Characterization of a novel microtubule-associated protein that is related to myoblast differentiation

• Project/Area Number: 18590082
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Kyoto Pharmaceutical University
• Principal Investigator: HIRAYAMA Etsuko Kyoto Pharmaceutical University, 薬学部, 助教 (10247786)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥630,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
• Keywords: 細胞分化 / 骨格筋 / 筋芽細胞 / 筋管形成 / 微小管 / 神経細胞様突起 / NCAM

Research Abstract

ウズラ胚筋芽細胞が筋管を形成する時に、発現量が増加する一遺伝子(AB128922)を得、その遺伝子産物の特性を調べたところ、本遺伝子産物が、細胞接着分子で脳や筋肉の発生に関係するNCAM (neural cell adhesion molecule)という蛋白質に結合する事が明らかになった為、これをMYONAP (myogenesis-related and NCAM-associated protein)と命名した。

Research Products

• [Journal Article] Identification and characterization of a novel cell adhesion molecule (NCAM)-associated protein from quail myoblasts : relationship to myotube formation and induction of neuritelike protrusions (2008)
  • Author(s): Etsuko Hirayama and Jeman Kim
  • Journal Title: Differentiation 76 Pages: 253-266
  • Peer Reviewed
• [Journal Article] Identification and characterization of a novel neural cell adhesion molecule (NCAM)-associated protein from quail myoblasts: relationship to myotube formation and induction of neurite-like protnisions (2008)
  • Author(s): Etsuko Hirayama and Jeman Kim
  • Journal Title: Differentiation 76 Pages: 253-266
  • Peer Reviewed
• [Presentation] A novel neural cell adhesion molecule (NCAM)-associated protein from quail myoblasts is related to myotube formation and induction of neurite-like protrusions (2008)
  • Author(s): Etsuko Hirayama and Jeman Kim
  • Organizer: The 9th International Congress on Cell Biology
  • Place of Presentation: COEX(ソウル、大韓民国)
  • Year and Date: 2008-10-10
• [Presentation] A novel neural cell adhesion molecule (NCAM)-associated protein from quail myoblasts is related to myotube formation and induction of neurite-like protrusions. (2008)
  • Author(s): 平山恵津子
  • Organizer: The 9th International Congress on Cell Biology
  • Place of Presentation: COEX、ソウル、大韓民国
  • Year and Date: 2008-10-10
• [Presentation] ウズラ胚筋芽細胞由来NCAM結合蛋白質の同定とその特性 : 筋管形成への関与と神経細胞様突起の誘導 (2007)
  • Author(s): 平山恵津子
  • Organizer: 第40回日本発生生物学会・第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡国際会館(福岡県)
  • Year and Date: 2007-05-30
• [Presentation] ウズラ胚筋芽細胞由来新規NCAM結合蛋白質の同定とその特性;筋管形成への関与と神経細胞様突起の誘導 (2007)
  • Author(s): 平山 恵津子
  • Organizer: 第40回日本発生物学会・第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡国際会館
  • Year and Date: 2007-05-30