The role of non-coding RNAin developmental toxicity by dioxin

• Project/Area Number: 18580298
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: Rakuno Gakuen University
• Principal Investigator: TERAOKA Hiroki Rakuno Gakuen University, School of Veterinary Medicine, Professor (50222146)
• Co-Investigator(Kenkyū-buntansha): ENDO Daiji Rakuno Gakuen University, School of Veterinary Medicine, Professor (40168828)
• Project Period (FY): 2006 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥3,830,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2006: ¥2,400,000 (Direct Cost: ¥2,400,000)
• Keywords: zebrafish / non-coding RNA / dioxin / TCD / developmental toxicology / aryl hydrocarbon receptor / cytochrome P450 / 循環毒性

Research Abstract

1) Development of novel DOP-PCR method with transcriptome as a target: We developed a novel degenerate oligonucleotide-primed PCR (DOP-PCR) with high reproducibility. We used mono-primers for DOP-PCR, as there were many sets of inverse-repeat sequence adequate for PCR reaction in transcriptome of zebrafish (Danio rerio). Primed part of primers (specific sequence part) was designed to obtain about 10 bands for each PCR reaction, using our developed computer program.
2) Differential display approach in search for transcripst increased by TCDD : We carried out differential display based on DOP-PCR described above and found CYP1C1 and 1C2 were dramatically upregulated by TCDD exposure. Gene knockdown of CYP1C2 rescued mesencephalic circulation from TCDD-induced failure, suggesting the possible rule of CYP1C2 in TCDD developmental toxicity.
3) Application of DOP-PCR for other fish species with zebrafish primers: DOP-PCR with the primers designed for zebrafish could be used for reproducible PCR products with medaka (Oryzias latips) and other 8 fish species. The same strategy could be applicable for various mammals or birds using DOP-PCR primers designed for rodents and domestic fowls.
4) Effects of dioxin on miRNA transcriptional status: Microarray media with 272 different miRNA spots was used to clarify the effect of TCDD on miRNA transcriptinal status. About 10 miRNA species showed two-fold changes or more in trasciptational level by TCDD exposure at 48 and 72 hours post fertilization, respectively. Most of these miRNA speceis overlap between two stages.

Research Products

• [Journal Article] Functional Disorder of the Retina in Manganese-Deficient Japanese Quail Reveale d by Electroretinography using a Contact Lens Electrode with Built-In Light (2008)
  • Author(s): Endo K, Itoh N, Maehara S., et. al.
  • Journal Title: Journal of Veterinary Medical Science 70 Pages: 139-144
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Functional disorder of the retina in manganese-deficient Japanese quail revealed by electroretinography using a contact lens electrode with built-in light source (2008)
  • Author(s): Endo K, Itoh N, Maehara S, Shinozaki A, Imagawa T, Uehara M, Mizuno S, Sasaki J, Hiraga T, Teraoka, H
  • Journal Title: J Vet Med Sci 70 Pages: 139-144
  • NAID: 110006613916
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Isolation of novel adenovirus from fruit bat(Pteropus dasymallus yayeyamae) (2008)
  • Author(s): Maeda K, Hondo E, Terakawa J, Kiso Y, Nakaichi N, Endoh D, Sakai K, Morikawa S, Mizutani, T
  • Journal Title: Emerg Infect Dis 14 Pages: 347-349
  • NAID: 120005761328
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Autoimmune glomerulonephritis induced in congenic mouse strain carrying telomeric region of chromosome 1 derived from MRL/MpJ (2008)
  • Author(s): Ichii O, Konno A, Sasaki N, Endoh D, Hashimoto Y, Kon, Y
  • Journal Title: Histol Histopathol 23 Pages: 411-422
  • NAID: 120005951839
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Functional Disorder of the Retina in Manganese-Deficient Japanese Quail Revealed by Electroretinography using a Contact Lens Electrode with Built-In Light (2008)
  • Author(s): Endo K, Itoh N, Maehara S., et. al.
  • Journal Title: Journal of Veterinary Medical Science 70 Pages: 139-144
  • Peer Reviewed
• [Journal Article] Heavy-metal contamination status of Japanese cranes(Gras japonensis) in East Hokkaido,Japan -Extensive mercury pollution (2007)
  • Author(s): Teraoka H, Kumagai Y, et. al.
  • Journal Title: Environmental Toxicology and Chemistry 26 Pages: 307-312
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Nonsense mutation of feline beta-hexosaminidase beta-subunit(HEXB) gene causing Sandhoff disease in a family of Japanese domestic cats (2007)
  • Author(s): Kanae Y, Endoh D., et. al.
  • Journal Title: Research in Veterinary Science 82 Pages: 54-60
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Enhancement of cytotoxicity against Vero E6 cells persistently infected with SAR S-CoV by Mycoplasma fermentans (2007)
  • Author(s): Mizutani T, Fukushi S., et. al.
  • Journal Title: Archives of Virology 152 Pages: 1019-1025
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Rapid genome sequencing of RNA viruses (2007)
  • Author(s): Mizutani T, Endoh D., et. al.
  • Journal Title: Emerging Infectious Disease 13 Pages: 322-324
  • NAID: 120005761147
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Isolation of novel adenovirus from fruit bat(Pteropus dasymallus yayey amae) (2007)
  • Author(s): Maeda K, Hondo E., et. al.
  • Journal Title: Emerging Infectious Disease 14 Pages: 347-349
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Autoimmune glomerulonephritis induced in congenic mouse strain carryi ng telomeric region of chromosome 1 derived from MRL/MpJ (2007)
  • Author(s): Ichii O, Konno A., et. al.
  • Journal Title: Histology and Histopathology 23 Pages: 411-422
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Trientine,a copper-chelating agent,induced apoptosis in murine fibrosa rcoma cells in vivo and in vitro (2007)
  • Author(s): Hayashi M, Nishiya H., et. al.
  • Journal Title: Journal of Veterinary Medical Science 69 Pages: 137-142
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Ovarian cysts in MRL/MpJ mice originate from rete ovarii (2007)
  • Author(s): Kon Y, Konno A., et. al.
  • Journal Title: Anatomia Histologia Embryologia 36 Pages: 172-178
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] An improved procedure for rapid determination of viral RNA sequences of avian RNA viruses (2007)
  • Author(s): Sakai K, Mizutani T., et. al.
  • Journal Title: Archives of Virology 152 Pages: 1763-1765
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Rapid determination of viral RNA sequences in mosquitoes collected in the field (2007)
  • Author(s): Kihara Y, Satho T., et. al.
  • Journal Title: Journal of Virological Methods 146 Pages: 372-374
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Combined effects of treatment with trientine,a copper-chelating agent,and x-irradiation on tumor growth in transplantation model of a murin e fibrosarcoma (2007)
  • Author(s): Hayashi M, Hirai R.
  • Journal Title: Journal of Veterinary Medical Science 69 Pages: 1039-1045
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Heavy metal contamination status of Japanese cranes(Grus japonensis) in east Hokkaido, Japan -Extensive mercury pollution (2007)
  • Author(s): Teraoka H, Kumagai Y, Iwai H, Haraguchi K, Ohba T, Nakai K, Satoh H, Sakamoto M, Momose K, Masatomi H, Hiraga, T
  • Journal Title: Environ Toxicol Chem 26 Pages: 307-312
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 2007. Nonsense mutation of feline beta-hexosaminidase beta-subunit(HEXB) gene causing Sandhoff disease in a family of Japanese domestic cats (2007)
  • Author(s): Kanae Y, Endoh D, Yamato O, Hayashi D, Matsunaga S, Ogawa H, Maede Y, Hayashi, M
  • Journal Title: Res Vet Sci 82 Pages: 54-60
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Enhancement of cytotoxicity against Vero E6 cells persistently infected with SARS-CoV by Mycoplasma fermentans (2007)
  • Author(s): Mizutani T, Fukushi S, Kenri T, Sasaki Y, Ishii K, Endoh D, Zamoto A, Saijo M, Kurane I, Morikawa, S
  • Journal Title: Arch Virol 152 Pages: 1019-1025
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Trientine, a copper-chelating agent, induced apoptosis in murine fibrosarcoma cells in vivo and in vitro (2007)
  • Author(s): Hayashi M, Nishiya H, Chiba T, Endoh D, Kon Y, Okui, T
  • Journal Title: J Vet Med Sci 69 Pages: 137-142
  • NAID: 110006201230
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Ovarian cysts in MRL/MpJ mice originate from rete ovarii (2007)
  • Author(s): Kon Y, Konno A, Hashimoto Y, Endoh, D
  • Journal Title: Anat Histol Embryol 36 Pages: 172-178
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] An improved procedure for rapid determination of vira RNA sequences of avian RNA viruses (2007)
  • Author(s): Sakai K, Mizutani T, Fukushi S, Saijo M, Endoh D, Kurane I, Takehara K, Morikawa, S
  • Journal Title: Arch Virol 152 Pages: 1763-1765
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Rapid determination of viral RNA sequences in mosquitoes collected in the field (2007)
  • Author(s): Kihara Y, Satho T, Eshita Y, Sakai K, Kotaki A, Takasaki T, Rongsriyam Y, Komalamisra N, Srisawat R, Lapcharoen P, Sumroiphon S, Iwanaga S, Ushijima H, Endoh D, Miyata T, Sakata A, Kashige N, Miake F, Fukushi S, Saijo M, Kurane I, Morikawa S, Mizutani, T
  • Journal Title: J Virol Methods 146 Pages: 372-374
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Combined effects of treatment with trientine, a copper-chelating agent, and x-irradiation on tumor growth in transplantation model of a murine fibrosarcoma (2007)
  • Author(s): Hayashi M, Hirai R, Ishihara Y, Horiguchi N, Endoh D, Okui, T
  • Journal Title: J Vet Med Sci 69 Pages: 1039-1045
  • NAID: 110006418723
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Heavy-metal contamination status of Japanese crances (Grus japonensis) in East Hokkaido, Japan-Extensive mercury pollution- (2007)
  • Author(s): Teraoka H, Kumagai Y, Iwai H. et al.
  • Journal Title: Environmental Toxicology and Chemistry 26 Pages: 307-312
• [Journal Article] Nonsense mutation of feline beta-hexosaminidase beta-subunit (HEXB) gene causing Sandhoff disease in a family of Japanese domestic cats. (2007)
  • Author(s): Kanae Y, Endoh D. et al.
  • Journal Title: Research in Veterinary Science 82 Pages: 54-60
• [Journal Article] Enhancement of cytotoxicity against Vero E6 cells persistently infected with SARS-CoV by Mycoplasma fermentans. (2007)
  • Author(s): Mizutani T, Fukushi S. et al.
  • Journal Title: Archives of Virology in press
• [Journal Article] PCR-based species-specific amplification of ITS of Mecistocirrus digitatusand its application in identification of GI nematode eggs in bovine faeces (2006)
  • Author(s): Mochizuki R, Endoh D., et. al.
  • Journal Title: Journal of Veterinary Medical Science 68 Pages: 345-351
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Expression of the PTEN tumor suppressor gene in malignant mammary gland to mors of dogs (2006)
  • Author(s): Kanae Y, Endoh D., et. al.
  • Journal Title: American Journal of Veterinary Research 67 Pages: 127-133
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Localization and secretion of epidermal growth factor in the parotid gland and it s intragastric kinetics in sheep (2006)
  • Author(s): Onaga T, Shimizu Y., et. al.
  • Journal Title: Liffe Sciences 79 Pages: 1616-1629
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Expression of the PTEN tumor suppressor gene in malignant mammary gland tumors of dogs (2006)
  • Author(s): Kanae Y, Endoh D, Yokota H, Taniyama H, Hayashi, M
  • Journal Title: Am J Vet Res 67 Pages: 127-133
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 2006. PCR-based species-specific amplification of ITS of Mecistocirrus digitatus and its application in identification of GI nematode eggs in bovine faeces (2006)
  • Author(s): Mochizuki R, Endoh D, Onuma M, Fukumoto, S
  • Journal Title: J Vet Med Sci 68 Pages: 345-351
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Localization and secretion of epidermal growth factor in the parotid gland and its intragastric kinetics in sheep (2006)
  • Author(s): Onaga T, Shimizu Y, Hayashi H, Tsuji M, Endoh D, Okada, H
  • Journal Title: Life Sciences 79 Pages: 1616-1629
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Retinal Neuronal Cell is a Toxicological Target of Tributyltin in Developing Zebrafish. (2006)
  • Author(s): Dong W, Muramoto W, Nagai Y et al.
  • Journal Title: Journal of Veterinary Medical Science 68 Pages: 573-579
• [Journal Article] PCR-based specific amplification ITS of Mecistocirrus digitatus and its application in identification of GI nematode eggs in bovine faeces. (2006)
  • Author(s): Mochizuki R, Endoh D. et al.
  • Journal Title: Journal of Veterinary Medical Science 68 Pages: 345-351
• [Journal Article] Muscarinic receptor subtypes involved in carbachol-induced contraction of mouse uterine smooth muscle
  • Author(s): Kitazawa T, Hirama R., et. al.
  • Journal Title: Naunyn-Schmiedeberg's Archives of Pharmacology (in press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Lead exposure induces pycnosis and enucleation of peripheral erhtyrocytes in.
  • Author(s): Hiraga T, Ohyama K., et. al.
  • Journal Title: Veterinary Journal (in press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Oocytes in Newborn MRL Mouse Testes
  • Author(s): Otsuka S, Konno A., et. al.
  • Journal Title: Biology and Reproduction (in press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Rapid genome sequencing of RNA viruses
  • Author(s): Mizutani T, Endoh D, Okamoto M, Shirato K, Shimizu H, Arita M, Fukushi S, Saijo M, Sakai K, Lim, CK, Ito M, Nerome R, Takasaki T, Ishii K, Suzuki T, Kurane I, Morikawa S, Nishimura, H
  • Journal Title: Emerg Infect Dis. 13 Pages: 322-324
  • NAID: 120005761147
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Lead exposure induces pycnosis and enucleation of peripheral erythrocytes in the domestic fowls
  • Author(s): Hiraga T, Ohyama K, Hashigaya A, Ishikawa T, Muramoto, W, Kitagawa H, Mizuno N, Teraoka, H
  • Journal Title: Vet J (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Muscarinic receptor subtypes involved in carbachol-induced contraction of mouse uterine smooth muscle
  • Author(s): Kitazawa T, Hirama R, Masunaga K, Nakamura T, Asakawa K, Cao J, Teraoka H, Unnno T, Komori S, Yamada M, Wess J, Taneike, T
  • Journal Title: Naunyn-Schmiedeberg Arch Pharmacol (in press)
  • NAID: 120005761368
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Oocytes in Newborn MRL Mouse Testes
  • Author(s): Otsuka S, Konno A, Hashimoto Y, Sasaki N, Endoh D, Kon, Y
  • Journal Title: Biol Reprod (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Muscarinic receptor subtypes involved in carbachol-induced contraction of mouse uterine smooth muscle
  • Author(s): Kitazawa T, Hirama R., et. al.
  • Journal Title: Naunyn-Schmiedeberg's Archives of Pharmacology (in press)
  • Peer Reviewed
• [Journal Article] Lead exposure induces pycnosis and enucleation of peripheral erhtyrocytes in
  • Author(s): Hiraga T, Ohyama K., et. al.
  • Journal Title: Veterinary Joumal (in press)
  • Peer Reviewed
• [Presentation] Improved differential display analysis based on degenerate oligonucleoti de- primed PCR (2008)
  • Author(s): Teraoka H, Igarashi K., et. al.
  • Organizer: 45th Annual Meeting of Society of Toxicology
  • Place of Presentation: Convention Center(Seattle,WA,USA)
  • Year and Date: 2008-03-20
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Improved differential display analysis based on degenerate oligonucleotide- primed PCR (2008)
  • Author(s): Teraoka H, Igarashi K, Itoh S, Ogawa A, Kubota A, Abou, Elmagd M, Hiraga T, Endoh, D
  • Organizer: 45th Annual Meeting of Society of Toxicology
  • Place of Presentation: Convention Center, Seattle, WA, USA
  • Year and Date: 2008-03-20
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Improved differential display analysis based on degenerate oligonucleotide-primed PCR (2008)
  • Author(s): Teraoka-H, Igarashi-K., et. al.
  • Organizer: Society of Toxicology 2008
  • Place of Presentation: Seattle,CA,USA
  • Year and Date: 2008-03-20
• [Presentation] 道東におけるタンチョウの水銀汚染:剥製試料を用いた歴史的考察 (2007)
  • Author(s): 寺岡 宏樹、田上 弓圭里, ほか
  • Organizer: 第10回環境ホルモン学会
  • Place of Presentation: 大宮ソニックシティ(さいたま市)
  • Year and Date: 2007-12-10
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Extensive and sever mercury contamination in Japanese cranes in Eastern Hokkaido, Japan : Retrospective estimates of merucury cotamination using feathers from stuffed specimens (2007)
  • Author(s): Teraoka H, Tagami Y, Matsumoto F, Ikoma S, Shimura R, Inoue M, Momose K, Masatomi H, Hiraga, T
  • Organizer: 10th Annual Meeting of Japan Society of Endocrine Disrupters Research
  • Place of Presentation: Omiya Sonic City Hall, Saitama
  • Year and Date: 2007-12-10
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 多様な魚種における遺伝子発現解析を目的としたDOP、PCR法の開発 (2007)
  • Author(s): 五十嵐 かほり、遠藤 大二, ほか
  • Organizer: 第13回小型魚類の会
  • Place of Presentation: 東京大学(東京都)
  • Year and Date: 2007-09-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Development of DOP-PCR for extensive analysis of gene expression in various fish species (2007)
  • Author(s): Igarashi K, Endoh D, Kounosu N, Itoh S, Ogawa A, Kubota A, Hiraga, T
  • Organizer: 13th Medaka and zebrafish Meeting
  • Place of Presentation: U. Tokyo, Tokyo
  • Year and Date: 2007-09-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 道東におけるタンチョウの水銀汚染:風切羽試料を用いた検討 (2007)
  • Author(s): 田上 弓圭里、星 光伊, ほか
  • Organizer: 第145回日本獣医学会
  • Place of Presentation: 酪農学園大学(北海道江別市)
  • Year and Date: 2007-09-03
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Mercury pollution of Japanese crane in east Hokkaido, Japan (2007)
  • Author(s): Tagami Y, Hoshi M, Kato M, Uebayashi A, Shimura R, Inoue M, Momose K, Masatomi Y, Hiraga T, Teraoka, H
  • Organizer: 145th Annual Meeting for the Japanese Society of Veterinary Science
  • Place of Presentation: Rakuno Gakuen U, Ebetsu
  • Year and Date: 2007-09-03
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] タンチョウの気管の形態学的考察-性差およびステージ差 (2007)
  • Author(s): 水田 晋介、志村 良治, ほか
  • Organizer: 第145回日本獣医学会
  • Place of Presentation: 酪農学園大学(北海道江別市)
  • Year and Date: 2007-09-02
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ナベヅルの前、後肢の筋肉における骨化の観察 (2007)
  • Author(s): 徐 朋詣、安田 宣紘, ほか
  • Organizer: 第145回日本獣医学会
  • Place of Presentation: 酪農学園大学(北海道江別市)
  • Year and Date: 2007-09-02
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Anatomy of trachea of Tancho, Grus japonensis (2007)
  • Author(s): Mizuta S, Shimura S, Inoue M, Uebayashi A, Momose K, Masatomi Y, Teraoka H, Hiraga, T
  • Organizer: 145th Annual Meeting for the Japanese Society of Veterinary Science
  • Place of Presentation: Rakuno Gakuen U, Ebetsu
  • Year and Date: 2007-09-02
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Ossification of muscle in the wing and posterior limb of Hooded crane, Grus monacha (2007)
  • Author(s): Shi M, Yasuda N, Teraoka H, Hiraga, T
  • Organizer: 145th Annual Meeting for the Japanese Society of Veterinary Science
  • Place of Presentation: Rakuno Gakuen U, Ebetsu
  • Year and Date: 2007-09-02
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Involvement of cycloxygenase-2-thromboxane pathway in pericardial ede ma caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin in developing zebrafish (2007)
  • Author(s): Teraoka H, Furuya M., et. al.
  • Organizer: 11th international Congress of Toxicology
  • Place of Presentation: Convention Center(Montreal,Canada)
  • Year and Date: 2007-07-18
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Involvement of cycloxygenase-2-thromboxane pathway in pericardial edema caused by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in developing zebrafish (2007)
  • Author(s): Teraoka H, Furuya M, Dong, W, Harada Y, Peterson, RE, Hiraga, T
  • Organizer: 11th international Congress of Toxicology
  • Place of Presentation: Convention Center, Montreal, Canada
  • Year and Date: 2007-07-18
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] LED内蔵型コンタクトレンズ電極を用いた鳥類網膜電図の (2006)
  • Author(s): 遠藤 健太郎、前原 誠也, ほか
  • Organizer: 第142回日本獣医学会学術集会
  • Place of Presentation: 山口大学(山口県山口市)
  • Year and Date: 2006-09-23
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Electroretinographic recording from Japanese quail using a contact lens electrode with built-in light source (2006)
  • Author(s): Endo K, Maehara S, Sasaki S, Itoh N, Teraoka H, Hiraga, T
  • Organizer: 142th Annual Meeting for the Japanese Society of Veterinary Science
  • Place of Presentation: Yamgaguchi U, Yagamuchi
  • Year and Date: 2006-09-23
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 記録新規アリハイドロカーボン受容体のゼブラフィッシュ初期発生における役割 (2006)
  • Author(s): 鴻巣 尚子、寺岡 宏樹, ほか
  • Organizer: 第142回日本獣医学会学術集会
  • Place of Presentation: 山口大学(山口県山口市)
  • Year and Date: 2006-09-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Involvement of a novel aryl hydrocarbon receptor in zebrafish development (2006)
  • Author(s): Kounosu N, Teraoka H, Nonoyama K, Dong, W, Hiraga, T
  • Organizer: 142th Annual Meeting for the Japanese Society of Veterinary Science
  • Place of Presentation: Yamgaguchi U, Yagamuchi
  • Year and Date: 2006-09-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 新規ダイオキシン受容体のゼブララィッシュ骨格筋形成における役割 (2006)
  • Author(s): 鴻巣 尚子、寺岡 宏樹, ほか
  • Organizer: 第12回小型魚類の会
  • Place of Presentation: 東レ総合研修センター(静岡県三島市)
  • Year and Date: 2006-09-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Role of a novel dioxin receptor in skeletal muscle formation in zebrafish (2006)
  • Author(s): Kounosu N, Teraoka H, Nonoyama K, Dong, W, Hiraga, T
  • Organizer: 12th Medaka and Zebrafish Meeting
  • Place of Presentation: Toray, Mishima
  • Year and Date: 2006-09-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Specific activation of aryl hydrocarbon receptor(AHR) soforms by 2,3,7, 8-tetrachlorodibenzo-p-dioxin in red seabream(Pagrus major) embryo (2006)
  • Author(s): Kim E-Y, Yamauchi M., et. al.
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology
  • Place of Presentation: 京都国際会議場(京都市)
  • Year and Date: 2006-06-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Specific activation of aryl hydrocarbon receptor(AHR) soforms by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in red seabream(Pagrus major) embryo (2006)
  • Author(s): Kim, E-Y, Yamauchi M, Iwata H, Teraoka H, Hiraga T, Tanabe, S
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology
  • Place of Presentation: Convention Center, Kyoto
  • Year and Date: 2006-06-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Involvement of cyclooxygenase 2 in mesencephalic circulation failure and apoptosis evoked by 2,3,7,8-tetrachlorodibenzo-p-dioxin in developingze brafish (2006)
  • Author(s): Teraoka H, Dong W., et. al.
  • Organizer: 7th International Conference on Zebrafish Development and Genetics
  • Place of Presentation: U.Wisconsin(Madison,WI,USA)
  • Year and Date: 2006-06-17
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Involvement of cyclooxygenase 2 in mesencephalic circulation failure and apoptosis evoked by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in developingzebrafish (2006)
  • Author(s): Teraoka H, Dong, W, Kounosu N, Furuya M, Nonoyama K, Hiraga, T
  • Organizer: 7th International Conference on Zebrafish Development and Genetics
  • Place of Presentation: U. Wisconsin, Madison, WI, US
  • Year and Date: 2006-06-17
  • Description: 「研究成果報告書概要(欧文)」より