Estblishment of curative therapy for Alzheimer's disease with Humanin peptides
| Project/Area Number |
18590106
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Keio University |
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Principal Investigator |
HASHIMOTO Yuichi Keio University, School of Medicine, Instructor (00317330)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥4,020,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | Alzheimer's disease / neurocnal cell death / Humanin / cytokine / receptor / STAT3 / small comoound / Transforming Growth Factor β |
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| Research Abstract |
In this research term, we focused on the identification of Humanin (HN) receptor and the search for small compounds which have HN activity.
1. Identification of HN receptor
I tried to identify the receptor for Humanin (HN), which is known as a medicinal seed for development of anti-Alzheimer's disease (AD) drug, using various molecular and cell biological techniques. From the results, I found that the HN receptor was consisted of WSX-1, ciliary neurotrophioc factor receptor (CNTFR), and gp1 30 consist of receptor. In addition, a novel splicing variant of WSX-1 was identified.
2. HN-like small compound search
To apply the clinical trila for AD patients, I tried to identify. the small molecule compound search. As mentioned above, one of component of HN receptor is "gp130", in frist, we tried to identify the molecules which can (a) bind to gp130, (2) show anti-AD insults activity, (3) activate STAT3, and(4) form the "WSX-1/CNTFR/gp130" complex. Until now, I found 2 molecules.
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Report
(3 results)
Research Products
(4 results)
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[Presentation] Humanin inhibits neuronal death via a CNTF receptor a/WSX-1/gp 130 complex2007
Author(s)
Yuichi, Hashimoto, Megumi, Kurita, Ikuo, Nishimoto, Sadakazu, Aiso, Masaaki, Matsuoka
Organizer
Society for Neuroscience 2007 Annual Meeting
Place of Presentation
San Diego, CA, USA
Year and Date
2007-11-06
Description
「研究成果報告書概要(欧文)」より
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