Analysis of the early liver morphogenesis during the embryonic period
Project/Area Number |
18590171
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General anatomy (including Histology/Embryology)
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Research Institution | Osaka City University |
Principal Investigator |
NAKATANI Kazuki Osaka City University, 大学院・医学研究科, 講師 (60295699)
|
Project Period (FY) |
2006 – 2009
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Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,100,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥600,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
|
Keywords | 発生 / 分化 / 細胞 / 組織 / 解剖学 / 細胞間結合 / 発生・分化 / 細胞・組織 / 組織化学 / 微細形態学 / 発生・文化 / 細胞組織 / 細胞接着 |
Research Abstract |
To reveal the process of hepatoblast differentiation and hepatoblastic tissue construction, I analyzed the embryonic and fetal liver using immunohistochemical and ultrastructural methods. Hepatoblasts become to be expressed N-cadherin, a molecule in adherence junction, when they are differentiated from endodermal epithelia of foregut. And N-cadherin is detected in hepatoblasts and fetal hepatocytes throughout embryonic and fetal period. I also revealed that hepatoblasts keep adherence junction between them during moving in transverse septum.
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Report
(6 results)
Research Products
(32 results)
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[Journal Article]2010
Author(s)
仲谷和記
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Journal Title
人体の解剖生理学(第8章 4-4.肝臓と胆嚢の構造と機能(金芳堂)
Pages: 262-264
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[Journal Article] Erythrophagocytosis by liver macrophages (Kupffer cells) promotes oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis: implications for the pathogenesis of human nonalcoholic steatohepatitis.2007
Author(s)
Otogawa K, Kinoshita K, Fujii H, Sakabe M, Shiga R, Nakatani K, Ikeda K, Nakajima Y, Ikura Y, Ueda M, Arakawa T, Hato F, Kawada N
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Journal Title
J Am Pathol 170(3)
Pages: 967-980
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Peer Reviewed
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[Book] Nova Science Publishers, Inc. (NY)2007
Author(s)
Nakatani K, Ikeda K, Nakajima Y, Seki S.
Publisher
Expression of molecules with a potential for modulating interaction with extra-cellular matrices on hepatic stellate cells : neural cell adhesion molecules and osteonectin. In : Trends in Liver Cirrhosis Research(Dillon KH. ed)
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