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Analysis of transcriptional regulation of RANK gene and osteoclastic differentiation in bone marrow microenvironment

Research Project

Project/Area Number 18590372
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionKobe University

Principal Investigator

KITAZAWA Riko  Kobe University, 医学研究科, 講師 (00273780)

Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywords破骨細胞 / RAMK / RANKL / 骨芽細胞 / 遺伝子プロモータ / サイトカイン / RANK
Research Abstract

マウス破骨細胞分化因子受容体RANKの遺伝子プロモータ領域をクローニングして発現制御機構を検討した。RANK遺伝子の転写開始部位より1kb以内には、血球分化に重要なPU.1(-480)、MITF(-100)結合配列が存在した。ゲルシフトアッセイにて、結合配列の蛋白DNA結合を証明し、変異を導入したプロモータを用いた解析にて、PU.1、MITFは、これらの結合配列に作用して、RANK転写を促進することを明らかにした。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (83 results)

All 2008 2007 2006

All Journal Article (35 results) (of which Peer Reviewed: 29 results) Presentation (45 results) Book (3 results)

  • [Journal Article] Modulation of mouse RANKL gene expression by Runx2 and vitamin D3 pathway2008

    • Author(s)
      Kitazawa R, Mori K, Yamaguchi A, Kondo T, Kitazawa S
    • Journal Title

      J Cell Biochem 105

      Pages: 1289-1297

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lipopolysaccharide suppresses RANK gene expression by macrophage through the down-regulation of PU.1 and MITF2008

    • Author(s)
      Ishii J, Kitazawa R, Mori K, McHugh KP, Kondo T, Kitazawa S
    • Journal Title

      J Cell Biochem 105

      Pages: 896-904

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dexamethasone promotes osteoclastogenesis by inhibiting osteoprotegerin through multiple levels2008

    • Author(s)
      Kondo T, Kitazawa R, Yamaguchi A ,Kitazawa S
    • Journal Title

      J Cell Biochem 103

      Pages: 335-345

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes2008

    • Author(s)
      Takahashi M, Takahashi Y, Takahashi K, Zolotaryov FN, Hong KS, Kitazawa R, Iida K, Okimura Y, Kaji H, Kitazawa S, Kasuga M,Chihara K
    • Journal Title

      FEBS Lett 582

      Pages: 573-578

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatic failure and enhanced oxidative stress in mitochondrial diabetes2008

    • Author(s)
      Takahashi Y, Iida K, Takeno R, Kitazawa R, Kitazawa S, Kitamura H, Fujioka Y, Yamada H, Kanda F, Ohta S, Nishimura K, Fujimoto M, Kondo T, Igucgi G, Takahashi K, Kaji H, Okimura Y, Chihara K
    • Journal Title

      Endocr J 55

      Pages: 509-514

    • NAID

      10021266426

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Taurin administration after appearance of proteinuria retards progression of diabetic nephropathy in rats2008

    • Author(s)
      Higo S, Miyata S, Jiang QY, Kitazawa R, Kitazawa S, Kasuga M
    • Journal Title

      Kobe J Med Sci 54

      Pages: 35-45

    • NAID

      110006648221

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypermethylation of epithelial-cadherin gene promoter is associated with Epstein-Barr virus in nasopharyngeal carcinoma2008

    • Author(s)
      Niemhom S, Kitazawa S, Kitazawa R, Maeda S, Leopairat J
    • Journal Title

      Cancer Detect Prev 32

      Pages: 127-134

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a major locus for islet inflammation and fibrosis in the Spontaneously Diabetic Torii rat2008

    • Author(s)
      Fuse M, Yokoi N, Shinohara M, Masuyama T, Kitazawa R, Kitazawa S,Seino S
    • Journal Title

      Physiological Genomics 35

      Pages: 96-105

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets2008

    • Author(s)
      Nishino N, Tamori Y, Tateya S, Kawaguchi T, Shibakusa T, Mizunoya W, Inoue K, Kitazawa R, Kitazawa S, Matsuki Y, Hiramatsu R, Masubuchi S, Omachi A, Kimura K, Saito M, Amo T, Ohta S, Yamaguchi T, Osumi T, Cheng J, Fujimoto T, Nakao H, NakaoK, Aiba A, Okamura H, Fushiki T, Kasuga M
    • Journal Title

      J Clin Invest 118

      Pages: 2808-2821

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] MeCP2expression and promoter methylation of cyclin D1gene are associated with cyclin D1expression in developing rat epididymalduc2008

    • Author(s)
      Darwanto A, Kitazawa R, Mori K, KondoT, Kitazawa
    • Journal Title

      Acta Histochem Cytochem 41

      Pages: 135-142

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] エピジェネティクスと病理2008

    • Author(s)
      北澤荘平, 近藤武史, 森清, 松田修一, 北澤理子
    • Journal Title

      臨床検査 52

      Pages: 665-661

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 話題 : メタボリック症候群2008

    • Author(s)
      北澤理子
    • Journal Title

      病理と臨床 26

      Pages: 518-519

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of mouse RANKL gene expression by Runx2 and vitamin D3 pathway.2008

    • Author(s)
      Kitazawa R., et al.
    • Journal Title

      J Cell Biochem 105

      Pages: 1289-1297

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lipopolysaccharide suppresses RANK gene expression by macrophage through the down-regulation of PU. 1 and MITF.2008

    • Author(s)
      Ishii J., et al.
    • Journal Title

      J Cell Biochem 105

      Pages: 896-904

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MeCP2 expression and promoter mcthylalion of cyclin D1 gene are associated with cyclin D1 expression in developing rat epididymalduct.2008

    • Author(s)
      Darwanto A., et al.
    • Journal Title

      Ada Histochcm Cylochem 41

      Pages: 135-142

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methylation status of a single CpG locus 3 bases upstream of TATA-box of RANKL gene promoter modulates cell- and tissue-specific RANKL expression and osteoclastogenesis2007

    • Author(s)
      Kitazawa R, Kitazawa S
    • Journal Title

      Mol Endocrnol 20

      Pages: 148-158

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Growth hormone reverses nonalcoholic steatohepatitis in a patient with adult growth hormone deficiency2007

    • Author(s)
      Takahashi Y, Iida K, Takahashi K, Yoshioka S, Fukuoka H, Takeno R, Imamura M, Nishizawa H, Takahashi M, Seo Y, Hayashi Y, Kondoh T, Okimura Y, Kaji H, Kitazawa R, Kitazawa S, Chihara K
    • Journal Title

      Gastroenterology 132

      Pages: 938-138

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histomorphometric analysis of Diabetic Osteopenia in Streptozotocin-induced Diabetic Mice : a Possible Role of Oxidative Stress2007

    • Author(s)
      Hamada Y, Kitazawa S, Kitazawa R, Fujii H, Kasuga M, Fukagawa M
    • Journal Title

      Bone 40

      Pages: 1408-1414

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of thioredoxin1in transgenic mice suppresses development of diabetic nephropathy2007

    • Author(s)
      Hamada Y, Miyata S, Nii-Kono T, Kitazawa R, Kitazawa S, Higo S, Fukunaga M, Ueyama S, Nakamura H, Yodoi J, Fukagawa M, Kasuga M
    • Journal Title

      Nephrol Dial Transplant 22

      Pages: 1547-1557

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dexamethasone Promotes Osteoclastogenesis by Inhibiting Osteoprotegerin through Multiple Levels.2007

    • Author(s)
      Kondo T., et. al.
    • Journal Title

      J Cell Biochem 103

      Pages: 335-345

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histomorphometric Analysis of Diabetic Osteopenia in Streptozotocin-induced Diabetic Mice: a Possible Role of Oxidative Stress2007

    • Author(s)
      Hamada Y., et. al.
    • Journal Title

      Bone 40

      Pages: 938-943

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unsuspected Uterine Leiomyosarcoma: MR Imaging Findings before and after Focused Ultrasound Surgery(FUS)2007

    • Author(s)
      Fukunishi H., et. al.
    • Journal Title

      Int J Gynecolog Cancer 17

      Pages: 724-728

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methylation status of a single CpG locus 3 bases upstream of TATA-box of RANKL gene promoter modulates cell- and tissue-specific RANKL expression and osteoclastogenesis2007

    • Author(s)
      Kitazawa R, et al.
    • Journal Title

      Mol Endocrnol 21・1

      Pages: 148-158

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Growth hormone reverses nonalcoholic steatohepatitis in a patient with adult growth hormone deficiency.2007

    • Author(s)
      Takahashi Y, et al.
    • Journal Title

      Gastroenterology (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression profiles of genes related to osteoclastogenesis in mouse growth plate and articular cartilage2006

    • Author(s)
      Kishimoto K, Kitazawa R, Kurosaka M, Maeda S, Kitazawa S
    • Journal Title

      Histochem Cell Biol 8

      Pages: 1-10

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] In situ detection of specific gene expression during and immediately after transcription at electron microscopic level2006

    • Author(s)
      Kitazawa S, Kitazawa R
    • Journal Title

      J Structural Biol 153

      Pages: 64-72

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of mouse RANKL gene expression by Runx2 and PKA pathway2006

    • Author(s)
      Mori K, Kitazawa R, Kondo T, Yamaguchi A, Maeda S, Kitazawa S
    • Journal Title

      J Cell Biochem 98

      Pages: 1629-1644

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] insulin resistance, and hepatic steatosis in obesity2006

    • Author(s)
      MCP-1 contributes to macrophage infiltration into adipose tissue
    • Journal Title

      J Clin Invest 166

      Pages: 1494-1505

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression and functional analysis of menin in a multiple endocrine neoplasia type I(MENI)patient with somatic loss of heterozygosity in chromosome 11q13 and unidentified germline mutation of the MEN1 gene2006

    • Author(s)
      Naito J, Kaji H, Sowa H, Kitazawa R, Kitazawa S, Tsukada T, Hendy GN, Sugimoto T, Chihara K
    • Journal Title

      Endocrine 29

      Pages: 485-490

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protruding disordered loop of gC1qR is specifically exposed and related to antiapoptotic property in germ cell lineage2006

    • Author(s)
      Kitazawa S, Takenaka A, Kondo T, Mizoguchi A, Kitazawa R
    • Journal Title

      Histochem Cell Biol 126

      Pages: 449-452

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 骨吸収、骨形成の相互作用 5. RANKL、OPGの転写制御2006

    • Author(s)
      北澤荘平,北澤理子,森清,近藤武史
    • Journal Title

      THE BONE 20

      Pages: 321-326

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protruding disordered loop of gClqR is specifically exposed and related to antiapoptotic property in germ cell lineage.2006

    • Author(s)
      Kitazawa S, et al.
    • Journal Title

      Histochem Cell Biol 126・6

      Pages: 665-677

    • Related Report
      2006 Annual Research Report
  • [Journal Article] MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity.2006

    • Author(s)
      Kanda H, et al.
    • Journal Title

      J Clin Invest 116・6

      Pages: 1494-1505

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Modulation of mouse RANKL gene expression by Runx2 and PKA pathway.2006

    • Author(s)
      Mori K, et al.
    • Journal Title

      J Cell Biochem 98・6

      Pages: 1629-1644

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Lung carcinosarcoma with liposarcoma element. an autopsy case.2006

    • Author(s)
      Kitazawa R, et al.
    • Journal Title

      Pathol Int 56・8

      Pages: 449-452

    • NAID

      10020332518

    • Related Report
      2006 Annual Research Report
  • [Presentation] Lipopolysaccharide Suppresses RANK Gene Thought the Down-Regulation of PU.1 and MITF2008

    • Author(s)
      Kitazawa R, Ishii J, Kondo T, Mori K, K.P.McHugh, Kitazawa S
    • Organizer
      ASBMR 30th Annual Meeting
    • Place of Presentation
      Motreal, Canada
    • Related Report
      2008 Final Research Report
  • [Presentation] BAMBI Gene Is Epigenetically Silenced in a Subset of High-grade Bladder Cancer2008

    • Author(s)
      Kitazawa S, S.Sanda Khin, Mori K, Kondo T, Kitazawa R
    • Organizer
      ASBMR 30th Annual Meeting
    • Place of Presentation
      Motreal, Canada
    • Related Report
      2008 Final Research Report
  • [Presentation] Lipopolysaccaharide(LPS)は転写因子PU.1、MITF抑制を介してRANKはつげんを抑制する2008

    • Author(s)
      北澤理子, 石井淳子, 森清, 近藤武史,北澤荘平
    • Organizer
      第26回日本骨代謝学会総会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] 破骨細胞分化の制御機構2008

    • Author(s)
      北澤理子, 近藤武史, 森清, 石井淳子, 北澤荘平
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Related Report
      2008 Final Research Report
  • [Presentation] マウスBAMBI遺伝子発現調節機構の解析2008

    • Author(s)
      近藤武史, 北澤理子, 森清, 北澤荘平
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Related Report
      2008 Final Research Report
  • [Presentation] 急性期酸化的ストレスを介する骨吸収亢進メカニズムとマウスsFRP-4遺伝子発現再活性化機構の解析2008

    • Author(s)
      森清, 北澤理子, 近藤武史, 濱田康弘, 北澤荘平
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Related Report
      2008 Final Research Report
  • [Presentation] Epigenetical alteration of BAMBI gene during bladder cancer progression2008

    • Author(s)
      Khin Sann Sanda, 北澤理子,Aye Than Than, Win Ne, 近藤武史, 森清, 北澤荘平
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Related Report
      2008 Final Research Report
  • [Presentation] マウスRANK 遺伝子プロモーターの解析2008

    • Author(s)
      石井淳子、北澤理子、近藤武史、森清ね北澤荘平
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Related Report
      2008 Final Research Report
  • [Presentation] 新生mRNAの動態解析(シンポジウム2)2008

    • Author(s)
      北澤荘平, 北澤理子, 森清, 近藤武史
    • Organizer
      第113回日本解剖学会
    • Place of Presentation
      大分
    • Related Report
      2008 Final Research Report
  • [Presentation] 破骨細胞分化の制御機構2008

    • Author(s)
      北洋埋子, 他
    • Organizer
      第97回日本病理学会総会ワークショップ
    • Place of Presentation
      金沢
    • Related Report
      2008 Annual Research Report
  • [Presentation] 破骨細胞分化を制御する分子機構の解析(A演説)2007

    • Author(s)
      北澤 理子
    • Organizer
      第53回日本病理学会秋期特別総会
    • Place of Presentation
      東京
    • Year and Date
      2007-12-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] 新規ケモカイン、メタボカイン1はインスリン感受性と脂質代謝を調節する2007

    • Author(s)
      高橋路子, 高橋裕, 高橋健一, Zolotaryov Fyodor N, 洪卿秀, 飯田啓二, 高橋健太郎, 竹野亮子, 福岡秀規, 今中真理, 西澤衡, 加治秀介, 置村康彦, 清成寛, 大島尚子, 相澤慎一, 北澤理子, 北澤荘平, 千原和夫
    • Organizer
      第80回日本内分泌学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-15
    • Related Report
      2008 Final Research Report
  • [Presentation] 破骨細胞分化を制御する分子機構の解析2007

    • Author(s)
      北澤理子
    • Organizer
      第53回日本病理学会秋期特別総会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 多様化する骨粗鬆症研究 糖尿病性骨減少症における酸化ストレスの関与 チオレドキシン1トランスジェニックマウスを用いた検討2007

    • Author(s)
      濱田康弘, 藤井秀毅, 北澤理子, 北澤荘平, 深川雅史
    • Organizer
      第9回日本骨粗鬆症学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 日本とミャンマーにおける膀胱腫瘍進展過程におけるBAMBI遺伝子のエピジェネティクス制御の変化2007

    • Author(s)
      サン サンダキン, 北澤理子, 近藤武史, 森清, タイタンエイ, ネウイン, 北澤荘平
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] 短期間酸化的ストレスによる骨代謝関連遺伝子発現の網羅的解析2007

    • Author(s)
      森清, 北澤理子, 近藤武史,濱田康弘, 北澤荘平
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] マウスBAMBI遺伝子発現調節機構2007

    • Author(s)
      近藤武史, 北澤理子, 森清, 北澤荘平
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] Modulation of Mouse RANKL Gene Expression by Runx2 and Vitamin D32007

    • Author(s)
      Kitazawa R, Mori K, Kondo T, Kitazawa S
    • Organizer
      ASBMR 29th Annual Meeting
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Kitazawa S. Molecular Cloning and Characterization of Mouse RANK Gene Promoter Region2007

    • Author(s)
      Ishii J, Kitazawa R, Kondo T, Mori K, McHugh K.P.
    • Organizer
      ASBMR 29th Annual Meeting
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Regulation of Mouse BAMBI Gene Expression2007

    • Author(s)
      Kondo T, Kitazawa R, Mori K, Kitazawa S
    • Organizer
      ASBMR 29th Annual Meeting
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Comprehensive Analysis of Bone-related Genes Expression Induced by Acute Oxidative Stress2007

    • Author(s)
      Mori K, Kitazawa R, Kondo T, Hamada Y, Kitazawa S
    • Organizer
      ASBMR 29th Annual Meeting
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Thioredoxin-1 Overexpression Attenuates Streptozotocin-induced Diabetic Osteopenia in Mice: A Novel Role of Oxidative Stress and Therapeutic Implications2007

    • Author(s)
      Hamada Y, Fujii H, Kitazawa R, Kitazawa S, Fukagawa M
    • Organizer
      ASBMR 29th Annual Meeting
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Runx2とvitaminn D3による破骨細胞分化因子(RANKL)発現制御2007

    • Author(s)
      北澤理子, 森清, 近藤武史, 北澤荘平
    • Organizer
      第25回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] マウスRANK遺伝子プロモーター領域の解析2007

    • Author(s)
      石井淳子, 北澤理子, 近藤武史, 森清, 北澤荘平
    • Organizer
      第25回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] マウスBAMBI遺伝子発現調節機構の解析2007

    • Author(s)
      近藤武史, 北澤理子, 森清, 北澤荘平
    • Organizer
      第25回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] 抗酸化物質チオレドキシン1の糖尿病性骨減少に及ぼす影響 : チオレドキシン1トランスジェニックマウスを用いた検討2007

    • Author(s)
      濱田康弘, 藤井秀毅, 北澤理子, 北澤荘平, 深川雅史
    • Organizer
      第25回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] 急性期酸化的ストレスによる骨代謝関連遺伝子発現の網羅的解析2007

    • Author(s)
      森清, 北澤理子, 近藤武史, 濱田康弘, 北澤荘平
    • Organizer
      第25回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] マウスRANK 遺伝子プロモーターの解析2007

    • Author(s)
      石井淳子, 北澤理子, 近藤武史, 北澤荘平
    • Organizer
      第96回日本病理学会総会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] TATA-box近傍のCpGメチル化による破骨細胞分化因子(RANKL)転写抑制機構2007

    • Author(s)
      北澤理子, 森清, 近藤武史, 北澤荘平
    • Organizer
      第96回日本病理学会総会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] マウスBAMBI遺伝子発現調節機構の解析2007

    • Author(s)
      近藤武史, 北澤理子, 北澤荘平
    • Organizer
      第96回日本病理学会総会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] 急性期酸化的ストレス下における骨代謝関連遺伝子発現の網羅的解析2007

    • Author(s)
      森清, 北澤理子, 近藤武史, 濱田康弘, 北澤荘平
    • Organizer
      第96回日本病理学会総会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] 子宮平滑筋腫における集束超音波治療(FUS)抵抗性の機序2007

    • Author(s)
      北澤荘平, 福西秀信, 舟木馨, 北澤理子
    • Organizer
      第96回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] SOD-1遺伝子異常の証明された家族性筋萎縮性側索硬化症の一例2007

    • Author(s)
      藤本昌代, 北澤理子, 近藤武史, 森清, 北澤荘平
    • Organizer
      第96回日本病理学会総会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] 日本、ミャンマー両国の膀胱腫瘍発生に関するエピジェネティクス解析2007

    • Author(s)
      Sann Sanda Khin, 北澤理子, 近藤武史, 森清, 北澤荘平
    • Organizer
      第96回日本病理学会総会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] 肺癌剖検症例における肺内アスベスト小体濃度についての検討2007

    • Author(s)
      出射由香, 松本省司, 釜田里江, 大西一男, 北澤理子, 北澤荘平
    • Organizer
      第96回日本病理学会総会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] 悪性中皮腫剖検例の免疫組織化学による再検討2007

    • Author(s)
      兵頭香織, 北澤理子, 近藤武史, 森清, 北澤荘平
    • Organizer
      第96回日本病理学会総会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] Regulation of Mouse BAMBI Gene Expression2006

    • Author(s)
      Kondo T, Kitazawa R, Kitazawa S
    • Organizer
      IOF+ANZBMS Combined Meeting
    • Place of Presentation
      Mirage, Australia
    • Related Report
      2008 Final Research Report
  • [Presentation] Regulation of Osteoclastogenesis by CpG Methylation of Mouse Receptor Activator of NF-kB Ligand(RANKL)Gene Promoter Region2006

    • Author(s)
      Kitazawa R, Mori K, Kondo T, Kitazawa S
    • Organizer
      ASBMR 28th Annual Meeting
    • Place of Presentation
      Philadeophia, Pennsylvania, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Regulation of Mouse BAMBI Gene Expression2006

    • Author(s)
      Kondo T, Kitazawa R, Kitazawa S
    • Organizer
      ASBMR 28th Annual Meeting
    • Place of Presentation
      Philadeophia, Pennsylvania, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Modulation of Mouse RANKL Gene Expression by Runx2 and the PKA Pathway2006

    • Author(s)
      Mori K, Kitazawa R, Kondo T, Yamaguchi A, Kitazawa S
    • Organizer
      ASBMR 28th Annual Meeting
    • Place of Presentation
      Philadeophia, Pennsylvania, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] In Situ of Specific Gene Expression During and Immediately After Transcription at Electron Microscopic Level2006

    • Author(s)
      Kitazawa S, Kitazawa R, Fujimoto M, Mori K, Sann Sanda Khin, Ishii J, Kondo T
    • Organizer
      In Situ of Specific Gene Expression During and Immediately After Transcription at Electron Microscopic Level
    • Place of Presentation
      Sapporo
    • Related Report
      2008 Final Research Report
  • [Presentation] In Situ of Specific Gene Expression During and Immediately After Transcription at Electron Microscopic Level2006

    • Author(s)
      北澤理子, 森清, 近藤武史, 北澤荘平
    • Organizer
      第24回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] マウスBAMBI遺伝子発現調節機構の解析2006

    • Author(s)
      近藤武史, 北澤理子, 北澤荘平
    • Organizer
      第24回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] ストレプトゾトシン誘発糖尿病マウスにおける骨病変は酸化ストレス亢進を伴った低回転骨である2006

    • Author(s)
      濱田康弘, 河野(新居)智子, 北澤理子, 北澤荘平, 深川雅史
    • Organizer
      第24回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Regulation of Mouse Osteoprotegerin Gene Expression by Glucocorticoids2006

    • Author(s)
      Kondo T, Kitazawa R, Kitazawa S
    • Organizer
      Ist International Conference on Osteoimmunology : Interactions of the Immune and Skeletal Systems
    • Place of Presentation
      Crete, Greece
    • Related Report
      2008 Final Research Report
  • [Book] DNA Methylation Research Trends, Epigenetic roles of CpG methylation at non-CpG-islands revealed (Editor ; Kobayashi TB)by morphology-oriented epigenetic research pp43-pp662007

    • Author(s)
      Kitazawa S, Mori K, Kondo T, Fujimoto M, Kitazawa R
    • Total Pages
      276
    • Publisher
      Nova Science Publishers, New York
    • Related Report
      2008 Final Research Report
  • [Book] DNA Methylation Research Trends2007

    • Author(s)
      T. B. Kobayashi
    • Total Pages
      200
    • Publisher
      Nova Science Publishers Inc
    • Related Report
      2007 Annual Research Report
  • [Book] Epigenetic roles of CpG methylation at non-CpG-islands revealed by morphology-oriented epigenetic research. In ; DNA Methylation Research2007

    • Author(s)
      Kitazawa S, et al.
    • Total Pages
      240
    • Publisher
      Nova Science Publishers, Inc. Hauppauge, New York
    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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