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Functional analysis of the voltage-dependent calcium channel β subunit in cardiac myocyte

Research Project

Project/Area Number 18590202
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General physiology
Research InstitutionAkita University

Principal Investigator

MURAKAMI Manabu  Akita University, 大学院・医学系研究科, 准教授 (80302090)

Co-Investigator(Kenkyū-buntansha) ONO Kyoichi  秋田大学, 大学院・医学系研究科, 教授 (70185635)
OHBA Takayoshi  秋田大学, 大学院・医学系研究科, 助教 (80431625)
IIJIMA Toshihiko  秋田大学, 名誉教授 (30004724)
Project Period (FY) 2006 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,130,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywords生体膜 / チャネル / トランスポーター / 能動輸送 / カルシウム / 交感神経 / 副腎髄質 / マウス / 電気生理 / STIM1 / TRP / 高血圧 / イオンチャネル / βサブユニット / 心筋
Research Abstract

Using gene-manipulated mice, we evaluated importance of voltage-dependent calcium channel β subunit in sympathetic nerve regulation system.
It is well known, that cardiac myocytes are regulated by sympathetic nerve system through voltage-dependent calcium channel. To evaluate the importance of the voltage-dependent calcium channel β subunit in the sympathetic nerve control, we made null-mutant and overexpression transgenic mice of β subunit. The null-mutant showed significantly decreased sympathetic nerve tonus, while the overexpression mice revealed increased nerve tonus, indicating the importance of the β subunit in the sympathetic nerve control system.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (81 results)

All 2010 2009 2008 2007 2006 Other

All Journal Article (49 results) (of which Peer Reviewed: 23 results) Presentation (31 results) Remarks (1 results)

  • [Journal Article] Behavioral and neurochemical characterization of mice deficient in the N-type Ca^<2+> channel α1B subunit2010

    • Author(s)
      Nakagawasai, O., Onogi, H., Mitazaki, S., Sato, A., Watanabe, K., Saito, H., Murai, S., Nakaya, S., Murakami, M., Takahashi, E., Tan-No, K., Takeshi Tadano, T.
    • Journal Title

      Behavioural Brain Research (in press)

    • Related Report
      2009 Final Research Report
  • [Journal Article] Decreased calcium channel currents and facilitated epinephrine release in the Ca^<2+> channel β3 subunit-null mice2010

    • Author(s)
      Ohta T, Ohba T, Suzuki T, Watanabe H, Sasano H, Murakami M.
    • Journal Title

      Biochemical & Biophysical Research Communications (in press)

    • Related Report
      2009 Final Research Report
  • [Journal Article] Behavioral and neurochemical characterization of mice deficient in the N-type Ca^<2+> channel α1B subunit2010

    • Author(s)
      Nakagawasai, O.
    • Journal Title

      Behav Brain Res 208

      Pages: 224-230

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased calcium channel currents and facilitated epinephrine release in the Ca^<2+> channel β3 subunit-null mice2010

    • Author(s)
      Ohta, T.
    • Journal Title

      Biochemical & Biophysical Research Communications 394

      Pages: 464-469

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Essential role of STIM1 in the development of cardiomyocyte hypertrophy2009

    • Author(s)
      Ohba, T., Watanabe, H., Murakami, M., Sato, T., Ono, K., Ito, H.
    • Journal Title

      Biochemical & Biophysical Research Communications 389

      Pages: 172-176

    • Related Report
      2009 Final Research Report
  • [Journal Article] Molecular and Electrical Remodeling of L- and T- type Ca^<2+> Channels in Rat Right Atrium with Monocrotaline-Induced Pulmonary Hypertension2009

    • Author(s)
      Koyama, T., Ono, K., Watanabe, H., Ohba, T., Murakami, M., Iino, K., Ito H.
    • Journal Title

      Circ.J. 73

      Pages: 256-263

    • NAID

      110007042199

    • Related Report
      2009 Final Research Report
  • [Journal Article] The pathological role of TRP channels in heart disease2009

    • Author(s)
      Watanabe, H., Murakami, M., Ohba, T., Ono, K., Ito, H.
    • Journal Title

      Circulation Journal (in press)

    • Related Report
      2009 Final Research Report
  • [Journal Article] Molecular and Electrical Remodeling of L- and T- type Ca^<2+> Channels in Rat Right Atrium with Monocrotaline-Induced Pulmonary Hypertension2009

    • Author(s)
      Koyama, T.
    • Journal Title

      Circulation Journal 73

      Pages: 256-263

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modified autonomic regulation in mice with a P/Q-type calcium channel mutation2009

    • Author(s)
      Ohba, T.
    • Journal Title

      Biochemical & Biophysical Research Communications 381

      Pages: 27-32

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Essential role of STIM1 in the development of cardiomyocyte hypertrophy2009

    • Author(s)
      Ohba, T.
    • Journal Title

      Biochemical & Biophysical Research Communications 389

      Pages: 172-176

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The pathological role of TRP channels in heart disease2009

    • Author(s)
      Watanabe, H.
    • Journal Title

      Circulation Journal 73

      Pages: 419-427

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modified autonomic regulation in mice with a P/Q-type calcium channel mutation2009

    • Author(s)
      Ohba, T.
    • Journal Title

      Biochemical & Biophysical Research Communications 331

      Pages: 27-32

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amlodipine inhibits cell proliferation via PKD1-related pathway2008

    • Author(s)
      Ohba, T., Watanabe, H., Murakami, M., Radovanovic, M., Iino, K., Ishida, M., Tosa, S., Ono, K., Ito, H.
    • Journal Title

      Biochemical & Biophysical Research Communications 369

      Pages: 376-381

    • Related Report
      2009 Final Research Report
  • [Journal Article] TRP channel and cardiovascular disease2008

    • Author(s)
      Watanabe H, Murakami M, Ohba T, Takahashi Y, Ito H.
    • Journal Title

      Pharmacology & Therapeutics 118

      Pages: 337-351

    • Related Report
      2009 Final Research Report
  • [Journal Article] Modified sympathetic nerve system activity with over-expression of the voltage-dependent calcium channel β3 subunit2008

    • Author(s)
      Murakami, M., Ohba, T., Xu, F., Satoh, E., Miyoshi, I., Suzuki, T., Takahashi, Y., Takahashi, E., Watanabe, Ono, K., Sasano, H., Kasai, N., Ito, H., Iijima, T.
    • Journal Title

      J.Biol.Chem. 283

      Pages: 24554-24560

    • Related Report
      2009 Final Research Report
  • [Journal Article] Modified sympathetic nerve system activity with over-expression of the voltage-dependent calcium channel β3 subunit2008

    • Author(s)
      Murakami, M., Ohba, T., Xu, F., Satoh, E., Miyoshi, I., Suzuki, T., Takahashi, Y., Takahashi, E., Watanabe, Ono, K., Sasano, H., Kasai, N., Ito, H. and Iijima, T.
    • Journal Title

      J. Biol. Chem 283

      Pages: 24554-24560

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] TRP channel and cardiovascular disease2008

    • Author(s)
      Watanabe H, Murakami M, Ohba T, Takahashi and YIto H.
    • Journal Title

      Pharmacology & Therapeutics 118

      Pages: 337-351

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Amlodipine inhibits cell proliferation via PKD1-related pathway2008

    • Author(s)
      Ohba, T.
    • Journal Title

      Biochemical & Biophysical Research Communications 369

      Pages: 376-381

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modified sympathetic nerve system activity with over-expression of the voltaee-dependent calcium β3 subunit2008

    • Author(s)
      Murakami, M.
    • Journal Title

      Journal of Biological Chemistry 36

      Pages: 24554-24560

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular and electrical remodeling of L- and T-type Ca^<2+> channels in rat right atrium with monocrotaline-induced pulmonary hypertension2008

    • Author(s)
      Koyama, T.
    • Journal Title

      Circulation Journal 73

      Pages: 256-263

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of TRPC1 in the Development of Cardiac Hypertrophy2007

    • Author(s)
      Ohba, T., Watanabe, H., Murakami, M., Takahashi, Y., Iino, K., Kuromitsu, S., Mori, Y., Ono, K., Iijima T., Ito, H.
    • Journal Title

      Journal of Molecular and Cellular Cardiology 42

      Pages: 498-507

    • NAID

      110008436654

    • Related Report
      2009 Final Research Report
  • [Journal Article] Involvement of transient receptor potential canonical 1 (TRPC1) in Angiotensin II-induced vascular smooth muscle cell hypertrophy2007

    • Author(s)
      Takahashi, Y., Watanabe, H., Murakami, M., Ohba, T., Radovanovic, M., Ono, K., Iijima, T., Ito, H.
    • Journal Title

      Atheroscrelosis 195

      Pages: 287-296

    • Related Report
      2009 Final Research Report
  • [Journal Article] Modified sympathetic regulation in N-type calcium channel null-mouse2007

    • Author(s)
      Murakami, M., Ohba, T., Wu, T-W., Fujisawa, S., Suzuki, T., Takahashi, Y., Takahashi, E., Watanabe, H., Miyoshi, I., Ono, K., Sasano, H., Ito, H. Iijima T.
    • Journal Title

      Biochemical & Biophysical Research Communications 354

      Pages: 1016-1020

    • Related Report
      2009 Final Research Report
  • [Journal Article] Involvement of the calcium channel beta3 subunit in olfactory signal transduction2007

    • Author(s)
      Shiraiwa, S., Kashiwayanagi, M., Iijima, T., Murakami, M.
    • Journal Title

      Biochemical & Biophysical Research Communications 355

      Pages: 1019-1024

    • Related Report
      2009 Final Research Report
  • [Journal Article] Essential role of the N-terminus of murine Orail in store-operated Ca^<2+> entry2007

    • Author(s)
      Takahashi, Y., Murakami, M., Watanabe, H., Hasegawa, H., Ohba, T., Munehisa, Y., Nobori, K., Ono, K., Iijima, T., Ito, H.
    • Journal Title

      Biochemical & Biophysical Research Communications 356

      Pages: 45-52

    • Related Report
      2009 Final Research Report
  • [Journal Article] Modified behavioral characteristics following ablation of the voltage-dependent calcium channel β3 subunit2007

    • Author(s)
      Murakami, M., Nakagawasai, O., Yanai, K., Nunoki, K., Tan-No, K., Tadano T. Iijima, T.
    • Journal Title

      Brain Research 1160

      Pages: 102-112

    • Related Report
      2009 Final Research Report
  • [Journal Article] Functional role of stromal interaction molecule 1 (STIM1) in vascular smooth muscle cells2007

    • Author(s)
      Takahashi, Y., Watanabe, H., Murakami, M., Ono, K., Munehisa, Y., Koyama, T., Nobori, K., Iijima, T., Ito, H.
    • Journal Title

      Biochemical & Biophysical Research Communications 361

      Pages: 934-940

    • Related Report
      2009 Final Research Report
  • [Journal Article] Genomic organization and expression of murine calcium channel subunit α1C. Saito Ho-on Kai Museum of Natural History2007

    • Author(s)
      Murakami, M., Ohba, T., Ono, K., Watanabe, H., Ito, H., Iijima, T.
    • Journal Title

      Research Bulletin 72

      Pages: 1-10

    • Related Report
      2009 Final Research Report
  • [Journal Article] Modified sympathetic regulation in N-type calcium channel null-mouse2007

    • Author(s)
      Murakami, M., Ohba, T., Wu, T-W., Fujisawa, S., Suzuki, T., Takahashi, Y., Takahashi, E., Watanabe, H., Miyoshi, I., Ono, K., Sasano, H., Ito, H. and Iijima T.
    • Journal Title

      Biochemical & Biophysical Research Communications 354

      Pages: 1016-1020

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Involvement of transient receptor potential canonical 1 (TRPC1) in Angiotensin II-induced vascular smooth muscle cell hypertrophy2007

    • Author(s)
      Takahashi, Y., Watanabe, H., Murakami, M., Ohba, T., Radovanovic, M., Ono, K., Iijima, T. and Ito, H.
    • Journal Title

      Atheroscrelosis 195

      Pages: 287-296

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of TRPC1 in the Development of Cardiac Hypertrophy2007

    • Author(s)
      Ohba, T., Watanabe, H., Murakami, M., Takahashi, Y., Iino, K., Kuromitsu, S., Mori, Y., Ono, K., Iijima T. and Ito, H.
    • Journal Title

      Journal of Molecular and Cellular Cardiology 42

      Pages: 498-507

    • NAID

      110008436654

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of TRPC1 in the Development of Cardiac Hypertrophy.2007

    • Author(s)
      Ohba, T., et. al.
    • Journal Title

      Journal of Molecular and Cellular Cardiology 42

      Pages: 498-507

    • NAID

      110008436654

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modified sympathetic regulation in N-type calcium chnnel null-mouse.2007

    • Author(s)
      Murakami, M., et. al.
    • Journal Title

      Biochem Biophys Res Commun 354

      Pages: 1016-1020

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of transient receptor potential canonical 1 (TRPC1) in Angiotensin II-induced vascular smooth muscle cell hypertrophy.2007

    • Author(s)
      Takahashi, Y., et. al.
    • Journal Title

      Atheroscrelosis 195

      Pages: 287-296

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional role of stromal interaction molecule 1 (STIM1) invascular smonth muscle cells.2007

    • Author(s)
      Takahashi, Y., et. al.
    • Journal Title

      Biochem Biophys Res Commun 361

      Pages: 934-940

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Essential role of the N-terminus of murine Orail in store-operated Ca^<2+> entry2007

    • Author(s)
      Takahashi, Y., et. al.
    • Journal Title

      Biochem Biophys Res Commun 356

      Pages: 45-52

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modified behavioral characteristics following ablation of the voltage-dependent calcium channel β3 subunit2007

    • Author(s)
      Murakami, M., et. al.
    • Journal Title

      Brain Research 1160

      Pages: 102-112

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of the calcium channel β3 subunit in olfactory signal transduction.2007

    • Author(s)
      Shiraiwa, S., et. al.
    • Journal Title

      Biochem Biophys Res Commun 355

      Pages: 1019-1024

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genomic Organization and expression of murine calcium channel subunit α1C2007

    • Author(s)
      Manabu Murakami, et. al.
    • Journal Title

      Resarch Bulletin 72

      Pages: 27-35

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of TRPC1 in the Development of Cardiac Hypertrophy.2007

    • Author(s)
      Ohba, T., et al.
    • Journal Title

      Journal of Molecular and Cellular Cardiology (in press)

    • NAID

      110008436654

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Involvement of transient receptor potential canonical 1 (TRPC1) in Angiotensin II-induced vascular smooth muscle cell hypertrophy.2007

    • Author(s)
      Takahashi, Y., et al.
    • Journal Title

      Atheroscrelosis (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Modified sympathetic regulation in N-type calcium channel null-mouse.2007

    • Author(s)
      Murakami, M., et al.
    • Journal Title

      Biochem Biophys Res Commun. (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Decreases in pheromonal responses at the accessory olfactory bulb of mice with a deficiency of the α1B or β3 subunits of voltage-dependent Ca^<2+>-channels2006

    • Author(s)
      Murakami, M., Matsui, H., Shiraiwa, T., Suzuki, T., Sasano, H., Takahashi E., Kashiwayanagi, M.
    • Journal Title

      Biological and Pharmaceutical Bulletin 29

      Pages: 437-442

    • Related Report
      2009 Final Research Report
  • [Journal Article] Involvement of Voltage-Dependent Ca Channel beta3 Subunit in the Autonomic Control of Heart Rate Variability2006

    • Author(s)
      Wu TW, Ono K, Murakami M, Iijima T.
    • Journal Title

      Pharmacology 76

      Pages: 170-179

    • Related Report
      2009 Final Research Report
  • [Journal Article] Identification of a cardiac isoform of the murine calcium channel α1C (Ca_V1.2-a) subunit and its preferential binding with the β2 subunit2006

    • Author(s)
      Murakami, M., Ohba, T., Takahashi, Y., Watanabe, H., Miyoshi, I., Nakayama, S., Ono, K., Ito, H., Iijima T.
    • Journal Title

      Journal of Molecular and Cellular Cardiology 41

      Pages: 115-125

    • Related Report
      2009 Final Research Report
  • [Journal Article] Regulatory role of neuron-restrictive silencing factor in the expression of TRPC12006

    • Author(s)
      Ohba, T., Watanabe, H., Takahashi, Y., Miyoshi, I., Nakayama, S., Satoh, E., Iino, K., Mori, Y., Kuromitsu, S., Imagawa, K., Saito, Y., Iijima, T., Ito, H., Murakami, M.
    • Journal Title

      Biochemical & Biophysical Research Communications 351

      Pages: 764-770

    • Related Report
      2009 Final Research Report
  • [Journal Article] Involvement of Voltage-Dependent Ca Channel β3 Subunit in the Autonomic Control of Heart Rate Variability.2006

    • Author(s)
      Wu, TW., et al.
    • Journal Title

      Pharmacology 76

      Pages: 170-179

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification of a cardiac isoform of the murine calcium channel α1C (Ca_v1.2-a) subunit and its preferential binding with the β2 subunit.2006

    • Author(s)
      Murakami, M., et al.
    • Journal Title

      Journal of Molecular and Cellular Cardiology 41

      Pages: 115-125

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Regulatory role of neuron-restrictive silencing factor in the expression of TRPC1.2006

    • Author(s)
      Ohba, T., et al.
    • Journal Title

      Biochem Biophys Res Commun. 351

      Pages: 764-770

    • Related Report
      2006 Annual Research Report
  • [Presentation] 心筋細胞肥大におけるSTIM1の役割2009

    • Author(s)
      大場貴喜
    • Organizer
      生理研研究会「イオンチャネルトランスポーターと心血管機能」
    • Place of Presentation
      生理学研究所(岡崎)
    • Year and Date
      2009-11-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Modified autonomic regulation in mice with a P/Q-type calcium channel mutation2009

    • Author(s)
      村上学
    • Organizer
      Society for Neuroscience, 39th Annual Meeting
    • Place of Presentation
      MacCORMICK PLACE (Chicago・USA)
    • Year and Date
      2009-10-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 電位依存性カルシウムチャネルと交感神経2009

    • Author(s)
      村上学
    • Organizer
      第37回薬物活性シンポジウム
    • Place of Presentation
      東北薬科大学(仙台)
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Molecular and electrical remodel of Ca^<2+> channels in rat right atrium with monocrotaline -induced pulmonary hypertension2009

    • Author(s)
      Kyoichi Ono
    • Organizer
      36th International Congress of Physiological Sciences
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2009-07-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Amlodipine and the role of PKD1-related pathway in human coronary artery smooth muscle cells2009

    • Author(s)
      Takayoshi Ohba
    • Organizer
      36th International Congress of Physiological Sciences
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2009-07-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] Modified sympathetic nerve system activity with over-expression of the voltage-dependent calcium channel β3 subunit2009

    • Author(s)
      村上学
    • Organizer
      36th International Congress of Physiological Sciences
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2009-07-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] Remodeling of Ca^<2+> channels in rat atrium with monocrotaline-induced pulmonary hypertension2009

    • Author(s)
      Takayoshi Ohba
    • Organizer
      17th APCC : Asia Pacific Congress of Cardiology
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2009-05-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] モノクロタリン誘導性肺高血圧ラット右心房におけるカルシウムチャネルの分子および電気的リモデリング2009

    • Author(s)
      大場貴喜
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-03-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 電位依存性カルシウムチャネルβ3サブユニット過剰発現による交感神経系の変化2009

    • Author(s)
      村上学
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-03-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] Modified autonomic regulation in mice with a P/Q-type calcium channel mutation2009

    • Author(s)
      Murakami M, Ohba T, Ono K
    • Organizer
      Society for Neuroscience, 39th Annual Meeting
    • Place of Presentation
      Chicago, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Modified sympathetic nerve system activity with over-expression of the voltage-dependent calcium channel β3 subunit2009

    • Author(s)
      Murakami M, Ohba T, Ono K
    • Organizer
      Congress of Physiological Sciences
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2009 Final Research Report
  • [Presentation] Amlodipine induces p21 (Waf1/Cip1) through PKD1-related pathway in Human Coronary Artery Smooth Muscle Cells2008

    • Author(s)
      Takayoshi Ohba
    • Organizer
      第25回国際心臓研究学会(ISHR)日本部会
    • Place of Presentation
      横浜
    • Year and Date
      2008-12-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒト冠動脈平滑筋増殖におけるAmlodipineの作用とPolycystic kidney Disease(PKD1)の役割2008

    • Author(s)
      大場貴喜
    • Organizer
      生理研セミナー : イオンチャネルトランスポーターと心血管機能 : 学際的取り組みによる新戦略
    • Place of Presentation
      岡崎
    • Year and Date
      2008-11-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Modified sympathetic nerve system activity with over expression of the voltage-dependent calcium channel β3 subunit2008

    • Author(s)
      Muramami, M.
    • Organizer
      Neuroscience2008
    • Place of Presentation
      Washington DC
    • Year and Date
      2008-11-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] Amlodipine increases p21 (Waf1/Cip1) through PKD1-related pathway in Human Coronary Artery Smooth Muscle Cells2008

    • Author(s)
      大場貴喜
    • Organizer
      第12回 Molecular cardiovascular conference
    • Place of Presentation
      北海道
    • Year and Date
      2008-09-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラット心筋細胞肥大形成におけるTRPC1発現増加2008

    • Author(s)
      大場貴喜
    • Organizer
      第1回心血管系調節因子研究会
    • Place of Presentation
      盛岡
    • Year and Date
      2008-06-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] Modified sympathetic nerve system activity with over-expression of the voltage-dependent calcium channel β3 subunit2008

    • Author(s)
      Murakami M, Ohba T, Ono K
    • Organizer
      Society for Neuroscience, 38th Annual Meeting
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Modified sympathetic nerve system activity with over-expression of the voltage-dependent calcium channel β3 subunit2008

    • Author(s)
      M. Murakami
    • Organizer
      38^<st> Annual Meeting Washington D.C.
    • Place of Presentation
      Society for Neuroscience
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Anti-proliferative Effect of amlodipine on Human Coronary Artery Smooth Muscle Cells2008

    • Author(s)
      T. Ohba, H. Watanabe, M. Murakami, H. Hasegawa and H. Ito
    • Organizer
      第12回日本心不全学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report 2008 Self-evaluation Report
  • [Presentation] ヒト冠動脈平滑筋におけるアムロジピン抗増殖作用の新規メカニズム2008

    • Author(s)
      大場貴喜, 村上学, 藤澤進, 渡邊博之, 尾野恭一, 伊藤宏, 飯島俊彦
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] N型カルシウムチャネル欠損マウスにおける交感神経制御機構2008

    • Author(s)
      村上学, 大場貴喜, 藤澤進, 渡邊博之, 尾野恭一, 伊藤宏, 飯島俊彦
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Cloning of novel isoforms of murine cardiac calcium channel α1 subunit and their different binding affinities with β2 subunit2007

    • Author(s)
      Murakami M, Ohba T, Takahashi Y, Ono K, Watanabe H, Ito H, Iijima T
    • Organizer
      Society for Neuroscience, 37th Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Cloning of novel isoforms of murine cardiac calcium channel α1 subunit and their different binding affinities with β2 subunit2007

    • Author(s)
      M. Murakami
    • Organizer
      37^<st> Annual Meeting San Diego
    • Place of Presentation
      Society for Neuroscience
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Cloning of novel isoforms of murine cardiac calcium channel α1 subnit and their different binding affinities with β2 subunit.2007

    • Author(s)
      Manabu Murakami
    • Organizer
      Society for Neuroscience, 37st Annual Meeting
    • Place of Presentation
      San Diego
    • Related Report
      2007 Annual Research Report
  • [Presentation] 冠動脈平滑筋におけるamlodipineの抗増殖作用はPKD1分子を介する2007

    • Author(s)
      大場貴喜
    • Organizer
      第58回日本薬理学会北部会
    • Place of Presentation
      札幌
    • Related Report
      2007 Annual Research Report
  • [Presentation] マウスOrai遺伝子のクローニングおよび機能解析2007

    • Author(s)
      村上 学
    • Organizer
      第58回日本薬理学会北部会
    • Place of Presentation
      札幌
    • Related Report
      2007 Annual Research Report
  • [Presentation] モノクロタリン誘発肺高血圧ラットの右心房におけるL型及びT型Caチャネルのリモデリング2007

    • Author(s)
      尾野恭一
    • Organizer
      第58回日本薬理学会北部会
    • Place of Presentation
      札幌
    • Related Report
      2007 Annual Research Report
  • [Presentation] 冠動脈平滑筋におけるPKD1分子の抗増殖作用2007

    • Author(s)
      大場貴喜
    • Organizer
      第3回TRP研究会
    • Place of Presentation
      岡崎
    • Related Report
      2007 Annual Research Report
  • [Presentation] モルモット洞房結節細胞におけるプロスタグランジンの自動能促進作用2007

    • Author(s)
      尾野恭一
    • Organizer
      第80回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Related Report
      2007 Annual Research Report
  • [Presentation] マウスOrai遺伝子の単離とSOCEにおける機能2007

    • Author(s)
      高橋陽一郎
    • Organizer
      第80回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Related Report
      2007 Annual Research Report
  • [Presentation] Neuron-restrictive silencing factor (NRSF) is responsible for cardiachyperphy by regulating expression of transient receptor potential channel 1 (TRPC1)2007

    • Author(s)
      大場貴喜
    • Organizer
      第71回日本循環器学会
    • Place of Presentation
      神戸
    • Related Report
      2007 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2009 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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