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Study for inhibitory regulation of auto reactive T-cell by DC-HIL

Research Project

Project/Area Number 18580323
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Clinical veterinary science
Research InstitutionNippon Veterinary and Life Science University

Principal Investigator

BONKOBARA Makoto  Nippon Veterinary and Life Science University, Department of veterinary medicine, Lecturer (50343611)

Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥2,600,000 (Direct Cost: ¥2,600,000)
Keywordsdendritic cells / T-cells / suppression / antigen / co-stimulation
Research Abstract

I investigated dendritic cell-mediated antigen specific T-cell proliferation and suppression in this year. The reaction was studied on animals in vivo in previous year ; however, the study was not enough to validate specific reaction of T-cells. Therefore, in vitro analysis system was developed this year (Tamura, et. al. Journal of Veterinary Medical Science 2007). Using antigen prepared from malignant melanoma or malignant lymphoma, dendritic cells were pulsed and proliferation of lymphocytes were examined. Although dendritic cells loaded with antigen prepared from malignant melanoma induced proliferation of lymphocytes, dendritic cells loaded with antigen prepared from malignant lymphoma failed proliferation of lymphocytes. Dendritic cells loaded with antigen prepared from malignant melanoma express undetectable levels of DC-HIL, while that loaded with antigen prepared from malignant lymphoma showed high level expression of DC-HIL. The data suggested that DC-HIL is a molecule closely associates suppression of T cell proliferation. From this study, it was considered that DC-HIL control antigen-specific suppression of T cell and its abnormality may disrupt tolerance of T cells to self-tissues.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (28 results)

All 2008 2007 2006

All Journal Article (19 results) (of which Peer Reviewed: 8 results) Presentation (9 results)

  • [Journal Article] Expression of canine Kdap in normal,hyperplastic and neoplastic epidermis2008

    • Author(s)
      Yagihara H
    • Journal Title

      Veterinary Journal (Inpress)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Generation of monoclonal antibody against canine neural-cell adhesion molecule2008

    • Author(s)
      Uematsu Y
    • Journal Title

      Journal of Veterinary Medical Science (Inpress)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Response of canine mast cell tumor to tyrosine kinase inhibitor imatinib mesylate2008

    • Author(s)
      Isotani M
    • Journal Title

      Journal of Veterinary internal Medicine (Inpress)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Expression of canine Kdap in normal, hyperplastic and neoplastic epidermis2008

    • Author(s)
      Yagihara, H
    • Journal Title

      Veterinary Journal. (In press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Generation of monoclonal antibody against canine neural-cell adhesion molecule2008

    • Author(s)
      Uematsu, Y
    • Journal Title

      Journal of Veterinary Medical Science (In press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Response of canine mast cell tumor to tyrosinekinase inhibitor imatinib mesylate2008

    • Author(s)
      Isotani, M
    • Journal Title

      Journal of Veterinary internal Medicine (In press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Expression of canine Kdap in normal, hyperplastic and neoplastic epidermis2008

    • Author(s)
      Yagihara H
    • Journal Title

      Veterinary Journal (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of monoclonal antibody against canine neural-cell adhesion molecule2008

    • Author(s)
      Uematsu Y
    • Journal Title

      Journal of Veterinary Medical Science (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Response of canine mast cell tumor to tyrosine kinase inhibitor imatinib mesylate2008

    • Author(s)
      Isotani M
    • Journal Title

      Journal of Veterinary internal Medicine (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of dendritic cell-mediated immune responses among canine malignant Cells2007

    • Author(s)
      Tamura K
    • Journal Title

      Journal of Veterinary Medical Science 69

      Pages: 925-930

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Comparison of dendritic cell-mediated immune responses among canine malignant cells2007

    • Author(s)
      Tamura, K
    • Journal Title

      Journal of Veterinary Medical Science 69

      Pages: 925-930

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Comparison of dendritic cell-mediated immune responses among canine malignant cells2007

    • Author(s)
      Tamura K
    • Journal Title

      Journal of Veterinary Medical Science 69

      Pages: 925-930

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Light-chain multiple myeloma in a cat.2007

    • Author(s)
      Yamada O
    • Journal Title

      Journal of Veterinary Diagnostic Investigation. 19(4)(In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Induction of dendritic cell-mediated immune responses against canine malignant melanoma cells.2007

    • Author(s)
      Tamura K
    • Journal Title

      Veterinary Journal (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Blastic natural killer cell leukaemia in a dog - A case report.2007

    • Author(s)
      Bonkobara M
    • Journal Title

      Veterinary Journal. (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Genomic organization of the T-cell receptor g gene and PCR detection of its clonal rearrangement in canine T-cell lymphoma/leukemia.2007

    • Author(s)
      Yagihara H
    • Journal Title

      Veterinary Immunology and Immunopathology. 115(3-4)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Establishment and biological characterization of canine histolytic sarcoma cell lines.2006

    • Author(s)
      Azakami D
    • Journal Title

      Journal of Veterinary Medical Science. 68(12)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification of a c-kit exon 8 internal tandem duplication in a feline mast cell tumor case and its favorable response to the tyrosine kinase inhibitor imatinib mesylate.2006

    • Author(s)
      Isotani M
    • Journal Title

      Veterinary Immunology and Immunopathology. 114(1-2)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Efficient generation of canine bone marrow-derived dendritic cells.2006

    • Author(s)
      Isotani M
    • Journal Title

      Journal of Veterinary Medical Science. 68(8)

    • Related Report
      2006 Annual Research Report
  • [Presentation] リンパ腫が疑われたイヌ70症例におけるTGRγ鎖およびIgH鎖遺伝子再構成の解析2008

    • Author(s)
      植松 洋介
    • Organizer
      日本獣医臨床病理学会
    • Place of Presentation
      埼玉県・大宮ソニックシティー
    • Year and Date
      2008-02-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 樹状細胞療法を実施したイヌの悪性黒色腫の8例2008

    • Author(s)
      田村 俊介
    • Organizer
      日本獣医臨床病理学会
    • Place of Presentation
      埼玉県・大宮ソニックシティー
    • Year and Date
      2008-02-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] リンパ腫が疑われたイヌ70症例におけるTCRγ鎖およびIgH鎖遺伝子再構成の解析2008

    • Author(s)
      植松洋介
    • Organizer
      日本獣医臨床病理学会
    • Place of Presentation
      埼玉県・大宮ソニックシティー
    • Year and Date
      2008-02-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] Gene rearrangement analysis of TCR gamma and IgH in dogs suspected lymphoma2008

    • Author(s)
      Uematsu, Y
    • Organizer
      The Japanese Society of Veterinary Clinical Pathology
    • Place of Presentation
      Saitama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Eight cases of malignant melanoma treated with dendritic cell vaccine2008

    • Author(s)
      Tamura, S
    • Organizer
      The Japanese Society of Veterinary Clinical Pathology
    • Place of Presentation
      Saitama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 犬末梢血単球由来樹状細胞の効率的な誘導条件の検討2007

    • Author(s)
      吉田 昌充
    • Organizer
      日本獣医学会学術集会
    • Place of Presentation
      北海道・酪農学園大学
    • Year and Date
      2007-09-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 犬の自己活性化型カスパーゼ3の作製とその活性の検討2007

    • Author(s)
      染谷 麻美
    • Organizer
      日本獣医学会学術集会
    • Place of Presentation
      北海道・酪農学園大学
    • Year and Date
      2007-09-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Efficient generation of dendritic cells from peripheral blood in dogs2007

    • Author(s)
      Yoshida, M
    • Organizer
      The Japanese Society of Veterinary Science
    • Place of Presentation
      Hokkaido
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Generation functional analysis of recombinant self-activated canine caspase 32007

    • Author(s)
      Someya, A
    • Organizer
      The Japanese Society of Veterinary Science
    • Place of Presentation
      Hokkaido
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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