Analysis of urinary dysfunction and drug discovery by in vivo measurement of drug-receptor binding

• Project/Area Number: 18590237
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General pharmacology
• Research Institution: University of Shizuoka
• Principal Investigator: YAMADA Shizuo University of Shizuoka, School of Pharmaceutical Sciences, Pharmacokinetics and Pharmacodynamis, Professor (80106434)
• Co-Investigator(Kenkyū-buntansha): OKI Tomomi University of Shizuoka, School of Pharmaceutical Sciences, Pharmacokinetics and Pharmacodynamis, Research associate (50405148)
• Project Period (FY): 2006 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥4,080,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2006: ¥2,000,000 (Direct Cost: ¥2,000,000)
• Keywords: Benign urostatic hvnernlasia / Overactive bladder / Urinary bladder / Neurotransmitter receptors / Cerebral infarction / Bladder outlet obstruction / Interstitial / 尿道部分閉塞 / 間質性膀胱炎 / 膀胱 / ムスカリン性受容体 / アンギオテンシン受容体 / ATP受容体 / 受容体拮抗薬 / 脊髄損傷 / 脳梗塞 / 尿道閉塞 / 膀胱ムスカリン性受容体 / 抗コリン薬

Research Abstract

The aim of this study is to characterize bladder neurotransmitter receptor binding and urodynamic parameters in rats with cerebral infarction, chronic bladder outlet obstruction, cyclophosphamide (CYP) and HCl-treated rats as models of urinary dysfunction due to benign prostatic hyperplasia (BPH) , overactive bladder (OAB) and interstitial cystitis (IC).
1) Bladder capacity and voided volume were significantly lower in the cerebral-infarcted than in the sham rats. Involuntary contractions before micturition were seen in the bladder outlet-obstructed rats but not in sham rats. The cerebral infarction but not bladder outlet obstruction in rats caused up-regulation of bladder muscarinic receptors, and that such regulation of bladder muscarinic receptors may be at least partly associated with the symptoms of detrusor overactivity subsequent to cerebral infarction.
2) In the cystometry of CYP-treated rats compared with control rats, the micturition interval and micturition volume were signifi cantly decreased and the frequency of micturition and basal pressure were significantly increased. These changes in urodynamic parameters may characterize the detrusor overactivity occurring in CYP-treated rats. Thus, CYP treatment has been shown to cause down-regulation of pharmacologically relevant receptors in the bladder of rats. The present study offers further pharmacological evidence that both muscarinic and purinergic mechanisms contribute significantly to the urinary dysfunction due to IC.
3) The angiotensin II (Ang II) receptor was significantly up-regulated in the rat bladder due to the bladder outlet obstruction. Repeated oral administration of telmisartan in rats completely prevented the development of a bladder outlet obstruction-induced up-regulation of bladder Ang II receptors. Telmisartan treatment also effectively attenuated the increase in bladder wet weight caused by urinary outlet obstruction. Thus, bladder Ang II may be at least partly associated with the pathogenesis of urinary dysfunction occurring subsequent to bladder outlet obstruction.
The present study raise the possibility that agonists or antagonists of pharmacologically relevant receptors in the bladder is a useful therapeutic drug for the treatment of urinary dysfunction.

Research Products

• [Journal Article] Comparative evaluation of central muscarinic receptor binding activity byoxybutynin,tolterodine and darifenacin used to treat overactive bladder (2007)
  • Author(s): Tomomi Oki, Aiko Kageyama, Yukiko Takagi, Shinya Uchida and Shizuo Yamada
  • Journal Title: J.Urol. 177 Pages: 766-770
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Urodynamics and bladder muscarinic receptors in rats with cerebral infarction and bladder outlet obstruction (2007)
  • Author(s): Shuji Maruyama, Souhei Kurosawa, Yukiko Takagi, Tomomi Oki, Yukiko Noguchi, Masashi Ukai, Hironori Yuyama, Akiyoshi Ohtake, Masanori Suzuki, Masao Sasayama and Shizuo Yamada
  • Journal Title: Neurosci.Lett. 414 Pages: 80-84
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Binding activities by propiverine and its N-oxide metabolites of voltage-dependent L-type calcium channel antagonist receptors in the rat bladder and brain (2007)
  • Author(s): Shinya Uchida, Souhei Kurosawa, Tomomi Fujino(Tomomi Oki), Yoshihisa Kato, Masato Nanri, Kenichiro Yoshida and Shizuo Yamada
  • Journal Title: Life Sci. 80 Pages: 2454-2460
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Comparative evaluation of central muscarinic receptor binding activity by oxybutynin, tolterodine and darifenacin used to treat overactive bladder (2007)
  • Author(s): Tomomi, Oki, Aiko, Kageyama, Yukiko, Takagi, Shinya, Uchida, Shizuo, Yamada
  • Journal Title: J. Urol 177 Pages: 766-770
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Muscarinic and alpha 1-adrenergic receptor binding characteristics of saw palmetto extract in rat lower urinary tract. (2007)
  • Author(s): Mayumi, Suzuki, Tomomi, Oki, Tomomi, Sugiyama, Keizo, Umegaki, Shinya, Uchida, Shizuo, Yamada
  • Journal Title: Urology 69 Pages: 1216-1220
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Brain neurotransmitter receptor-binding characteristics in rats after oral administration of haloperidol, risperidone and olanzapine (2007)
  • Author(s): Shinya, Uchida, Yasuhiro, Kato, Kazufumi, Hirano, Yoshiyuki, Kagawa, Shizuo, Yamada
  • Journal Title: Life Sci 80 Pages: 1635-1640
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Comparative measurement of spinal CSF microdialysate concentrations and concomitant antinociception of morphine and morphine-6β-glucuronide in rats. (2007)
  • Author(s): Takashi, Okura, Noriyuki, Komiyama, Yuki, Morita, Midori, Kimura, Yoshiharu, Deguchi, Shizuo, Yamada
  • Journal Title: Life Sci 80 Pages: 1319-1326
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Urodynamics and bladder muscarinic receptors in rats with cerebral infarction and bladder outlet obstruction (2007)
  • Author(s): Shuji, Maruyama, Souhei, Kurosawa, Yukiko, Takagi, Tomomi, Oki, Yukiko, Noguchi, Masashi, Ukai, Hironori, Yuyama, Akiyoshi, Ohtake, Masanori, Suzuki Masao, Sasayama, Shizuo, Yamada
  • Journal Title: Neurosci. Lett 414 Pages: 80-84
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Different effects of morphine and morphine-60-glucuronide on formalin-evoked spinal glutamate release in conscious and freely moving rats. (2007)
  • Author(s): Takashi, Okura, Noriyuki, Komiyama, Yuki, Morita, Midori, Kimura, Shizuo, Yamada
  • Journal Title: Neurosci. Lett 415 Pages: 169-173
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] from plasma concentrations of silodosin, tamsulosin and terazosin to treat urinary obstruction in benign prostatic hyperplasia.Biol. (2007)
  • Author(s): Shizuo, Yamada, Yasuhiro, Kato, Takashi, Okura, Yoshiyuki, Kagawa, Kazuki, Kawabe Prediction of a_1-adrenoceptor occupancy in the human prostate
  • Journal Title: Pham. Bull 30 Pages: 1237-1241
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Binding activities by propiverine and its N-oxide metabolites of voltage-dependent L-type calcium channel antagonist receptors in the rat bladder and brain (2007)
  • Author(s): Shinya, Uchida, Souhei, Kurosawa, Tomomi, Fujino (Oki), Yoshihisa, Kato Masato, Nanri, Kenichiro, Yoshida, Shizuo, Yamada
  • Journal Title: Life Sci 80 Pages: 2454-2460
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A Novel mechanism for polychlorinated biphenyl-induced decrease in serum throxine level in rats. (2007)
  • Author(s): Yoshihisa, Kato, Shin-ichi, Ikushiro, Rie, Takiguchi, Koichi, Haraguchi, Nobuyuki, Koga, Shinya, Uchida, Toshiyuki, Sakaki, Shizuo, Yamada, Jun, Kanno, Masakuni, Degawa
  • Journal Title: Drug Metab. Dispos 35 Pages: 1949-1955
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Bioactive analogues and drug delivery systems of vasoactive intestinal peptide (VIP) for the treatment of asthma/COPD. (2007)
  • Author(s): Satomi, Onoue, Shizuo, Yamada, Takehiko, Yajima
  • Journal Title: Peptides 28 Pages: 1640-1650
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Comparative evaluation of central muscarinic receptor binding activity byoxybutynin, tolterodine and darifenacin used to treat overactive bladder (2007)
  • Author(s): Tomomi Oki, Aiko Kageyama, Yukiko Takagi, Shinya Uchida and Shizuo Yamada:
  • Journal Title: J. Urol. 177 Pages: 766-770
  • Peer Reviewed
• [Journal Article] Urodynamics and bladder muscarirnic receptors in rats with cerebral infarction and bladder outlet obstruction (2007)
  • Author(s): Shuji Maruyama, Souhei Kurosawa, Yukiko Takagi, Tomomi Oki, Yukiko Noguchi, Masashi Ukai, Hironori Yuyama, Akiyoshi Ohtake, Masanori Suzuki, Masao Sasayama and Shizuo Yamada
  • Journal Title: Neurosci. Lett. 414 Pages: 80-84
  • Peer Reviewed
• [Journal Article] Binding activities by propiverine and its N-oxide metabolites of voltage-dependent L-type calcium channel antagonist receptors in the rat bladder and brain (2007)
  • Author(s): Shinya Uchida, Souhei Kurosawa, Tomomi Fujino(Oki), Yoshihisa Kato, Masato Nanri, Kenichiro Yoshida and Shizuo Yamada
  • Journal Title: Life Sci. 80 Pages: 2454-2460
  • Peer Reviewed
• [Journal Article] Characterization of muscarinic receptor binding and inhibition of salivation after oral administration of tolterodine in mice (2006)
  • Author(s): Tomomi Oki, Shuji Maruyama, Yukiko Takagi, Henry I.Yamamura and Shizuo Yamada
  • Journal Title: Eur.J.Pharmacol. 529 Pages: 157-163
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Advantage for transdermal over oral oxybutynin to treat overactive bladder:muscarinic receptor binding,plasma drug concentration and salivary secretion (2006)
  • Author(s): Tomomi Oki, Ayako Toma-Okura and Shizuo Yamada
  • Journal Title: J.Pharmacol.Exp.Ther. 316 Pages: 1137-1145
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Human muscarinic receptor binding characteristics of antimuscarinic agents to treat overactive bladder (2006)
  • Author(s): Shuji Maruyama, Tomomi Oki, Atsushi Otsuka, Hitoshi Sninbo, Seichiro Ozono, Shinji Kageyama, Isao Araki, Yuuki Mikami, Masayuki Takeda and Shizuo Yamada
  • Journal Title: J.Urol. 175 Pages: 365-369
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Comparative evaluation of exocrine muscarinic receptor binding characteristics and inhibition of salivation of solifbnacin in mice (2006)
  • Author(s): Tomomi Oki, Chihiro Takeuchi and Shizuo Yamada
  • Journal Title: Biol.Pharm.Bull. 29 Pages: 1397-1400
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Demonstration of M_3 muscarinic receptor subtype selectivity of darifbnacin in mice (2006)
  • Author(s): Shizuo Yamada, Shuji Maruyama, Yukiko Takagi, Shinya Uchida and Tomomi Oki
  • Journal Title: Life Sci. 80 Pages: 127-132
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Characterization of muscarinic receptor binding and inhibition of salivation after oral administration of tolterodine in mice. (2006)
  • Author(s): Tomomi, Oki, Shuji, Maruyama, Yukiko, Takagi, Henry I., Yamamura, Shizuo, Yamada
  • Journal Title: Eur. J. Pharmacol 529 Pages: 157-163
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Advantage for transdermal over oral oxybutynin to treat overactive bladder: muscarinic receptor binding, plasma drug concentration and salivary secretion. (2006)
  • Author(s): Tomomi, Oki, Ayako, Toma-Okura, Shizuo, Yamada
  • Journal Title: J. Pharmacol. Exp. Ther 316 Pages: 1137-1145
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Human muscarinic receptor binding characteristics of antimuscarinic agents to treat overactive bladder. (2006)
  • Author(s): Shuji, Maruyama, Tomomi, Oki, Atsushi, Otsuka, Hitoshi, Sninbo, Seichiro, Ozono, Shinji, Kageyama, Isao, Araki, Yuuki, Mikami, Masayuki, Takeda, Shizuo, Yamada
  • Journal Title: J. Urol 175 Pages: 365-369
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Selective protection of curcumin against carbon tetrachloride-induced inactivation of hepatic cytochrome P450 isozymes in rats (2006)
  • Author(s): Tomomi, Sugiyama, Jun-ichi, Nagata, Azumi, Yamagishi, Kaori, Endoh, Morio, Saito Kazuhiko, Yamada, Shizuo, Yamada, Keizo, Umegaki
  • Journal Title: Life Sci 78 Pages: 2188-2193
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Development of dry powder inhalation system of novel vasoactive intestinal peptide (VIP) analogue for pulmonary administration (2006)
  • Author(s): Yuki, Ohmori, Satomi, Onoue, Kosuke, Endo, Asami, Matsumoto, Shinya, Uchida, Shizuo, Yamada
  • Journal Title: Life Sci 79 Pages: 138-143
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Comparative evaluation of exocrine muscarinic receptor binding characteristics and inhibition of salivation of solifenacin in mice. (2006)
  • Author(s): Tomomi, Oki, Chihiro, Takeuchi, Shizuo, Yamada
  • Journal Title: Biol. Pharm. Bull 29 Pages: 1397-1400
  • NAID: 110005602309
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Monospecific antipeptide antibodies against human heptatic UDP-glucuronosyltransferase 1A subfamily (UGT1A) isoforms (2006)
  • Author(s): Ikushiro, S, Emi, Y, Kato, Y, Shizuo, Yamada, Sakai, T
  • Journal Title: Drug Metab. Pharmacokinet 21 Pages: 70-74
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Stereochemical diversity-oriented conformational restriction strategy. Development of potent histamine H_3 and/or H_4 receptor antagonists with a imidazolylcyclopropane structure. (2006)
  • Author(s): Mizuki, Watanabe, Yuji, Kazuta, Hideki, Hayashi, Shizuo, Yamada, Akira, Matsuda, Satoshi, Shuto
  • Journal Title: J. Med. Chem 49 Pages: 5587-5596
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of Ginkgo biloba extract on pharmacokinetics and pharmacodynamics of tolbutamide and midazolam in healthy volunteers. (2006)
  • Author(s): Shinya, Uchida, Hiroshi, Yamada, Xiao, Dong, Li, Syuji, Maruyama, Yuki, Ohmori, Tomomi, Oki, Hiroshi, Watanabe, Keizo, Umegaki, Kyoichi, Ohashi, Shizuo, Yamada
  • Journal Title: J. Clin. Pharmacol 46 Pages: 1290-1298
  • NAID: 130005023904
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] In vivo demonstration of M_3 muscarinic receptor subtype selectivity of darifenacin in mice. (2006)
  • Author(s): Shizuo, Yamada, Shuji, Maruyama, Yukiko, Takagi, Shinya, Uchida, Tomomi, Oki
  • Journal Title: Life Sci 80 Pages: 127-132
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Characterization of muscarinic receptor binding and inhibition of salivation after oral administration of tolterodine in mice (2006)
  • Author(s): Tomomi Oki, Shuji Maruyama, Yukiko Takagi, Henry I. Yamamura, Shizuo Yamada
  • Journal Title: Eur. J. Pharmacol. 529 Pages: 157-163
• [Journal Article] Advantage for transdermal over oral oxybutynin to treat overactive bladder : muscarinic receptor binding, plasma drug concentration and salivary secretion. (2006)
  • Author(s): Tomomi Oki, Ayako Toma-Okura, Shizuo Yamada)
  • Journal Title: J. Pharmacol.Exp. Ther. 316 Pages: 1137-1145
• [Journal Article] Human muscarinic receptor binding characteristics of antimuscarinic agents to treat overactive bladder. (2006)
  • Author(s): Shuji Maruyama, Tomomi Oki, Atsushi Otsuka, Hitoshi Sninbo, Seichiro Ozono, Shinji Kageyama, Isao Araki, Yuuki Mikami, Masayuki Takeda, Shizuo Yamada
  • Journal Title: J. Urol. 175 Pages: 365-369
• [Journal Article] Comparative evaluation of exocrine Muscatine receptor binding characteristics and inhibition of salivation of solifenacin in mice. (2006)
  • Author(s): Tomomi Oki, Chihiro Takeuchi, Shizuo Yamada
  • Journal Title: Biol. Pharm. Bull. 29 Pages: 1397-1400
• [Journal Article] Demonstration of M_3 muscarinic receptor subtype selectivity of darifenacin in mice (2006)
  • Author(s): Shizuo Yamada, Shuji Maruyama, Yukiko Takagi, Shinya Uchida, Tomomi Oki
  • Journal Title: Life Sci. 80 Pages: 127-132
• [Presentation] Long-lasting analogues and drug delivery systems of vasoactive intestinal peptide for the treatment of COPD (2007)
  • Author(s): Satomi, Onoue, Shingen, Misaka, Takehiko, Yajima, Shizuo, Yamada
  • Organizer: 5th Mt. Symp. on Pharm. Chem
  • Place of Presentation: Istanbul
  • Year and Date: 2007-09-07
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] In vivo analysis of drug-receptor binding characteristics in drug discovery (2007)
  • Author(s): Shizuo, Yamada, Satomi, Onoue
  • Organizer: 5th Int. Symp. on Pharm. Chem
  • Place of Presentation: Istanbul
  • Year and Date: 2007-09-06
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Structure-activity relationship of receptor binding of some 1,4-dihydropyridine derivatives (2007)
  • Author(s): Shizuo, Yamada, Daiki, Takahashi, Luvsandorj, Oyunzul, Satomi, Onoue, Yoshihiko, Ito. Shinva, Uchida, Rahime, Simsek, Miyase, Gozde Gunduz, Cihat, Safak
  • Organizer: 5th Mt. Symp. on Pharm. Chem
  • Place of Presentation: Istanbul
  • Year and Date: 2007-09-05
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Antinociceptive effect of extracts of medical herbs in mice and their interaction with morphine (2007)
  • Author(s): Shinya, Uchida, Keita, Hirai, Junko, Hanato, Yukiko, Shinme, Shizuo, Yamada
  • Organizer: The 3rd China-Japan Joint Meeting ofBasic and Clinical Pharmacology
  • Place of Presentation: Dailen, Chaina
  • Year and Date: 2007-08-24
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] In vivo analysis of brain muscarinic receptor occupancy after oral oxybutynin in conscious rhesus monkey by using positron emission tomography (PET) (2007)
  • Author(s): Shuji, Maruyama, Hideo, Tsukada, Shizuo, Yamada
  • Organizer: 37th Annual Meeting of the Int. Continence Soc.
  • Place of Presentation: Rotterdam, Netherlands
  • Year and Date: 2007-08-23
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Direct quantification of muscarinic receptor subtypes in human detrusor muscle, mucosa and parotid gland by irreversible inactivation of M3 receptors by 4-DAMP musterd (2007)
  • Author(s): Kazuhiro, Suzuki, Shuji, Maruyama, Masayuki, Takeda, Atsushi, Otsuka, Siichiro, Ozono, Shizuo, Yamada
  • Organizer: 37th Annual Meeting of the Mt. Continence Soc.
  • Place of Presentation: Rotterdam, Netherlands
  • Year and Date: 2007-08-23
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 膀胱ムスカリン牲受容体を標的とした頻尿・尿失禁治療薬の受容体結合動態 (2007)
  • Author(s): 山田 静雄, 他2名
  • Organizer: 第80回日本薬理学会年会シンポジウム「下部尿路障害治療薬-基礎と臨床」(名古屋)
  • Place of Presentation: 名古屋
  • Year and Date: 2007-03-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Comparative evaluation of human mucosa and detrusor muscarinic receptor binding by anticholinergic agents in the treatment of overactive bladder (2006)
  • Author(s): Tomomi, Oki, Luvsandorj, Oyunzul, Kazuhiro, Suzuki, Aiko, Kageyama, Atsushi, Otsuka, Hitoshi, Shinbo, Seiichiro, Ozono, Shizuo, Yamada
  • Organizer: Int. Continence Ann. Meeting
  • Place of Presentation: Christchurch , New Zealand
  • Year and Date: 2006-12-01
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] A possible mechanism for the decrease in serum thyroxine level by polychlorinated biphenyls in Wistar and Gunn rats (2006)
  • Author(s): Yoshihisa, Kato, Shin-ichi, Ikushiro, Rie, Takiguchi, Sekihiro, Tamaki, Koichi, Haraguchi, Toshiyuki, Sakaki, Shizuo, Yamada, Jun, Kanno, Masakuni, Degawa
  • Organizer: 26th International Symposium on Halogenated Persistent Organic Pollutants
  • Place of Presentation: Oslo, Norway
  • Year and Date: 2006-08-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Effects of ursodeoxycholic acid on the CYP3A activity and pharmacokinetics of midazolam in rats (2006)
  • Author(s): Shinva, Uchida, Shohei, Kurosawa, Shingen, Misaka, XiaoDong, Li, DongMei, Yan, Hiroshi, Watanabe, Kyoichi, Ohashi, Shizuo, Yamada
  • Organizer: The 15th World Congress of Pharmacology
  • Place of Presentation: Beijing, China
  • Year and Date: 2006-07-04
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Plasma concentration and muscarinic receptor binding characteristics of novel anticholinergic agents directed toward the therapy of overactive bladder (2006)
  • Author(s): Tomomi, Oki, Shizuo, Yamada
  • Organizer: The 15th World Congress of Pharmacolog
  • Place of Presentation: Beijing, China
  • Year and Date: 2006-07-03
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Effects of Ursodeoxycholic acid on the CYP3A activity and pharmacokinetics of midazolam in rats and healthy volunteers (2006)
  • Author(s): Shinya, Uchida, Shohei, Kurosawa, Shingen, Misaka, Hiroshi, Watanabe, Kyoichi, Ohashi Shizuo, Yamada
  • Organizer: The 1st Asia Pacific ISSX Meeting
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2006-05-24
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Pharmacokinetic, Receptor binding and Pharmacodynamic Anlaysis of CNS Drugs (2006)
  • Author(s): Shizuo, Yamada, Kazufumi, Hirano, Tomomi, Oki, Akihiko, Urayama, Shinya, Uchida
  • Organizer: CINP Asia Pacific Regional Meeting
  • Place of Presentation: Pattaya, Thailand
  • Year and Date: 2006-03-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Hiroshi Watanabe Influences of CYP2C9 genotype on pharmacokinetics and pharmacodynamics of benzbromarone (2006)
  • Author(s): Shinya, Uchida, Kayoko., Shimada, Shingen, Misaka, Don Mei, Yan, Xiao Dong, Li, Shinichiro, Nishio, Hiromitu, Imai, Kyoichi, Ohashi, Shizuo, Yamada
  • Organizer: 2005 Annual Meeting ofAmerican Society for Clinical Pharmacologyand Therapeutic
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2006-03-08
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Muscarinic and purinergic receptors are altered in the bladder of rat models with interstitial cystitis (2006)
  • Author(s): Aiko, Kageyama, Tomomi, Oki, Luvsandorj, Oyunzul, Shohei, Kurosawa, Shizuo, Yamada
  • Organizer: Int. Continence Ann. Meeting
  • Place of Presentation: Christchurch , New Zealand
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The active metabolite (DPr-P-4(N→O)) of propiverine hydrochloride may contribute to the bladder selectivity of this drug to treat patients with overactive bladder (2006)
  • Author(s): Shizuo, Yamada, Tomomi, Oki, Shuji, Maruyama, Kenichiro, Yoshida, Masato, Nanri, Masayuki, Takeda
  • Organizer: Int. Continence Ann. Meeting
  • Place of Presentation: Christchurch , New Zealand
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Propiverine and oxybutynin inhibit Ca^<2+> influx mediated by the activation of a specific receptor, transient recepter potential vanilloid subtype 1 (TRPV1)
  • Author(s): Aiko, Kageyama, Yusaku, Iwasaki, Tatsuo, Watanabe, Masato, Nanri, Kenichiro, Yoshida, Shizuo, Yamada
  • Organizer: 37th Annual Meeting of the Int. Continence Soc.
  • Place of Presentation: Rotterdam, Netherlands
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Demonstration of muscarinic and nicotinic receptor binding acticities of acetylcholinesterase inhibitors to treat impaired detrusor contractility
  • Author(s): Kazumi, Fushimi, Yuki, Ishida, Taketsugu, Harada, Yoshihiko, Ito, Saori, Nishijima, Kimio, Sugaya, Shizuo, Yamada
  • Organizer: 37th Annual Meeting of the Int. Continence Soc.
  • Place of Presentation: Rotterdam, Netherlands
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Propiverine and its N-oxide metabolite bind significantly to L-type calcium channel antagonist receptors in rat bladder
  • Author(s): Shizuo, Yamada, Yoshihiko, Ito, Tomomi, Fujino, Masato, Nanri, Kenichiro, Yoshida
  • Organizer: 37th Annual Meeting of the Mt. Continence Soc.
  • Place of Presentation: Rotterdam, Netherlands
  • Description: 「研究成果報告書概要(欧文)」より