| Project/Area Number |
18580201
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fisheries chemistry
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| Research Institution | Muroran Institute of Technology |
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Principal Investigator |
HASEGAWA Yasushi Muroran Institute of Technology, 工学部, Professor (80261387)
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| Project Period (FY) |
2006 – 2007
|
| Project Status |
Completed (Fiscal Year 2007)
|
| Budget Amount *help |
¥3,800,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | lipolysis / waste product / effective utilization / scallop shell |
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| Research Abstract |
We previously showed that the organic components in scallop shell (scallop shell extract) promote lipolysis in differentiated 3T3-L1 and C3H10T1/2 adipocyte cells and that incorporating scallop shell powder into the diet of rats reduced the amount of white adipose tissue. Feeding of scallop shell powder increased mRNA levels of UCP1 and UCP2 in white adipose tissue. By centrist, scallop shell powder had no effect on the expression of UCP1 in brown adipose tissue, although the expression level of UCP2 mRNA was significantly decreased. These results suggested that feeding the scallop shell powder increases gene expression of UCP1 that may regulate energy metabolism in white adipose tissue, resulting in the observed reduction in weight of white adipose tissue. In addition, the scallop shell extract suppressed adipose differentiation in 3T3-L1 cells. The scallop shell extract may prevent obesity through the suppression of adipocyte differentiation.
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