Nitric oxide (NO) negatively regulates endothelium-derived hyperporizing factor (EDHF)

• Project/Area Number: 18590250
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Mukogawa Women's University
• Principal Investigator: KAGOTA Tomomi Mukogawa Women's University, 薬学部, 講師 (00291807)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,210,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥510,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
• Keywords: 内皮由来過分極因子 / 一酸化窒素 / 内皮依存性弛緩反応 / 内皮由来過分局因子

Research Abstract

酸素や栄養を運搬する血液が流れている導管「動脈」のしなやかな動きは,からだを正常に保つために重要です。このような動脈の動きは,動脈を構成する細胞である「内皮細胞」が作り出す様々な物質によって調節されています。この研究では,そのような物質の中から2種類(一酸化窒素NO および内皮由来過分極因子EDHF)に着目し,お互いどのように調節しあっているのかについて調べました。その結果,NO が大量に存在する時にはEDHFを抑制する機構が存在することをみいだしました

Research Products

• [Journal Article] Beneficial effect of coenzyme Q10 on increased oxidative and nitrative stress and inflammation and individual netabolic components developing in a rat model of metabolic syndrome. (2008)
  • Author(s): Kunitomo M, Yamaguchi Y, Kagota S, Otsubo K.
  • Journal Title: J Pharmacol Sci 107 Pages: 128-137
  • Peer Reviewed
• [Journal Article] Beneficial effect of coenzyme Q10 on increased oxidative and nitrative stress and inflammation and individual netabolic components developing in a rat model of metabolic syndrome. (2008)
  • Author(s): Kunitomo M, et al.
  • Journal Title: J Pharmacol Sci. 107 Pages: 128-137
  • Peer Reviewed
• [Journal Article] Peroxynitrite is involved in the dysfunction of vasorelaxation in SHR/NDmcr-cp rats, spontaneously hypertensive obese rats. (2007)
  • Author(s): Kagota S, Tada Y, Kubota Y, Nejime N, Yamaguchi Y, Nakamura K, Kunitomo M, Shinozuka K.
  • Journal Title: J Cardiovasc Pharmacol 50 Pages: 677-685
  • Peer Reviewed
• [Journal Article] Increased systemic oxidative and nitrative stress in a new congenic model of metabolic syndrome derived from stroke-prone spontaneously hypertensive rats and Zucker fatty rats. (2007)
  • Author(s): Yamaguchi Y, Yoshikawa N, Nagase M, Kagota S, Haginaka J, Nakamura K, Kunitomo M.
  • Journal Title: Clin Exp Pharmacol Physiol 34
  • Peer Reviewed
• [Journal Article] Abnormalities of nitric oxide-mediated vasorelaxations in a rat model of metabolic syndrome: Involvement of peroxynitrite formation. (2007)
  • Author(s): Kagota S, Tada Y, Yamaguchi Y, Kubota Y, Nejime N, Nakamura K, Kunitomo M, Shinozuka K.
  • Journal Title: Clin Exp Pharmacol Physiol. 34
  • Peer Reviewed
• [Journal Article] Impaired effect of salt loading on nitric oxide-mediated relaxation in aortas from stroke-prone spontaneously hypertensive rats. (2007)
  • Author(s): Kagota S, Kubota Y, Nejime N, Nakamura K, Kunitomo M, Shinozuka K.
  • Journal Title: Clin Exp Pharmacol Physiol 34 Pages: 48-54
  • Peer Reviewed
• [Journal Article] Peroxynitrite is involved in the dysfunction of vasorelaxation in SHR/ND mcr-cp rats,spontaneously hypertensive obese rats (2007)
  • Author(s): Kagota S, Tada Y, Kubota Y, Nejime N, Yamaguchi Y, Nakamura K, Kunitomo M, Shinozuka K
  • Journal Title: Journal of Cardiovascular Pharmacology 50(6) Pages: 677-685
  • Peer Reviewed
• [Journal Article] Abnormalities of nitric oxide-mediated vasorelaxations in a rat model of metabolic syndrome:Involvement of peroxynitrite formation (2007)
  • Author(s): Kagota S, Tada Y, Yamaguchi Y, Kubota Y, Nejime N, Nakamura K, Kunitomo M, Shinozuka K.
  • Journal Title: Clinical Experimental Pharmacology and Physiology 34 Pages: 23-5
  • Peer Reviewed
• [Journal Article] Increased systemic oxidative and nitrative stress in a new congenic model of metabolic syndrome derived from stroke-prone spontaneously hypertensive rats and Zucker fatty rats (2007)
  • Author(s): Yamaguchi Y, Yoshikawa N, Nagase M, Kagota S, Haginaka J, Nakamura K, Kunitomo M.
  • Journal Title: Clinical Experimental Pharmacology and Physiology 34 Pages: 26-8
  • Peer Reviewed
• [Journal Article] Impaired effect of salt loading on nitric oxide-mediated relaxation in aortasfrom stroke-prone spontaneously hypertensive rats (2007)
  • Author(s): Kagota S, Kubota Y, Nejime N, Nakamura K, Kunitomo M, Shinozuka K.
  • Journal Title: Clinical Experimental Pharmacology and Physiology 34(1-2) Pages: 48-54
  • Peer Reviewed
• [Journal Article] Impaired effect of salt loading on nitric oxide-mediated relaxtion in aortas from stroke-prone spontaneously hypertensive rats. (2007)
  • Author(s): Kagota S et al.
  • Journal Title: Clinical and Experimental Pharmacology and Physiology 4(1-2) Pages: 48-54
• [Journal Article] Elevated circulating levels of markers of oxidative-nitrative stress and inflammation in a genetic rat model of metabolic syndrome (2006)
  • Author(s): Yamaguchi Y, Kagota S, Nakamura K, Haginaka J, Kunitomo M.
  • Journal Title: Nitric Oxide 15 Pages: 380-6
  • Peer Reviewed
• [Journal Article] Disturbances in nitric oxide/cyclic guanosine monophosphate system in SHR/NDmcr-cp rats, a model of metabolic syndrome (2006)
  • Author(s): Kagota S, Yamaguchi Y, Tanaka N, Kubota Y, Kobayashi K, Nejime N, Nakamura K, Kunitomo M, Shinozuka K.
  • Journal Title: Life Sci 78 Pages: 1187-96
  • Peer Reviewed
• [Journal Article] Effects of Ginkgo biloba Extract Feeding on Salt-Induced Hypertensive Dahl Rats. (2006)
  • Author(s): Kubota Y, Tanaka N, Kagota S, Nakamura K, Kunitomo M, Umegaki K, Shinozuka K.
  • Journal Title: Biol Pharm Bull 29 Pages: 266-9
  • NAID: 110005663956
  • Peer Reviewed
• [Journal Article] Effects of Ginkgo biloba extract on blood pressure and vascular endothelial response by acetylcholine in spontaneously hypertensive rats. (2006)
  • Author(s): Kubota Y, Tanaka N, Kagota S, Nakamura K, Kunitomo M, Umegaki K, Shinozuka K.
  • Journal Title: J Pharm Pharmacol 58 Pages: 243-9
  • Peer Reviewed
• [Journal Article] Disturbances in nitric oxide/cyclic guanosine monophosphate system in SHR/NDmcr-cp rats, a model of metabolic syndrome. (2006)
  • Author(s): Kagota S et al.
  • Journal Title: Life Sciences 78(11) Pages: 1187-96
• [Journal Article] Effects of Ginkgo biloba extract on blood pressure and vascular endothelial response by acetylcholine in spontaneously hypertensive rats. (2006)
  • Author(s): Kubota Y, Kagota S et al.
  • Journal Title: Journal of Pharmacy and Pharmacology 58(2) Pages: 243-9
• [Journal Article] Effects of Ginkgo biloba Extract Feeding on Salt-Induced Hypertensive Dahl Rats (2006)
  • Author(s): Kubota Y, Kagota S et al.
  • Journal Title: Biological and Pharmaceutical Bulletin 29(2) Pages: 266-9
  • NAID: 110005663956
• [Journal Article] Elevated circulating levels of markers of oxidative-nitrative stress and inflammation in a genetic rat model of metabolic syndrome (2006)
  • Author(s): Yamaguchi Y, Kagota S et al.
  • Journal Title: Nitric Oxide 15(4) Pages: 380-6
• [Journal Article] Chronic production of peroxynitrite in the vascular wall impairs vasorelaxation function in SHR/NDmcr-cp rats, an animal model of metabolic syndrome.
  • Author(s): Kagota S, Tada Y, Nejime N, Nakamura N, Kunitomo M, Shinozuka K.
  • Journal Title: J Pharmacol Sci in press Pages: 0-0
  • NAID: 10025735851
  • Peer Reviewed
• [Journal Article] Chronic production of peroxynitrite in the vascular wall impairs vasorelaxation function in SHR/NDmcr-cp rats, an animal model of metabolic syndrome.
  • Author(s): Kagota S, et al.
  • Journal Title: J Pharmacol Sci. (In press)
  • NAID: 10025735851
  • Peer Reviewed
• [Presentation] 血管壁で慢性的に産生されるパーオキシナイトライトがメタボリックシンドロームラットの血管拡張機能障害に関与する (2009)
  • Author(s): 籠田智美ら
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-03-17
• [Presentation] Depressed cardiac function in SHR/NDmcr-cp rats, an animal model of metabolic syndrome. (2008)
  • Author(s): Tada Y, et al.
  • Organizer: Hypertension 2008
  • Place of Presentation: Berlin
  • Year and Date: 2008-06-18
• [Presentation] Angiotensin II type 1 receptor and antagonist ameriorates abnormal vasorelaxation in SHRSP.ZF rats, a new animal model of metabolic syndrome. (2008)
  • Author(s): Kagota S, et al.
  • Organizer: Hypertension 2008
  • Place of Presentation: Berlin
  • Year and Date: 2008-06-17
• [Presentation] Angiotensin II type 1 receptor and antagonist ameriorates abnormal vasorelaxation in SHRSP. ZF rats, a new animal model of metabolic syndrome. (2008)
  • Author(s): Kagota S, et al.
  • Organizer: Hypertension 2008
  • Place of Presentation: Berlin
  • Year and Date: 2008-06-17
• [Presentation] AT1受容体拮抗薬は新規メタボリックシンドロームラットSHRSP.Z-Lepr^<fa>/IzmDmcrの血管弛緩機能障害を予防する. (2008)
  • Author(s): 籠田智美ら
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-18
• [Presentation] AT1受容体拮抗薬は新規メタボリックシンドロームラットSHRSP.Z-Lepr^<fa>/IzmDmcrの血管弛緩機能障害を予防する (2008)
  • Author(s): 籠田 智美、多田 有加里、禰占 奈美江、中村 一基、国友 勝、篠塚 和正
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-18
• [Presentation] メタボリックシンドロームラットSHRSP.Z-Lepr^<fa>/IzmDmcrの冠状動脈および腸間膜動脈の拡張機能とアンジオテンシンII 受容体拮抗薬の効果 (2008)
  • Author(s): 籠田智美ら
  • Organizer: 第44回高血圧関連疾患モデル学会
  • Place of Presentation: 島根
• [Presentation] Angiotensin II is critical in the development of abnormal vasorelaxation in SHRSP.ZF rats, an animal model of metabolic syndrome. (2008)
  • Author(s): Kagota S, et al.
  • Organizer: 13^<th> International SHR symposium
  • Place of Presentation: Praque
• [Presentation] Angiotensin II is critical in the development of abnormal vasorelaxation in SHRSP. ZF rats, an animal model of metabolic syndrome. (2008)
  • Author(s): Kagota S, et al.
  • Organizer: 13^<th> International SHR symposium
  • Place of Presentation: Praque
• [Presentation] メタボリックシンドロームラットSHRSP. Z-Lepr^<fa>/IzmDmcrの冠状動脈および腸間膜動脈の拡張機能とアンジオテンシンII受容体格抗薬の効果 (2008)
  • Author(s): 龍田智美, ら
  • Organizer: 第44回高血圧関連疾患モデル学会
  • Place of Presentation: 島根
• [Presentation] メタボリックシンドロームの抗酸化ストレス治療戦略 (2007)
  • Author(s): 國友勝ら
  • Place of Presentation: 金沢
  • Year and Date: 2007-09-13
• [Presentation] メタボリックシンドロームラットSHRSP.Z-Lepr^<fa>/IzmDmcrの血管弛緩反応の減弱とアンジオテンシンII受容体拮抗薬による改善効果 (2007)
  • Author(s): 籠田智美ら
  • Organizer: 生理機能と創薬シンポジウム
  • Place of Presentation: 金沢
  • Year and Date: 2007-09-13
• [Presentation] メタボリックシンドロームラットSHRSP.Z-Lepz^<fa>/IzmDmcrの血管弛緩反応の減弱とアンジオテンシンII受容体拮抗薬による改善効果 (2007)
  • Author(s): 籠田 智美、多田 有加里、禰占 奈美江、中村 一基、国友 勝、篠塚 和正
  • Organizer: 生理機能と創薬シンポジウム
  • Place of Presentation: 金沢
  • Year and Date: 2007-09-13
• [Presentation] メタボリックシンドロームの抗酸化ストレス治療戦略 (2007)
  • Author(s): 国友 勝, 山口 優、籠田 智美
  • Organizer: 生理機能と創薬シンポジウム
  • Place of Presentation: 金沢
  • Year and Date: 2007-09-13
• [Presentation] 生活習慣病モデルラット腸間膜動脈における血管弛緩反応の減弱とテルミサルタンによる改善効果 (2007)
  • Author(s): 籠田智美ら
  • Organizer: 第80回日本薬理学会年会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-03-14
• [Presentation] 新規メタボリックシンドロームモデルラットの腸間膜動脈における血管弛緩反応性 (2007)
  • Author(s): 籠田智美ら
  • Organizer: 第36回心血管作動物質学会
  • Place of Presentation: 徳島
  • Year and Date: 2007-02-09
• [Presentation] Coenzyme Q10 attenuates increases in oxidative stress, inflammation, insulin resistance, and blood pressure developing in metabolic syndrome model rats. (2007)
  • Author(s): Kunitomo M, et al.
  • Organizer: 第5回国際コエンザイムQ10カンファレンス
  • Place of Presentation: 神戸
• [Presentation] Changes in cardiac chronotropic and inotropic responses to beta and musucarinic receptor agonists in SHR/NDmcr-cp rats, an animal model of metabolic syndrome. (2007)
  • Author(s): Tada Y, et al.
  • Organizer: 第5回国際受容体・シグナリング・薬物作用シンポジウム
  • Place of Presentation: 静岡
• [Presentation] Changes in cardiac chronotropic and inotropic responses to beta and musucarinic receptor agonists in SHR/NDmcr-cp rats,an animal model of metabolic svndrome (2007)
  • Author(s): Tada Y, Kagota S, Nejime N, Nakamura K, Kunitomo M, Shinozuka K.
  • Organizer: 第5回国際受容体・シグナリング・薬物作用シンポジウム
  • Place of Presentation: 静岡
• [Presentation] Coenzyme Q10 attenuates increases in oxidative stress,inflammation,insulinresistance,and blood pressure developing in metabolic syndrome model rats (2007)
  • Author(s): Kunitomo M, Yamaguchi Y, Kagota S, Otsubo K.
  • Organizer: 第5回国際コエンザイムQ10カンファレンス
  • Place of Presentation: 神戸
• [Presentation] Abnormalities of nitric oxide-mediated vasorelaxations in a rat model of metabolic syndrome : Involvement of peroxynitrite formation. (2006)
  • Author(s): Kagota S, et al.
  • Organizer: 2^<nd> International Symposium on Lifestyle Related Diseases
  • Place of Presentation: Nishinomiya
  • Year and Date: 2006-12-22
• [Presentation] Vascular endothelial dysfunction in metabolic syndrome. (2006)
  • Author(s): Kagota S, et al.
  • Organizer: 2^<nd> International Symposium on Lifestyle Related Diseases
  • Place of Presentation: Nishinomiya
  • Year and Date: 2006-10-22
• [Presentation] Changes in oxidative-nitrative stress in a new animal model of metabolic syndrome, SHR/SPZF rats. (2006)
  • Author(s): Yamaguchi Y, et al.
  • Organizer: 2^<nd> International Symposium on Lifestyle Related Diseases
  • Place of Presentation: Nishinomiya
  • Year and Date: 2006-10-22
• [Presentation] Peroxinitrite formation is involved in vascular endothelial dysfunction in a rat model of metabolic syndrome. (2006)
  • Author(s): Kagota S, et al.
  • Organizer: 21^<st> Scientific meeting of the international society of hypertension.
  • Place of Presentation: Fukuoka
  • Year and Date: 2006-10-19
• [Presentation] Mechanisms for abnormalities of nitric oxide-mediated vasorelaxations in SHR/NDmcr-cp (cp/cp) rats, an animal model of metabolic syndrome. (2006)
  • Author(s): Kagota S, et al.
  • Organizer: 15^<th> World Congress of Pharmacology
  • Place of Presentation: Beijing, China
  • Year and Date: 2006-07-02
• [Presentation] テルミサルタンはメタボリックシンドロームモデルラット腸間膜動脈の弛緩反応低下を改善する (2006)
  • Author(s): 籠田智美ら
  • Organizer: 第6回日本NO学会
  • Place of Presentation: 東京
  • Year and Date: 2006-05-25
• [Remarks] 武庫川女子大学薬学部HP:
  • URL: http://ph.mukogawa-u.ac.jp/