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Analyses of Ca^<2+> signaling mechanisms of vascular and nerve formation using Ca^<2+> transporter-deficient mice

Research Project

Project/Area Number 18590251
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General pharmacology
Research InstitutionFukuoka University

Principal Investigator

IWAMOTO Takahiro  Fukuoka University, Faculty of Medicine, Professor (20300973)

Co-Investigator(Kenkyū-buntansha) ARAI Yuji  National Cardiovascular Center Research Institute, Department of Bioscience, Laboratory Chief (30202724)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥4,080,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2006: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsNa^+ / Ca^<2+> exchanger / Ion transporter / Angiogenesis / NO synthase / Knockout mice
Research Abstract

The Na^+/Ca^2+ exchanger type-1 (NCX1) is considered to be involved in endothelial nitric oxide (NO) production. In this study, we examined the role of NCX1 in angiogenic response to acute hindlimb ischemia by using heterozygous NCX1 knockout (NCX1^<+/->) mice. Furthermore, since Lipo-PGE1 (prostaglandin El encapsulated into lipid microsphere) is well known as a useful drug for peripheral arterial disease, we examined the effect of Lipo-PGE1 in hindlimb ischemia-induced angiogenesis. We surgically induced unilateral hindlimb ischemia and monitored the blood flow recovery by Laser Doppler imaging for 4 weeks. Lipo-PGE1 treatment enhanced the blood flow recovery and capillary density in wild-type mice. Western blotting at 28 day showed that Lipo-PGE1 increased VEGF and phospho-Akt expression levels in the ischemic muscles. Interestingly, the blood flow recovery in NCX^<+/-> mice was significantly augmented compared with that in wild-type mice, although it was similarly enhanced by Lipo-PGE1 treatment. Moreover, to study possible involvement of endothelial NO synthase, we administered N^G-nitro-L-arginine methyl ester (L-NAME) to mice with hindlimb ischemia. L-NAME treatment eliminated the enhanced blood flow recovery observed in both NCX1^<+/-> mice and Lipo-PGE1-treated mice. These results suggest that NCX1, as well as Lipo-PGE1, is involved in endothelial NO synthase-dependent angiogenesis.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (134 results)

All 2008 2007 2006 Other

All Journal Article (62 results) (of which Peer Reviewed: 25 results) Presentation (70 results) Remarks (2 results)

  • [Journal Article] Involvement of Na^+-Ca^<2+> exchange in cAMP-mediated relaxation in mice aorta:Evaluation using transgenic mice2007

    • Author(s)
      Karashima, E.
    • Journal Title

      Br J Pharmacol 150

      Pages: 434-444

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Mechanism of Na^+/Ca^<2+> exchanger activation by hydrogen peroxide in guinea-pig ventricular myocytes2007

    • Author(s)
      Hinata, M.
    • Journal Title

      J Pharmacol Sci 103

      Pages: 283-292

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Inhibitory mechanism of SN-6,a novel benzyloxyphenyl Na^+/Ca^<2+> exchange inhibitor2007

    • Author(s)
      Kita, S.
    • Journal Title

      Ann N Y Acad Sci 1099

      Pages: 529-533

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The role of Na^+/Ca^<2+> exchanger in endothelin-1-aggravated hypoxia/reoxygenation-induced injury in renal epithelial cells2007

    • Author(s)
      Kita, S.
    • Journal Title

      Ann N Y Acad Sci 1099

      Pages: 473-477

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Involvement of Na^+/Ca^<2+> exchanger type-1 in ischemia-induced neovascularization in the mouse hindlimb2007

    • Author(s)
      Matsui, Y.
    • Journal Title

      Ann N Y Acad Sci 1099

      Pages: 478-480

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Electrophysiological Effects of SN-6,a Novel Na^+/Ca^<2+> Exchange Inhibitor on Membrane Currents in Guinea Pig Ventricular Myocytes2007

    • Author(s)
      Niu, C.F.
    • Journal Title

      Ann N Y Acad Sci 1099

      Pages: 534-539

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Three Na^+/Ca^<2+> Exchanger(NCX)variants are expressed in mouse osteoclasts and mediate calcium transport during bone resorption2007

    • Author(s)
      Li, J.-P.
    • Journal Title

      Endocrinology 148

      Pages: 2116-2125

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Knock-In Mouse Model of Dilated Cardiomyopathy Caused by Troponin Mutation2007

    • Author(s)
      Du, C.K.
    • Journal Title

      Circ.Res. 101

      Pages: 185-194

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Characterization of SN-6,a Novel Na^+/Ca^<2+> Inhibitor in Guinea Pig Cardiac Ventricular Myocytes2007

    • Author(s)
      Niu, C.F.
    • Journal Title

      Eur J Pharmacol 573

      Pages: 161-169

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Endoplasmic reticulum is a key organella in bradykinin-triggered ATP release from cultured smooth muscle cells2007

    • Author(s)
      Zhao, Y.
    • Journal Title

      J Pharmacol Sci 105

      Pages: 57-65

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Bradykinin-induced microglial migration mediated by B1-bradykinin receptors depends on Ca^<2+> influx via reverse-mode of Na^+/Ca^<2+> exchanger2007

    • Author(s)
      Ifuku, M.
    • Journal Title

      J Neurosci 27

      Pages: 13065-13073

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Na^+/Ca^<2+> exchange as a drug target-Insights from molecular pharmacology and genetic engineering2007

    • Author(s)
      Iwamoto, T.
    • Journal Title

      Ann N Y Acad Sci 1099

      Pages: 516-528

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Na^+/Ca^<2+> exchange inhibitors:A new class of calcium regulators2007

    • Author(s)
      Iwamoto, T.
    • Journal Title

      Current Drug Targets-Cardiovasc&Hemat Dis 7

      Pages: 188-198

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Na^+/Ca^<2+> exchanger2007

    • Author(s)
      岩本 隆宏
    • Journal Title

      腎と透析 63

      Pages: 474-477

    • NAID

      10018811553

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] 食塩感受性高血圧におけるNCX1の役割2007

    • Author(s)
      岩本 隆宏
    • Journal Title

      医学のあゆみ 223

      Pages: 1141-1145

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] 心血管病における1型Na^+/Ca^<2+>交換体(NCX1)の役割2007

    • Author(s)
      岩本 隆宏
    • Journal Title

      日薬理誌 129

      Pages: 262-265

    • NAID

      10019563302

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Involvement of Na^+/Ca^<2+> exchanger in cAMP-mediated relaxation in mice aorta: evaluation using transgenic mice.2007

    • Author(s)
      Karashima E
    • Journal Title

      Br. J. Pharmacol. 150(4)

      Pages: 434-444

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Mechanism of Na^+/Ca^<2+> exchanger activation by hydrogen peroxide in guinea-pig ventricular myocytes.2007

    • Author(s)
      Hinata M
    • Journal Title

      Pharmacol. Sci. 103(3)

      Pages: 283-292

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The Role of Na^+/Ca^<2+> Exchanger in Endothelin-1- Aggravated Hypoxia/Reoxygenation-Induced Injury in Renal Epithelial Cells.2007

    • Author(s)
      Kita S
    • Journal Title

      Ann. N. Y. Acad. Sci. 1099

      Pages: 473-477

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Inhibitory Mechanism of SN-6, a Novel Benzyloxyphenyl Na^+/Ca^<2+> Exchange Inhibitor.2007

    • Author(s)
      Kita S
    • Journal Title

      Ann. N.Y. Acad. Sci. 1099

      Pages: 529-533

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Involvement of Na^+/Ca^<2+> Exchanger Type-i in Isehemia-Induced Neovascularization in the Mouse Hindlimb.2007

    • Author(s)
      Matsui Y
    • Journal Title

      Ann. N. Y. Acad. Sci. 1099

      Pages: 478-480

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Electrophysiological Effects of SN-6, a Novel Na^+/Ca^<2+> Exchange Inhibitor on Membrane Currents in Guinea Pig Ventricular Myocytes.2007

    • Author(s)
      Niu CF
    • Journal Title

      Ann. N. Y. Acad. Sci. 1099

      Pages: 534-539

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Three Na^+/Ca^<2+> exchanger (NCX) variants are expressed in mouse osteoclasts and mediate calcium transport during bone resorption.2007

    • Author(s)
      Li JP
    • Journal Title

      Endocrinology 148(5)

      Pages: 2116-2125

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Knock-In Mouse Model of Dilated Cardiomyopathy Caused by Troponin Mutation.2007

    • Author(s)
      Du CK
    • Journal Title

      Circ, Res 101(2)

      Pages: 185-194

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Characterization of SN-6, a Novel Na^+/Ca^<2+> Inhibitor in Guinea Pig Cardiac Ventricular Myocytes.2007

    • Author(s)
      Niu CF
    • Journal Title

      Eur. J. Phamiacol. 573

      Pages: 161-169

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Endoplasmic reticulum is a key organella in bradykinin-triggered ATP release from cultured smooth muscle cells.2007

    • Author(s)
      Zhao Y
    • Journal Title

      J Pharmacol Sci. 105(1)

      Pages: 57-65

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Ifuku M, Bradykinin-induced microglial migration mediated by B1-bradykinin receptors depends on Ca^<2+>influx via reverse-mode of Na^+/Ca^<2+> exchanger.2007

    • Author(s)
      Ifuku M
    • Journal Title

      J. Neurosci. 27(48)

      Pages: 13065-13073

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Iwamoto T, Na^+/Ca^<2+> exchange as a drug target - Insights from molecular pharmacology and genetic engineering.2007

    • Author(s)
      Iwamoto T
    • Journal Title

      Ann. N. Y. Acad. Sci. 1099

      Pages: 516-528

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Na^+/Ca^<2+> exchanger(NCX1) and cardiovascular disease.2007

    • Author(s)
      Iwamoto T
    • Journal Title

      FoliaPharmacol. Jpn. 129

      Pages: 262-265

    • NAID

      10019563302

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Na^+/Ca^<2+> exchange inhibitors : a new class of calcium regulators.2007

    • Author(s)
      Iwamoto T
    • Journal Title

      Cardiovasc. Hematol. Disord. Drug Targets. 7

      Pages: 188-198

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Na^+/Ca^<2+> exchanger.2007

    • Author(s)
      Iwamoto T
    • Journal Title

      Kidney and Dialysis 63(4)

      Pages: 474-477

    • NAID

      10018811553

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The role of NCX1 in salt-sensitive hypertension.2007

    • Author(s)
      Iwamoto T
    • Journal Title

      J Clin Experimental Med 23(13)

      Pages: 1141-1145

    • NAID

      40015746233

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Involvement of Na^+-Ca^<2+>exchanger in cAMP-mediated relaxation in miceaorta:Evaluation using transgenic mice2007

    • Author(s)
      Karashima, E.
    • Journal Title

      Br J Pharmacol 150

      Pages: 434-444

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three Na^+/Ca^<2+> exchanger(NCX)variants are expressed in mouseosteoclasts and mediate calcium transport during bone resorption2007

    • Author(s)
      Li, J.-P
    • Journal Title

      Endocrinology 148

      Pages: 2116-2125

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of Na^+/Ca^<2+> exchanger type-1 in ischemia-inducedneovascularization in the mouse hindlimb2007

    • Author(s)
      Matsui, Y.
    • Journal Title

      Ann N Y Acad Sci 1099

      Pages: 478-480

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Na^+/Ca^<2+>exchange as a drug target-Insights from molecularpharmacology and genetic engineering2007

    • Author(s)
      Iwamoto, T.
    • Journal Title

      Ann N Y Acad Sci 1099

      Pages: 516-528

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory mechanism of SN-6,a novel benzyloxyphenyl Na^+/Ca^<2+>exchange inhibitor2007

    • Author(s)
      Kita, S.
    • Journal Title

      Ann N Y Acad Sci 1099

      Pages: 529-533

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Na^+/Ca^<2+>exchange inhibitors:A new class of calcium regulators2007

    • Author(s)
      Iwamoto, T.
    • Journal Title

      Current Drug Targets-Cardiovasc & Hemat Dis 7

      Pages: 188-198

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of Na^+-Ca^<2+> exchanger in cAMP-mediated relaxation in mice aorta : Evaluation using transgenic mice.2007

    • Author(s)
      Karashima, E.
    • Journal Title

      Br J Pharmacol 150・4

      Pages: 434-444

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Three Na^+/Ca^<2+> rcvhsnhrt (NCX) variants are expressed in mouse osteoclasts and mediate calcium transport during bone resorption.2007

    • Author(s)
      Li, J.-P.
    • Journal Title

      Endocrinology (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Involvement of Na^+/Ca^<2+> exchanger type-1 in ischemia-induced neovascularization in the mouse hindlimb.2007

    • Author(s)
      Matsui, Y.
    • Journal Title

      Ann N Y Acad Sci (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Na^+/Ca^<2+> exchange as a drug target - Insights from molecular pharmacology and genetic engineering.2007

    • Author(s)
      Iwamoto, T.
    • Journal Title

      Ann N Y Acad Sci (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Inhibitory mechanism of SN-6, a novel benzyloxyphenyl Na^+/Ca^<2+> exchange inhibitor.2007

    • Author(s)
      Kita, S.
    • Journal Title

      Ann N Y Acad Sci (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The role of Na^+/Ca^<2+> exchanger in endothelin-1-aggravated hypoxia/reoxygenation-induced injury in renal epithelial cells.2007

    • Author(s)
      Kita, S.
    • Journal Title

      Ann N Y Acad Sci (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Na^+/Ca^<2+> exchange inhibitors : A new class of calcium regulators.2007

    • Author(s)
      Iwamoto, T.
    • Journal Title

      current Drug Targets - Cardiovasc & Hemat Dis (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Na^+/Ca^<2+> exchanger (NCX1) and cardiovascular disease.2007

    • Author(s)
      Iwamoto, T.
    • Journal Title

      Folia Pharmacol Jpn (In press)

    • NAID

      10019563302

    • Related Report
      2006 Annual Research Report
  • [Journal Article] YM-244769,a novel Na^+/Ca^<2+> exchange inhibitor that preferentially inhibits NCX3,efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage2006

    • Author(s)
      Iwamoto, T.
    • Journal Title

      Mol Pharmacol 70

      Pages: 2075-2083

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 食塩感受性高血圧とNa^+/Ca^<2+>交換体:食塩負荷から血管トーヌス亢進への古くて新しい機序2006

    • Author(s)
      岩本 隆宏
    • Journal Title

      日薬理誌 127

      Pages: 387-392

    • NAID

      10018061856

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Hypertension,Na^+/Ca^<2+> exchanger,and Na^+,K^+-ATPase2006

    • Author(s)
      Iwamoto, T.
    • Journal Title

      Kidney Int 69

      Pages: 2148-2154

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Topics on the Na^+/Ca^<2+> exchanger:Role of vascular NCX1 in salt-dependent hypertension2006

    • Author(s)
      Iwamoto, T.
    • Journal Title

      J Pharmacol Sci 102

      Pages: 32-36

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Na^+/Ca^<2+>交換体2006

    • Author(s)
      喜多 紗斗美
    • Journal Title

      日薬理誌 127

      Pages: 387-392

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Iwamoto T, YM-244769, a novel Na^+/Ca^<2+> exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxialreoxygenation-induced SH-SY5Y neuronal cell damage.2006

    • Author(s)
      Iwamoto T
    • Journal Title

      Mol. Pharmacol. 76(6)

      Pages: 2075-2083

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Salt-sensitive hypertension and Na^+/Ca^<2+> exchange : old and new mechanisms for linking high salt intake to vascular tone.2006

    • Author(s)
      Takahiro I
    • Journal Title

      Folia Pharmacol. Jpn. 127(5)

      Pages: 387-392

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Iwamoto T, Hypertension, Na^+/Ca^<2+> exchanger, and Na^+, K^+ ATPase.2006

    • Author(s)
      Iwamoto T
    • Journal Title

      Kidney mt. 69(12)

      Pages: 2148-2154

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Iwamoto T Kita S. Topics in Na^+/Ca^<2+> exchanger: Role of vascular NCXI in salt-dependent hypertension.2006

    • Author(s)
      Iwamoto T
    • Journal Title

      J. Pharmacol. Sci. 102(1)

      Pages: 32-36

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Na^+/Ca^<2+> exchanger.2006

    • Author(s)
      Kita S
    • Journal Title

      Folia Pharmacol. Jpn. 128(4)

      Pages: 269-271

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] YM-244769, a novel Na^+/Ca^<2+> exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage.2006

    • Author(s)
      Iwamoto, T.
    • Journal Title

      Mol Pharmacol 70・6

      Pages: 2075-2083

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cardiac ischemia activates vascular endothelial cadherin promoter in both preexisting vascular cells and bone marrow cells involved in neovascularization.2006

    • Author(s)
      Kogata, S.
    • Journal Title

      Circ Res 98・7

      Pages: 897-904

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Vascular Na^+/Ca^<2+> exchanger : Implications for the pathogenesis and therapy of salt-dependent hypertension.2006

    • Author(s)
      Iwamoto, T.
    • Journal Title

      Am J Physiol 290・3

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Hypertension, Na^+/Ca^<2+> exchanger, and Na^+, K^+-ATPase.2006

    • Author(s)
      Iwamoto, T.
    • Journal Title

      Kidney Int 69・12

      Pages: 2148-2154

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Topics in Na^+/Ca^<2+> exchanger : Role of vascular NCX1 in salt-dependent hypertension.2006

    • Author(s)
      Iwamoto, T.
    • Journal Title

      J Pharmacol Sci 102・1

      Pages: 32-36

    • NAID

      10020346055

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Na^+/Ca^<2+> exchanger.2006

    • Author(s)
      Kita, S.
    • Journal Title

      Folia Pharmacol Jpn 128・4

      Pages: 269-271

    • Related Report
      2006 Annual Research Report
  • [Presentation] 血管平滑筋細胞においてLPAが誘導する繊因子発現の機序2008

    • Author(s)
      伊豫田 拓也
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] Na^+/Ca^?2+?交換輸送体(NCX)高発現膀胱における自発収縮亢進の構造解析2008

    • Author(s)
      村田 秀道
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] 心不全の発症・進展におけるNa^+/Ca^<2+>交換輸送体の役割2008

    • Author(s)
      喜多 紗斗美
    • Organizer
      第37回日本心脈管作動物質学会
    • Place of Presentation
      仙台
    • Year and Date
      2008-02-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] LPA刺激によって血管平滑筋細胞に誘導される,組織因子発現に関与するシグナル伝達機構2008

    • Author(s)
      伊豫田 拓也
    • Organizer
      第37回日本心脈管作動物質学会
    • Place of Presentation
      仙台
    • Year and Date
      2008-02-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The role of Na^+/Ca^<2+> exchanger in heart failuar2008

    • Author(s)
      Kita S
    • Organizer
      The 37th Japanese Society for Circulation Research
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2008-02-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mechanism of LPA-induced tissue factor expression in rat vascular smooth muscle cells.2008

    • Author(s)
      Iyoda T
    • Organizer
      The 37th Japanese Society for Circulation Research
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2008-02-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] LPA刺激によって血管平滑筋細胞に誘導される、組織因子発現に関与するシグナル伝達機構2008

    • Author(s)
      伊豫田 拓也
    • Organizer
      第37回日本心脈管作動物質学会
    • Place of Presentation
      仙台
    • Year and Date
      2008-02-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] Na/Ca交換体・カチオンチャネル共役系による血管トーヌス制御2008

    • Author(s)
      岩本 隆宏
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] ABCG4脂質膜輸送体のアルツハイマー病への作用2008

    • Author(s)
      上原 吉就
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 血管平滑筋特異的TRPC3/TRPC6遺伝子導入マウスの血管反応2008

    • Author(s)
      喜多 紗斗美
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 心筋特異的PIPKIα遺伝子導入マウスの心肥大反応2008

    • Author(s)
      喜多 紗斗美
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 血管平滑筋細胞においてLPAが誘導する組織因子発現の機序2008

    • Author(s)
      伊豫田 拓也
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 高食塩負荷はアンジオテンシンIIによるラット血管平滑筋細胞の増殖をERK1/2依存的に増加させる2008

    • Author(s)
      リュウコウ
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Na^+/Ca^<2+>交換輸送体(NCX)高発現膀胱における自発収縮亢進の機構解析2008

    • Author(s)
      村田 秀道
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 心臓のNCX電流に対する新規NCX抑制薬YM-244769の電気生理学的作用2008

    • Author(s)
      渡邊 泰秀
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Regulation of arterial tone by Na^+/Ca^<2+> exchanger/cation channel coupling.2008

    • Author(s)
      Iwamoto T
    • Organizer
      The 81st Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Yokohama, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Roles of ABCG4 cholesterol transporter in Alzheimer's disease.2008

    • Author(s)
      Uehara Y
    • Organizer
      The 81st Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Yokohama, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Vascular responses of smooth muscle-specific transgenic mice with TRPC3/TRPC6 genes.2008

    • Author(s)
      Kita S
    • Organizer
      The 81st Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Yokohama, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cardiac hypertrophic responses of heart-specific transgenic mice with PIPKIa genes.2008

    • Author(s)
      Kita S
    • Organizer
      The 81st Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Yokohama, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mechanism of LPA-induced tissue factor expression in rat vascular smooth muscle cells.2008

    • Author(s)
      Iyoda T
    • Organizer
      The 81st Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Yokohama, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] High sodium augments angiotensin II-induced proliferation of rat vascular smooth muscle cells through an ERK1/2-dependent pathway.2008

    • Author(s)
      Liu G
    • Organizer
      The 81st Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Yokohama, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mechanism underlying enhanced spontaneous contractions in urinary bladder smooth muscle of Na^+/Ca^<2+> exchanger(NCX) overexpressing mice.2008

    • Author(s)
      Murata H
    • Organizer
      The 81st Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Yokohama, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Electrophysiological effects of YM-244769, a novel NCX inhibitor on INcx in hearts.2008

    • Author(s)
      Watanabe Y
    • Organizer
      The 81st Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      yokohama, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] α1受容体刺激による血管収縮におけるNCX1/TRPC3共役系の役割2007

    • Author(s)
      喜多 紗斗美
    • Organizer
      第17回日本循環薬理学会
    • Place of Presentation
      大阪
    • Year and Date
      2007-11-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] The role of NCX1/TRPC3 coupling in vascular contraction induced by ai receptor stimulation2007

    • Author(s)
      Kita S
    • Organizer
      The 17th, Japanese Association of Cardiovascular Pharmacology
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2007-11-30
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 心筋特異的PIPsKα遺伝子改変マウスの心機能特性2007

    • Author(s)
      喜多紗 斗美
    • Organizer
      第60回日本薬理学会西南部会
    • Place of Presentation
      宮崎
    • Year and Date
      2007-11-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] アルツハイマー病におけるABCG4脂質膜輸送体の役割2007

    • Author(s)
      上原 吉就
    • Organizer
      第60回日本薬理学会西南部会
    • Place of Presentation
      宮崎
    • Year and Date
      2007-11-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] CARDIAC-SPECIFIC OVEREXPRESSION OF NCX1.1 MUTANT INDUCES DILATED CARDIOMYOPATHY IN MICE2007

    • Author(s)
      Kita S
    • Organizer
      第30回心筋代謝研究会
    • Place of Presentation
      京都
    • Year and Date
      2007-07-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] 血管平滑筋におけるNa^+/Ca^<2+>交換輸送体の収縮調節機構への寄与2007

    • Author(s)
      村田 秀道
    • Organizer
      第80回日本薬理学会年会
    • Place of Presentation
      名古屋市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Na^+/Ca^<2+>交換輸送体(NCX)過剰発現膀胱平滑筋における細胞内Ca^<2+>動態の変化2007

    • Author(s)
      堀田 真吾
    • Organizer
      第80回日本薬理学会年会
    • Place of Presentation
      名古屋市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] NCX2ヘテロノックアウトマウスにおける腎機能異常および腎虚血再灌流障害の悪化2007

    • Author(s)
      古田 綾子
    • Organizer
      第80回日本薬理学会年会
    • Place of Presentation
      名古屋市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 新規選択的NCX3阻害薬YM-244769は低酸素・再酸素化による神経細胞障害を保護する2007

    • Author(s)
      喜多 紗斗美
    • Organizer
      第80回日本薬理学会年会
    • Place of Presentation
      名古屋市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 拡張型心筋症を発症する変異型NCX1.1高発現マウス心臓のDNAマイクロアレイ解析2007

    • Author(s)
      岩本 隆宏
    • Organizer
      第80回日本薬理学会年会
    • Place of Presentation
      名古屋市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] α1受容体刺激による血管収縮におけるNCX1膜輸送分子複合体の役割2007

    • Author(s)
      喜多 紗斗美
    • Organizer
      第49回日本平滑筋学会総会
    • Place of Presentation
      奈良
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] CARDIAC-SPECIFIC OVEREXPRESSION OF NCX1.1 MUTANT INDUCES DILATED CARD IOMYOPATHY IN MICE2007

    • Author(s)
      Kita S.
    • Organizer
      第30回心筋代謝研究会
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ATP-binding cassette transporter G4(ABCG4)is highly expressed in Alzheimer brain.アルツハイマー病におけるABCG4脂質膜輸送体の役割2007

    • Author(s)
      Uehara Y.
    • Organizer
      第25回国際老年精神医学会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Changes in Ca^<2+> mobilization in urinary bladder smooth muscle overexpressing Na^+/Ca^<2+> exchanger(NCX).2007

    • Author(s)
      Hotta S
    • Organizer
      The 80th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Nagoya, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Subtle renal dysfunction and augmentation of renal ischemia/reperfusion injury in heterozygous NCX2-deficient mice.2007

    • Author(s)
      Furuta A
    • Organizer
      The 80th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Nagoya, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] YM-244769, a novel NCX3-selective inhibitor, efficiently protects against neuronal hypoxia/reoxygenation injury.2007

    • Author(s)
      Kita S
    • Organizer
      The 80th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Nagoya, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Microarray analysis of cardiac gene expression in NCX1. 1 mutant-transgenic mice with dilated cardiomyopathy.2007

    • Author(s)
      Iwamoto T
    • Organizer
      The 80th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Nagoya, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The role of NCX1 tranportsome in vascular contraction induced by al receptor stimulation2007

    • Author(s)
      Kita S
    • Organizer
      The 49th Nihon Heikafsukin Gakkai
    • Place of Presentation
      Nara, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] CARDIAC-SPECIFIC OVEREXPRESSION OF NCX1 .1 MUTANT INDUCES DILATED CARDIOMYOPATHY IN MICE.2007

    • Author(s)
      Kita S
    • Organizer
      The 30th Annual Meeting of the Japanese Working Group Cardiac Structure and Metabolism
    • Place of Presentation
      Kyoto, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ATP-binding cassette transporter G4(ABCG4) is highly expressed in Alzheimer brain.2007

    • Author(s)
      Uehara Y
    • Organizer
      The 25th International Psychogeriatric Congress
    • Place of Presentation
      Osaka, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Na^+/Ca^<2+> Exchange Inhibitors:Therapeutic Potential in Cardiovascular Diseases2006

    • Author(s)
      Iwamoto T.
    • Organizer
      The 15th World Congress of Pharmacology
    • Place of Presentation
      Beijing,China
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The Role of Vascular Na^+/Ca^<2+> Exchanger(NCX1)in Salt-Dependent Hypertension2006

    • Author(s)
      Kita S.
    • Organizer
      The 15th World Congress of Pharmacology
    • Place of Presentation
      Beijing,China
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effect of SN-6,a novel benzyloxyphenyl derivative NCX inhibitor in cardiac ventricular myocytes2006

    • Author(s)
      Niu CF.
    • Organizer
      The 15th World Congress of Pharmacology
    • Place of Presentation
      Beijing,China
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Na^+/Ca^<2+> exchange as a drug target-Insights from molecular pharmacology and genetic engineering2006

    • Author(s)
      Iwamoto T.
    • Organizer
      5th International Conference on Na/Ca exchange
    • Place of Presentation
      Brussels,Belgium
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Involvement of prostaglandin E1 and Na/Ca exchanger in ischemia-induced neovascularization of mice hindlimb2006

    • Author(s)
      Matsui Y.
    • Organizer
      5th International Conference on Na/Ca exchange
    • Place of Presentation
      Brussels,Belgium
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The role of Na^+/Ca^<2+> exchanger in endothelin-1-aggravated hypoxia/reoxygenation-induced injury in renal epithelial cells2006

    • Author(s)
      Kita S.
    • Organizer
      5th International Conference on Na/Ca exchange
    • Place of Presentation
      Brussels,Belgium
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Inhibitory mechanism of SN-6,a novel benzyloxyphenyl Na^+/Ca^<2+> exchanger inhibitor2006

    • Author(s)
      Kita S.
    • Organizer
      5th International Conference on Na/Ca exchange
    • Place of Presentation
      Brussels,Belgium
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Characterzation of SN-6,a novel benzyloxyphenyl derivative NCX inhibitor in guinea pig single cardiac ventricular cells2006

    • Author(s)
      Watanabe Y.
    • Organizer
      5th International Conference on Na/Ca exchange
    • Place of Presentation
      Brussels,Belgium
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Expression of three Na^+/Ca^<2+> exchanger(NCX)variants in mouse osteoclasts and their functional role during bone resorption2006

    • Author(s)
      Okabe K.
    • Organizer
      American Society for Bone and Mineral Research 28th Annual Meeting
    • Place of Presentation
      Pennsylvania Convention Center,Philadelphia,PA,USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Involvement of Na^+/Ca^<2+> exchanger in retinal cell death2006

    • Author(s)
      Inokuchi Y.
    • Organizer
      Neuroscience 2006 meeting
    • Place of Presentation
      Atlanta,USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] How Renal Salt Retention Causes Hypertension2006

    • Author(s)
      Zhang J.
    • Organizer
      The International Society of Hypertension(ISH)satellite meeting on the"Kidney&Hypertension"
    • Place of Presentation
      Sendai,Japan
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] CARDIAC-SPECIFIC OVEREXPRESSION OF NCX1.1 MUTANT INDUCES DILATED CARDIOMYOPATHY IN MICE2006

    • Author(s)
      Kita S.
    • Organizer
      The 23rd Annual Meeting of ISHR Japanese Section
    • Place of Presentation
      千葉市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effects of SN-6,a Novel NCX Inhibitor on Membrane Currents in Guinea Pig Cardiac Ventricular Myocytes2006

    • Author(s)
      Watanabe Y.
    • Organizer
      The 23rd Annual Meeting of ISHR Japanese Section
    • Place of Presentation
      千葉市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Na^+/Ca^<2+> Exchange Inhibitors : Therapeutic Potential in Cardiovascular Diseases. The 15th World Congress of Pharmacology.2006

    • Author(s)
      Iwamoto T
    • Organizer
      The 15th World Congress of Pharmacology
    • Place of Presentation
      Beijing, China
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The Role of Vascular Na^+/Ca^<2+> Exchanger(NCX1) in Salt-Dependent Hypertension.2006

    • Author(s)
      Kita S
    • Organizer
      The 15th World Congress of Pharmacology
    • Place of Presentation
      Beijing, China
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effect of SN-6, a novel benzyloxyphenyl derivative NCX inhibitor in cardiac ventricular myocytes.2006

    • Author(s)
      Niu CF
    • Organizer
      The 15th World Congress of Pharmacology
    • Place of Presentation
      Beijing, China
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Na^+/Ca^<2+> exchange as a drug target-Insights from molecular pharmacology and genetic engineering.2006

    • Author(s)
      Iwamoto T
    • Organizer
      5th International Conference on Na/Ca exchange
    • Place of Presentation
      Brussels, Belgium
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Involvement of prostaglandin El and Na/Ca exchanger in ischemia-induced neovascularization of mice hindlimb.2006

    • Author(s)
      Matsui Y
    • Organizer
      5th International Conference on Na/Ca exchange
    • Place of Presentation
      Brussels, Belgium
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The role of Na^+/Ca^<2+> exchanger in endothelin-1-aggravated hypoxia/reoxygenation-induced injury in renal epithelial cells.2006

    • Author(s)
      Kita S
    • Organizer
      5th International Conference on Na/Ca exchange
    • Place of Presentation
      Brussels, Belgium
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Inhibitory mechanism of SN-6, a novel benzyloxyphenyl Na^+/Ca^<2+> exchanger inhibitor.2006

    • Author(s)
      Kita S
    • Organizer
      5th International Conference on Na/Ca exchange
    • Place of Presentation
      Brussels, Belgium
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Characterzation of SN-6, a novel benzyloxyphenyl derivative NCX inhibitor in guinea pig single cardiac ventricular cells.2006

    • Author(s)
      Watanabe Y
    • Organizer
      5th International Conference on Na/Ca exchange
    • Place of Presentation
      Brussels, Belgium
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Expression of three Na^+/Ca^<2+> exchanger(NCX) variants in mouse osteoclasts and their functional role during bone resorption.2006

    • Author(s)
      Okabe K
    • Organizer
      American Society for Bone and Mineral Research 28th Annual Meeting, Pennsylvania Convention Center
    • Place of Presentation
      Philadelphia, PA, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Involvement of Na^+e/Ca^<2+>exchanger in retinal cell death.2006

    • Author(s)
      Inokuchi Y
    • Organizer
      Neuroscience 2006 meeting
    • Place of Presentation
      Atlanta USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] How Renal Salt Retention Causes Hypertension.2006

    • Author(s)
      Zhang J
    • Organizer
      The International Society of Hypertension(ISH) satellite meeting on the Kidney & Hypertension
    • Place of Presentation
      Sendai, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Functional roles of Na^+/Ca^<2+> exchanger on the regulation of Ca^<2+> activated K^+ channels in vascular smooth muscle.2006

    • Author(s)
      Murata H
    • Organizer
      The 80th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Nagoya, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] CARDIAC-SPECIFIC OVEREXPRESSION OF NCX1. 1 MUTANT INDUCES DILATED CARDIOMYOPATHY IN MICE.

    • Author(s)
      Kita S
    • Organizer
      The 23rd Annual Meeting of ISHR Japanese Section
    • Place of Presentation
      Chiba, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effects of SN-6, a Novel NCX Inhibitor on Membrane Currents in Guinea Pig Cardiac Ventricular Myocytes.

    • Author(s)
      Watanabe Y
    • Organizer
      The 23rd Annual Meeting of ISHR Japanese Section
    • Place of Presentation
      Chiba, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.med.fukuoka-u.ac.jp/pharmaco/index.html

    • Related Report
      2007 Final Research Report Summary
  • [Remarks]

    • URL

      http://www.med.fukuoka-u.ac.jp/pharmaco/index.html#

    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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