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Detection of clinically insignificant prostate cancer by allelic imbalance analysis

Research Project

Project/Area Number 18590350
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionJikei University School of Medicine

Principal Investigator

TAKAHASHI Hiroyuki  Jikei University School of Medicine, School of Medicine, Professor Assistant Professor (00246414)

Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,320,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywordscancer / pathology / cell. tissue / 前立腺癌 / 微小癌 / ラテント癌 / LOH
Research Abstract

The criterion tumor volume (TV) for clinically insignificant prostate cancer has been reported, but it differs from study to study : some have reported TV < 200 mm^3 ; others, <500 mm^3. The aim of the present study was to distinguish clinically insignificant cancers from significant ones using molecular biological methods. A total of 184 microscopic cancers (MC) defined as limited within a 3 mm circle and 82 main tumor (MT) nodules were selected. Thirteen microsatellite loci at 6q22, 8p23.2-23, 13q14 and 13q33 were evaluated for loss of heterozygosity (LOH). MT were subgrouped as TV <500 mm^3 or > 500 mm^3 ; TV < 200 mm^3 or > 200 mm^3 ; and TV < 200 mm^3 or 200 mm^3 〓 TV < 500 mm^3 or〓500 mm^3 ; and frequencies of LOH were compared between these three groups. Frequencies of LOH at 6q16-21, 6q22, 8p23.1, 8p23.2, 13q14 were significantly lower in MC (1.0%, 2.7%, 1.9%, 1.1% and 5.4%) than in MT (30.9%, 40.4%, 12%, 8.7% and 20.6%). No significant differences in LOH frequencies were found at any of these TV settings. When insignificant tumor is defined as TV < 200 mm^3 or < 500 mm^3, it should include tumors with malignant potential equivalent to larger tumors. It is suggested that in order to identify insignificant tumor within a strict safety range, TV should be set lower.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (6 results)

All 2008 2007 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (3 results)

  • [Journal Article] Prediction of clinically insignificant prostate cancer by detection of allelic imbalance at 6q,8p and 13q2008

    • Author(s)
      Nakano M, Takahashi H, et. al.
    • Journal Title

      Pathol Int

      Pages: 415-420

    • NAID

      10027377096

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Prediction of clinically insignificant prostate cancer by detection of allelic imbalance at 6q, 8p and 13q2008

    • Author(s)
      Nakano, M, Takahashi, H, et. al.
    • Journal Title

      Pathol Int 58

      Pages: 415-420

    • NAID

      10027377096

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Prediction of clinically insignificant prostate cancer by detection of allelicimbalance at 6q,8p and 13q

    • Author(s)
      Nakano M, Takahashi H, et. al.
    • Journal Title

      Pathol Int (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Therapeutic applications of allelic imbalance and immunohistochemistry in prostate cancers2007

    • Author(s)
      Takahashi H
    • Organizer
      The Asia-Pacific society for molecular and immunohistology
    • Place of Presentation
      シンガポール
    • Year and Date
      2007-05-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Therapeutic applications of allelic imbalance and immunohistochemistry in prostate cancers2007

    • Author(s)
      Takahashi, H
    • Organizer
      The Asia-Pacific society for molecular and immunohistology
    • Place of Presentation
      Singapore
    • Year and Date
      2007-05-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 13q,6q,8p領域LOH解析による前立腺微小癌と主腫瘍の差2007

    • Author(s)
      中野 雅貴, 鷹橋 浩幸, ら
    • Organizer
      第96回日本病理学会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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