Development of control technique of infectious diseases with immunomodifiers.
| Project/Area Number |
18580306
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
HIROTA Yoshikazu Tokyo University of Agriculture and Technology, Institute of Symbiotic Science and Technology, Professor (10134511)
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| Co-Investigator(Kenkyū-buntansha) |
ISOBE Takashi National Institute of Animal Health, Animal Disease Control Center, Director (60355170)
HAYASHIDANI Hideki Tokyo University of Agriculture and Technology, Institute of Symbiotic Science and Technology, Associate Professor (30180988)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2006: ¥2,600,000 (Direct Cost: ¥2,600,000)
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| Keywords | Safety of foods / Immunomodifiers / Immunosupression / Endotoxin shock / Control of antibiotics-resistant bacteria / Septemia / Recycle / Decrease of environmental load |
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| Research Abstract |
It is essential to establish the food production system including agricultural products with high quality of safety. Agriculture in the 21st century needs to take comprehensively basic opinions such as environment, recycling of natural resources and animal welfare into consideration. We have been searching useful immunomodifiers which have improving effects on animal productivity and studying its biological characteristics. Different kinds of native/natural immunomodifiers such sugar cane (Saccharum officinarum L.) extract (SCE) and an immunopotentiater of lipopolysaccharide derived from Pantoea agglomerans (IP-PA1) and a synthesized immunomodifier such as synthesized peptides derived from the beetle Allomyrina dichotoma defensin were used to evaluated their biological properties in animal model. In summary, (1) SCE showed recovery effects on histological and functional reconstitution in cyclophosphamide-induced immunosuppression in chickens. (2) Dextran sulfate-induced colititis is improved by oral administration of SCE. In addition, SCE has an alleviative effect on cisplantin-induced renal toxicity (3) Oral administration of IP-PA1 induced reduced fasting stress
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Report
(3 results)
Research Products
(124 results)
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[Journal Article] Rush allergen specific immunotherapy protocol in feline atopic dermatitis : a pilot study of four cats.2007
Author(s)
Y., Hirota
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Journal Title
Veterinary Dermatology (Ann M. Trimmer, Craig E. Griffin, Mona, J. Boord, Wayne, S. Rosenkrantz, Ed. Joan Rest),Blackwell Publishing Ltd., Oxford, UK 16
Pages: 324-329
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] "Chapter 3 Angiostrongylus infection, Chapter 18 Canine Lungworm, Chapter 21 Canine Tracheal Worm, Chapter 31 Cuterebriasis, Chapter 43 Feline Lungworm, Chapter 50 Heartworm Disease : Cats, and Chapter 51 Heartworm Disease : Dogs", In : 5-Minute Veterinary Consult Clinical Companion2007
Author(s)
Y., Hirota
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Journal Title
Canine and Feline Infectious Diseases and Parasitology (eds.), Inters Publishing Co. Ltd., Tokyo
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Masked, control study to investigate the efficiency of a Staphylococcus intermedius autogenous bacterin for the control of canine idiopathic recurrent superficial pyoderma2007
Author(s)
Y., Hirota
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Journal Title
Veterinary Dermatology (Curtis, C. F., Lamport, A. I., and Lloyd, D. H. Ed. Joan Rest), Blackwell Publishing Ltd., Oxford, UK 17(1)
Pages: 51-56
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Immunostimulating effects of the polyphenol-rich fraction of sugar cane(Saccharum officinarum L.) extract in chickens2007
Author(s)
Hikosaka, K., El-Absy, M., Koyama, Y., Motobu, M., Koge, K., Isobe, T., Kang, C-B, Hayashidani, H., Onodera, T., Wang, P-C., Matsumura, M., Hirota, Y.
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Journal Title
Phytotherapy Reseach 21・2
Pages: 120-125
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[Journal Article] Leucocytozoon.2006
Author(s)
T., Isobe
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Journal Title
Color Atlas of Veterinary Infectious Disease II, Buneido Publishing co., LTD
Pages: 565-566
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Protective effects of suger cane extracton endotoxin shock in mice2006
Author(s)
Motobu, M., Amer, S., Koyama, Y., Hikosaka, K., Sameshima, T., Yamada, M., nakamura, K., Koge, K., Kang, C-B, Hayashidani, H, Hirota, Y.
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Journal Title
Phytotherapy Research 20・2
Pages: 359-363
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[Journal Article] Protective effects of antimicrobial peptides derived from the beetle Allomyrina dichotoma defensin of endotoxic shock in mice2006
Author(s)
Koyama, Y., Motobu M., Hikosaka K., Yamada Mnabu, Nakamura Kikuyasu, Saido-sakanaka H, Adaoka A., Yamakawa M., Sekikawa K., Kitani H., Nakai Y., Hirota Y.
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Journal Title
International Immunopharmacology 6・2
Pages: 234-240
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[Journal Article] Cytotoxicity and antigenicity of antimicrobial synthesized peptides derived from the beetle Allomyrina dichotoma defensin in mice2006
Author(s)
Koyama, Y., Motobu, M., Hikosaka, K., Yamada, M., Nakamura, K., Saido-Sakanaka, H., Asaoka, A., Yamakawa, M., Isobe, T., Shimura, K., Kang, C-B., Hayashidani, H., Nakai, Y., Hirota, Y.
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Journal Title
Internatyonal Immunopharmacology 6・6
Pages: 1748-1753
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[Journal Article] Suggar cane (Saccharum officinarum L.) extract reduces lipopolysaccharide (LPS)-induced nitric oxide production in peritoneal macrophages and inhibits LPS-induced lethal shock in mice.2006
Author(s)
Hikosaka, K., Koyama, Y., Motobu, M., Nakamura, K., Koge, K., Shimura, K., Isode, T., Tsuji, N., Kang, C-B., Hayashidani, H., Wang, P., Matsumura, M., Hirota, Y.
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Journal Title
Bioscience, Biotechonology, and Biochemistry 70・12
Pages: 2853-2858
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[Presentation] 鶏マラリア2007
Author(s)
磯部 尚
Organizer
第21回日本動物原虫病学会
Place of Presentation
つくば市
Year and Date
2007-04-05
Description
「研究成果報告書概要(和文)」より
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[Book] 微生物の辞典 家禽の原虫
Author(s)
磯部 尚
Publisher
朝倉書店(印刷中)
Description
「研究成果報告書概要(和文)」より
Related Report
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[Patent(Industrial Property Rights)] 昆虫抗微生物タンパク質改変ペプチド, およびその利用.2007
Inventor(s)
山川 稔, 石橋 純, 坂中寿子, 山家又祐, 中村菊保, 山田 学, 廣田好和
Industrial Property Rights Holder
山川 稔, 石橋 純, 坂中寿子, 山家又祐, 中村菊保, 山田 学, 廣田好和
Industrial Property Number
2007-050352
Filing Date
2007-02-28
Description
「研究成果報告書概要(和文)」より
Related Report
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[Patent(Industrial Property Rights)] 昆虫抗微生物タンパク質改変ペプチド, およびその利用.2007
Inventor(s)
山川 稔, 石橋 純, 坂中寿子, 山家又祐, 中村菊保, 山田 学, 廣田好和
Industrial Property Rights Holder
山川 稔, 石橋 純, 坂中寿子, 山家又祐, 中村菊保, 山田 学, 廣田好和
Patent Publication Number
2007-284421
Acquisition Date
2007-11-01
Description
「研究成果報告書概要(和文)」より
Related Report
