Study on self-regeneration of the central nervous system by perineuronal progenitor cell
| Project/Area Number |
18590191
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Osaka City University |
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Principal Investigator |
KATAOKA Yosuke Osaka City University, Graduate School of Medicine, Lecturer (40291033)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,450,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | perineuronal progenitor cell / proliferation / differentiation / central nervous system / cerebral cortex / oligodendrocyte / repair / progenitor cell / Perineuronal germinal cell / 脱分極波 / Spreading depression / Perineuronal satellite cell / 再生 / 脱分極 |
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| Research Abstract |
In the rat cerebral cortex, cells which exist around neuronal cell somata and have a potent proliferative activity were found. We named the cells "perineuronal progenitor cells". The perineuronal progenitor cells differentiated into immature inhibitory neurons and astrocytes as well as oligodendrocytes, under physiological condition. The cells showed the facilitation of proliferation under neuronal degeneration or excessive excitation of neurons. These results indicated that the perineuronal progenitor cells play an important role in tissue repair of the central nervous system.
We explored substances which induce proliferation or differentiation of the perineuronal progenitor cells by using a DNA mic roarray system, and could find some substances. The number of the perineuronal progenitor cells decreased in aged animals. This phenomenon suggests that the cells are involved in atrophy of the brain or cognitive disfunction. More studies on the cells will bring about new concepts on mechanism of the occurrence of neurological disorders.
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Report
(3 results)
Research Products
(69 results)
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[Journal Article] Innovation of drug development and pathophysiological diagnosis using molecular imaging technique2008
Author(s)
Watanabe, Y., Suzuki, M., Onoe, H., Doi, H., Wada, Y., Kataoka, Y., Enomoto, S
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Journal Title
Med. Frontline 63
Pages: 116-138
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Anti-fatigue effects of fursulthiamine on muscle fatigue of swimming rats2007
Author(s)
Jin, G., Yamato, M., Okuyama, K., Eguchi, A., Nozaki, S., Kataoka, Y., et. al.
Organizer
Jpn. Soc. Fatigue Sci
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Presentation] Evaluation of pathophysiological features of migraine by micro PET study using rats2007
Author(s)
Cui, Y., Wada Y., Yamato, M., Tamura, Y., Kataoka, Y., Watanabe, Y
Organizer
Neuro 2007
Description
「研究成果報告書概要(欧文)」より
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[Book] Innovation of drug development and pathophysiological diagnosis using molecular imaging technique2008
Author(s)
Watanabe, Y., Suzuki, M., Onoe, H., Doi, H., Wada, Y., Kataoka, Y., Enomoto, S
Publisher
J. Jpn. Med. Association
Description
「研究成果報告書概要(欧文)」より
Related Report
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