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Molecular mechanisms of associations between abnormal differentiation and altered regulations of gene expressions.

Research Project

Project/Area Number 18590308
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathological medical chemistry
Research InstitutionAichi Cancer Center Research Institute

Principal Investigator

OSADA Hirotaka  Aichi Cancer Center Research Institute, Division of Molecular Oncology, Section Head (30204176)

Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,820,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2006: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordslung cancer / neuroendocrine / epigenetic / miRNA / histone modification / chromatin / 肺癌 / microRNA
Research Abstract

The proneural basic-helix-loop-helix protein achaete-scute homologue 1(ASH1) is expressed in a very limited spectrum in a lineage-specific manner, including normal pulmonary neuroendocrine cells and lung cancer cells with neuroendocrine features. Our previous results indicated that ASH1 may play a crucial role in the growth and survival of lung cancers with neuroendocrine features. In the present study, we report for the first time that ASH1 functions as a dual transcription factor by activating neuroendocrine differentiation markers and also repressing putative tumor suppressors. This protein was found to inactivate DKK1 and DKK3, negative regulators of Wnt/β-catenin signaling, E-cadherin, and integrinβ1 through ASH 1-mediated deacetylation and repressive trimethylation of lysine 27(H3K27me3) of histone H3 in the promoter regions of DKK1 and E-cadherin. Our results provide important clues for a better understanding of the molecular and cellular biological roles of ASH1 in the process … More of carcinogenesis of lung cancers with neuroendocrine features and warrant future investigations to shed light on the lineage-specific dependency of this transcription factor with dual functions.
We previously reported the amplification and overexpression of the miR-17-92 microRNAs(miRNA) cluster at 13q31.3 in lung cancers. In the present study, we show that inhibition of miR-17-5p and miR-20a with antisense oligonucleotides can induce apoptosis selectively in lung cancer cells overexpressing miR-17-92, suggesting the possibility of 'OncomiR addiction' to expression of these miRNAs in a subset of lung cancers. During the course of this study, we also found that enforced expression of a genomic region, termed C2, residing 3' to miR-17-92 in the intron 3 of C13orf25 led to marked growth inhibition in association with double stranded RNA-dependent protein kinase activation. Taken together, the present findings contribute towards better understanding of the oncogenic roles of miR-17-92, which might ultimately lead to the future translation into clinical applications. Less

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (63 results)

All 2008 2007 2006 Other

All Journal Article (41 results) (of which Peer Reviewed: 17 results) Presentation (18 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Roles of achaete-scute homologue 1 in DKK1 and E-cadherin repression and neuroendocrine differentiation in lung cancer2008

    • Author(s)
      Osada H, et. al.
    • Journal Title

      Cancer Research 68

      Pages: 1647-55

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Roles of achaete-scute homologue 1 in DKK1 and E-cadherin repression and neuroendocrine differentiation in lune cancer.2008

    • Author(s)
      Osada H, Tomida S, Yatabe Y, Tatematsu Y, Takeuchi T, Murakami H, Kondo Y, Sekido Y, Takahashi T.
    • Journal Title

      Cancer Res 68

      Pages: 1647-55

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] MicroRNAs in Biological and Carcinogenic Processes.2007

    • Author(s)
      Osada H, et. al.
    • Journal Title

      Carcinogenesis 28

      Pages: 2-12

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] CLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells.2007

    • Author(s)
      Nagai H, et. al.
    • Journal Title

      Oncogene 26

      Pages: 4025-31

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach.2007

    • Author(s)
      Tomida S, et. al.
    • Journal Title

      Oncogene 26

      Pages: 4600-8

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92.2007

    • Author(s)
      Matsubara H, et. al.
    • Journal Title

      Oncogene 26

      Pages: 6099-6105

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] RhoB is frequently downregulated in non-small-cell lung cancer and resides in the 2p24 homozygous deletion region of a lung cancer cell line.2007

    • Author(s)
      Sato N, et. al.
    • Journal Title

      Int.J.Cancer 120

      Pages: 543-551

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Human DREF regulates cell proliferation and ribosomal protein genes.2007

    • Author(s)
      Yamashita D, et. al.
    • Journal Title

      Mol.Cell.Biol 27

      Pages: 2003-13

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Novel NBS1 heterozygous germ line mutation causing MRE11-binding domain loss predisposes to common types of cancer.2007

    • Author(s)
      Ebi H, et. al.
    • Journal Title

      Cancer Research 67

      Pages: 11158-65

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas.2007

    • Author(s)
      Kondo Y, et. al.
    • Journal Title

      Hepatol Research 37

      Pages: 974-983

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1.2007

    • Author(s)
      Tanaka H, et. al.
    • Journal Title

      Cancer Research 67

      Pages: 6007-6011

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] MicroRNAs in Biological and Carcinogenic Processes.2007

    • Author(s)
      Osada H and Takahashi T.
    • Journal Title

      Carcinogenesis 28

      Pages: 2-12

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] CLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells.2007

    • Author(s)
      Nagai H, Sugito N, Matsubara H, Tatematsu Y, Hida T, Sekido Y, Nagino M, Nimura Y, Takahashi T, and Osada H.
    • Journal Title

      Oncogene 26

      Pages: 4025-4031

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcnptome approach.2007

    • Author(s)
      Tomida S, Yanagisawa K, Koshikawa K, Yatabe Y, Mitsudomi T, Osada H, and Takahashi T.
    • Journal Title

      Oncogene 26

      Pages: 4600-4608

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92.2007

    • Author(s)
      Matsubara H, Takeuchi T, Nishikawa E, Yanagisawa K, Hayashita Y, Ebi H, Yamada H, Suzuki M, Nagino M, Nimura Y, Osada H and Takahashi T
    • Journal Title

      Oncogene 26

      Pages: 6099-6105

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] RhoB is frequently downregulated in non-small-cell lung cancer and resides in the 2p24 homozygous deletion region of a lung cancer cell line.2007

    • Author(s)
      Sato N, Fukui T, Taniguchi T, Yokoyama T,Kondo M, Nagasaka T, Goto Y, Gao W, Ueda Y, Yokoi K, Minna JD, Osada H, Kondo Y, and Sekido Y
    • Journal Title

      Int J Cancer. 120

      Pages: 543-51

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Human DREF regulates cell proliferation and ribosomal protein genes.2007

    • Author(s)
      Yamashita D, Sano Y, Adachi Y, Okamoto Y, Takahashi T, Osada H, Yamaguchi T, Osumi T and Hirose F
    • Journal Title

      Mol. Cell. Biol 27

      Pages: 2003-13

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Novel NBS1 heterozygous germ line mutation causing MRE11-binding domain loss predisposes to common types of c.ancer2007

    • Author(s)
      Ebi, H., Matsuo, K., Sugito, N., Suzuki, M., Osada. H., Tajima, K., Ueda, R. and Takahashi, Ta.
    • Journal Title

      Cancer Res 67

      Pages: 11158-11165

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas.2007

    • Author(s)
      Kondo, Y., Shen, L., Suzuki, S., Kurokawa, T., Masuko, K., Tanaka, Y., Kato, H., Mizuno, Y., Yokoe, M., Sugauchi, F., Hirashima, N., Orito, E., Osada, H., Ueda, R., Guo, Y., Chen, X., Issa, JP. and Sekido, Y.
    • Journal Title

      Hepatol Res 37

      Pages: 974-983

    • NAID

      10019773990

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1.2007

    • Author(s)
      Tanaka, H., Yanagisawa, K., Shinjo, K., Taguchi, A., Maeno, K., Tomida, S., Shmiada, Y., Osada, H., Kosaka, T., Matsubara, H., Mitsudomi, T., Sekido, Y., Tammoto, M., Yatabe, Y and Takahashi Ta.
    • Journal Title

      Cancer Res 67

      Pages: 6007-6011

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] CLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells2007

    • Author(s)
      Nagai H, et. al.
    • Journal Title

      Oncogene 26

      Pages: 4025-31

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human DREF regulates cell proliferation and ribosomal protein genes.2007

    • Author(s)
      Yamashita D, et. al.
    • Journal Title

      Mol. Cell. Biol 27

      Pages: 2003-13

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RhoB is frequently downregulated in non-small-cell lung cancer and resides in the 2p24 homozygous deletion region of a lung cancer cell line.2007

    • Author(s)
      Sato N, et. al.
    • Journal Title

      Int. J. Cancer 120

      Pages: 543-51

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92.2007

    • Author(s)
      Matsubara H. et al.
    • Journal Title

      Oncogene (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach.2007

    • Author(s)
      Tomida S. et al.
    • Journal Title

      Oncogene (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] CLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells.2007

    • Author(s)
      Nagai H. et al.
    • Journal Title

      Oncogene (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] hDREF regulates cell proliferation and expression of ribosomal protein genes.2007

    • Author(s)
      Yamashita D. et al.
    • Journal Title

      Molecular and Cellular Biology 27・6

      Pages: 2003-13

    • Related Report
      2006 Annual Research Report
  • [Journal Article] RhoB is frequently downregulated in non-small-cell lung cancer and resides in the 2p24 homozygous deletion region of a lung cancer cell line.2007

    • Author(s)
      Sato N.et al.
    • Journal Title

      International Journal of Cancer 120・3

      Pages: 543-51

    • Related Report
      2006 Annual Research Report
  • [Journal Article] MicroRNAs in biological processes and carcinogenesis.2007

    • Author(s)
      Osada H., Takahashi T.
    • Journal Title

      Carcinogenesis 28・1

      Pages: 2-12

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors.2006

    • Author(s)
      Takeuchi T, et. al.
    • Journal Title

      J Clin Oncol 24

      Pages: 1679-1688

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Altered regulation of c-jun and its involvement in anchorage-independent growth of human lung cancers.2006

    • Author(s)
      Maeno K, et. al.
    • Journal Title

      Oncogene 25

      Pages: 271-277

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] EGFR point mutation in non-small cell lung cancer is occasionally accompanied with second mutation or amplification.2006

    • Author(s)
      Yokoyama T, et. al.
    • Journal Title

      Cancer Science 97

      Pages: 753-759

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes.2006

    • Author(s)
      Chen G-Y, et. al.
    • Journal Title

      Proc Natl Acad Sci USA. 103

      Pages: 16894-9

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors.2006

    • Author(s)
      Takeuchi T, Tomida S, Yatabe Y, Kosaka T, Osada H, Yanagisawa K, Mitsudomi T and Takahashi T.
    • Journal Title

      J Clin Oncol 24

      Pages: 1679-1688

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Altered regulation of c-jun and its involvement in anchorage-independent growth of human lung cancers.2006

    • Author(s)
      Maeno K, Masuda A, Yanagisawa K, Konishi H, Osada H, Saito T, Ueda R, and Takahashi T.
    • Journal Title

      Oncogene 25

      Pages: 271-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] EGFR point mutation in non-small cell lung cancer is occasionally accompanied with second mutation or amplification.2006

    • Author(s)
      Yokoyama T, Kondo M, Goto Y, Fukui T, Yoshioka H, Yokoi K, Osada H, Imaizumi K, Hasegawa Y, Shimokata K, and Sekido Y.
    • Journal Title

      Cancer Sci 97

      Pages: 753-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes2006

    • Author(s)
      Chen G-Y, Osada H, Santamaria-Babi L-F, and Kannagi R.
    • Journal Title

      Proc Natl Acad Sci U S A. 103

      Pages: 16894-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes2006

    • Author(s)
      Chen G-Y et al.
    • Journal Title

      Proc Natl Acad Sci U S A. 103(45)

      Pages: 16894-9

    • Related Report
      2006 Annual Research Report
  • [Journal Article] EGFR point mutation in non-small cell lung cancer is occasionally accompanied by a second mutation or amplification.2006

    • Author(s)
      Yokoyama T. et al.
    • Journal Title

      Cancer Science 97・8

      Pages: 753-9

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors.2006

    • Author(s)
      Takeuchi T. et al.
    • Journal Title

      Journal of Clinical Oncology 24・11

      Pages: 1679-88

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Altered regulation of c-jun and its involvement in anchorage-independent growth of human lung cancers.2006

    • Author(s)
      Maeno K. et al.
    • Journal Title

      Oncogene 25・2

      Pages: 271-7

    • Related Report
      2006 Annual Research Report
  • [Presentation] 神経内分泌分化誘導因子ASH1によるWntシグナル抑制因子DKK1の発現抑制2007

    • Author(s)
      長田啓隆, 他
    • Organizer
      第30回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Roles of achaete-scute homologue 1in DKK1 and E-cadherin repression and neuroendocrine differentiation in lung cancer.2007

    • Author(s)
      Osada H, et. al.
    • Organizer
      30th Annual Meeting of the Molecular Biology Society of Japan.
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-12-13
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] シンポジウム肺癌の分子生物学と治療の進歩:神経内分泌分化肺癌におけるASH1遺伝子の機能2007

    • Author(s)
      長田啓隆
    • Organizer
      第66回 日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Lung Cancer Symposium Roles of achaete-scute homologue 1 in DKK1 and E-cadherin repression and neuroendocrine differentiation in lung cancer.2007

    • Author(s)
      Osada H.
    • Organizer
      66th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-10-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ASH1 Gene may be a Prototypic "Lineage-Survival Oncogene" and a Specific Therapeutic Target for Lung Cancers with Neuroendocrine Features2007

    • Author(s)
      Osada H, et. al.
    • Organizer
      Japanese Society of Gene Therapy The 13th Annual Meeting
    • Place of Presentation
      名古屋
    • Year and Date
      2007-06-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ASH1 gene may be prototypic "lineage-survival oncogene" and specific therapeutic target for lung cancers with neuroendocrine features.2007

    • Author(s)
      Osada H, et. al.
    • Organizer
      Japanese Society of Gene Therapy The 13th Annual Meeting
    • Place of Presentation
      Nagoya
    • Year and Date
      2007-06-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ASH1 gene may be prototypic "lineage-survival oncogene" and specific therapeutic target for lung cancers with neuroendocrine features.2007

    • Author(s)
      Osada H, et. al.
    • Organizer
      第13回日本遺伝子治療学会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-06-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] CLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells.2007

    • Author(s)
      Osada H, et. al.
    • Organizer
      AACR annual meeting
    • Place of Presentation
      米国 ロサンジェルス
    • Year and Date
      2007-04-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] CLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells.2007

    • Author(s)
      Osada H, et. al.
    • Organizer
      AACR annual meeting
    • Place of Presentation
      Los Angels, USA
    • Year and Date
      2007-04-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] CLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells.2007

    • Author(s)
      Osada H, et. al.
    • Organizer
      AACR annual meeting
    • Place of Presentation
      米国
    • Year and Date
      2007-04-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] The ASH1 Gene may be a Prototypic "Lineage-Survival Oncogene" and a Specific Therapeutic Target for Lung Cancers with Neuroendocrine Features.2007

    • Author(s)
      Osada H
    • Organizer
      First JCA-AACR Special Joint Conference: The Latest Advances in Lung Cancer Research
    • Place of Presentation
      名古屋
    • Year and Date
      2007-03-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The ASH1 Gene may be a Prototypic "Lineage-Survival Oncogene" and a Specific the Rapeutic Target for Lung Cancers with Neuroendocrine Features.2007

    • Author(s)
      Osada H.
    • Organizer
      First JCA-AACR Special Joint Conference : The Latest Advances in Lung Cancer Research : From Basic Science to Therapeutics.
    • Place of Presentation
      Nagoya
    • Year and Date
      2007-03-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Role of ASH1 gene in the development of neuroendocrine lung cancer.2007

    • Author(s)
      Osada H, et. al.
    • Organizer
      4th 21st Century COE International Symposium.
    • Place of Presentation
      名古屋
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Role of ASH 1 gene in the development of neuroendocrine lung cancer.2007

    • Author(s)
      Osada H.
    • Organizer
      4th 21st Century COE International Symposium.
    • Place of Presentation
      Nagoya
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 神経内分泌分化誘導因子ASH1によるWntシグナル抑制因子DKK1の発現抑制2006

    • Author(s)
      長田啓隆, 他
    • Organizer
      第65回 日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2006-09-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ASH1 induces neuroendocrine differentiation and represses DKK1, an inhibitor of Wnt signaling.2006

    • Author(s)
      Osada H, Tatematsu Y, Takeuchi T, Tomida S, Yatabe Y, Mitsudomi T, Sekido Y, Takahashi T.
    • Organizer
      65th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-09-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A polycistronic miRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation.2006

    • Author(s)
      Hayashita Y, et. al.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      京都
    • Year and Date
      2006-06-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A polycistronic miRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation.2006

    • Author(s)
      Hayashita Y, Osada H, Tatematsu Y, Yamada H, Yanagisawa K, Tomida S, Yatabe Y, Kawahara K,Sekido Y, and Takahashi T.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-06-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.pref.aichi.jp/cancer-center/400/420/421/421-03.html

    • Related Report
      2007 Final Research Report Summary
  • [Remarks] 愛知県がんセンター研究所 分子腫瘍学部 Webページ

    • URL

      http://www.pref.aichi.jp/cancer-center/400/420/421/421-03.html

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 癌の新規治療用組成物2006

    • Inventor(s)
      高橋隆・柳澤聖・長田啓隆
    • Industrial Property Rights Holder
      名古屋大学・愛知県
    • Filing Date
      2006-04-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Overseas
  • [Patent(Industrial Property Rights)] 癌の新規治療用組成物2006

    • Inventor(s)
      高橋 隆, 柳澤 聖, 長田 啓隆
    • Industrial Property Rights Holder
      名古屋大学, 愛知県
    • Filing Date
      2006-04-27
    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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