Analysis of molecular basis for occurance of Hodgkin lympnoma and anaplastic large cell lymphoma
| Project/Area Number |
18590345
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kitasato University |
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Principal Investigator |
HORIE Ryouichi Kitasato University, School of Medicine, Associate Prof. (80229228)
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| Co-Investigator(Kenkyū-buntansha) |
HIGASHIHARA Masaaki Kitasato University, School of Medicine, Prof (80165084)
WATANABE Toshiki University of Tokyo, Graduate School of Frontier Sciences, Prof (30182934)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥4,010,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | Hodgkin lymphoma / anaplastic large cell lymphoma / NF-κB / NPM-ALK / P80 / JunB / NF-kB |
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| Research Abstract |
High expression of CD30 and JunB is characteristic of tumor cells in anaplastic large cell lymphoma (ALCL) and Hodgkin lymphoma (HL). The possible inter-relationships of CD30 and JunB were examined in this study. We found that the CD30 promoter in tumor cells of both nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) positive and NPM-ALK negative ALCL and HL is regulated by a constitutively active CD30-extracellular signal-regulated kinase (ERK) 1/2 mitogen-activated protein kinase (MAPK). Phosphorylated ERK1/2 MAPK was confirmed in nuclei of tumor cells in biopsies of ALCL and HL. CD30-ERK1/2 MAPK signals induce JunB expression which maintains high activity of the CD30 promoter. JunB induction appears to be largely independent of NF-KB in ALCL and HL. These results demonstrate a common mechanism of CD30 overexpression in ALCL and HL although the results of CD30 signaling differ between NPM- ALK positive ALCL and other subgroups ; NPM-ALK negative ALCL, cutaneous ALCL and HL as we recently reported.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] Dehydroxymethylepoxyquinomicin(DHMEQ)therapy reduces tumor formation in mice inoculated with tax-deficient adult T-cell leukemia-derived cell lines2007
Author(s)
Ohsugi, T, Kumasaka, T, Okada, S, Ishida, T, Yamaguchi, K, Horie, R, Watanabe, T, Umezawa, K
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Journal Title
Cancer Lett 257(2)
Pages: 206-15
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] TRAF activation of C/EBPb (NF-IL6) via p38 MAPK induces HIV-1 gene expression in monocytes/macrophages2007
Author(s)
Horie, R, Ishida, T, Maruyama-Nagai, M, Ito, K, Watanabe, M, Yoneyama, A, Higashihara, M, Kimura, S, Watanabe, T
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Journal Title
Microbes Infect 48
Pages: 721-8
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] IkBalpa independent induction of NF-kappaB and its inhibition b DHMEQ in Hodgkin-Reed-Sternberg cells2007
Author(s)
Watanabe, M, Dewan, MZ, Taira, M, Shoda, M, Honda, M, Sata, T, Higashihara, M, Kadin, ME, Watanabe, T, Yamamoto, N, Umezawa, K, Horie, R
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Journal Title
Lab Invest 87
Pages: 372-82
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] DHMEQ, a new NF-kappaB inhibitor, induces apoptosis and enhances fludarabine effects on chronic lymphocytic leukemia cells2006
Author(s)
Horie, R, Watanabe, M, Okamura, T, Taira, M, Shoda, M, Motoji, T, Utsunomiya, A, Watanabe, T, Higashihara, M, Umezawa, K
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Journal Title
Leukemia 20
Pages: 800-806
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Transactivation of the ICAM-1 gene by CD30 in Hodgkin's lymphoma2006
Author(s)
Uchihara, JN, Matsuda, T, Okudaira, T, Ishikawa, C, Masuda, M, Rorie, R, Watanabe, T, Ohta, T, Takasu, N, Mori, N
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Journal Title
Int J Cancer 118
Pages: 1098-1107
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] In vitro and in vivo antitumor activity of the NF-kappaB inhibitor DHMEQ in the human T-cell leukemia virus type I-infected cell line, HUT-1022006
Author(s)
Ohsugi, T, Kumasaka, T, Ishida, A, Ishida, T, Rorie, R, Watanabe, T, Umezawa, K, Yamaguchi, K
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Journal Title
Description
「研究成果報告書概要(欧文)」より
Related Report
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