Prevention of metabolic syndrome using food factors

• Project/Area Number: 18580133
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Food science
• Research Institution: Chubu University
• Principal Investigator: TSUDA Takanori Chubu University, College of Bioscience and Biotechnology, Associate Professor (90281568)
• Project Period (FY): 2006 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥3,930,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2006: ¥2,500,000 (Direct Cost: ¥2,500,000)
• Keywords: metabolic syndrome / adiponectin / food factor / adipocyte / diabetes

Research Abstract

Adipocyte dysfunction is strongly associated with the development of obesity and insulin resistance. It is accepted that the regulation of adipocytokine expression is one of the most important targets for the prevention of obesity and improvement of insulin sensitivity. In this study, we have demonstrated that anthocyanin (cyanidin 3-glucoside; C3G) which is a pigment widespread in the plant kingdom, ameliorates hyperglycemia and insulin sensitivity due to the reduction of retinol binding protein 4 (RBP4) expression in type2 diabetic mice. These findings indicate that C3G has significant potency in an anti-diabetic effect through the regulation of Glut4-RBP4 system and the related inflammatory adipocytokines.

Research Products

• [Journal Article] Regulation of Adipocyte Function by Anthocyanins;Possibility of Preventing the Metabolic Syndrome (2008)
  • Author(s): Tsuda, Takanori
  • Journal Title: J.Agric.Food Chem. 56 Pages: 642-646
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Regulation of Adipocyte Function by Anthocyanins; Possibility of Preventing the Metabolic Syndrome (2008)
  • Author(s): Tsuda, Takanori
  • Journal Title: J. Agric. Food Chem. 56 Pages: 642-646
  • Peer Reviewed
• [Journal Article] Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice (2007)
  • Author(s): Sasaki, R, et. al.
  • Journal Title: Biochem. Pharmacol. 74 Pages: 1619-1627
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Enhanced absorption of anthocyanins after oral administration of phytic acid in rats and humans (2007)
  • Author(s): Matsumoto, H, et. al.
  • Journal Title: J.Agric.Food Chem. 55 Pages: 2489-2496
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Enhanced absorption of anthocyanins after oral administration of phytic acid in rats and humans (2007)
  • Author(s): Matsumoto, H., Ito, K., Yonekura K., Tsuda, T., Ichiyanagi, T., Hirayama, M., Konishi, T.
  • Journal Title: J. Agric. Food Chem 55 Pages: 2489-2496
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice. (2007)
  • Author(s): Sasaki, R., Nishimura, N., Hoshino H., Isa, Y., Kadowaki, M., Ichi, T., Tanaka, A., Nishiumi, S., Fukuda, I., Ashida, H., Horio, F., Tsuda, T.
  • Journal Title: Biochem. Pharmacol. 74 Pages: 1619-1627
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] J. Agric. Food Chem. (2007)
  • Author(s): Tsuda, T. Regulation of Adipocyte Function by Anthocyanins ; Possibility of Preventing the Metabolic Syndrome.
  • Journal Title: 56 Pages: 642-646
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice. (2007)
  • Author(s): Sasaki, R, et. al.
  • Journal Title: Biochem. Pharmacol. 74 Pages: 1619-1627
  • Peer Reviewed
• [Journal Article] Enhanced absorption of anthocyanins after oral administration of phytic acid in rats and humans. (2007)
  • Author(s): Matsumoto, H, et. al.
  • Journal Title: J. Agric. Food Chem. 55 Pages: 2489-2496
  • Peer Reviewed
• [Journal Article] Microarray profiling of gene expression in human adipocytes in response to anthocyanins (2006)
  • Author(s): Tsuda, T., et. al.
  • Journal Title: Biochem.Pharmacol 71 Pages: 1184-1197
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Ingested delphinidin-3-rutinoside is primarily excreted to urine as the intact form and to bile as the methylated form in rats (2006)
  • Author(s): Matsumoto, H., et. al.
  • Journal Title: J.Agric.Food Chem. 54 Pages: 578-582
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Microarray profiling of gene expression in human adipocytes in response to anthocyanins. (2006)
  • Author(s): Tsuda, T., Ueno, Y., Yoshikawa, T., Kojo, H., Osawa, T.
  • Journal Title: Biochem. Pharmacol. 71 Pages: 1184-1197
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Ingested delphinidin-3-rutinoside is primarily excreted to urine as the intact form and to bile as the methylated form in rats. (2006)
  • Author(s): Matsumoto, H., Ichiyanagi, T., Iida, H., Ito, K., Tsuda, T., Hirayama, M., Konishi, T.
  • Journal Title: J. Agric. Food Chem. 54 Pages: 578-582
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Microarray profiling of gene expression in human adiposytes in response to anthocyanins. (2006)
  • Author(s): Tsuda, T. et al.
  • Journal Title: Biochem. Pharmacol. 71 Pages: 1184-1197
• [Journal Article] Ingested delphinidin-3-rutinoside is primarily excreted to urine as the intact form and to bile as the methylated form in rats. (2006)
  • Author(s): Matsumoto, H. et al.
  • Journal Title: J. Agric. Food Chem. 54 Pages: 578-582
• [Journal Article] Ascorbic acid deficiency stimulates hepatic expression of inflammatory chemokine, cytokine-induced neutrophil chemoattractant-1, in scurvy-prone ODS rats. (2006)
  • Author(s): Horio, F. et al.
  • Journal Title: J. Nutr. Sci. Vitaminol. 52 Pages: 28-32
• [Presentation] 2型糖尿病モデルマウスにおけるシアニジン-3-グルコシドの抑制効果とその機構 (2007)
  • Author(s): 佐々木 理恵, 他
  • Organizer: 日本食品科学工学会第54回大会
  • Place of Presentation: 福岡市
  • Year and Date: 2007-09-08
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Molecular mechanism for anti-diabetic Effect of anthocyanin (2007)
  • Author(s): Sasaki, R., et. al.
  • Organizer: The Japanese Society for Food Science and Technology
  • Year and Date: 2007-09-08
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 2型籍尿病モデルマウスにおけるシアニジン-3-グルコシドの抑制効果とその機構 (2007)
  • Author(s): 佐々木理恵, 他
  • Organizer: 日本食品科学工学会第54回大会
  • Place of Presentation: 福岡市
  • Year and Date: 2007-09-08
• [Presentation] 2型糖尿病モデルマウスにおけるシアニジン-3-グルコシドの作用 (2007)
  • Author(s): 佐々木 理恵, 他
  • Organizer: 日本農芸化学会2007年度大会
  • Place of Presentation: 東京都
  • Year and Date: 2007-03-26
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Anti-diabetic effect of anthocyanin (2007)
  • Author(s): Sasaki, R., et. al.
  • Organizer: Japan Society for Bioscience, Biotechnology, and Agrochemistry, 2007.
  • Year and Date: 2007-03-26
  • Description: 「研究成果報告書概要(欧文)」より
• [Remarks] 「研究成果報告書概要(和文)」より
  • URL: http://stu.isc.chubu.ac.jp/bio/public/Food_Nutr_Sci/labo/tsuda_lab/index.html
• [Remarks]
  • URL: http://stu.isc.chubu.ac.jp/bio/public/Food_Nutr_Sci/labo/tsuda_lab/index.html