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Basic research for quantification of mitochondrial DNA copy number and mutations associated with aging

Research Project

Project/Area Number 18590317
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human genetics
Research InstitutionTokyo Metropolitan Institute of Gerontology

Principal Investigator

NISHIGAKI Yutaka  Tokyo Metropolitan Institute of Gerontology, 東京都老人総合研究所, 研究副部長 (80296988)

Co-Investigator(Kenkyū-buntansha) TANAKA Masashi  財団法人東京都高齢者研究・福祉振興財団, 東京都老人総合研究所, 研究部長 (60155166)
FUKU Noriyuki  財団法人東京都高齢者研究・福祉振興財団, 東京都老人総合研究所, 主任研究員 (40392526)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,860,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywordsゲノム / ミトコンドリア / 加齢 / ゲノム定量
Research Abstract

1.【ミトコンドリアゲノム多型および変異の網羅的解析】ヒトのミトコンドリアゲノム(ミトコンドリアDNA, 以下mtDNA)の加齢に伴う影響を検討した。mtDNAは、核DNAに比較して多様性が高く、多くの遺伝子多型が存在し、また、糖尿病や難聴などの症状を呈するミトコンドリア病の原因遺伝子変異が、数多く報告されている。mtDNAの加齢に伴う影響を検討する際には、これらの遺伝子多型および病因遺伝子変異を的確に同定する必要がある。遺伝子多型を明らかにするためには、数千人を対象とした大規模関連解析を行うことが必要であり、mtDNA多型を網羅的かつ迅速に分析するシステムの開発が必須であった。また、mtDNA病因変異は、ミトコンドリア病のみならず、糖尿病などの生活習慣病の原因になり、さらにその変異率の量的変化は、加齢による影響を直接的・間接的に受ける。したがって、蛍光ビーズを利用して主要な42種類のmtDNA病因変異を迅速に分析する解析システムを開発した。
2.【健康長寿に関連するmtDNA遺伝的背景の解明】 東京都老人総合研究所・自立促進と介護予防研究チーム「お達者健診」における、約500人の健常高齢男女、また、社会参加とヘルスプロモーション研究チームの65歳以上の住民を対象とした介護予防健診「草津町にっこり健診」650人から、それぞれ適正なインフォームド・コンセントの手続きを経て収集した血液試料ならびに関連情報を解析し、糖尿病・メタボリック症候群・脳梗塞・心筋梗塞・慢性腎臓病などの生活習慣病と、それらに関連するmtDNAおよび核DNA多型を分析した。(一部解析終了)
3.【mtDNAの加齢の影響の検討】 加齢に伴うmtDNAの量的変化の迅速解析法を開発することを目的とした。一方、mtDNA多型や病因変異は一般的に母系遺伝し、遺伝的体質や寿命との関係が明らかになっている。したがって双方を解析する事で、個人の遺伝的体質のみならず加齢に伴うmtDNAを網羅的に評価する事が可能である。収集した唾液から抽出したmtDNAにおける加齢の影響は明らかではなかったが、骨格筋などでは研究代表者らが開発したmtDNA定量法は、mtDNAの核DNAとの相対比率を評価することにより、mtDNAの増減を明らかにできる。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (84 results)

All 2009 2008 2007 2006 Other

All Journal Article (40 results) (of which Peer Reviewed: 21 results) Presentation (43 results) Book (1 results)

  • [Journal Article] Association of a polymorphism of apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome.2009

    • Author(s)
      Yoshida T, Kato K, Fujimaki T, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nishigaki Y, Tanaka M, Nozawa Y, Yamada Y.
    • Journal Title

      Genomics 93

      Pages: 221-226

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of genetic variants with chronic kidney disease in Japanese individuals with type 2 diabetes mellitus.2009

    • Author(s)
      Yoshida T, Kato K, Yokoi K, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nishigaki Y, Suzuki T, Nozawa Y, Yamada Y.
    • Journal Title

      Int J Mol Med 23

      Pages: 529-537

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of gene polymorphisms with chronic kidney disease in high-risk or low-risk subjects defined by conventional risk factors2009

    • Author(s)
      Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nishigaki Y, Nozawa Y, Yamada Y.
    • Journal Title

      Int J Mol Med 23

      Pages: 785-792

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of genetic vriants with myocardial infarction in Japanese individuals with chronic kidney disease.2009

    • Author(s)
      Fujimaki T, Kato K, Yoshida T, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nishigaki Y, Tanaka M, Nozawa Y, Kimura G, Yamada Y.
    • Journal Title

      Thromb Haemost 101

      Pages: 963-968

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of candidate gene polymorphisms with chronic kidney disease in Japanese individuals with hypertension.2009

    • Author(s)
      Yoshida T, Kato K, Yokoi K, Watanabe S, Metoki N, Satoh K, Aoyagi Y, Nishigaki Y, Nozawa Y, Yamada Y.
    • Journal Title

      Hypertens Res 32

      Pages: 411-418

    • NAID

      10026122841

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of genetic variants with chronic kidney disease in individuals with different lipid profiles.2009

    • Author(s)
      Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nishigaki Y, Nozawa Y, Yamada Y.
    • Journal Title

      Int J Mol Med 24

      Pages: 233-246

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 蛍光ビーズアレイを用いたミトコンドリアDNAの網羅的迅速解析法2009

    • Author(s)
      西垣裕、上野仁美、細矢博子、福典之、田中雅嗣
    • Journal Title

      基礎老化研究 33

      Pages: 23-26

    • NAID

      10024808387

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 第5章神経の変性・老化とミトコンドリア2009

    • Author(s)
      西垣裕、田中雅嗣
    • Journal Title

      脳内老化制御とバイオマーカー

      Pages: 65-76

    • Related Report
      2008 Final Research Report
  • [Journal Article] その他の寿命関連遺伝子-ミトコンドリア遺伝子.アンチエイジング医学-基礎・臨床研究の進歩-2009

    • Author(s)
      西垣裕、田中雅嗣
    • Journal Title

      日本臨床 67

      Pages: 1299-1305

    • Related Report
      2008 Final Research Report
  • [Journal Article] Functionally Dominant Mitochondrial DNA Mutation2008

    • Author(s)
      Sacconi S, Salviati L, Nishigaki Y, 以下省略12.
    • Journal Title

      Hum Mol Genet 17

      Pages: 1814-20

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial DNA Haplogroup D4a is a Marker for Extreme Longevity in Japan.2008

    • Author(s)
      Bilal E, Rabadan R, Alexe G, Fuku N, Ueno H, Nishigaki Y, Fujita Y, Ito M, Arai Y, Hirose N, Ruckenstein A, Bhanot G, Tanaka M.
    • Journal Title

      PLoS ONE 3

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] ミトコンドリアと酸化ストレス、アポトーシス2008

    • Author(s)
      西垣裕、福典之、田中雅嗣
    • Journal Title

      Medical Science Digest 34

      Pages: 339-342

    • Related Report
      2008 Final Research Report
  • [Journal Article] 「Industry News」蛍光ビーズアレイを用いたミトコンドリアDNA網羅的迅速解析法の有用性2008

    • Author(s)
      阿部由紀子、西垣裕
    • Journal Title

      Medical Science Digest 34

      Pages: 361-365

    • Related Report
      2008 Final Research Report
  • [Journal Article] ミトコンドリアDNAと寿命, 遺伝子変異蓄積とポリプラズミーのメカニズム, Mitochondrial DNA and longevity: Polyplasmy and accumulation of mtDNA mutation2008

    • Author(s)
      西垣裕、田中雅嗣
    • Journal Title

      医学のあゆみ 227

      Pages: 567-572

    • Related Report
      2008 Final Research Report
  • [Journal Article] Mitochondrial DNA Haplogroup D4a is a Marker for Extreme Longevity in Japan2008

    • Author(s)
      Bilal E
    • Journal Title

      PLoS ONE 3

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ミトコンドリアと酸化ストレス、アポトーシス2008

    • Author(s)
      西垣裕
    • Journal Title

      Medical Science Digest 34

      Pages: 339-342

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 蛍光ビーズアレイを用いたミトコンドリアDNA網羅的迅速解析法の有用性2008

    • Author(s)
      阿部由紀子
    • Journal Title

      Medical Science Digest 34

      Pages: 361-365

    • Related Report
      2008 Annual Research Report
  • [Journal Article] ミトコンドリアDNAと寿命, 遺伝子変異蓄積とポリプラズミーのメカニズム2008

    • Author(s)
      西垣裕
    • Journal Title

      医学のあゆみ 227

      Pages: 567-572

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 蛍光ビーズアレイを用いたミトコンドリアDNAの網羅的迅速解析法2008

    • Author(s)
      西垣裕
    • Journal Title

      基礎老化研究 33

      Pages: 23-26

    • NAID

      10024808387

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Women with mitochondrial haplogroup N9a are protected against metabolic syndrome.2007

    • Author(s)
      Tanaka M, Fuku N, Nishigaki Y, Matsuo H, Segawa T, Watanabe S, Kato K, Yokoi K, Yamaguchi S, Nozawa Y, Yamada Y.
    • Journal Title

      Diabetes 56

      Pages: 518-521

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial haplogroup N9b is protective against myocardial infarction in Japanese males.2007

    • Author(s)
      Nishigaki Y, Yamada Y, Fuku N, Matsuo H, Segawa T, Watanabe S, Kato K, Yokoi K, Yamaguchi S, Nozawa Y, Tanaka M.
    • Journal Title

      Hum Genet 120

      Pages: 827-836

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians.2007

    • Author(s)
      Fuku N, Park KS, Yamada Y, Nishigaki Y, Cho YM, Matsuo H, Segawa T, Watanabe S, Kato K, Yokoi K, Nozawa Y, Lee HK, Tanaka M.
    • Journal Title

      Am J Hum Genet 80

      Pages: 407415-407415

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial haplogroup A is a genetic riskfactor for atherothrombotic cerebral infarction in Japanese females.2007

    • Author(s)
      Nishigaki Y, Yamada Y, Fuku N, Matsuo H, Segawa T, Watanabe S, Kato K, Yokoi K, Yamaguchi S, Nozawa Y, Tanaka M.
    • Journal Title

      Mitochondrion 7

      Pages: 72-79

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enrichment of longevity phenotype in mtDNA haplogroups D4b2b, D4a, and D5 in the Japanese population.2007

    • Author(s)
      Alexe G, Fuku N, Bilal E, Ueno H, Nishigaki Y, Fujita Y, Ito M, Arai Y, Hirose N, Bhanot G, Tanaka M.
    • Journal Title

      Hum Genet 121

      Pages: 347-356

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Letter to the Editor, Therapeutic potential of pyruvate therapy for mitochondrial diseases.2007

    • Author(s)
      Tanaka M, Nishigaki Y, Ibi T, Sahashi K. Koga Y.
    • Journal Title

      Mitochondrion 7

      Pages: 399-401

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] ミトコンドリア機能異常と老年病(総説)2007

    • Author(s)
      西垣裕、福典之、田中雅嗣
    • Journal Title

      老年医学update 2007-08, メジカルビュー社

      Pages: 154-163

    • Related Report
      2008 Final Research Report
  • [Journal Article] Therapeutic potential of pyruvate therapy for mitochondrial diseases.2007

    • Author(s)
      Tanaka M
    • Journal Title

      Mitochondrion 7

      Pages: 399-401

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ミトコンドリア心筋症(Mitochondrlal cardiomyopathy)-診断と治療戦略-2007

    • Author(s)
      西垣 裕
    • Journal Title

      分子心血管病 8

      Pages: 119-129

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Mitochondrial haplogroup N9b is protective against myocardial infarction in Japanese males.2007

    • Author(s)
      Nishigaki Y
    • Journal Title

      Hum Genet 120・6

      Pages: 827-836

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Mitochondrial haplogroup A is a genetic risk factor for artherothrombotic cerebral infarction in Japanese females.2007

    • Author(s)
      Nishigaki Y
    • Journal Title

      Mitochondrion 7・1

      Pages: 72-79

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Women with mitochondrial haplogroup N9a are protected against metabolic syndrome.2007

    • Author(s)
      Tanaka M
    • Journal Title

      Diabetes 56・2

      Pages: 518-521

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians.2007

    • Author(s)
      Fuku N
    • Journal Title

      Am J Hum Genet 80・3

      Pages: 407-415

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Enrichment of lonevity phenotype in mtDNA haplogroups D4b2b, D4a, and D5 in the Japanese population.2007

    • Author(s)
      Alexe G
    • Journal Title

      Hum Genet 121・3

      Pages: 347-356

    • Related Report
      2006 Annual Research Report
  • [Journal Article] ミトコンドリア機能異常と老年病2006

    • Author(s)
      西垣 裕
    • Journal Title

      日本老年医学会雑誌 43・3

      Pages: 274-282

    • NAID

      10018178336

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 老化に関連するミトコンドリアゲノム多型2006

    • Author(s)
      西垣 裕
    • Journal Title

      日本農芸化学会会誌・化学と生物 44・10

      Pages: 674-680

    • NAID

      10018252487

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Analysis of mitochondrial DNA variants in Japanese patients with schizophrenia.

    • Author(s)
      Ueno H, Nishigaki Y, Kong QP, Fuku N, Kojima S, Iwata N, Ozaki N, Tanaka M.
    • Journal Title

      Mitochondrion (印刷中)

      Pages: 0-0

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of polymorphisms of THBS2 and HSPA8 with hypertension in Japanese individuals with chronic kidney disease.

    • Author(s)
      Oguri M, Kato K, Yokoi K, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nishigaki Y, Yoshida H, Nozawa Y, Yamada Y.
    • Journal Title

      Mol Med Rep (印刷中)

      Pages: 0-0

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of genetic variants with chronic kidney disease in Japanese individuals.

    • Author(s)
      Yoshida T, Kato K, Fujimaki T, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nishigaki Y, Tanaka M, Nozawa Y, Kimura G, Yamada Y.
    • Journal Title

      Clin J Am Soc Nephrol (印刷中)

      Pages: 0-0

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of genetic variants with myocardial infarction in Japanese individuals with metabolic syndrome

    • Author(s)
      Oguri M, Kato K, Yokoi K, Itoh T, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nishigaki Y, Tanaka M, Nozawa Y, Yamada Y.
    • Journal Title

      Atherosclerosis (印刷中)

      Pages: 0-0

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial haplogroups associated with lifestyle-related diseases and longevity in the Japanese population. In: Gerontology and Geriatrics Science: Gene to Longevity, Takubo K, Maruyama N (eds)

    • Author(s)
      Nishigaki Y, Fuku N, Tanaka M.
    • Journal Title

      Wiley-Blackwell, Hoboken, NJ (印刷中)

      Pages: 0-0

    • Related Report
      2008 Final Research Report
  • [Presentation] The establishment of an expanded simultaneous swift diagnosing system for mitochondrial DNA pathological mutations.2009

    • Author(s)
      Nishigaki Y
    • Organizer
      61st Annual Meeting of the American Academy of Neurology
    • Place of Presentation
      Seattle, U.S.A.
    • Year and Date
      2009-04-25
    • Related Report
      2008 Final Research Report
  • [Presentation] 日本人トップアスリートに関連するミトコンドリアハプログループ2008

    • Author(s)
      三上恵里
    • Organizer
      日本ミトコンドリア学会第8回年会
    • Place of Presentation
      東京
    • Year and Date
      2008-12-18
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Leigh脳症およびミトコンドリア心筋症に対するピルビン酸ナトリウム経口投与の安全性と有効性の検証2008

    • Author(s)
      田中雅嗣
    • Organizer
      日本ミトコンドリア学会第8回年会
    • Place of Presentation
      東京
    • Year and Date
      2008-12-18
    • Related Report
      2008 Final Research Report
  • [Presentation] 厚生労働省 精神・神経疾患研究委託費「筋ジストロフィーに関連する疾患の病態解明と治療法の開発に関する研究」2008

    • Author(s)
      西垣裕
    • Organizer
      砂田班班会議「蛍光ビーズ多重解析システムを用いたミトコンドリアゲノム病因変異の迅速かつ網羅的診断法の確立」
    • Place of Presentation
      東京
    • Year and Date
      2008-12-14
    • Related Report
      2008 Final Research Report
  • [Presentation] ミトコンドリア病の網羅的かつ迅速診断を目的とした蛍光ビーズアレイ・システムの構築2008

    • Author(s)
      西垣裕
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-09
    • Related Report
      2008 Final Research Report
  • [Presentation] 日本人統合失調症患者におけるミトコンドリアDNAの解析2008

    • Author(s)
      上野仁美
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-09
    • Related Report
      2008 Final Research Report
  • [Presentation] ミトコンドリア病の網羅的かつ迅速診断を目的とした蛍光ビーズアレイ・システムの構築2008

    • Author(s)
      西垣裕
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2008-12-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 日本人統合失調症患者におけるミトコンドリアDNAの解析2008

    • Author(s)
      上野仁美
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2008-12-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] A new comprehensive diagnosing system for mitochondrial DNA mutations using suspension array technology.2008

    • Author(s)
      Nishigaki Y
    • Organizer
      5th Meeting of Asian Society for Mitochondrial Research and Medicine (ASMRM)
    • Place of Presentation
      Tianjin, China.
    • Year and Date
      2008-11-09
    • Related Report
      2008 Final Research Report
  • [Presentation] A new comprehensive diagnosing system for mitochondria DNA mutations using suspension array technology2008

    • Author(s)
      Yutaka Nishigaki
    • Organizer
      5th Meeting of Asian Society for Mitochondrial Research and Medicine (ASMRM)
    • Place of Presentation
      中国天津市
    • Year and Date
      2008-11-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 蛍光ビーズ多重解析システムを用いたミトコンドリア病病因変異の迅速・網羅的検出法の確立2008

    • Author(s)
      西垣裕
    • Organizer
      日本人類遺伝学会第53回大会
    • Place of Presentation
      東京
    • Year and Date
      2008-09-28
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 日本人統合失調症患者におけるミトコンドリアDNA多型の解析2008

    • Author(s)
      上野仁美
    • Organizer
      日本人類遺伝学会第53回大会
    • Place of Presentation
      東京
    • Year and Date
      2008-09-28
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 統合失調症患者で検出された新規ミトコンドリアDNA変異13418G>A(ND5: Gly361Glu)2008

    • Author(s)
      上野仁美
    • Organizer
      日本人類遺伝学会第53回大会
    • Place of Presentation
      東京
    • Year and Date
      2008-09-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 統合失調症患者で検出された新規ミトコンドリアDNA変異13418G>A(ND5:Gly361Glu)2008

    • Author(s)
      上野仁美
    • Organizer
      日本人類遺伝学会第53回大会
    • Place of Presentation
      東京
    • Year and Date
      2008-09-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] A new comprehensive diagnosing system for mitochondrial DNA mutations using fluorescent beads2008

    • Author(s)
      Yutaka Nishigaki
    • Organizer
      The 7th European Meeting on Mitochondrial Pathology (Euromit 7)
    • Place of Presentation
      Stockholm, スウェーデン
    • Year and Date
      2008-06-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] A new comprehensive diagnosing system for mitochondrial DNA mutations using fluorescent beads.2008

    • Author(s)
      Nishigaki Y
    • Organizer
      The 7th European Meeting on Mitochondrial Pathology (Euromit 7)
    • Place of Presentation
      Stockholm, Sweden.
    • Year and Date
      2008-06-11
    • Related Report
      2008 Final Research Report
  • [Presentation] A novel comprehensive diagnosing system for mitochondrial DNA mutations using suspension array technology2008

    • Author(s)
      Yutaka Nishigaki
    • Organizer
      60 Annual Meeting of the American Academy of Neurology
    • Place of Presentation
      Chicago, U. S. A
    • Year and Date
      2008-04-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] A novel comprehensive diagnosing system for mitochondrial DNA mutations using suspension array technology.2008

    • Author(s)
      Nishigaki Y
    • Organizer
      60th Annual Meeting of the American Academy of Neurology
    • Place of Presentation
      Chicago, U.S.A.
    • Year and Date
      2008-04-12
    • Related Report
      2008 Final Research Report
  • [Presentation] 統合失調症患者におけるミトコンドリアDNA多型の解析2007

    • Author(s)
      上野 仁美
    • Organizer
      日本ミトコンドリア学会第7回年会
    • Place of Presentation
      鹿児島県鹿児島市
    • Year and Date
      2007-12-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] ミトコンドリアハプログループは長寿に関連する2007

    • Author(s)
      福 典之
    • Organizer
      日本ミトコンドリア学会第7回年会
    • Place of Presentation
      鹿児島県鹿児島市
    • Year and Date
      2007-12-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] 蛍光ビーズアレイを用いたミトコンドリア病病因変異の網羅的迅速診断システムの構築2007

    • Author(s)
      西垣 裕
    • Organizer
      日本ミトコンドリア学会第7回年会
    • Place of Presentation
      鹿児島県鹿児島市
    • Year and Date
      2007-12-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] ミトコンドリア病に対するピルビン酸療法の可能性.2007

    • Author(s)
      田中 雅嗣
    • Organizer
      日本ミトコンドリア学会第7回年会
    • Place of Presentation
      鹿児島県鹿児島市
    • Year and Date
      2007-12-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] 蛍光ビーズアレイを用いたミトコンドリア病病因変異の網羅的迅速診断システムの構築2007

    • Author(s)
      西垣裕
    • Organizer
      日本ミトコンドリア学会第7回年会
    • Place of Presentation
      鹿児島
    • Year and Date
      2007-12-20
    • Related Report
      2008 Final Research Report
  • [Presentation] ミトコンドリア病に対するピルビン酸療法の可能性2007

    • Author(s)
      田中雅嗣
    • Organizer
      日本ミトコンドリア学会第7回年会
    • Place of Presentation
      鹿児島
    • Year and Date
      2007-12-20
    • Related Report
      2008 Final Research Report
  • [Presentation] 統合失調症患者におけるミトコンドリアDNA多型の解析2007

    • Author(s)
      上野仁美
    • Organizer
      日本ミトコンドリア学会第7回年会
    • Place of Presentation
      鹿児島
    • Year and Date
      2007-12-20
    • Related Report
      2008 Final Research Report
  • [Presentation] ミトコンドリアハプログループは長寿に関連する2007

    • Author(s)
      福典之
    • Organizer
      日本ミトコンドリア学会第7回年会
    • Place of Presentation
      鹿児島
    • Year and Date
      2007-12-20
    • Related Report
      2008 Final Research Report
  • [Presentation] ミトコンドリア病の主要病因変異における網羅的迅速診断法の構築と検討2007

    • Author(s)
      西垣裕
    • Organizer
      日本ミトコンドリア学会第8回年会
    • Place of Presentation
      東京
    • Year and Date
      2007-12-18
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] ミトコンドリアゲノム多型研究の生活習慣病一次予防への活用-ミトコンドリアゲノム一塩基多型網羅的・迅速解析系の確立-2007

    • Author(s)
      西垣裕
    • Organizer
      花王健康科学研究会第4回研究成果報告会
    • Place of Presentation
      東京
    • Year and Date
      2007-12-08
    • Related Report
      2008 Final Research Report
  • [Presentation] 厚生労働省 精神・神経疾患研究委託費「筋ジストロフィーに関連する疾患の病態解明と治療法の開発に関する研究」2007

    • Author(s)
      西垣裕
    • Organizer
      清水班 班会議「蛍光ビーズ多重解析システムを用いたミトコンドリアゲノム病因変異の迅速かつ網羅的診断法の確立」
    • Place of Presentation
      東京
    • Year and Date
      2007-12-07
    • Related Report
      2008 Final Research Report
  • [Presentation] Ageing and mitochondrial neurogastrointestinal encephalomyopathy(MNGIE):an autosomal recessive mitochondrial disorder.2007

    • Author(s)
      Yutaka Nishigaki
    • Organizer
      The 8th Asia/Oceania Regional Congress of Gerontology and Geriatrics,.
    • Place of Presentation
      Beijing,China
    • Year and Date
      2007-10-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] Ageing and mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): an autosomal recessive mitochondrial disorder.2007

    • Author(s)
      Nishigaki Y
    • Organizer
      The 8th Asia/Oceania Regional Congress of Gerontology and Geriatrics
    • Place of Presentation
      Beijing, China.
    • Year and Date
      2007-10-22
    • Related Report
      2008 Final Research Report
  • [Presentation] 生活習慣病に関連するミトコンドリアハプログループの検索を目的としたミトコンドリアゲノム-塩基多型網羅的・迅速解析系の確立.2007

    • Author(s)
      西垣 裕
    • Organizer
      日本人類遺伝学会第52回大会
    • Place of Presentation
      東京
    • Year and Date
      2007-09-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] 生活習慣病に関連するミトコンドリアハプログループの検索を目的としたミトコンドリアゲノム一塩基多型網羅的・迅速解析系の確立.2007

    • Author(s)
      西垣裕
    • Organizer
      日本人類遺伝学会第52回大会
    • Place of Presentation
      東京
    • Year and Date
      2007-09-12
    • Related Report
      2008 Final Research Report
  • [Presentation] Ageing and an autosomal recessive mitochondrial disorder: mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).2007

    • Author(s)
      西垣裕
    • Organizer
      日本基礎老化学会第30回年会
    • Place of Presentation
      札幌
    • Year and Date
      2007-06-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Mitochondrial haplogroup D4a is enriched in Japanese semi-supercentenarians.2007

    • Author(s)
      田中雅嗣
    • Organizer
      日本基礎老化学会第30回年会
    • Place of Presentation
      札幌
    • Year and Date
      2007-06-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Enrichment of longevity phenotype in mtDNA haplogroups D4b2b, D4a, and D5 in the Japanese.2007

    • Author(s)
      田中雅嗣
    • Organizer
      日本基礎老化学会第30回年会
    • Place of Presentation
      札幌
    • Year and Date
      2007-06-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Ageing and an autosomal recessive mitochondrial disorder:mitochondrial neurogastrointestinal encephalomyopathy(MNGIE).2007

    • Author(s)
      西垣 裕
    • Organizer
      日本基礎老化学会第30回年会
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2007-06-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Mitochondrial haplogroup D4a is enriched in Japanese semi-supercentenarians.2007

    • Author(s)
      田中 雅嗣
    • Organizer
      日本基礎老化学会第30回年会
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2007-06-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Enrichment of longevity phenotype in mtDNA haplogroups D4b2b,D4a,and D5 in the Japanese.2007

    • Author(s)
      福 典之
    • Organizer
      日本基礎老化学会第30回年会
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2007-06-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Women with mitochondriaI haplogroup A are susceptible to atherothrombotic cerebral infarction.2007

    • Author(s)
      Yutaka Nishigaki
    • Organizer
      59th Annual Meeting of the American Academy of Neurology,
    • Place of Presentation
      Boston,U.S.A
    • Year and Date
      2007-05-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] Women with mitochondrial haplogroup A are susceptible to atherothrombotic cerebral infarction.2007

    • Author(s)
      Nishigaki Y
    • Organizer
      59th Annual Meeting of the American Academy of Neurology
    • Place of Presentation
      Boston, U.S.A.
    • Year and Date
      2007-04-28
    • Related Report
      2008 Final Research Report
  • [Presentation] Mitochondrial haplogroups are associated with atherosclerosis-related diseases in Japanese.2007

    • Author(s)
      Nishigaki Y
    • Organizer
      4th ASMRM (Asian Society for Mitochondrial Research and Medicine), Mitochondria
    • Place of Presentation
      Seoul, South Korea.
    • Year and Date
      2007-02-04
    • Related Report
      2008 Final Research Report
  • [Presentation] Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians.2007

    • Author(s)
      Fuku N
    • Organizer
      4th ASMRM (Asian Society for Mitochondrial Research and Medicine), Mitochondria
    • Place of Presentation
      Seoul, South Korea.
    • Year and Date
      2007-02-04
    • Related Report
      2008 Final Research Report
  • [Book] 老年医学update2007-082007

    • Author(s)
      西垣 裕
    • Publisher
      メジカルビュー社
    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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