Functional analysis of the voltage-dependent calcium channel β subunit in cardiac myocyte

• Project/Area Number: 18590202
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General physiology
• Research Institution: Akita University
• Principal Investigator: MURAKAMI Manabu Akita University, 大学院・医学系研究科, 准教授 (80302090)
• Co-Investigator(Kenkyū-buntansha): ONO Kyoichi 秋田大学, 大学院・医学系研究科, 教授 (70185635) ; OHBA Takayoshi 秋田大学, 大学院・医学系研究科, 助教 (80431625) ; IIJIMA Toshihiko 秋田大学, 名誉教授 (30004724)
• Project Period (FY): 2006 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,130,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥630,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2006: ¥1,400,000 (Direct Cost: ¥1,400,000)
• Keywords: 生体膜 / チャネル / トランスポーター / 能動輸送 / カルシウム / 交感神経 / 副腎髄質 / マウス / 電気生理 / STIM1 / TRP / 高血圧 / イオンチャネル / βサブユニット / 心筋

Research Abstract

Using gene-manipulated mice, we evaluated importance of voltage-dependent calcium channel β subunit in sympathetic nerve regulation system.
It is well known, that cardiac myocytes are regulated by sympathetic nerve system through voltage-dependent calcium channel. To evaluate the importance of the voltage-dependent calcium channel β subunit in the sympathetic nerve control, we made null-mutant and overexpression transgenic mice of β subunit. The null-mutant showed significantly decreased sympathetic nerve tonus, while the overexpression mice revealed increased nerve tonus, indicating the importance of the β subunit in the sympathetic nerve control system.

Research Products

• [Journal Article] Behavioral and neurochemical characterization of mice deficient in the N-type Ca^<2+> channel α1B subunit (2010)
  • Author(s): Nakagawasai, O., Onogi, H., Mitazaki, S., Sato, A., Watanabe, K., Saito, H., Murai, S., Nakaya, S., Murakami, M., Takahashi, E., Tan-No, K., Takeshi Tadano, T.
  • Journal Title: Behavioural Brain Research (in press)
• [Journal Article] Decreased calcium channel currents and facilitated epinephrine release in the Ca^<2+> channel β3 subunit-null mice (2010)
  • Author(s): Ohta T, Ohba T, Suzuki T, Watanabe H, Sasano H, Murakami M.
  • Journal Title: Biochemical & Biophysical Research Communications (in press)
• [Journal Article] Behavioral and neurochemical characterization of mice deficient in the N-type Ca^<2+> channel α1B subunit (2010)
  • Author(s): Nakagawasai, O.
  • Journal Title: Behav Brain Res 208 Pages: 224-230
  • Peer Reviewed
• [Journal Article] Decreased calcium channel currents and facilitated epinephrine release in the Ca^<2+> channel β3 subunit-null mice (2010)
  • Author(s): Ohta, T.
  • Journal Title: Biochemical & Biophysical Research Communications 394 Pages: 464-469
  • Peer Reviewed
• [Journal Article] Essential role of STIM1 in the development of cardiomyocyte hypertrophy (2009)
  • Author(s): Ohba, T., Watanabe, H., Murakami, M., Sato, T., Ono, K., Ito, H.
  • Journal Title: Biochemical & Biophysical Research Communications 389 Pages: 172-176
• [Journal Article] Molecular and Electrical Remodeling of L- and T- type Ca^<2+> Channels in Rat Right Atrium with Monocrotaline-Induced Pulmonary Hypertension (2009)
  • Author(s): Koyama, T., Ono, K., Watanabe, H., Ohba, T., Murakami, M., Iino, K., Ito H.
  • Journal Title: Circ.J. 73 Pages: 256-263
  • NAID: 110007042199
• [Journal Article] The pathological role of TRP channels in heart disease (2009)
  • Author(s): Watanabe, H., Murakami, M., Ohba, T., Ono, K., Ito, H.
  • Journal Title: Circulation Journal (in press)
• [Journal Article] Molecular and Electrical Remodeling of L- and T- type Ca^<2+> Channels in Rat Right Atrium with Monocrotaline-Induced Pulmonary Hypertension (2009)
  • Author(s): Koyama, T.
  • Journal Title: Circulation Journal 73 Pages: 256-263
  • Peer Reviewed
• [Journal Article] Modified autonomic regulation in mice with a P/Q-type calcium channel mutation (2009)
  • Author(s): Ohba, T.
  • Journal Title: Biochemical & Biophysical Research Communications 381 Pages: 27-32
  • Peer Reviewed
• [Journal Article] Essential role of STIM1 in the development of cardiomyocyte hypertrophy (2009)
  • Author(s): Ohba, T.
  • Journal Title: Biochemical & Biophysical Research Communications 389 Pages: 172-176
  • Peer Reviewed
• [Journal Article] The pathological role of TRP channels in heart disease (2009)
  • Author(s): Watanabe, H.
  • Journal Title: Circulation Journal 73 Pages: 419-427
  • Peer Reviewed
• [Journal Article] Modified autonomic regulation in mice with a P/Q-type calcium channel mutation (2009)
  • Author(s): Ohba, T.
  • Journal Title: Biochemical & Biophysical Research Communications 331 Pages: 27-32
  • Peer Reviewed
• [Journal Article] Amlodipine inhibits cell proliferation via PKD1-related pathway (2008)
  • Author(s): Ohba, T., Watanabe, H., Murakami, M., Radovanovic, M., Iino, K., Ishida, M., Tosa, S., Ono, K., Ito, H.
  • Journal Title: Biochemical & Biophysical Research Communications 369 Pages: 376-381
• [Journal Article] TRP channel and cardiovascular disease (2008)
  • Author(s): Watanabe H, Murakami M, Ohba T, Takahashi Y, Ito H.
  • Journal Title: Pharmacology & Therapeutics 118 Pages: 337-351
• [Journal Article] Modified sympathetic nerve system activity with over-expression of the voltage-dependent calcium channel β3 subunit (2008)
  • Author(s): Murakami, M., Ohba, T., Xu, F., Satoh, E., Miyoshi, I., Suzuki, T., Takahashi, Y., Takahashi, E., Watanabe, Ono, K., Sasano, H., Kasai, N., Ito, H., Iijima, T.
  • Journal Title: J.Biol.Chem. 283 Pages: 24554-24560
• [Journal Article] Modified sympathetic nerve system activity with over-expression of the voltage-dependent calcium channel β3 subunit (2008)
  • Author(s): Murakami, M., Ohba, T., Xu, F., Satoh, E., Miyoshi, I., Suzuki, T., Takahashi, Y., Takahashi, E., Watanabe, Ono, K., Sasano, H., Kasai, N., Ito, H. and Iijima, T.
  • Journal Title: J. Biol. Chem 283 Pages: 24554-24560
  • Peer Reviewed
• [Journal Article] TRP channel and cardiovascular disease (2008)
  • Author(s): Watanabe H, Murakami M, Ohba T, Takahashi and YIto H.
  • Journal Title: Pharmacology & Therapeutics 118 Pages: 337-351
  • Peer Reviewed
• [Journal Article] Amlodipine inhibits cell proliferation via PKD1-related pathway (2008)
  • Author(s): Ohba, T.
  • Journal Title: Biochemical & Biophysical Research Communications 369 Pages: 376-381
  • Peer Reviewed
• [Journal Article] Modified sympathetic nerve system activity with over-expression of the voltaee-dependent calcium β3 subunit (2008)
  • Author(s): Murakami, M.
  • Journal Title: Journal of Biological Chemistry 36 Pages: 24554-24560
  • Peer Reviewed
• [Journal Article] Molecular and electrical remodeling of L- and T-type Ca^<2+> channels in rat right atrium with monocrotaline-induced pulmonary hypertension (2008)
  • Author(s): Koyama, T.
  • Journal Title: Circulation Journal 73 Pages: 256-263
  • Peer Reviewed
• [Journal Article] Up-regulation of TRPC1 in the Development of Cardiac Hypertrophy (2007)
  • Author(s): Ohba, T., Watanabe, H., Murakami, M., Takahashi, Y., Iino, K., Kuromitsu, S., Mori, Y., Ono, K., Iijima T., Ito, H.
  • Journal Title: Journal of Molecular and Cellular Cardiology 42 Pages: 498-507
  • NAID: 110008436654
• [Journal Article] Involvement of transient receptor potential canonical 1 (TRPC1) in Angiotensin II-induced vascular smooth muscle cell hypertrophy (2007)
  • Author(s): Takahashi, Y., Watanabe, H., Murakami, M., Ohba, T., Radovanovic, M., Ono, K., Iijima, T., Ito, H.
  • Journal Title: Atheroscrelosis 195 Pages: 287-296
• [Journal Article] Modified sympathetic regulation in N-type calcium channel null-mouse (2007)
  • Author(s): Murakami, M., Ohba, T., Wu, T-W., Fujisawa, S., Suzuki, T., Takahashi, Y., Takahashi, E., Watanabe, H., Miyoshi, I., Ono, K., Sasano, H., Ito, H. Iijima T.
  • Journal Title: Biochemical & Biophysical Research Communications 354 Pages: 1016-1020
• [Journal Article] Involvement of the calcium channel beta3 subunit in olfactory signal transduction (2007)
  • Author(s): Shiraiwa, S., Kashiwayanagi, M., Iijima, T., Murakami, M.
  • Journal Title: Biochemical & Biophysical Research Communications 355 Pages: 1019-1024
• [Journal Article] Essential role of the N-terminus of murine Orail in store-operated Ca^<2+> entry (2007)
  • Author(s): Takahashi, Y., Murakami, M., Watanabe, H., Hasegawa, H., Ohba, T., Munehisa, Y., Nobori, K., Ono, K., Iijima, T., Ito, H.
  • Journal Title: Biochemical & Biophysical Research Communications 356 Pages: 45-52
• [Journal Article] Modified behavioral characteristics following ablation of the voltage-dependent calcium channel β3 subunit (2007)
  • Author(s): Murakami, M., Nakagawasai, O., Yanai, K., Nunoki, K., Tan-No, K., Tadano T. Iijima, T.
  • Journal Title: Brain Research 1160 Pages: 102-112
• [Journal Article] Functional role of stromal interaction molecule 1 (STIM1) in vascular smooth muscle cells (2007)
  • Author(s): Takahashi, Y., Watanabe, H., Murakami, M., Ono, K., Munehisa, Y., Koyama, T., Nobori, K., Iijima, T., Ito, H.
  • Journal Title: Biochemical & Biophysical Research Communications 361 Pages: 934-940
• [Journal Article] Genomic organization and expression of murine calcium channel subunit α1C. Saito Ho-on Kai Museum of Natural History (2007)
  • Author(s): Murakami, M., Ohba, T., Ono, K., Watanabe, H., Ito, H., Iijima, T.
  • Journal Title: Research Bulletin 72 Pages: 1-10
• [Journal Article] Modified sympathetic regulation in N-type calcium channel null-mouse (2007)
  • Author(s): Murakami, M., Ohba, T., Wu, T-W., Fujisawa, S., Suzuki, T., Takahashi, Y., Takahashi, E., Watanabe, H., Miyoshi, I., Ono, K., Sasano, H., Ito, H. and Iijima T.
  • Journal Title: Biochemical & Biophysical Research Communications 354 Pages: 1016-1020
  • Peer Reviewed
• [Journal Article] Involvement of transient receptor potential canonical 1 (TRPC1) in Angiotensin II-induced vascular smooth muscle cell hypertrophy (2007)
  • Author(s): Takahashi, Y., Watanabe, H., Murakami, M., Ohba, T., Radovanovic, M., Ono, K., Iijima, T. and Ito, H.
  • Journal Title: Atheroscrelosis 195 Pages: 287-296
  • Peer Reviewed
• [Journal Article] Up-regulation of TRPC1 in the Development of Cardiac Hypertrophy (2007)
  • Author(s): Ohba, T., Watanabe, H., Murakami, M., Takahashi, Y., Iino, K., Kuromitsu, S., Mori, Y., Ono, K., Iijima T. and Ito, H.
  • Journal Title: Journal of Molecular and Cellular Cardiology 42 Pages: 498-507
  • NAID: 110008436654
  • Peer Reviewed
• [Journal Article] Up-regulation of TRPC1 in the Development of Cardiac Hypertrophy. (2007)
  • Author(s): Ohba, T., et. al.
  • Journal Title: Journal of Molecular and Cellular Cardiology 42 Pages: 498-507
  • NAID: 110008436654
  • Peer Reviewed
• [Journal Article] Modified sympathetic regulation in N-type calcium chnnel null-mouse. (2007)
  • Author(s): Murakami, M., et. al.
  • Journal Title: Biochem Biophys Res Commun 354 Pages: 1016-1020
  • Peer Reviewed
• [Journal Article] Involvement of transient receptor potential canonical 1 (TRPC1) in Angiotensin II-induced vascular smooth muscle cell hypertrophy. (2007)
  • Author(s): Takahashi, Y., et. al.
  • Journal Title: Atheroscrelosis 195 Pages: 287-296
  • Peer Reviewed
• [Journal Article] Functional role of stromal interaction molecule 1 (STIM1) invascular smonth muscle cells. (2007)
  • Author(s): Takahashi, Y., et. al.
  • Journal Title: Biochem Biophys Res Commun 361 Pages: 934-940
  • Peer Reviewed
• [Journal Article] Essential role of the N-terminus of murine Orail in store-operated Ca^<2+> entry (2007)
  • Author(s): Takahashi, Y., et. al.
  • Journal Title: Biochem Biophys Res Commun 356 Pages: 45-52
  • Peer Reviewed
• [Journal Article] Modified behavioral characteristics following ablation of the voltage-dependent calcium channel β3 subunit (2007)
  • Author(s): Murakami, M., et. al.
  • Journal Title: Brain Research 1160 Pages: 102-112
  • Peer Reviewed
• [Journal Article] Involvement of the calcium channel β3 subunit in olfactory signal transduction. (2007)
  • Author(s): Shiraiwa, S., et. al.
  • Journal Title: Biochem Biophys Res Commun 355 Pages: 1019-1024
  • Peer Reviewed
• [Journal Article] Genomic Organization and expression of murine calcium channel subunit α1C (2007)
  • Author(s): Manabu Murakami, et. al.
  • Journal Title: Resarch Bulletin 72 Pages: 27-35
  • Peer Reviewed
• [Journal Article] Up-regulation of TRPC1 in the Development of Cardiac Hypertrophy. (2007)
  • Author(s): Ohba, T., et al.
  • Journal Title: Journal of Molecular and Cellular Cardiology (in press)
  • NAID: 110008436654
• [Journal Article] Involvement of transient receptor potential canonical 1 (TRPC1) in Angiotensin II-induced vascular smooth muscle cell hypertrophy. (2007)
  • Author(s): Takahashi, Y., et al.
  • Journal Title: Atheroscrelosis (in press)
• [Journal Article] Modified sympathetic regulation in N-type calcium channel null-mouse. (2007)
  • Author(s): Murakami, M., et al.
  • Journal Title: Biochem Biophys Res Commun. (in press)
• [Journal Article] Decreases in pheromonal responses at the accessory olfactory bulb of mice with a deficiency of the α1B or β3 subunits of voltage-dependent Ca^<2+>-channels (2006)
  • Author(s): Murakami, M., Matsui, H., Shiraiwa, T., Suzuki, T., Sasano, H., Takahashi E., Kashiwayanagi, M.
  • Journal Title: Biological and Pharmaceutical Bulletin 29 Pages: 437-442
• [Journal Article] Involvement of Voltage-Dependent Ca Channel beta3 Subunit in the Autonomic Control of Heart Rate Variability (2006)
  • Author(s): Wu TW, Ono K, Murakami M, Iijima T.
  • Journal Title: Pharmacology 76 Pages: 170-179
• [Journal Article] Identification of a cardiac isoform of the murine calcium channel α1C (Ca_V1.2-a) subunit and its preferential binding with the β2 subunit (2006)
  • Author(s): Murakami, M., Ohba, T., Takahashi, Y., Watanabe, H., Miyoshi, I., Nakayama, S., Ono, K., Ito, H., Iijima T.
  • Journal Title: Journal of Molecular and Cellular Cardiology 41 Pages: 115-125
• [Journal Article] Regulatory role of neuron-restrictive silencing factor in the expression of TRPC1 (2006)
  • Author(s): Ohba, T., Watanabe, H., Takahashi, Y., Miyoshi, I., Nakayama, S., Satoh, E., Iino, K., Mori, Y., Kuromitsu, S., Imagawa, K., Saito, Y., Iijima, T., Ito, H., Murakami, M.
  • Journal Title: Biochemical & Biophysical Research Communications 351 Pages: 764-770
• [Journal Article] Involvement of Voltage-Dependent Ca Channel β3 Subunit in the Autonomic Control of Heart Rate Variability. (2006)
  • Author(s): Wu, TW., et al.
  • Journal Title: Pharmacology 76 Pages: 170-179
• [Journal Article] Identification of a cardiac isoform of the murine calcium channel α1C (Ca_v1.2-a) subunit and its preferential binding with the β2 subunit. (2006)
  • Author(s): Murakami, M., et al.
  • Journal Title: Journal of Molecular and Cellular Cardiology 41 Pages: 115-125
• [Journal Article] Regulatory role of neuron-restrictive silencing factor in the expression of TRPC1. (2006)
  • Author(s): Ohba, T., et al.
  • Journal Title: Biochem Biophys Res Commun. 351 Pages: 764-770
• [Presentation] 心筋細胞肥大におけるSTIM1の役割 (2009)
  • Author(s): 大場貴喜
  • Organizer: 生理研研究会「イオンチャネルトランスポーターと心血管機能」
  • Place of Presentation: 生理学研究所(岡崎)
  • Year and Date: 2009-11-25
• [Presentation] Modified autonomic regulation in mice with a P/Q-type calcium channel mutation (2009)
  • Author(s): 村上学
  • Organizer: Society for Neuroscience, 39th Annual Meeting
  • Place of Presentation: MacCORMICK PLACE (Chicago・USA)
  • Year and Date: 2009-10-17
• [Presentation] 電位依存性カルシウムチャネルと交感神経 (2009)
  • Author(s): 村上学
  • Organizer: 第37回薬物活性シンポジウム
  • Place of Presentation: 東北薬科大学(仙台)
  • Year and Date: 2009-10-10
• [Presentation] Molecular and electrical remodel of Ca^<2+> channels in rat right atrium with monocrotaline -induced pulmonary hypertension (2009)
  • Author(s): Kyoichi Ono
  • Organizer: 36th International Congress of Physiological Sciences
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2009-07-30
• [Presentation] Amlodipine and the role of PKD1-related pathway in human coronary artery smooth muscle cells (2009)
  • Author(s): Takayoshi Ohba
  • Organizer: 36th International Congress of Physiological Sciences
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2009-07-29
• [Presentation] Modified sympathetic nerve system activity with over-expression of the voltage-dependent calcium channel β3 subunit (2009)
  • Author(s): 村上学
  • Organizer: 36th International Congress of Physiological Sciences
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2009-07-29
• [Presentation] Remodeling of Ca^<2+> channels in rat atrium with monocrotaline-induced pulmonary hypertension (2009)
  • Author(s): Takayoshi Ohba
  • Organizer: 17th APCC : Asia Pacific Congress of Cardiology
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2009-05-21
• [Presentation] モノクロタリン誘導性肺高血圧ラット右心房におけるカルシウムチャネルの分子および電気的リモデリング (2009)
  • Author(s): 大場貴喜
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-03-17
• [Presentation] 電位依存性カルシウムチャネルβ3サブユニット過剰発現による交感神経系の変化 (2009)
  • Author(s): 村上学
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-03-17
• [Presentation] Modified autonomic regulation in mice with a P/Q-type calcium channel mutation (2009)
  • Author(s): Murakami M, Ohba T, Ono K
  • Organizer: Society for Neuroscience, 39th Annual Meeting
  • Place of Presentation: Chicago, USA
• [Presentation] Modified sympathetic nerve system activity with over-expression of the voltage-dependent calcium channel β3 subunit (2009)
  • Author(s): Murakami M, Ohba T, Ono K
  • Organizer: Congress of Physiological Sciences
  • Place of Presentation: Kyoto, Japan
• [Presentation] Amlodipine induces p21 (Waf1/Cip1) through PKD1-related pathway in Human Coronary Artery Smooth Muscle Cells (2008)
  • Author(s): Takayoshi Ohba
  • Organizer: 第25回国際心臓研究学会(ISHR)日本部会
  • Place of Presentation: 横浜
  • Year and Date: 2008-12-06
• [Presentation] ヒト冠動脈平滑筋増殖におけるAmlodipineの作用とPolycystic kidney Disease(PKD1)の役割 (2008)
  • Author(s): 大場貴喜
  • Organizer: 生理研セミナー : イオンチャネルトランスポーターと心血管機能 : 学際的取り組みによる新戦略
  • Place of Presentation: 岡崎
  • Year and Date: 2008-11-19
• [Presentation] Modified sympathetic nerve system activity with over expression of the voltage-dependent calcium channel β3 subunit (2008)
  • Author(s): Muramami, M.
  • Organizer: Neuroscience2008
  • Place of Presentation: Washington DC
  • Year and Date: 2008-11-15
• [Presentation] Amlodipine increases p21 (Waf1/Cip1) through PKD1-related pathway in Human Coronary Artery Smooth Muscle Cells (2008)
  • Author(s): 大場貴喜
  • Organizer: 第12回 Molecular cardiovascular conference
  • Place of Presentation: 北海道
  • Year and Date: 2008-09-06
• [Presentation] ラット心筋細胞肥大形成におけるTRPC1発現増加 (2008)
  • Author(s): 大場貴喜
  • Organizer: 第1回心血管系調節因子研究会
  • Place of Presentation: 盛岡
  • Year and Date: 2008-06-06
• [Presentation] Modified sympathetic nerve system activity with over-expression of the voltage-dependent calcium channel β3 subunit (2008)
  • Author(s): Murakami M, Ohba T, Ono K
  • Organizer: Society for Neuroscience, 38th Annual Meeting
  • Place of Presentation: Washington DC, USA
• [Presentation] Modified sympathetic nerve system activity with over-expression of the voltage-dependent calcium channel β3 subunit (2008)
  • Author(s): M. Murakami
  • Organizer: 38^<st> Annual Meeting Washington D.C.
  • Place of Presentation: Society for Neuroscience
• [Presentation] Anti-proliferative Effect of amlodipine on Human Coronary Artery Smooth Muscle Cells (2008)
  • Author(s): T. Ohba, H. Watanabe, M. Murakami, H. Hasegawa and H. Ito
  • Organizer: 第12回日本心不全学会学術集会
  • Place of Presentation: 東京
• [Presentation] ヒト冠動脈平滑筋におけるアムロジピン抗増殖作用の新規メカニズム (2008)
  • Author(s): 大場貴喜, 村上学, 藤澤進, 渡邊博之, 尾野恭一, 伊藤宏, 飯島俊彦
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
• [Presentation] N型カルシウムチャネル欠損マウスにおける交感神経制御機構 (2008)
  • Author(s): 村上学, 大場貴喜, 藤澤進, 渡邊博之, 尾野恭一, 伊藤宏, 飯島俊彦
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
• [Presentation] Cloning of novel isoforms of murine cardiac calcium channel α1 subunit and their different binding affinities with β2 subunit (2007)
  • Author(s): Murakami M, Ohba T, Takahashi Y, Ono K, Watanabe H, Ito H, Iijima T
  • Organizer: Society for Neuroscience, 37th Annual Meeting
  • Place of Presentation: San Diego, USA
• [Presentation] Cloning of novel isoforms of murine cardiac calcium channel α1 subunit and their different binding affinities with β2 subunit (2007)
  • Author(s): M. Murakami
  • Organizer: 37^<st> Annual Meeting San Diego
  • Place of Presentation: Society for Neuroscience
• [Presentation] Cloning of novel isoforms of murine cardiac calcium channel α1 subnit and their different binding affinities with β2 subunit. (2007)
  • Author(s): Manabu Murakami
  • Organizer: Society for Neuroscience, 37st Annual Meeting
  • Place of Presentation: San Diego
• [Presentation] 冠動脈平滑筋におけるamlodipineの抗増殖作用はPKD1分子を介する (2007)
  • Author(s): 大場貴喜
  • Organizer: 第58回日本薬理学会北部会
  • Place of Presentation: 札幌
• [Presentation] マウスOrai遺伝子のクローニングおよび機能解析 (2007)
  • Author(s): 村上 学
  • Organizer: 第58回日本薬理学会北部会
  • Place of Presentation: 札幌
• [Presentation] モノクロタリン誘発肺高血圧ラットの右心房におけるL型及びT型Caチャネルのリモデリング (2007)
  • Author(s): 尾野恭一
  • Organizer: 第58回日本薬理学会北部会
  • Place of Presentation: 札幌
• [Presentation] 冠動脈平滑筋におけるPKD1分子の抗増殖作用 (2007)
  • Author(s): 大場貴喜
  • Organizer: 第3回TRP研究会
  • Place of Presentation: 岡崎
• [Presentation] モルモット洞房結節細胞におけるプロスタグランジンの自動能促進作用 (2007)
  • Author(s): 尾野恭一
  • Organizer: 第80回日本薬理学会年会
  • Place of Presentation: 名古屋
• [Presentation] マウスOrai遺伝子の単離とSOCEにおける機能 (2007)
  • Author(s): 高橋陽一郎
  • Organizer: 第80回日本薬理学会年会
  • Place of Presentation: 名古屋
• [Presentation] Neuron-restrictive silencing factor (NRSF) is responsible for cardiachyperphy by regulating expression of transient receptor potential channel 1 (TRPC1) (2007)
  • Author(s): 大場貴喜
  • Organizer: 第71回日本循環器学会
  • Place of Presentation: 神戸
• [Remarks] ホームページ等