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Analysis for factors determining cancer stem cells ; aiming for their visualization

Research Project

Project/Area Number 18590329
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionOsaka University

Principal Investigator

MORII Eiichi  Osaka University, Department of Pathology, Associate Professor (10283772)

Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥4,010,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordscancer stem cells / pathology / immunohistochemitry / 遺伝子発現機構
Research Abstract

To aim for visualization of cancer stem cells, we first determined the molecules highly expressed in the side population of cancer cell lines, in which cancer stem cells are known to be contained. We isolated several candidates of molecules highly eapiessod in side population of breast cancer cell line MCIF7, such as CD55. Cells with CD55-high character expressed anti-apoptotic molecules abundantly, and formed colonies in vitro more efficiently. In the transplantation to NOD/Scid mice, cells with CD55-high character were more tumorigenic than cells with CD55-low character. In addition, we found breast cancer cases with ample CD55-high tumor cells showed poor prognosis as compared to the caces with scarce CD55-high tumor cells. These showed that the quantity of cancer stem cells might determine the prognosis of tumors. Besides CD55, we found several molecules, such as Notch2, would be a marker for tumorigenic cells of lymphoma cell line.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (35 results)

All 2008 2007 2006 Other

All Journal Article (29 results) (of which Peer Reviewed: 13 results) Presentation (4 results) Book (2 results)

  • [Journal Article] High tolerance to apoptotic stimuli induced by serum depletion and ceramide in side-population cells: high expression of CD55 as a novel character for side-population2007

    • Author(s)
      Xu JX, Morii E, et. al.
    • Journal Title

      Exp Cell Res 313

      Pages: 1877-1885

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] PBX1 regulates expression of VCP, a gene involved in cancer growth.2007

    • Author(s)
      Qiu Y, Morii E, et. al.
    • Journal Title

      Am J Pathol 170

      Pages: 152-159

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type developing in gonarthritis deformans2007

    • Author(s)
      Ikeda J, Morii E, et. al.
    • Journal Title

      J Clin Oncol 25

      Pages: 4310-4312

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Development of mast cells: analysis with mutant mice2007

    • Author(s)
      Morii E
    • Journal Title

      Int J Hematol 86

      Pages: 22-26

    • NAID

      10018515437

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Alveolar macrophages are the primary interferon-alpha produced in response to lung RNA virus infection.2007

    • Author(s)
      Kumagai Y, Morii E, et. al.
    • Journal Title

      Immunity 27

      Pages: 240-252

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Mediastinal lymphangiomatosis coexisting with occult thymic carcinoma2007

    • Author(s)
      Ikeda J, Morii E, et. al.
    • Journal Title

      Virchows Arch 450

      Pages: 211-214

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] PGAP1 knockout mice show otocephaly and male infertility.2007

    • Author(s)
      Ueda Y, Morii E, et. al.
    • Journal Title

      J Biol Chem 282

      Pages: 30373-30380

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Prognostic significance of CD100 expression in soft tissue sarcoma.2007

    • Author(s)
      Ch'ng E, Morii E, et. al.
    • Journal Title

      Cancer 110

      Pages: 164-172

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Expression level of hepatoma-derived growth factor correlates with tumor recurrence of esophageal carcinoma.2007

    • Author(s)
      Yamamoto S, Morii E, et. al.
    • Journal Title

      Ann Surg Oncol 14

      Pages: 2141-2149

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] E74-like factor 2 regulates valosin-containing protein expression.2007

    • Author(s)
      Zhang B, Morii E, et. al.
    • Journal Title

      Biochem Biophys Res Comm 356

      Pages: 536-541

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] High tolerance to apoptotic stimuli induced by serum depletion and ceramide in side-population cells : high expression of CD55 as a novel character for side-population2007

    • Author(s)
      Xu, JX, Morii, E, et. al.
    • Journal Title

      Exp Cell Res 313

      Pages: 1877-1885

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] PBX1 regulates expression of VCP, a gene involved in cancer growth2007

    • Author(s)
      Qiu, Y, Morii, E, et. al.
    • Journal Title

      Am J Pathol 170

      Pages: 1877-1885

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type developing in gonarthritis deformans2007

    • Author(s)
      Ikeda, J, Morii, E, et. al.
    • Journal Title

      J Clin Oncol 25

      Pages: 4310-4312

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Development of mast cells : analysis with mutant 'mice2007

    • Author(s)
      Morii, E
    • Journal Title

      Int J Hematol 86

      Pages: 22-26

    • NAID

      10018515437

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Alveolar macrophages are the primary interferon-alpha produced in response to lung RNA virus infection2007

    • Author(s)
      Kumagai, Y, Morii, E, et. al.
    • Journal Title

      Immunity 27

      Pages: 240-252

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Mediastinal lymphangiomatosis coexisting with occult thymic carcinoma2007

    • Author(s)
      Ikeda, J, Morii, E, et. al.
    • Journal Title

      Virchows Arch 450

      Pages: 211-214

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] PGAP1 knockour mice show otocephaly and male infertility2007

    • Author(s)
      Ueda, Y, Morii, E, et. al.
    • Journal Title

      J Biol Chem 282

      Pages: 30373-30380

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Prognostic significance of CD100 expression in soft tissue sarcoma2007

    • Author(s)
      Ch'ng, E, Morii, E, et. al.
    • Journal Title

      Cancer 110

      Pages: 164-172

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Expression level of hepatoma-derived growth factor correlates with tumor recurrence of esophageal carcinoma2007

    • Author(s)
      Yamamoto, S, Morii, E, et. al.
    • Journal Title

      Ann Surg Oncol 14

      Pages: 2141-2149

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] E74-like factor 2 regulates valosin-containing protein expression2007

    • Author(s)
      Zhang, B, Morii, E, et. al.
    • Journal Title

      Biochem Biophys Res Comm 350

      Pages: 536-541

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Prognostic significance of CD100 expression in soft tissue sarcoma.2007

    • Author(s)
      Ch' ng E, Morii E, et. al.
    • Journal Title

      Cancer 110

      Pages: 164-172

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pre-B-cell leukemia transcription factor 1 regulates expression of valosin-containing protein, a gene involved in cancer growth.2007

    • Author(s)
      Qui Y et al.
    • Journal Title

      Am J Pathol 170・1

      Pages: 152-159

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Epigenetic regulation of the expression of the novel stem cell marker CDCP1 in cancer cells.2006

    • Author(s)
      Ikeda JI et al.
    • Journal Title

      J Pathol 210・1

      Pages: 75-84

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Role of DNA methylation for expression of novel stem cell marker CDCP1 in hematopoietic cells.2006

    • Author(s)
      Kimura H et al.
    • Journal Title

      Leukemia 20・9

      Pages: 1551-1556

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Methotrexate-associated lymphoproliferative disorder mimicking composite lymphoma.2006

    • Author(s)
      Ikeda JI et al.
    • Journal Title

      Int J Hematol 83・4

      Pages: 363-365

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Prognostic significance of CD55 expression in breast cancer

    • Author(s)
      Ikeda J, Morii E, et. al.
    • Journal Title

      Clin Cancer Res (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Prognostic significance of CD55 expression in breast cancer

    • Author(s)
      Ikeda, J, Morii, E, et. al.
    • Journal Title

      Clin Cancer Res (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Prognostic significance of CD55 expression in breast cancer

    • Author(s)
      Ikeda J, Morii E, et. al.
    • Journal Title

      Clin Cancer Res (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mediastinal lymphoangiomatosis coexisting with occult thymic carcinoma.

    • Author(s)
      Ikeda JI et al.
    • Journal Title

      Virchows Arch (In press)

    • Related Report
      2006 Annual Research Report
  • [Presentation] Mechanism of expression of a novel tyrosine kinase CDCP1 in hematopoietic cell lines2008

    • Author(s)
      Morii, E
    • Organizer
      Congress of Japan Society of Hematology
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2008-10-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] High expression of CD55 is a novel marker for side-population cells and useful for evaluating their characters2008

    • Author(s)
      Morii, E
    • Organizer
      Congress of Japan Society of Cancer
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2008-10-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 白血病細胞株を用いた新規レセプター型チロシンキナーゼCDCP1の腫瘍における発現調節機構2007

    • Author(s)
      森井 英一
    • Organizer
      第69回(平成19年度)日本血液学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] High expression of CD55 is a novel marker for side-population cells and useful for evaluating their characters.2007

    • Author(s)
      森井 英一
    • Organizer
      第66回(平成19年度)日本癌学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Book] Cancer stem cells: an overview. In Methods of Cancer Diagnosis, The rapy and Prognosis.

    • Author(s)
      Morii E, et. al.
    • Publisher
      Springer(In press)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Cancer stem cells: an overview. In Methods of Cancer Diagnosis, Therapy and Prognosis.

    • Author(s)
      Morii E, et. al.
    • Publisher
      Springer (In press)
    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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