| Project/Area Number |
18580288
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Iwate University |
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Principal Investigator |
TANIGUCHI Kazuyuki Iwate University, Iwate University, Faculty of Agriculture, Professor (70148089)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Yoshio Iwate University, Faculty of Agriculture, Professor (10252123)
TANIGUCHI Kazumi Kitasato University, School of Veterinary Medicine and Animal Science, Lecturer (00171843)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,800,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | veterinary medicine / brain・nerve / cell・tissue / olfaction / pheromone |
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| Research Abstract |
The vomeronasal organ (VNO) is concerned with the pheromone perception, and its sensory neurons project to the accessory olfactory bulb. Neurons in the accessory olfactory bulb project via the amygdaloid body to the medial preoptic area of hypothalamus and control the secretion of sex hormones through GnRH neurons of the preoptic area. In addition, dopamine cells of the tubero-infundibular system are known to suppress the release of sex hormones from the adenohypophysis. These reports suggest that the removal of the VNO leads to the changes in the density and distribution of GnRH neurons and TH neurons of the hypothalamus and influences the reproduction control mechanism. Therefore, we removed the rat VNO and examined the immuniohistochemical changes of the LHRH and TH neurons in the hypothalamus. Rats were used at 64, 98 and 164 days after removal of the VNO. There were no significant differences in the distribution density of GnRh1- and GnRH3-positive cells and nerves between experimental and control groups. Removal of the VNO did not influence the distribution of TH-positive fibers in the olfactory tubercle and TH-positive cells and fibers around the third ventricle. Although GnRH neurons and TH neurons in the central nervous between experimental and control groups. Removal of the VNO did not influence the distribution of TH-positive fibers in the olfactory tubercle and TH-positive cells and fibers around the third ventricle. Although GnRH neurons and TH neurons in the central nervous system were not influenced by the removal of the VNO, GnRH3-positive nerves and fibers tended to increase slightly after the removal of the VNO. These findings suggest that the removal of the VNO did not influence the sex hormone secretory mechanism in the central nervous system of the rats over 64 days after removal of the VNO.
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