Studies on Novel Anti-Cancer Drugs binding to Allosteric site
| Project/Area Number |
18590099
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Kumamoto Health Science University |
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Principal Investigator |
OKAWARA Takashi Kumamoto Health Science University, Faculty of Health Science, Professor (60040325)
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| Co-Investigator(Kenkyū-buntansha) |
鈴木 啓太郎 熊本大学, 大学院医学薬学研究部, 助教授 (10154535)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,650,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | Moleculat Targeted Drug / mutation / allosteric inhinition / Galloyl group / structure optimization / anti-cancer drug / docking / hetero ring / 異変 / 抗がん剤 |
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| Research Abstract |
After anti-cancer drugs are used, cancers quickly mutate into resistant form against them. Drugs were designed to bind to allosteric site by using molecular docking method. Candidate compounds were selected, prepared, and assayed using topoisomerase and cancer cell lines. Results showed to inhibit the cancer growth.
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Report
(3 results)
Research Products
(1 results)
