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Analyses of roles of nutritional factors in brain function using mouse genetics and application for the treatment of brain disease

Research Project

Project/Area Number 18580129
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionTokyo University of Agriculture

Principal Investigator

KIDA Satoshi  Tokyo University of Agriculture, Faculty of Applied Bioscience, Associate Professor (80301547)

Co-Investigator(Kenkyū-buntansha) SUZUKI Akinobu  Tokyo University of Agriculture, Faculty of Applied Bioscience, Post-doctorial fellow (40424684)
KATO Kenichi  Tokyo University of Agriculture, Faculty of Applied Bioscience, Technical staff (30424683)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,920,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2006: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsRetinoic Acid / Retinoic Acid Receptor / Brain Function / Mouse Genetics / Learning and Memory / Trwtophan / Emotional behavior / Hippocampus / 転写調節
Research Abstract

To understand roles of nutritional factors in brain function and develop the treatment for brain diseases, we have investigated roles of Vitamin A (Retinoic Acid) and essential amino acid tryptophan (TRP) in brain function.
(1) Generation and Analyses of Transgenic mice that enable to regulate expression of wild type or dominant negative Retinoic Acid Receptor (RAR) in forebrain.
Retinoic acid receptors (RARs) ubiquitously and highly express in brain. Previous studies have shown that RA-deficient mice and RARs knock out mice exhibit impairments of both hippocampal LTP and spatial memory, suggesting an essential role of RARs in learning and memory. To further clarify the roles of RARs in learning and memory, we generated conditional mutant mice that enable to regulate forebrain-specific overexpression of RAR-alpha or dominant negative mutant (dn) of RAR-alpha using tetracycline system. Biochemical analyses showed that overexpression of RAR-alpha leads to an increase in expression of RARs- … More target gene in forebrain, suggesting the activation of retinoid signaling pathway in these mutant mice. Importantly, behavioral analyses revealed that RAR-alpha overexpression mice show enhancement of formation of spatial, social recognition and contextual fear memories. Taken together with previous findings, we suggest that RAR-alpha functions as a positive regulator for learning and memory.
(2) Roles of TRP in brain function and the application of TRP on the treatment for anxiety-related behavior.
The depletion of systemic TRP is an important tool to study the effects of reduced 5-HT on cognition. We first examined the effects of chronic consumption of a low TRP diet on memory formation in mice. TRP-limited mice showed impaired formation of contextual fear memory that is hippocampus-dependent. In contrast, these mice showed normal hippocampus-dependent spatial memory, as well as in cued fear and conditioned taste aversion memories, which are amygdala-dependent memory processes. Thus, dietary TRP restriction appears to result in selective impairments in hippocampus-dependent contextual fear memory formation in mice.
We have shown that limitation of TRP-intake also affect emotional behaviors in mice. To develop the treatment of anxiety-related behavior, we next examined effects of TRP-limitation on anxiety related behavior observed in transgenic mice overexpressing alplaCaMKII in forebrain. TRP-limitation leads to the improvement of anxiety-related behavior in CaMKII transgenic mice, raising the possibility that TRP-limitation is applicable for the treatment of anxiety-related disease. Less

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (180 results)

All 2008 2007 2006 Other

All Journal Article (34 results) (of which Peer Reviewed: 15 results) Presentation (145 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans2007

    • Author(s)
      Hikida, T., Jaaro-Peled, H., Seshadri, S., Oishi, K., HookWay, C., Kong, S., Wu, D., Xue, R., Andrade, M., Tankou, S., Mori, S., Gallagher, M., Ishizuka, K., Pletnikov, M., Kida, S., Sawa, A.
    • Journal Title

      Proc.Natl.Acad.Sci.U.S.A. 104

      Pages: 14501-14506

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Chronic reduction in dietary tryptophan leads to a selective impairment of contextual fear memory in mice2007

    • Author(s)
      Uchida, S., Umeeda, H., Kitamoto, A., Masushige, S., Kida, S.
    • Journal Title

      Brain Res 1149

      Pages: 149-56

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Characterization of the Promoter of the Mouse Preproorexin Gene2007

    • Author(s)
      Kato, H, Hosoda, H., Fukuda, T, Masushige, S, Kida, S.
    • Journal Title

      Biosci.Biotechnol.Biochem 71

      Pages: 840-843

    • NAID

      10027513166

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 「研究成果報告書概要(欧文)」より2007

    • Author(s)
      Hikida, T., Jaaro-Peled, H., Seshadri, S., Oishi, K., Hookway, C., Kong, S., Wu, D., Xue, R., AndradO, M., Tankou, S., Mori, S., Gallagher, M., Ishizuka, K., Pletnikov, M., Kida, S., *Sawa, A
    • Journal Title

      Proc. Natl. Acad. Sci. U.S.A 104

      Pages: 14501-6

    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Chronic reduction in dietary tryptophan leads to a selective impairment of contextual fear memory in mice2007

    • Author(s)
      Uchida, S., Umeeda, H., Kitamoto, A., Masushige, S., Kida, S
    • Journal Title

      Brain Res 1149

      Pages: 149-56

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Characterization of the Promoter of the Mouse Preproorexin Gene2007

    • Author(s)
      Kato, H., Hosoda, H., Fukuda, T., Masushige, S., Kida, S
    • Journal Title

      Biosci. Biotechnol. Biochem 71

      Pages: 840-3

    • NAID

      10027513166

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans.2007

    • Author(s)
      Hikida, T., Jaaro-Peled, H., Seshadri, S., Oishi, K., Hookway, C., Kong, S., Wu, D., Xue, R., Andrade, M., Tankou, S., Mori, S., Gallagher, M., Ishizuka, K., Pletnikov, M., Kida, S. & ^*Sawa, A.
    • Journal Title

      Proc. Natl. Acad. Sci. U.S.A. 104

      Pages: 14501-6

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronic reduction in dietary tryptophan leads to a selective impairment of contextual fear memory in mice.2007

    • Author(s)
      Uchida, S., Umeeda, H., Kitamoto, A., Masushige, S. & ^*Kida, S.
    • Journal Title

      Brain Res. 1149

      Pages: 149-56

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the Promoter of the Mouse Preproorexin Gene.2007

    • Author(s)
      Kato, H, Hosoda, H., Fukuda, T, Masushige, S & ^*Kida, S.
    • Journal Title

      Biosci. Biotechnol. Biochem. 71

      Pages: 840-3

    • NAID

      10027513166

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the Promoter of the Mouse Preproorexin Gene.2007

    • Author(s)
      Kato, H, Hosoda, H., Fukuda, T, Masushige, S, Kida, S.
    • Journal Title

      Biosci. Biotechnol. Biochem. 71

      Pages: 840-843

    • NAID

      10027513166

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Recent advances in basic neurosciences and brain disease:from synapses to behavior2006

    • Author(s)
      Bi. G-Q., 他
    • Journal Title

      Mol.Pain. 2

      Pages: 38-38

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Stability of recent and remote contextual fear memory2006

    • Author(s)
      Frankland, P.W., Ding, H-K., Takahashi, E., Suzuk, iA., Kida, S., Silva, A.J.
    • Journal Title

      Learn.Mem. 13

      Pages: 451-457

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Involvement of cAMP response element-binding protein activation in salivary secretion2006

    • Author(s)
      Yamada, K, , Inoue, H., Kida, S., Masushige, S., Nishiyama, T., Mishima, K., Saito, I.
    • Journal Title

      Pathobiology 70

      Pages: 1-7

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] レチノイン酸受容体コンディショナル変異マウスにおける脳内レチノイン酸情報伝達経路活性化による不安行動の亢進2006

    • Author(s)
      喜田 聡、内田 周作、崔 泰樹、宮尾 貴久、本間 清一、舛重 正一
    • Journal Title

      必須アミノ酸研究 176

      Pages: 6-11

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Stability of recent and remote contextual fear memory2006

    • Author(s)
      Frankland, P.W., Ding, H-K., Takahashi, E., Suzuk,i A., Kida, S., Silva, A.J
    • Journal Title

      Learn. Mem 13

      Pages: 451-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Involvement of cAMP response element-binding protein activation in salivary secretion2006

    • Author(s)
      Yamada, K., Inoue, H., Kida, S., Masushige, S., Nishiyama, T., Mishima, K., Saito, I
    • Journal Title

      Pathobiology 73

      Pages: 1-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Molecular identification and characterization of a family of kinases with homology to CaMKI/CaMKI2006

    • Author(s)
      Ohmae, S., Takemoto-Kimura, S., Okamura, M., Adachi-Morishima, A., Nonaka, M., Fuse, T., Kida, S., Tanji, M., Furuyashiki, T., Arakawa, Y., Narumiya, S., Okuno, H., Bito, H
    • Journal Title

      J. Biol. Chem 281

      Pages: 20427-39

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Tight regulation of transgene expression by tetracycline-dependent activatol and repressor in brain2006

    • Author(s)
      Uchida, S., Sakai, S., Furuichi, T., Hosoda, H., Toyota, K., Ishii, T., Kitamoto, A., Sekine, M., Koike, K., Masushige, S., Murphy, G., Silva, A.J., Kida, S
    • Journal Title

      Genes Brain Behay 5

      Pages: 96-106

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Recent advances in basic neurosciences and brain disease : from synapses to behavior2006

    • Author(s)
      Bi, G-Q., Bolshakov, V., Bu, G., Cahill, C., M., Chen, Z-F., Collingridge, GL., Cooper, R.L., Coorssen, J., R., El-Husseini, A., Galhardo, V., Gan, W-B., Gu, J., Inoue, K., Isaac, J., Iwata, K., Jia, Z., Kaang, B-K., Kawamata, M., Kida, S., Klann, E., Kohno, T., Li, M., Li. X.-L., MacDonald, J.F., Nader, K., Nguyen, P.V., Oh, U., Ren, K., Roder, J.C., Salter, M.W., Song, W., Sugita, S., Tang, S.-J., Tao, Y., Wang, YT., Woo, N., Woodin, M.A., Yan, Z., Yoshimura. M., Xu. M., Xu. Z.C., Zhang. X., Zhen. M., Zhuo. M
    • Journal Title

      Mol. Pain 2

      Pages: 38-38

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Stability of recent and remote contextual fear memory.2006

    • Author(s)
      Frankland, P.W., Ding, H-K., Takahashi, E., Suzuk, i A., Kida, S., Silva, A.J.
    • Journal Title

      Learn. Mem. 13

      Pages: 451-457

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Involvement of cAMP response element-binding protein activation in salivary secretion.2006

    • Author(s)
      Yamada, K., Inoue, H., Kida, S., Masushige, S., Nishiyama, T., Mishima, K., Saito, I.
    • Journal Title

      Pathobiology. 73

      Pages: 1-7

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Molecular identification and characterization of a family of kinases with homology to CaMKI/CaMKI.2006

    • Author(s)
      Ohmae, S., Takemoto-Kimura, S., Okamura, M., Adachi-Morishima, A., Nonaka, M., Fuse, T., Kida, S., Tanji, M., Furuyashiki, T., Arakawa, Y., Narumiya, S., Okuno, H., Bito H.
    • Journal Title

      J. Biol. Chem. 281

      Pages: 20427-20439

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Tight regulation of transgene expression by tetracycline-dependent activator and repressor in brain.2006

    • Author(s)
      Uchida, S., Sakai, S., Furuichi, T., Hosoda, H., Toyota, K., Ishii, T., Kitamoto, A., Sekine, M., Koike, K., Masushige, S., Murphy, G., Silva, A.J., Kida S.
    • Journal Title

      Genes Brain Behav. 5

      Pages: 96-106

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Activation of LVGCCs and CB1 receptors required for destabilization of reactivated contextual fear memories

    • Author(s)
      Suzuki, A., Mukawa, T., Tsukagoshi, A., Frankland, P.W., Kida, S.
    • Journal Title

      Learn.Mem. (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Genetic Enhancement of Trace Fear Memory and Cingulate Potentiation in Mice Overexpressing Ca2+/Calmodulin-Dependent Protein Kinase IV

    • Author(s)
      Wu, L.-J., Zhang, X-H., Fukushima, H., Zhang, F., Wang, H., Tbyoda, T., Li, B.-M., Kida, S., Zhuo, M.
    • Journal Title

      Eunr.J.Neurosci. (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Activin in the Brain Modulates Anxiety-Related Behavior and Adult Neurogenesis

    • Author(s)
      Ageta, H., Murayama, A., Migishima, R., Kida, S., Tsuchida, K., Yokoyama, M., Inokuchi, K.
    • Journal Title

      PLoS ONE (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Activation of LVGCCs and CB1 receptors required for destabilization of reactivated contextual fear memories

    • Author(s)
      Suzuki, A., Mukawa, T., Tsukagoshi, A., Frankland, P. W., *Kida., S
    • Journal Title

      Learn. Mem (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Genetic Enhancement of Trace Fear Memory and Cingulate Potentiation in Mice Overexpressing Ca2+/Calmodulin-Dependent Protein Kinase IV

    • Author(s)
      Wu, L.-J., Zhang, X-H., Fukushima, H., Zhang, F., Wang, H., Toyoda, T., Li, B.-M., *Kida, S., *Zhuo, M
    • Journal Title

      Eur. J. Neurosci (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Activin in the Brain Modulates Anxiety-Related Behavior and Adult Neurogenesis

    • Author(s)
      Ageta, H., Murayama, A., Migishima, R., Kida, S., Tsuchida, K., Yokoyama, M., *Inokuchi, K
    • Journal Title

      PLoS ONE (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Activation of LVGCCs and CB1 receptors required for destabilization of reactivated contextual fear memories.

    • Author(s)
      Suzuki, A., Mukawa, T., Tsukagoshi, A, Frankland, P.W. & ^*Kida, S.
    • Journal Title

      Learn. Mem. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic Enhancement of Trace Fear Memory and Cingulate Potentiation in Mice Overexpressing Ca2+/Calmodulin-Dependent Protein Kinase IV.

    • Author(s)
      Wu, L.-J., Zhang, X-H., Fukushima, H., Zhang, F., Wang, H., Toyoda, T., Li, B.-M., ^*Kida, S. & ^*Zhuo, M.
    • Journal Title

      Eur. J. Neurosci. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activin in the Brain Modulates Anxiety-Related Behavior and Adult Neurogenesis.

    • Author(s)
      Ageta, H., Murayama, A., Migishima, R., Kida, S., Tsuchida, K., Yokoyama, M. & ^*Inokuchi, K.
    • Journal Title

      PLoS ONE (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronic reduction in dietary tryptophan leads to a selective impairment of contextual fear memory in mice.

    • Author(s)
      Uchida, S., Umeeda, H., Kitamoto, A., Masushige, S., Kida, S.
    • Journal Title

      Brain Res. (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Recent advances in basic neurosciences and brain disease : from synapses to behavior.

    • Author(s)
      Bi.G.-Q.他
    • Journal Title

      Mol. Pain. (in press)

    • Related Report
      2006 Annual Research Report
  • [Presentation] Roles of Transcription Factor CREB in Memory Formation2008

    • Author(s)
      喜田 聡
    • Organizer
      International Meeting of Molecular Cellular Cognition Society-Asia2008
    • Place of Presentation
      Bangalore,India
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] CREB-CBP間相互作用亢進による記憶形成能力の向上2008

    • Author(s)
      鈴木 章円、岡野 絵美子、遠藤 健吾、夢川 琢也、喜田 聡
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 時計遺伝子BMAL1は記憶形成に必須である2008

    • Author(s)
      長谷川 俊介、細田 浩司、本間 清一、喜田 聡
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 前能特異的αCaMKII過剰発現マウスにおける不安障害発現のメカニズムの解析2008

    • Author(s)
      古市 隆大、遠藤 健悟、吉田 太郎、佐度 恵、梶井 靖、喜田 聡
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 記憶再固定化と消去の相互作用には海馬の活性制御が重要である2008

    • Author(s)
      間宮 則、鈴木 章円、松山 善宰、喜田 聡
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 受動的回避記憶における記憶再固定化と強化のメカニズムの解析2008

    • Author(s)
      福島 穂高、鈴木 章円、喜田 聡
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 空間記憶固定化、再固定化の分子メカニズムの解析2008

    • Author(s)
      金亮、本間 清一、喜田 聡
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 受動的回避記憶再固定化制御に関わる脳領域の解析2008

    • Author(s)
      張悦、福島 穂高、喜田 聡
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 前脳領域特異的コンディショナル変異を用いた転写因子SRFの学習・記憶に対する役割の解析2008

    • Author(s)
      野本 真順、梅枝 久裕、吉田 有理紗、佐渡 恵、本間 清一、喜田 聡
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Pinl遺伝子欠損マウスにおける行動異常の解析2008

    • Author(s)
      大野 春香、鈴木 章円、内田 隆史、喜田 聡
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 恐怖記憶想起後の海馬における記憶不安定化の分子機構の解析2008

    • Author(s)
      夢川 琢也、鈴木 章円、塚越 昭紀、喜田 聡
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Roles of Transcription Factor CREB in Memory Formation2008

    • Author(s)
      Satoshi, Kida
    • Organizer
      International Meeting of Molecular Cellular Cognition Society-Asia 2008, (Invited)
    • Place of Presentation
      Bangalore, India
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analysis of roles of CREB-CBP interaction on memory consolidation2008

    • Author(s)
      Suzuki, A., Okano, E., Endo, K., Mukawa, T., Kida, S
    • Organizer
      Annual Meeting of Japan Society for Bioscience, Biotechnology, and Agrichemistry
    • Place of Presentation
      Nagoya
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Roles of Transcription Factor CREB in Memory Formation.2008

    • Author(s)
      喜田聡
    • Organizer
      International Meeting of Molecular Cellular Cognition Society-Asia 2008
    • Place of Presentation
      Bangalore, India.
    • Related Report
      2007 Annual Research Report
  • [Presentation] 時計遺伝子BMALIは記憶形成に必須である2008

    • Author(s)
      長谷川俊介、細田浩司、本間清一、喜田聡
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Related Report
      2007 Annual Research Report
  • [Presentation] Pin1遺伝子欠損マウスにおける行動異常の解析2008

    • Author(s)
      大野春香、鈴木章円、内田隆史、喜田聡
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Related Report
      2007 Annual Research Report
  • [Presentation] Mechanisms of Memory Formation by Transcription Factors2007

    • Author(s)
      喜田 聡
    • Organizer
      第30回日本神経科学大会シンポジウム
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] CREB-CBP間相互作用促進による記憶固定化能力の向上2007

    • Author(s)
      鈴木 章円、岡野 絵美子、夢川 琢也、福島 穂高、Min Zhuo、喜田 聡
    • Organizer
      第30回日本分子生物学会年会、第80回日本生化学会大会、合同大会(BMB2007)ワークショップ
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] コンディショナル変異マウスを用いた脳内レチノイン酸情報伝達系の海馬依存的学習・記憶能力に対する役割の解析2007

    • Author(s)
      榎本 初音、崔 泰樹、内田 周作、宮尾 貴久、喜田 聡
    • Organizer
      第30回日本分子生物学会年会、第80回日本生化学会大会、合同大会(BMB2007)ワークショップ
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of memory stability after retrieval2007

    • Author(s)
      喜田 聡
    • Organizer
      IBRO 2007 International Conference of Neuroscience
    • Place of Presentation
      Melbourne,Australia
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mechanism for the destabilization of retrieved contextual fear memory2007

    • Author(s)
      Suzuki, A., Tsukagoshi, A., Mukawa, T., Kida, S.
    • Organizer
      37th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Lowering the threshold of CREB-CBP interaction leads to an enhancement of memory consolidation2007

    • Author(s)
      Suzuki, A., Okano, E., Fukushima, H., Endo, K., Hasegawa, S., Zhuo, M., Kida, S.
    • Organizer
      37th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Transcription factor BMAL1 plays critical roles in memory formation2007

    • Author(s)
      Hasegawa, S., Hosoda, H., Kida, S.
    • Organizer
      37th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] CaMKIV overexpression enhances formation of long-term memory and improves age-related menory deficits2007

    • Author(s)
      Fukushima, H., Maeda, R., Suzuki, A., Zhuo, M., Kida, S.
    • Organizer
      37th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 前脳特異的なCREB活性化による記憶固定化能力向上のメカニズムの解析2007

    • Author(s)
      鈴木 章円、福島 穂高、Min Zhuo、喜田 聡
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 生細胞内におけるαCaMKIIの自己リン酸化とCa^<2+>依存的活性制御機構の解析2007

    • Author(s)
      加藤 健一、岩本 拓、喜田 聡
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 転写因子BMAL1は記憶形成に重要な役割を担う2007

    • Author(s)
      長谷川 俊介、細田 浩司、喜田 聡
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 前脳特異的αCaMKII過剩発現における不安障害発現のメカニズムの解析2007

    • Author(s)
      古市 隆大, 遠藤 健悟, 吉田 太郎, 佐度 恵, 梶井 靖, 喜田 聡
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 恐怖記憶再固定化・消去の相互作用メカニズムの解析2007

    • Author(s)
      間宮 則、鈴木 章円、喜田 聡
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 受動的回避反応課題を用いた記憶再固定化と記憶強化の解析2007

    • Author(s)
      福島 穂高、鈴木 章円、喜田 聡
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 空間記憶の再固定化・消去のメカニズムの解析2007

    • Author(s)
      金 亮、吉田 有理紗、鈴木 章円、喜田 聡
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 物体認知記憶固定化・再固定化に対する遺伝子発現制御の役割の解析2007

    • Author(s)
      岡野 絵美子、鈴木 章円、遠藤 健悟、喜田 聡
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] BMAL1機能の抑制は記憶形成を障害する2007

    • Author(s)
      長谷川 俊介、細田 浩司、喜田 聡
    • Organizer
      第30回日本分子生物学会年会、第80回日本生化学会大会、合同大会(BMB2007)
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 前脳特異的□CaMKII過剰発現マウスにおける不安行動とadult neurogenesisの解析2007

    • Author(s)
      古市 隆大、遠藤 健悟、吉田 太郎、佐度 恵、湯浅 茂樹、梶井 靖、喜田 聡
    • Organizer
      第30回日本分子生物学会年会、第80回日本生化学会大会、合同大会(BMB2007)
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 恐怖記憶再固定化と消去の相互作用には海馬の活性制御が重要である2007

    • Author(s)
      間宮 則、鈴木 章円、松山 善宰、喜田 聡
    • Organizer
      第30回日本分子生物学会年会、第80回日本生化学会大会、合同大会(BMB2007)
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] CaMKIV過剰発現による記憶固定化能力の向上と加齢に伴う記憶固定化能力減退の抑制2007

    • Author(s)
      福島 穂高、前田 良太、鈴木 良祐、鈴木 章円、遠藤 健悟、Zhuo Min、喜田 聡
    • Organizer
      第30回日本分子生物学会年会、第80回日本生化学会大会、合同大会(BMB2007)
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 受動的回避記憶の固定化に関与する脳内部位の同定と固定化に対する役割の解析2007

    • Author(s)
      張悦、福島 穂高、喜田 聡
    • Organizer
      第30回日本分子生物学会年会、第80回日本生化学会大会、合同大会(BMB2007)
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] CREB新規相互作用因子Adult Retina Proteinの同定とその機能解析2007

    • Author(s)
      林 純一、江副 浩和、岩永 敦、高橋 清文、細田 浩司、喜田 聡
    • Organizer
      第30回日本分子生物学会年会、第80回日本生化学会大会、合同大会(BMB2007)
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 認知記憶に対するCREBを介した新規造伝子発現の役割の解析2007

    • Author(s)
      岡野 絵美子、夢川 琢也、鈴木 章円、遠藤 健悟、八塚 友子、喜田 聡
    • Organizer
      第30回日本分子生物学会年会、第80回日本生化学会大会、合同大会(BMB2007)
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 恐怖記憶想起後の海馬における記憶不安定化の分子機構の解析2007

    • Author(s)
      夢川 琢也、鈴木 章円、塚越 昭紀、喜田 聡
    • Organizer
      第30回日本分子生物学会年会、第80回日本生化学会大会、合同大会(BMB2007)
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 記憶固定化・再固定化の分子メカニズム2007

    • Author(s)
      喜田 聡、鈴木 章円
    • Organizer
      日本農芸化学会2007年度大会シンポジウム
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] コンディショナル変異マウスを用いた脳内レチノイン酸情報伝達系の学習・記憶能力に対する役割の解析2007

    • Author(s)
      榎本 初音、崔 泰樹、内田 周作、宮尾 貴久、本間 清一、舛重 正一、喜田 聡
    • Organizer
      第51回日本農芸化学会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 物体認知記憶固定化・再固定化に対する遺伝子発現制御の役割の解析2007

    • Author(s)
      岡野 絵美子、鈴木 章円、遠藤 健悟、喜田 聡
    • Organizer
      第51回日本農芸化学会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 前脳特異的αCaMKII過剰発現マウスにおける不安障害発現のメカニズムの解析2007

    • Author(s)
      古市 隆大、遠藤 健悟、吉田 太郎、佐度 恵、梶井 靖、喜田 聡
    • Organizer
      第51回日本農芸化学会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] コンディショナル変異を用いた時計遺伝子BMAL1の学習・記憶形成に対する役割の解析2007

    • Author(s)
      長谷川 俊介、細田 浩司、喜田 聡
    • Organizer
      第51回日本農芸化学会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 受動的回避反応解析を用いた記憶固定化、再固定化、及び消去機構の解析2007

    • Author(s)
      福島 穂高, 鈴木 章円, 本間 清一, 喜田 聡
    • Organizer
      第51回日本農芸化学会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] CaMKIV過剰発現による加齢に伴う記憶能力減衰の抑制2007

    • Author(s)
      坂東 真一, 福島 穂高, 鈴木 章円, 前田 良太, 鈴木 良祐, 遠藤 健吾, 喜田 聡
    • Organizer
      第51回日本農芸化学会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] HDAC3とCBPの協調作用によるCLOCK/BMAL1依存的転写活性化の抑制2007

    • Author(s)
      細田 浩司、舛重 正一、喜田 聡
    • Organizer
      第51回日本農芸化学会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 恐怖記憶再固定化と消去の相互作用機構の解析2007

    • Author(s)
      間宮 則、鈴木 章円、本間 清一、喜田 聡
    • Organizer
      第51回日本農芸化学会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 前脳特異的なCREB活性化による記憶固定化能力の向上のメカニズムの解析2007

    • Author(s)
      鈴木 章円、福島 穂高、Min Zhuo、喜田 聡
    • Organizer
      第51回日本農芸化学会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] FRETを利用した細胞種特異的αCaMKII活性化機構の解析2007

    • Author(s)
      加藤 健一、岩本 拓、喜田 聡
    • Organizer
      第51回日本農芸化学会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 味覚条件付け嫌悪学習課題を用いた記憶消去の分子機構の解析2007

    • Author(s)
      大澤 康雄、喜田 聡
    • Organizer
      第51回日本農芸化学会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 遺伝子発現による空間記憶再固定化制御機構の解析2007

    • Author(s)
      金 亮、茂木 亮一、梅枝 裕久、鈴木 章円、喜田 聡
    • Organizer
      第51回日本農芸化学会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 転写調節因子CREBの新規相互作用因子Adult Retina Proteinの機能解析2007

    • Author(s)
      林 純一、江副 浩和、岩永 敦、高橋 清文、細田 浩司、喜田 聡
    • Organizer
      第51回日本農芸化学会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 受動的回避反応解析を用いた記億の固定化に関与する脳領域の解析2007

    • Author(s)
      張 悦、福島 穂高、喜田 聡
    • Organizer
      第51回日本農芸化学会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 海馬における恐怖条件付け文脈記憶固定化・再固定化の分子機構の解析2007

    • Author(s)
      塚越 昭紀、鈴木 章円、夢川 琢也、本間 清一、喜田 聡
    • Organizer
      第51回日本農芸化学会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Improvement of memory formation by enhancement of CREB-signaling pathway2007

    • Author(s)
      Satoshi, Kida
    • Organizer
      International Conference of Neurons and Brain Disease, (Invited)
    • Place of Presentation
      Toronto, Canada
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of memory stability after retrieval2007

    • Author(s)
      Satoshi, Kida
    • Organizer
      IBRO 2007 International Conference of Neuroscience, (Invited)
    • Place of Presentation
      Melbourne, Australia
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mechanisms of Memory Formation by Transcription Factors2007

    • Author(s)
      Satoshi, Kida
    • Organizer
      The 30th Annual Meeting of the Japan Neuroscience Society, (Symposium)
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Enhancement of Memory Formation and LTP by up-regulation of CREB activity2007

    • Author(s)
      Suzuki, A., Fukushima, H., Zhuo, M., Kida, S
    • Organizer
      The 30th Annual Meeting of the Japan Neuroscience Society, 2007
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Lowering the threshold of CREB-CBP interaction leads to an enhancement of memory consolidation2007

    • Author(s)
      Suzuki, A., Okano, E., Mukawa, T., Fukushima, H., Zhuo, M., Kida, S
    • Organizer
      80th Annual Meeting of the Japanese Biochemical Society and 30th Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular mechanisms for interaction between reconsolidation and extinction2007

    • Author(s)
      Kida, S
    • Organizer
      The 29th Annual Meeting of the Japan Neuroscience Society, (Symposium)
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mechanisms of Memory Formation by Transcription Factors.2007

    • Author(s)
      喜田 聡
    • Organizer
      第30回日本神経科学大会シンポジウム
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] CREB-CBP間相互作用促進による記憶固定化能力の向上.2007

    • Author(s)
      鈴木章円、 岡野絵美子、 夢川琢也、 福島穂高、 Min Zhuo、 喜田聡
    • Organizer
      第30回日本分子生物学会年会、第80回日本生化学会大会、合同大会(BMB2007)ワークショップ
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] コンディショナル変異マウスを用いた脳内レチノイン酸情報伝達系の海馬依存的学習・記憶能力に対する役割の解析.2007

    • Author(s)
      榎本初音、崔泰樹、内田周作、宮尾貴久、喜田聡
    • Organizer
      第30回日本分子生物学会年会、第80回日本生化学会大会、合同大会(BMB2007)ワークショップ
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Regulation of memory stability after retrieval.2007

    • Author(s)
      喜田聡
    • Organizer
      IBRO 2007 International Conference of Neuroscience
    • Place of Presentation
      Melbourne, Australia.
    • Related Report
      2007 Annual Research Report
  • [Presentation] Mechanism for the destabilization of retrieved contextual fear memory.2007

    • Author(s)
      Suzuki, A., Tsukagoshi, A., Mukawa, T. & Kida, S.
    • Organizer
      37th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego.
    • Related Report
      2007 Annual Research Report
  • [Presentation] Lowering the threshold of CREB-CBP interaction leads to an enhancement of memory consolidation.2007

    • Author(s)
      Suzuki, A., Okano, E., Fukushima, H., Endo, K., Hasegawa, S., Zhuo, M. & Kida, S.
    • Organizer
      37th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego.
    • Related Report
      2007 Annual Research Report
  • [Presentation] Transcription factor BMAL1 plays critical roles in memory formation.2007

    • Author(s)
      Hasegawa, S., Hosoda, H. & Kida, S.
    • Organizer
      37th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego.
    • Related Report
      2007 Annual Research Report
  • [Presentation] CaMKIV overexpression enhances formation of long-term memory and improves age-related memory deficits.2007

    • Author(s)
      Fukushima, H., Maeda, R., Suzuki, A., Zhuo, M. & Kida, S.
    • Organizer
      37th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego.
    • Related Report
      2007 Annual Research Report
  • [Presentation] 前脳特異的なCREB活性化による記憶固定化能力向上のメカニズムの解析.2007

    • Author(s)
      鈴木章円、福島穂高、Min Zhuo、喜田聡
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 生細胞内におけるαCaMKIIの自己リン酸化とCa^<2+>依存的活性制御機構の解析.2007

    • Author(s)
      加藤健一、岩本拓、喜田聡
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 転写因子BMAL1は記憶形成に重要な役割を担う.2007

    • Author(s)
      長谷川俊介、細田浩司、喜田聡
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 前脳特異的αCaMKII過剰発現における不安障害発現のメカニズムの解析.2007

    • Author(s)
      古市隆大, 遠藤健悟, 吉田太郎, 佐度恵, 梶井靖, 喜田聡
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 恐怖記憶再固定化・消去の相互作用メカニズムの解析.2007

    • Author(s)
      間宮則、鈴木章円、喜田聡
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 受動的回避反応課題を用いた記憶再固定化と記憶強化の解析.2007

    • Author(s)
      福島穂高、鈴木章円、喜田聡
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 空間記憶の再固定化・消去のメカニズムの解析.2007

    • Author(s)
      金亮、吉田有理紗、鈴木章円、喜田聡
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 物体認知記憶固定化・再固定化に対する遺伝子発現制御の役割の解析.2007

    • Author(s)
      岡野絵美子、鈴木章円、遠藤健悟、喜田聡
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] BMAL1機能の抑制は記憶形成を障害する.2007

    • Author(s)
      長谷川俊介、細田浩司、喜田聡
    • Organizer
      第30回日本分子生物学会年会、第80回日本生化学会大会、合同大会(BMB2007)
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 前脳特異的αCaMKII過剰発現マウスにおける不安行動とadult neurogenesisの解析2007

    • Author(s)
      古市隆大、遠藤健悟、吉田太郎、佐度恵、湯浅茂樹、梶井靖、喜田聡
    • Organizer
      第30回日本分子生物学会年会、第80回日本生化学会大会、合同大会(BMB2007)
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 認知記憶に対するCREBを介した新規遺伝子発現の役割の解析2007

    • Author(s)
      岡野絵美子、夢川琢也、鈴木章円、遠藤健悟、八塚友子、喜田聡
    • Organizer
      第30回日本分子生物学会年会、第80回日本生化学会大会、合同大会(BMB2007)
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 恐怖記憶形成と安定性制御のメカニズム2006

    • Author(s)
      喜田 聡
    • Organizer
      第37回山口県ニューロサイエンス研究会
    • Place of Presentation
      宇部
    • Year and Date
      2006-06-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 恐怖記憶想起後の安定性制御のメカニズム2006

    • Author(s)
      喜田 聡
    • Organizer
      第29回日本神経科学大会シンポジウム
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] αCaMKIIの情動行動制御に対する役割の解析2006

    • Author(s)
      喜田 聡、古市 隆大, 吉田 太郎, 遠藤 健悟, 梶井 靖
    • Organizer
      第49回日本神経化学会シンポジウム
    • Place of Presentation
      名古屋
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular mechanisms for the destabilization of retrieved contextual fear memory2006

    • Author(s)
      Kida, S
    • Organizer
      2nd Molecular and Cellular Cognition Society-Europe Meeting
    • Place of Presentation
      Vienna
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mechanism of interaction between reconsoldiation and extinction of contextual fear memory2006

    • Author(s)
      Kida, S.
    • Organizer
      International Conference of Synapses, Memory, Drug Addiction and Pain
    • Place of Presentation
      Toronto
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analysis of roles of transcription factor CREB in memory consolidationusing conditional mutant mice2006

    • Author(s)
      Kida, S.
    • Organizer
      The 19th Annual and International Meeting of the Japanese Association for Animal Cell Technology
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analyses of anxiety-related behavior in transgenic mice overexpressing CaMKII in forebrain2006

    • Author(s)
      Furuichi, T., Endo, K., Yoshida, T., Sado, M., Kaiji, Y., Kida, S.
    • Organizer
      36th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Atlanta
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analyses of brain regions showing CREB activation in reconsolidation and extinction phases of contextual fear memory2006

    • Author(s)
      Mamiya, N., Suzuki, A., Kida, S
    • Organizer
      36th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Atlanta
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular mechanism for the destabilization of reactivated contextual fear memory2006

    • Author(s)
      Suzuki, A., Kida, S.
    • Organizer
      36th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Atlanta
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mechanism of interaction between reconsoldiation and extinction of contextual fear memory2006

    • Author(s)
      Suzuki, A., Kida, S.
    • Organizer
      5th Forum of European Neuroscience
    • Place of Presentation
      Vienna
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analyses of anxiety-related behavior in transgenic mice overexpressing CaMKII in forebrain2006

    • Author(s)
      Furuichi, T., Endo, K., Yoshida, T., Sado, M., Kaiji, Y, Kida, S.
    • Organizer
      20th International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Conditional disruption of BMAL1 function leads to an impairment of memory formation2006

    • Author(s)
      Hasegawa, S., Hosoda, H., Kida, S.
    • Organizer
      20th International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Temporal and biochemical signatures of reconsolidation and extinction in passiveavoidance task2006

    • Author(s)
      Fukushima, H., Suzuki, A., Kida, S.
    • Organizer
      20th International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analyses of brain regions showing CREB activation in reconsolidation and extinction phases of contextual fear memory2006

    • Author(s)
      Mamiya, N., Suzuki, A., Kida, S.
    • Organizer
      20th International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analysis of molecular mechanism for the destabilization of reactivated fear memory2006

    • Author(s)
      Suzuki, A., Kida, S.
    • Organizer
      20th International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analyses of cell type-dependent regulation of alpha CaMKII activation using FRET2006

    • Author(s)
      Kato, K., Iwamoto, T., Kida, S.
    • Organizer
      20th International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] αCaMKII過剰発現による不安障害モデルマウスの開発とその不安行動異常発現のメカニズムの解析2006

    • Author(s)
      古市 隆大、遠藤 健悟、吉田 太郎、佐渡 恵、梶井 靖、喜田 聡
    • Organizer
      第29回日本神経科学大会
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] BMAL1は記憶形成に必須である2006

    • Author(s)
      長谷川 俊介、細田 浩司、喜田 聡
    • Organizer
      第29回日本神経科学大会
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 受動的回避反応課題を用いた再固定化と消去の解析2006

    • Author(s)
      福島 穂高、鈴木 章円、喜田 聡
    • Organizer
      第29回日本神経科学大会
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 恐怖記憶の再固定化と消去を制御する脳領域の同定2006

    • Author(s)
      間宮 則、鈴木 章円、喜田 聡
    • Organizer
      第29回日本神経科学大会
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 想起後の恐怖記憶不安定化のメカニズムの解析2006

    • Author(s)
      鈴木 章円、喜田 聡
    • Organizer
      第29回日本神経科学大会
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] CREBは空間記憶の再固定化に必須である2006

    • Author(s)
      茂木 亮一、金亮、梅枝 久裕、鈴木 章円、喜田 聡
    • Organizer
      第29回日本神経科学大会
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 生細胞内におけるαCaMKIIの細胞種特異的活性制御機構のモニタリング2006

    • Author(s)
      加藤 健一、岩本 拓、喜田 聡
    • Organizer
      第29回日本神経科学大会
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 転写調節因子CRESTドミナントネガティブ変異体の作製2006

    • Author(s)
      下 拓三、加藤 健一、細田 浩司、喜田 聡
    • Organizer
      第29回日本神経科学大会
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 味覚条件付け嫌悪学習課題を用いた記憶の消失時におけるD-cycloserine投与の影響の解析2006

    • Author(s)
      大澤 康雄、喜田 聡
    • Organizer
      第29回日本神経科学大会
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 受動的回避反応解析を用いた記憶の固定化に関わる脳領域の解析2006

    • Author(s)
      張 悦、福島 穂高、喜田 聡
    • Organizer
      第29回日本神経科学大会
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] コンディショナル変異を用いた脳内レチノイン酸情報伝達経路活性化による不安行動の充進2006

    • Author(s)
      崔 泰樹、内田 周作、宮尾 貴久、本間 清一、舛重 正一、喜田 聡
    • Organizer
      第60回日本栄養・食糧学会大会
    • Place of Presentation
      静岡
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular mechanisms for the destabilization of retrieved contextual fear memory2006

    • Author(s)
      Kida, S
    • Organizer
      2nd Molecular and Cellular Cognition Society-Europe Meeting. (Symposium)
    • Place of Presentation
      Vienna
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mechanism of interaction between reconsoldiation and extinction of contextual fear memory2006

    • Author(s)
      Kida, S
    • Organizer
      International Conference of Synapses, Memory, Drug Addiction and Pain. (Invited)
    • Place of Presentation
      Toronto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analysis of roles of transcription factor CREB in memory consolidation using conditional mutant mice2006

    • Author(s)
      Kida, S
    • Organizer
      The 19th Annual and International Meeting of the Japanese Association for Animal Cell Technology
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Lowering the threshold of CREB-CBP interaction leads to an enhancemeni of memory consolidation

    • Author(s)
      Suzuki, A., Okano, E., Fukushima, H., Endo, K., Hasegawa, S., Zhuo, M., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Transcription factor BMALI plays critical roles in memory formation

    • Author(s)
      Hasegawa, S., Hosoda, H., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] CaMKIV overexpression enhances formation of long-term memory and improves age-related memory deficits

    • Author(s)
      Fukushima, H., Maeda, R., Suzuki, A., Zhuo, M., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of alpha CaMKII activation by its autophosphorylation and change in Ca^<2+> level in living cells

    • Author(s)
      Kato, K., Iwamoto, T., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Transcription factor BMAL1 plays critical roles in memory formation

    • Author(s)
      Hasegawa, S., Hosoda, H., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mechanisms of memory reconsolidation associated with memory enhancement in passive avoidance task

    • Author(s)
      Fukushima, H., Suzuki, A., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mechanism of reconsolidation and extinction of spatial memory

    • Author(s)
      Kim, R., Yoshida, Y., Suzuki, A., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] (Dep of Bioscience, Tokyo University of Agriculture) : Roles of gene expression regulation in consolidation and reconsolidation of object recognition memory

    • Author(s)
      Okano, E., Suzuki, A., Endo, K., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] (Dep of Bioscience Tokyo University of Agriculture) : Roles of retinoic acid receptors in learning and memory

    • Author(s)
      Enomoto, H., Choi, T., Uchida, S., Miyao, T., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Conditional inhibition of BMALI function impairs memory formation

    • Author(s)
      Hasegawa, S., Hosoda, H., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analysis of adult neurogenesis in hippocampus of forebrain-specificaCaMKII overexpression mice showing increase in anxiety-related behavior

    • Author(s)
      Furuichi, T., Endo, K., Yoshida, T., Sado, M., Yuasa, S., Kajii, Y., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of hippocampal activity is important for the interaction between reconsolidation and extinction of contextual fear memory

    • Author(s)
      Mamiya, N., Suzuki, A., Matsuyama, Z., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] CaMKIV overexpression enhances formation of long-term memory and improves age-related memory deficits

    • Author(s)
      Fukushima, H., Maeda, R., Suzuki, R.,- Suzuki, A., Endo, K., Zhuo, M., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analysis of brain regions activated during consolidation of passive avoidance memory using immunocytochemistry

    • Author(s)
      Zhang, Y., Fukushima, H., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Functional analysis of novel CREB-interacting factor ARP

    • Author(s)
      Hayashi, J., Ezoe, H., Iwanaga, A., Takahashi, K., Hosoda, H., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analyses of roles of protein synthesis and CREB in memory consolidation and reconsolidation of recognition memory

    • Author(s)
      Okano, E., Mukawa, T., Suzuki, A., Endo, K., Yatsuzuka, Y., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analyses of molecular mechanism for the destabilization of reactivated memory in hippocampus

    • Author(s)
      Mukawa, T., Suzuki, A., Tsukagoshi, A., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analyses of roles of retinoic acid signaling pathway in hippocampus dependent learning and memory using conditional mutant mice

    • Author(s)
      Enomoto, H., Choi T., Uchida, S., Miyao, T., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] BMALI is required for memory formation

    • Author(s)
      Hasegawa, S., Hosoda, H., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mechanisms of increase in anxiety by overexpressing of CaMKII in forebrain

    • Author(s)
      Furuichi, T., Endo, K., Yoshida, T., Sado, M., Kajii, Y., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of hippocampal activity is important for the interaction between reconsolidation and extinction of fear memory

    • Author(s)
      Mamiya, N., Suzuki, A., Matsuyama, Z., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mechanisms of memory reconsolidation and enhancement following memory retrieval in passive avoidance task

    • Author(s)
      Fukushima, H., Suzuki, A., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular mechanism of consolidation and reconsolidation of spatial memory

    • Author(s)
      Kim, R., Homma, S., kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analysis of brain regions activating following activation of passive avoidance memory

    • Author(s)
      Zhang, Y., Fukushima, H., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analysis of a role of transcription factor SRF in learning and memory using forebrain-specific conditional mutation

    • Author(s)
      Nomoto, M., Umeeda, H., Yoshida, Y., Sado, M., Homma, S., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analysis of roles of the prolyl isomerase Pinl in emotional behavior

    • Author(s)
      Ohno, H., Suzuki, A., Uchida, T., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analyses of molecular mechanism for the destabilization of reactivated memory in hippocampus

    • Author(s)
      Mukawa, T., Suzuki, A., Tsukagoshi, A., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analyses of brain regions showing CREB activation in reconsolidation and extinction phases of contextual fear memory

    • Author(s)
      Mamiya, N., Suzuki, A., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular mechanism for the destabilization of reactivated contextual fear memory

    • Author(s)
      Suzuki, A., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Conditional disruption of BMALI function leads to an impairment of memory formation

    • Author(s)
      Hasegawa, S., Hosoda, H., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Temporal and biochemical signatures of reconsolidation and extinction in passive avoidance task

    • Author(s)
      Fukushima, H., Suzuki, A., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analyses of brain regions showing CREB activation in reconsolidation and extinction phases of contextual fear memory

    • Author(s)
      Mamiya, N., Suzuki, A., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analysis of molecular mechanism for the destabilization of reactivated fear memory

    • Author(s)
      Suzuki, A., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analyses of cell type-dependent regulation of alpha CaMKII activation using FRET

    • Author(s)
      Kato, K., Iwamoto, T., Kida, S
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 学習能力及び記憶力が向上したトランスジェニックマウス及び該トランスジェニックマウスを作製する方法2007

    • Inventor(s)
      喜田 聡
    • Industrial Property Rights Holder
      学校法人東京農業大学
    • Industrial Property Number
      2007-229028
    • Filing Date
      2007-09-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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