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Regulation of proteoglycan metabolism by adiponectin in vascular smooth muscle cells

Research Project

Project/Area Number 18590124
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental pharmacy
Research InstitutionHokuriku University

Principal Investigator

YAMAMOTO Chika  Hokuriku University, Pharmaceutical science, Associate professor (70230571)

Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,980,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2006: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywordsvascular smooth muscle cells / proteoglycan / adiponectin / homocysteine / TNF-α / versican / decorin / atherosclerosis / 血管
Research Abstract

Adiponectin is an adipose-specific plasma protein that exhibits antiatherogenic activities. Proteoglycans macromolecules comprising a core protein and glycosaminoglycan side chains are postulated to be the key molecules in atherosclerosis progression. In the present study, proteoglycans obtained from cultured human coronary artery smooth muscle cells after treatment with adiponectin, were characterized by biochemical techniques. The results indicated that adiponectin induces the synthesis of decorin, a small dermatan sulfate proteoglycan, in the smooth muscle cells. Furthermore, the length of dermatan sulfate chains of the decorin molecule appeared to remain unchanged, but the epimerization of glucuronic acid in the chains decreased. Although the significance of adiponectin regulation of decorin synthesis remains to be determined, the present study, for the first time, demonstrates that adiponectin regulates vascular smooth muscle cell proteoglycan synthesis.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (37 results)

All 2008 2007 2006 2005 Other

All Journal Article (16 results) (of which Peer Reviewed: 7 results) Presentation (17 results) Remarks (4 results)

  • [Journal Article] 動脈硬化進展の鍵分子プロテオグリカン:その特性および合成調節2008

    • Author(s)
      浦野 晶子
    • Journal Title

      薬学雑誌 128

      Pages: 365-375

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 血管内皮細胞のプロテオグリカン代謝の制御を介した外来性糖鎖の活性2008

    • Author(s)
      佐藤 友子
    • Journal Title

      薬学雑誌 128

      Pages: 717-723

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Homocysteine Inhibits proteoglycan synthesis in cultured bovine aortic smooth muscle cells2008

    • Author(s)
      Yasuyuki Fujiwara
    • Journal Title

      J.Health Sci 54

      Pages: 56-65

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Biological Effects of Depolymerized Sodium Spirulan and Sulfated Colominic Acid on Vascular Cells are Beneficial in Preventing Atherosclerosis2008

    • Author(s)
      Chika Yamamoto
    • Journal Title

      J.Health Sci 54

      Pages: 56-65

    • NAID

      110006251367

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Proteoglycan as a key molecule in atherosclerosis progression : Characteristics of the structure and regulation of the synthesis.2008

    • Author(s)
      Urano A, Yamamoto C, Fujiwara Y, Kaji T.
    • Journal Title

      Yakugakuzashi 128(3)

      Pages: 365-375

    • NAID

      110006646589

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Biological activities of exogenous polysaccharides via controlling endogenous proteoglycan metabolism in vascular endothelial cells.2008

    • Author(s)
      Sato T, Yamamoto C, Fujiwara Y, Kaji T.
    • Journal Title

      Yakugakuzashi 128(5)

      Pages: 717-723

    • NAID

      110006668266

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Homocysteine Inhibits proteoglycan synthesis in cultured bovine aortic smooth muscle cells.2008

    • Author(s)
      Fujiwara Y, Mikami C, Nagai M, Yamamoto C, Hirooka T, satoh M, Kaji T.
    • Journal Title

      J. Health Sci 54(1)

      Pages: 56-65

    • NAID

      110006570804

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Homocysteine Inhibits proteoglycan synthesis in cultured bovine aortic smooth muscle cells2008

    • Author(s)
      Yasuyuki Fujiwara
    • Journal Title

      J. Health Sci 54

      Pages: 56-65

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The vascular endothelial growth factor VEGF165 induces perlecan synthesis via VEGF receptor-2 in cultured human brain microvascular endothelial cells2006

    • Author(s)
      Toshiyuki Kaji
    • Journal Title

      Biochim Biophys Acta 1760

      Pages: 1465-1474

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Colominic acid inhibits the proliferation of cultured bovine aortic endothelial cells and injures their monolayers:cell density-dependent effects prevented by sulfation2006

    • Author(s)
      Chika Yamamoto
    • Journal Title

      Life Sci. 78

      Pages: 205-210

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The vascular endothelial growth factor VEGF165 induces perlecan synthesis via VEGF receptor-2 in cultured human brain microvascular endothelial cells.2006

    • Author(s)
      Kaji T, Yamamoto C, Oh-i M, Fujiwara Y, Yamazaki Y, Morita T, Plaas AH, Wight TN
    • Journal Title

      Biochim Biophys Acta. 1760(9)

      Pages: 1465-1474

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The Biological Effects of Depolymerized Sodium Spirulan and Sulfated Colominic Acid on Vascular Cells are Beneficial in Preventing Atherosclerosis.2006

    • Author(s)
      Yamamoto C, Fujiwara Y, Kaji T.
    • Journal Title

      J. Health Sci 52(3)

      Pages: 205-210

    • NAID

      110006251367

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The vascular endothelial growth factor VEGF165 induces perlecan synthesis via VEGF receptor-2 in cultured human brain microvascular endothelial cells.2006

    • Author(s)
      Toshiyuki Kaji
    • Journal Title

      Biochim. Biophys. Acta 1760・9

      Pages: 1465-1474

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Colominic acid inhibits the proliferation of cultured bovine aortic endothelial cells and injures their monolayers : cell density-dependent effects prevented by sulfation.2006

    • Author(s)
      Chika Yamamoto
    • Journal Title

      Life Sci. 78・8

      Pages: 844-850

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The biological effects of depolymerized sodium spirulan and sulfated colominic acid on vascular cells are beneficial in preventing atherosclerosis.2006

    • Author(s)
      Chika Yamamoto
    • Journal Title

      J. Health Sci. 52・3

      Pages: 205-210

    • NAID

      110006251367

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Colominic acid inhibits the proliferation of cultured bovine aortic endothelial cells and injures their monolayers : cell density-dependent effects prevented by sulfation.2005

    • Author(s)
      Yamamoto C, Morita Y, Yamaguchi S, Hayashi T, Kaji T.
    • Journal Title

      Life Sci. 78(8)

      Pages: 844-850

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] アディポネクチンによる血管平滑筋細胞デコリン合成の誘導2007

    • Author(s)
      浦野 晶子
    • Organizer
      第8回Pharmaco-Hematologyシンポジウム
    • Place of Presentation
      金沢
    • Year and Date
      2007-06-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] TNF-αによる血管平滑筋細胞プロテオグリカン合成の調節2007

    • Author(s)
      佐藤 友子
    • Organizer
      第8回Pharmaco-Hematologyシンポジウム
    • Place of Presentation
      金沢
    • Year and Date
      2007-06-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] アディポネクチンによる血管平滑筋細胞デコリン合成の誘導2007

    • Author(s)
      山本 千夏
    • Organizer
      第8回Pharmaco-Hematologyシンポジウム
    • Place of Presentation
      金沢エクセルホテル東急
    • Year and Date
      2007-06-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] ホモシステインによる血管平滑筋細胞プロテオグリカン合成の阻害2007

    • Author(s)
      藤原 泰之
    • Organizer
      第8回Pharmaco-Hematologyシンポジウム
    • Place of Presentation
      金沢
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Induction of decorin synthesis by adiponectin in vascular smooth muscle cells.2007

    • Author(s)
      Akiko Urano.
    • Organizer
      The 8th Pharmaco-Hematology symposium
    • Place of Presentation
      Kanazawa
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of proteoglycan synthesis by TNF-α in vascular smooth muscle cells.2007

    • Author(s)
      Tomoko Sato.
    • Organizer
      The 8th Pharmaco-Hematology symposium
    • Place of Presentation
      Kanazawa
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Inhibition of proteoglycan synthesis by homocysteine in vascular smooth muscle cells.2007

    • Author(s)
      Yasuyuki Fujiwara
    • Organizer
      The 8th Pharmaco Hematology symposium
    • Place of Presentation
      Kanazawa
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of proteoglycan synthesis by adiponectin in coronary smooth muscle cells.2007

    • Author(s)
      Akiko Urano
    • Organizer
      Forum 2007 : Pharmaceutical Health Science and Environmental Toxicology
    • Place of Presentation
      Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] TNF-α regulates versican synthesis in aortic smooth muscle cells.2007

    • Author(s)
      Tomoko Sato
    • Organizer
      Forum 2007 : Pharmaceutical Health Science and Environmental Toxicology
    • Place of Presentation
      Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of proteoglycan synthesis by adiponectin in cultured human coronary smooth muscle cells.2007

    • Author(s)
      Akiko Urano
    • Organizer
      The 7th Pharmaco-Hematology symposium
    • Place of Presentation
      Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of proteoglycan synthesis by TNF-α in cultured bovine aortic smooth muscle cells.2007

    • Author(s)
      Tomoko Sato
    • Organizer
      The 7th Pharmaco-Hematology symposium
    • Place of Presentation
      Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of proteoglycan synthesis by tumor necrosis factor-alpha in vascular smooth muscle cells.2007

    • Author(s)
      Tomoko Sato
    • Organizer
      35th Annual meeting of the Japanese Society of Connective Tissue Research
    • Place of Presentation
      Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] アディポネクチンによる冠動脈平滑筋細胞プロテオグリカン合成の制御2006

    • Author(s)
      浦野 晶子
    • Organizer
      フォーラム2006 衛生薬学・環境トキシコロジー
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] TNF-αによる血管平滑筋細胞プロテオグリカン合成の調節2006

    • Author(s)
      佐藤 友子
    • Organizer
      フォーラム2006 衛生薬学・環境トキシコロジー
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 培養ヒト冠動脈平滑筋細胞プロテオグリカン合成のアディポネクチンによる調節2006

    • Author(s)
      浦野 晶子
    • Organizer
      第7回Pharmaco-Hematologyシンポジウム
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 培養ウシ大動脈平滑筋細胞プロテオグリカン合成に対するTNF-αの調節2006

    • Author(s)
      佐藤 友子
    • Organizer
      第7回Pharmaco-Hematologyシンポジウム
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 腫瘍壊死因子-αによる血管平滑筋細胞プロテオグリカン合成の調節2006

    • Author(s)
      佐藤 友子
    • Organizer
      第38回 日本結合組織学会学術大会
    • Place of Presentation
      群馬
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.hokuriku-u.ac.jp/frontier/index.html

    • Related Report
      2007 Final Research Report Summary
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.hokuriku-u.ac.jp/yakugaku/kankyo2/

    • Related Report
      2007 Final Research Report Summary
  • [Remarks]

    • URL

      http://www.hokuriku-u.ac.jp/frontier/index.html

    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.hokuriku-u.ac.jp/yakugaku/kankyo2/

    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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