Research on the mechanism of stimulated mucin secrefion by dietary fiber ingestion and its physiological effects
| Project/Area Number |
18580116
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Shizuoka University |
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Principal Investigator |
MORITA Tatsuya Shizuoka University, Faculty of Agriculture, Professor (90332692)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIYAMA Kimio Shizuoka Univeisity, Faculty of Agriculture, Professor (00126781)
MATSUDA Tsukasa Nagoya University, Faculty of Agriculture, Professor (20144131)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | mucin / dietary fiber / settling volume in water / bulk-forming effect / dietary antigen / bulk-formingeffect |
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| Research Abstract |
The aim of this study was to clarify the mechanism of stimulated mucin secretion by dietary fiber ingestion and its physiological effects. In summary, the present research program clarified the followings:
1. The small intestinal and colonic mucins are secreted in proportion to the settling volume in water (a numerical representation for bulk-forming property) of dietary indigestible components.
2. Stimulated mucin secretion by insoluble dietary fiber reaches its maximum at 5 days after starting IDF ingestion and disappears at 5 days after ceasing insoluble dietary fiber ingestion, suggesting that this stimulatory effect is accordance with the replenishing cycle of epithelial cells.
3. The measurement of O-linked oligosaccharide chain as a mucin marker is highly correlated with mucins directly determined by a newly established ELISA.
4. Insoluble dietary fiber exerts a significant increase in luminal mucin content, but the increased capacity of luminal mucin secretion itself does not disturb the nutrient absorption.
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Report
(3 results)
Research Products
(14 results)
