A analysis for the cell proliferation mechanisms of hormone independent breast cancers. ERnegative and HER2 negative breast cancers and transcriptional factors
| Project/Area Number |
18590348
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Tokai University |
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Principal Investigator |
UMEMURA Shinobu Tokai University, 医学部, 准教授 (20276794)
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| Co-Investigator(Kenkyū-buntansha) |
長村 義之 東海大学, 医学部, 教授 (10100992)
徳田 裕 東海大学, 医学部, 教授 (20163975)
竹腰 進 東海大学, 医学部, 准教授 (70216878)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEKOSHI Susumu 東海大学, 医学部, 准教授 (70216878)
TOKUDA Yutaka 東海大学, 医学部, 教授 (20163975)
OSAMURA Yoshiyuki 東海大学, 医学部, 教授 (10100992)
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| Project Period (FY) |
2006 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥3,970,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥570,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | 乳癌 / 細胞増殖 / ER陰性 / HER2陰性 / 転写因子 / E2F-5 / estrogen receptor / human epidermal growth factor receptor-2 / 転写因子 E2F-5 / triple negative breast cancer / basal phenotype / Estrogen receptor / HER2 / リン酸化Akt |
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| Research Abstract |
Estrogen receptor α(ERα)および human epidermal growth factor receptor-2(HER2)いずれも陰性の乳癌について検討し、細胞周期関連転写因子E2Fの高発現が認められることを明らかにした。E2F-5遺伝子変異(E2F-5遺伝子点突然変異解析、E2F-5遺伝子増幅)の有無について検討し、E2F-5陽性乳癌の臨床病理学的特徴を明らかにした。
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Metastin inhibits migration and invasion of renal cell carcinoma with overexpression of metastinc receptor2008
Author(s)
Shoji S, Tang XY, Umemura S, Itoh J, Takekoshi S, Shima M, Usui Y, Nagata Y, Uchida T, Osamura RY, Terachi T.
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Journal Title
Eur Urol 55
Pages: 441-451
Related Report
Peer Reviewed
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[Journal Article] Impaired tight junction sealing and precocious involution in mammary glands of PKN1 transgenic mice2007
Author(s)
Fischer A, Stuckas H, Gluth M, Russel TD, Rudolph MC, Beeman NE, Bachmann S, Umemura S, Ohashi Y, Neville MC, Theuring F.
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Journal Title
J Cell Science 120
Pages: 2272-2283
Related Report
Peer Reviewed
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[Journal Article] Comparison of evaluations for hormone receptors in breast carcinoma using two manual and three automated immunohistochemical stainings2007
Author(s)
Arihiro K, Umemura S, Kurosumi M, T Moriya, T Oyama, H Yamashita, Y Umekita, Y Komoike, C Shimizu, H Fukushima, H Kajiwara, F Akiyama
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Journal Title
Am J Clin Pathol 127
Pages: 1-10
Related Report
Peer Reviewed
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