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Research on Identification and Characterization of Growth Factor in Abalone

Research Project

Project/Area Number 18580190
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General fisheries
Research InstitutionKitasato University

Principal Investigator

MORIYAMA Shunsuke  Kitasato University, 海洋生命科学部, 准教授 (50222352)

Research Collaborator TAKAHASHI Akiyoshi  北里大学, 海洋生命科学部, 教授 (10183849)
AMANO Masafumi  北里大学, 海洋生命科学部, 教授 (10296428)
UCHIDA Katsuhisa  新潟大学, 自然科学系, 助教 (50360508)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,010,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywords成長ホルモン / 脳下垂体ホルモン / 分子進化 / アワビ / 成長促進因子 / 受容体 / 成長促進因子受容体 / サケ成長ホルモン
Research Abstract

本研究は、成長ホルモン遺伝子が無脊椎動物に起源する仮説およびサケ成長ホルモンがエゾアワビ稚貝の成長を促進する発見に基づいて、軟骨魚類と無顎類の成長促進に関与するホルモン受容体を同定した。また、アワビの脳神経節にサケの成長ホルモン抗体に対する免疫反応陽性細胞群を検出し、その組織から成長促進因子および遺伝子を単離するとともに成長促進因子受容体を探索した

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (30 results)

All 2009 2008 2007 2006 Other

All Journal Article (18 results) (of which Peer Reviewed: 15 results) Presentation (9 results) Book (3 results)

  • [Journal Article] cDNA cloning and isolation of somatolactin in Mozambique tilapia andeffects of seawater acclimation,confinement stress, and fasting on itspituitary expression2009

    • Author(s)
      Uchida K, Moriyama S, Breves JP, Fox BK, Pierce AL, Borski RJ, Hirano T, Grau EG.
    • Journal Title

      Gen. Comp. Endocrinol. 161

      Pages: 162-170

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene structure and functional characterrrizationof growth hormone in dogfish,Squalus acanthias2008

    • Author(s)
      Moriyama S, Oda M, Yamazaki T, Yamaguchi K, Amiya N, Takahashi A, Amano M, GotoT, Nozaki M, Meguro H, Kawauchi H.
    • Journal Title

      Zool. Sci. 25

      Pages: 604-613

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ability of salmon growth hormone to accelerate the somatic growthof juvenile abalone Haliotis discushannai2008

    • Author(s)
      Moriyama S, Tashiro K, Furukawa S, Kawauchi H.
    • Journal Title

      Fis. Sci. 74

      Pages: 860-866

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of posttranslational processing of proopiomelanocortinin the banded houndshark pituitary bycombined cDNA cloning and massspectrometry2008

    • Author(s)
      Takahashi A, Kobayashi Y, Moriyama S, Hyodo S.
    • Journal Title

      Gen. Comp. Endocrinol. 157

      Pages: 41-48

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] RFamide peptides inhibit the expression of melanotropin and growth hormone genes in the pituitary of an Agnathan, the sea lamprey, Petromyzon marinus.2008

    • Author(s)
      Moriyama, S., 他3名
    • Journal Title

      Fish. Sci. 76

      Pages: 860-866

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene structure and functional characterization of growth hormone in dogfish, Squalus acanthias.2008

    • Author(s)
      Moriyama, S., 他10名
    • Journal Title

      Zool. Sci. 25

      Pages: 604-613

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RFamide peptides inhibit the expression of melanotropin and growth hormone genes in the pituitary of an Agnathan,the sea lamprey, Petromyzon marinus.2008

    • Author(s)
      Moriyama, S., 他7名
    • Journal Title

      Endocrinology 148

      Pages: 3740-3749

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RFamide peptides inhibit the expression of melanotropin andgrowth hormone genes in the pituitary ofan Agnathan, the sea lamprey, Petromyzon marinus2007

    • Author(s)
      Moriyama S, Kasahara M, Amiya N, Takahashi A, Amano M, Sower SA, YamamoriK, Kawauchi H.
    • Journal Title

      Endocrinology 148

      Pages: 3740-3749

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Occurrence of two functionally distinct proopiomelanocortin genes inall modern lampreys2006

    • Author(s)
      Takahashi A, Nakata O, Moriyama S, Nozaki M, Joss MPJ, Sower SA, KawauchiK.
    • Journal Title

      Gen. Comp. Endocrinol. 148

      Pages: 72-78

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genomic structure of the sea lamprey growth hormone-encoding gene2006

    • Author(s)
      Moriyama S, Oda M, Takahashi A, Sower SA, Kawauchi H.
    • Journal Title

      Gen. Comp. Endocrinol. 148

      Pages: 33-40

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of sea lamprey GTHb-like cDNA andits evolutionary implications2006

    • Author(s)
      Sower SA, Moriyama S, Kasahara M, Takahashi A, Nozaki M, Uchida K,Dahlstrom JM, Kawauchi H.
    • Journal Title

      Gen. Comp. Endocrinol. 148

      Pages: 22-32

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of sea lamprey GTHb-like cDNA and its evolutionary implications.2006

    • Author(s)
      Sower S. A, 他7名
    • Journal Title

      Gen. Comp. Endocrinol. 148

      Pages: 22-32

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Genomic structure of the sea lamprey growth hormone-encoding gene.2006

    • Author(s)
      Moriyama S., 他4名
    • Journal Title

      Gen. Comp. Endocrinol. 148

      Pages: 33-40

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification of growth hormone-releasing hormone, somatostatin and growth hormone in elasmobranch, dogfish, Triakis scyllium.2006

    • Author(s)
      Moriyama S., 他7名
    • Journal Title

      Proceedings of the Japan Society for Comparative Endocrinology 21

      Pages: 53-53

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Growth stimulation of juvenile abalone, Haliotis discus hannai, by feeding with salmon growth hormone in sodium alginate

    • Author(s)
      Moriyama S, Furukawa S, Kawauchi H.
    • Journal Title

      gel. Fis. Sci. (In press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Growth stimulation of juvenile abalone, Haliotis discus hannai, by feeding with salmon growth hormone in sodium alginate gel.

    • Author(s)
      Moriyama, S., 他2名
    • Journal Title

      Fish. Sci. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ability of salmon growth hormoe to accelerate the somatic growth of juvenile abalone Haliotis discus hannai.

    • Author(s)
      Moriyama, S., 他3名
    • Journal Title

      Fish.Sci. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene structure and functional characterization of growth hormone in dogfish,squalus acanthias.

    • Author(s)
      Moriyama, S., 他10名
    • Journal Title

      Zool.Sci. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 軟骨魚類のプロラクチン放出ペプチドホモログの単離、組織分布と生物活性2008

    • Author(s)
      森山俊介, 阿見弥典子, 天野勝文, 高橋明義, 兵藤晋
    • Organizer
      第33回日本比較内分泌学会大会およびシンポジウム
    • Place of Presentation
      広島
    • Year and Date
      2008-12-05
    • Related Report
      2008 Final Research Report
  • [Presentation] 無顎類からみた腺性下垂体ホルモンの進化2007

    • Author(s)
      野崎眞澄, 下谷豊和, 内田勝久, 森山俊介, 高橋明義, 川内浩司, Stacia A Sower
    • Organizer
      第32回日本比較内分泌学会大会およびシンポジウム
    • Place of Presentation
      日光
    • Year and Date
      2007-10-12
    • Related Report
      2008 Final Research Report
  • [Presentation] 魚類の成長ホルモンと成長促進機構2007

    • Author(s)
      森山俊介
    • Organizer
      動物学会関連集会「ホメオスタシス研究会」
    • Place of Presentation
      弘前
    • Year and Date
      2007-09-20
    • Related Report
      2008 Final Research Report
  • [Presentation] ドチザメの成長促進に関与する視床下部・下垂体ホルモン2006

    • Author(s)
      森山俊介
    • Organizer
      東京大学海洋研究所共同利用研究集会「軟骨魚類を探る」
    • Place of Presentation
      東京
    • Year and Date
      2006-12-01
    • Related Report
      2008 Final Research Report
  • [Presentation] 軟骨魚類の成長促進に関与する視床下部および下垂体ホルモンの同定2006

    • Author(s)
      森山俊介, 熊田ひかり, 西野愛子, 前田知里, 阿見弥典子, 天野勝文, 兵藤晋, 川内浩司
    • Organizer
      第31回日本比較内分泌学会大会及びシンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2006-11-03
    • Related Report
      2008 Final Research Report
  • [Presentation] 軟骨魚類の成長促進に関与する視床下部および下垂体ホルモンの同定2006

    • Author(s)
      森山俊介, 熊田ひかり, 前田知里, 阿見弥典子, 天野勝文, 兵藤晋, 川内浩司
    • Organizer
      日本下垂体研究会第21回学術集会
    • Place of Presentation
      静岡
    • Year and Date
      2006-08-03
    • Related Report
      2008 Final Research Report
  • [Presentation] 魚類のプロラクチン放出ペプチドの構造と生物活性2006

    • Author(s)
      森山俊介, 阿見弥典子, 天野勝文, 兵藤晋,高橋明義, 野崎眞澄, Sower, S.A., 川内浩司.
    • Organizer
      第19回「遺伝子とその周辺」研究会
    • Place of Presentation
      相模原
    • Year and Date
      2006-08-02
    • Related Report
      2008 Final Research Report
  • [Presentation] Structures and tissues distributions of growth hormone and insulin-like growth factor-I receptors in salmon2006

    • Author(s)
      Moriyama, S.
    • Organizer
      VIIth International Congress on the Biology of Fish
    • Place of Presentation
      Newfoundland, Canada
    • Year and Date
      2006-07-22
    • Related Report
      2008 Final Research Report
  • [Presentation] 魚類のプロラクチン放出ペプチドの構造と生物活性2006

    • Author(s)
      森山俊介, 阿見弥典子, 天野勝文, 兵藤晋,高橋明義, 野崎眞澄, Sower, S.A., 川内浩司
    • Organizer
      第3回GPCR 研究会
    • Place of Presentation
      東京
    • Year and Date
      2006-05-13
    • Related Report
      2008 Final Research Report
  • [Book] ホルモンハンドブック2007

    • Author(s)
      森山俊介. 成長因子
    • Publisher
      南江堂
    • Related Report
      2008 Final Research Report
  • [Book] 培風館. シリーズ21世紀の動物科学 (10) 内分泌と生命現象2007

    • Author(s)
      川内浩司, 高橋明義, 森山俊介
    • Publisher
      下垂体ホルモンの多様性
    • Related Report
      2008 Final Research Report
  • [Book] Fish Physiology : Fish Neuroendocrinology(Vol. 28, In press)

    • Author(s)
      Kawauchi H, Sower SA, Moriyama S.
    • Publisher
      Chapter 5 : The neuroendocrine regulation of prolactin andsomatolactin secretion. Elsevier
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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