of family 105 unsaturated rhamnogalacturonyl hydrolase complexed with a disaccharide in comparison with family 88 enzyme complexed with the disaccharide2006

    • Author(s)
      Takafumi Itoh
    • Journal Title

      Journal of Molecular Biology 360・3

      Pages: 573-585

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A biosystem for alginate metabolism in Agrobacterium tumefaciens strain C58 : Molecular identification of Atu3025 as an exotype family PL-15 alginate lyase2006

    • Author(s)
      Akihito Ochiai
    • Journal Title

      Research in Microbiology 157・7

      Pages: 642-649

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Substrate recognition by unsaturated glucuronyl hydrolase from Bacillus sp. GL12006

    • Author(s)
      Takafumi Itoh
    • Journal Title

      Biochemical and Biophysical Research Communication 344・1

      Pages: 1021-1029

    • Related Report
      2006 Annual Research Report
  • [Presentation] サルモネラ菌由来機能不明タンパク質YihSの構造・機能解析:ポスト構造ゲノミクスに向けて2008

    • Author(s)
      伊藤貴文
    • Organizer
      日本農芸化学会平成20年度大会
    • Place of Presentation
      名城大学
    • Year and Date
      2008-03-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structural and functional analysis of Salmonella enterica YihS with function unknown : Road map for post-structural genomics2008

    • Author(s)
      Takafumi, Itoh, Bunzo, Mikami, Wataru, Hashimoto, Kousaku, Murata
    • Organizer
      Annual Meeting of Japan Society for Bioscience, Biotechnology, and Agrochemistry
    • Place of Presentation
      Meijo University
    • Year and Date
      2008-03-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 多糖リアーゼにおけるエンド型/エキソ型の作用様式に関わる構造要因:ポスト構造ゲノミクスに向けて2008

    • Author(s)
      落合秋人
    • Organizer
      日本農芸化学会
    • Place of Presentation
      名城大学
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] ファミリーGH73ペプチドグリカン分解酵素の機能・構造解析2008

    • Author(s)
      橋本 渉
    • Organizer
      日本農芸化学会
    • Place of Presentation
      名城大学
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] サルモネラ菌由来機能不明タンパク質YihSの構造・機能解析:ポスト構造ゲノミクスに向けて2008

    • Author(s)
      伊藤貴文
    • Organizer
      日本農芸化学会
    • Place of Presentation
      名城大学
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] 細菌由来メタロペプチダーゼファミリーM16酵素の構造・機能解析2008

    • Author(s)
      丸山如江
    • Organizer
      日本農芸化学会
    • Place of Presentation
      名城大学
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] 微生物による海洋資源アルギン酸のバイオエネルギーへの変換2008

    • Author(s)
      村田幸作
    • Organizer
      日本農芸化学会
    • Place of Presentation
      名城大学
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] 窒素固定細菌Azotobacter vinelandiiの窒素と酸素に対する分子応答2008

    • Author(s)
      宮本裕希子
    • Organizer
      日本農芸化学会関西支部第453会講演会
    • Place of Presentation
      京大会館
    • Year and Date
      2008-02-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] 植物細胞壁分解酵素ラムノガラクツロナンリアーゼの分子変換:エキソ型からエンド型へ2007

    • Author(s)
      落合秋人
    • Organizer
      日本生物工学会
    • Place of Presentation
      広島大学
    • Year and Date
      2007-09-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 植物細胞壁分解酵素ラムノガラクツロナンリアーゼの構造・機能相関2007

    • Author(s)
      川眞田明子
    • Organizer
      日本農芸化学会関西支部第451会講演会
    • Place of Presentation
      名城大学
    • Year and Date
      2007-09-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] Sphingomonas sp. A1株由来フラジェリンの立体構造に基づく多糖結合能と細胞表層局在性2007

    • Author(s)
      丸山如江
    • Organizer
      日本農芸化学会関西支部第449会講演会
    • Place of Presentation
      京都府立大学
    • Year and Date
      2007-05-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 枯草菌による植物細胞壁の分解:多糖ラムノガラクツロナンリアーゼYesWのX線結晶構造2007

    • Author(s)
      落合秋人
    • Organizer
      日本農芸化学会関西支部第449会講演会
    • Place of Presentation
      京都府立大学
    • Year and Date
      2007-05-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 連鎖球菌による宿主細胞外マトリクス・グリコサミノグリカンの分解2007

    • Author(s)
      橋本 渉
    • Organizer
      日本農芸化学会平成19年度大会
    • Place of Presentation
      東京農業大学
    • Year and Date
      2007-03-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 不飽和グルクロニルヒドロラーゼの基質認識と反応機構2007

    • Author(s)
      伊藤貴文
    • Organizer
      日本農芸化学会平成19年度大会
    • Place of Presentation
      東京農業大学
    • Year and Date
      2007-03-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structure and function of glycosaminoglycan-degrading enzyme from streptococci2007

    • Author(s)
      Wataru, Hashimoto, Yukie, Maruyama, Takafumi, Itoh, Bunzo, Mikami, Kousaku, Murata
    • Organizer
      Annual Meeting of Japan Society for Bioscience, Biotechnology, and Agrochemistry
    • Place of Presentation
      Tokyo University of Agriculture
    • Year and Date
      2007-03-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Substrate recognition and catalytic mechanism of bacterial unsaturated galacturonyl hydrolase responsible for degradation of plant cell walls2007

    • Author(s)
      Takafumi, Itoh, Akihito, Ochiai, Bunzo, Mikami, Wataru, Hashimoto, Kousaku, Murata
    • Organizer
      Annual Meeting of Japan Society for Bioscience, Biotechnology, and Agrochemistry
    • Place of Presentation
      Tokyo University of Agriculture
    • Year and Date
      2007-03-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Bacterial unsaturated glycoside hydrolases as virulent factors: novel catalytic reaction mechanism2006

    • Author(s)
      伊藤貴文
    • Organizer
      日本生物物理学会平成18年度大会
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      2006-11-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Bacterial unsaturated glycoside hydrolases as virulent factors novel catalytic reaction mechanism2006

    • Author(s)
      Takafumi, Itoh, Akihito, Ochiai, Bunzo, Mikami, Wataru, Hashimoto, Kousaku, Murata
    • Organizer
      Annual Meeting of Japan Society for Biophysics
    • Place of Presentation
      Okinawa Convention Center
    • Year and Date
      2006-11-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 新規な糖質加水分解酵素ファミリー105:植物細胞壁に作用する枯草菌由来不飽和ガラクツロニルヒドロラーゼYteRの機能と高次構造2006

    • Author(s)
      伊藤貴文
    • Organizer
      日本農芸化学会平成18年度関西支部大会
    • Place of Presentation
      京都工芸繊維大学
    • Year and Date
      2006-10-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A novel glycoside family 105 : Function and structure of Bacillus subtilis unsaturated galacturonyl hydrolase YteR responsible for plant cell wall degradation2006

    • Author(s)
      Takafumi, Itoh, Akihito, Ochiai, Bunzo, Mikami, Wataru, Hashimoto, Kousaku, Murata
    • Organizer
      Annual Meeting of Japan Society for Bioscience, Biotechnology, and Agrochemistry, Kansai Branch
    • Place of Presentation
      Kyoto Institute of Technology
    • Year and Date
      2006-10-01
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 動物細胞外マトリクスを分解する細菌酵素「不飽和グルクロニルヒドロラーゼ」の機能と構造2006

    • Author(s)
      伊藤貴文
    • Organizer
      日本農芸化学会平成18年度関西支部例会
    • Place of Presentation
      京都府立大学
    • Year and Date
      2006-05-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Bacterial enzyme for degrading mammalian extracellular matrix : Function and structure of unsaturataed glucuronyl hydrolase2006

    • Author(s)
      Takafumi, Itoh, Wataru, Hashimoto, Bunzo, Mikami, Kousaku, Murata
    • Organizer
      Regular Meeting of Japan Society for Bioscience, Biotechnology, and Agrochemistry, Kansai Branch
    • Place of Presentation
      Kyoto Prefectural University
    • Year and Date
      2006-05-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 遺伝子から見た応用微生物学2008

    • Author(s)
      橋本 渉
    • Publisher
      朝倉出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 遺伝子から見た応用微生物学2008

    • Author(s)
      橋本 渉
    • Publisher
      朝倉書店
    • Related Report
      2007 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi