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ROLE OF IMIDAZOLINE RECEPTORS IN THE PLATELET ACTIVATION SYSTEM

Research Project

Project/Area Number 18580316
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Clinical veterinary science
Research InstitutionTottori University

Principal Investigator

HIKASA Yoshikai  Tottori University, 農学部, 教授 (30165071)

Co-Investigator(Kenkyū-buntansha) 松田 浩珍  東京農工大学, 大学院・共生科学技術研究部, 教授 (80145820)
佐藤 耕太  北海道大学, 獣医学部, 准教授 (50283974)
Co-Investigator(Renkei-kenkyūsha) MATSUDA Hiroshi  東京農工大学, 大学院・共生科学技術研究部, 教授 (80145820)
SATO Kota  北海道大学, 獣医学部, 准教授 (50283974)
Research Collaborator 松鵜 松鵜  鳥取大学, 農学部獣医内科学, 准教授
M.H. Talukder  山口大学, 大学院・連合獣医学研究科臨床獣医学, 専攻生
神田 鉄平  山口大学, 大学院・連合獣医学研究科臨床獣医学, 専攻生
伊藤 宏泰  山口大学, 大学院・連合獣医学研究科臨床獣医学, 専攻生
高橋 元  鳥取大学, 農学部獣医内科学, 講座専攻生
佐藤 加奈子  鳥取大学, 農学部獣医内科学, 講座専攻生
松田 彬  鳥取大学, 農学部獣医内科学, 講座専攻生
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,880,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywords血小板 / 薬物受容体 / イミダゾリン / 細胞膜 / 凝集 / アドレナリン / GTP 結合蛋白質 / ウシ / ラット / ヨヒンビン / クロニジン / 血小板凝集 / コラーゲン / ADP / GTP結合蛋白質 / ノルエピネフリン / ウマ
Research Abstract

血小板活性化機構におけるイミダゾリン受容体(I-受容体)の役割を解明するために、ウシ、ウマ、ラットの血小板におけるI-受容体およびα_2-アドレナリン受容体(α_2-受容体)のサブタイプとその情報伝達経路を検討し、I-受容体を介する血小板凝集能を解析した。その結果、ウシ、ウマおよびラット血小板にはα_2-受容体がなく、I-受容体の2つのサブタイプの存在を明らかにした。ウマの血小板I-受容体数はイヌとネコに比べ多く、I 1-受容体はGTP結合蛋白質に共役していることを明らかにした。さらに、血小板凝集の解析より、ウシ血小板凝集を抑制する作用はI 1-受容体を介すことを示唆した。このような動物種による血小板の種類や数の相違はI-受容体の作用の解明に有用である。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (22 results)

All 2009 2008 2007 2006

All Journal Article (14 results) (of which Peer Reviewed: 12 results) Presentation (8 results)

  • [Journal Article] Antagonistic effects of atipamezole and yohimbine on medetomidine induced diuresis in healthy dogs2009

    • Author(s)
      Talukder M. H., Hikasa Y., Takahashi H.,Sato K. and Matsuu A.
    • Journal Title

      Can. J. Vet. Res. (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diureticeffects of medetomidine compared withxylazine in healthy dogs2009

    • Author(s)
      Talukder M. H. and Hikasa Y.
    • Journal Title

      Can. J. Vet. Res. (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antagonistic effects ofatipamezole and yohimbine on xylazineinduced diuresis in healthy dogs2009

    • Author(s)
      Talukder M. H., Hikasa Y., Matsuu A.and Kawamura H.
    • Journal Title

      J. Vet.Med. Sci. 71

      Pages: 539-548

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antagonistic effects of atipamezole and yohimbine on xylazine-induced diuresis in healthy dogs2009

    • Author(s)
      M. H. Talukder, Y. Hikasa, et al.
    • Journal Title

      Journal of Veterinary Medical Science 71

      Pages: 539-548

    • NAID

      130000134362

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diuretic effects of medetomidine compared with xylazine in healthy dogs2009

    • Author(s)
      M. H. Talukder, Y. Hikasa
    • Journal Title

      Canadian Journal of Veterinary Research (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antagonistic effects of atipamezole and yohimbine on medetomidine induced diuresis in healthy dogs2009

    • Author(s)
      M. H. Talukder, Y. Hikasa, et al.
    • Journal Title

      Canadian Journal of Veterinary Research (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of medetomidine and midazolam alone or in combination on the metabolic and neurohormonal responses in healthy cats2008

    • Author(s)
      Kanda T. and Hikasa Y.
    • Journal Title

      Can. J. Vet. Res. 72

      Pages: 332-339

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neurohormonaland metabolic effects of medetomidinecompared with xylazine in healthy cats2008

    • Author(s)
      Kanda T.and Hikasa Y.
    • Journal Title

      Can. J. Vet. Res. 72

      Pages: 278-286

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antagonistic effects of atipamezole, flumazenil, and 4-aminopyridine against anaesthesia with medetomidine, midazolam, and ketamine combination in cats2008

    • Author(s)
      Ueoka N, and Hikasa Y.
    • Journal Title

      J. Feline Med. Surg. 10

      Pages: 47-54

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antagonistic effects of atipamezole, flumazenil, and 4-aminopyridine againstanaesthesia with medetomidine, midazolam, and ketamine combination in cats2008

    • Author(s)
      N, Ueoka, Y. Hikasa
    • Journal Title

      Journal of Feline Medicine and Surgery 10

      Pages: 47-54

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurohormonal and metabolic effects of medetomidine compared with xylazine inhealthy cats2008

    • Author(s)
      T. Kanda, Y. Hikasa
    • Journal Title

      Canadian Journal of Veterinary Research 72

      Pages: 278-286

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exophthalmos caused by chronic sinusitis in a horse2007

    • Author(s)
      T. Kanda, Y. Hikasa, et. al.
    • Journal Title

      Journal of Equine Veterinary Science 27

      Pages: 539-541

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 猫におけるフサリウム症の1例2006

    • Author(s)
      上岡尚民, 上岡孝子, 日笠喜朗, 村瀬敏之, 小菅旬子, 坂井聡
    • Journal Title

      日本獣医師会雑誌 59

      Pages: 551-554

    • NAID

      10017643394

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 蓄膿症および鼻ポリープを伴う慢性副鼻腔炎の馬1例2006

    • Author(s)
      和田枝実子, 島田章則, 澤田倍美, 森田剛仁, 佐藤加奈子, 辻野久美子, 日笠喜朗, 天谷友彦
    • Journal Title

      日本獣医師会雑誌 59

      Pages: 112-115

    • NAID

      10017249021

    • Related Report
      2006 Annual Research Report
  • [Presentation] 犬におけるメデトミジンの利尿作用に対するアチパメゾールおよびヨヒンビンの桔抗効果2008

    • Author(s)
      M. H. Talukder, 佐藤加奈子, 松鵜彩, 日笠喜朗
    • Organizer
      平成20年度日本小動物獣医学会
    • Place of Presentation
      米子市
    • Year and Date
      2008-10-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 犬におけるメデトミジンの利尿作用に対するアチパメゾールおよびヨヒンビンの拮抗効果2008

    • Author(s)
      M.H. Talukder、佐藤加奈子、松鵜彩、日笠喜朗
    • Organizer
      平成20 年度日本小動物獣医学会[中国]、講演要旨集
    • Place of Presentation
      米子市(57)
    • Related Report
      2008 Final Research Report
  • [Presentation] Diuretic effects of medetomidine andxylazine in healthy dogs2007

    • Author(s)
      Talukder M.H., Hikasa Y., TakahashiH.
    • Organizer
      Proceedings of 13th International Veterinary Emergency and Critical Care Symposium (IVECCS)
    • Place of Presentation
      Hilton Riverside Hotel, New Orleans,USA(928)
    • Year and Date
      2007-09-27
    • Related Report
      2008 Final Research Report
  • [Presentation] Antagonistic effects of atipamezole and yohimbine against medetomidine induced diuresis in healthy dogs. Proceedings of 13th International Veterinary Emergency and Critical Care Symposium (IVECCS)2007

    • Author(s)
      Hikasa Y., Talukder M.H., Sato K.
    • Organizer
      Hilton Riverside Hotel
    • Place of Presentation
      New Orleans,USA(919)
    • Year and Date
      2007-09-27
    • Related Report
      2008 Final Research Report
  • [Presentation] Antagonistic effects of atipamezole and yohimbine against medetomidine induced diuresis in healthy dogs2007

    • Author(s)
      Hikasa Y, et. al.
    • Organizer
      13th International Veterinay Emergency and Critical Care Symposium
    • Place of Presentation
      Hilton Riverside Hotel, New Orleans
    • Year and Date
      2007-09-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] 組織ドプラ法を用いたイヌの心機能に及ぼす各種自律神経作用薬の影響2007

    • Author(s)
      日笠喜朗, 松田彬, 松鵜彩, 伊藤宏泰
    • Organizer
      平成19年度日本小動物獣医学会[中国]、講演要旨集
    • Place of Presentation
      山口市(44)
    • Related Report
      2008 Final Research Report
  • [Presentation] 犬におけるキシラジンおよびメデトミジンの利尿効果の比較2007

    • Author(s)
      Talukder Hasanuzzaman、高橋元、佐藤加奈子、日笠喜朗
    • Organizer
      第144回日本獣医学会学術集会、講演要旨集
    • Place of Presentation
      酪農学園大学、江別市(153)
    • Related Report
      2008 Final Research Report
  • [Presentation] 猫におけるメデトミジンとミダゾラムの併用が神経内分泌および代謝に及ぼす影響2007

    • Author(s)
      神田鉄平、松鵜彩、日笠喜朗
    • Organizer
      第144回日本獣医学会学術集会、講演要旨集
    • Place of Presentation
      酪農学園大学、江別市(153)
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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