Analysis of transcriptional regulation of RANK gene and osteoclastic differentiation in bone marrow microenvironment
| Project/Area Number |
18590372
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Kobe University |
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Principal Investigator |
KITAZAWA Riko Kobe University, 医学研究科, 講師 (00273780)
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| Project Period (FY) |
2006 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | 破骨細胞 / RAMK / RANKL / 骨芽細胞 / 遺伝子プロモータ / サイトカイン / RANK |
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| Research Abstract |
マウス破骨細胞分化因子受容体RANKの遺伝子プロモータ領域をクローニングして発現制御機構を検討した。RANK遺伝子の転写開始部位より1kb以内には、血球分化に重要なPU.1(-480)、MITF(-100)結合配列が存在した。ゲルシフトアッセイにて、結合配列の蛋白DNA結合を証明し、変異を導入したプロモータを用いた解析にて、PU.1、MITFは、これらの結合配列に作用して、RANK転写を促進することを明らかにした。
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Report
(4 results)
Research Products
(83 results)
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[Journal Article] Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes2008
Author(s)
Takahashi M, Takahashi Y, Takahashi K, Zolotaryov FN, Hong KS, Kitazawa R, Iida K, Okimura Y, Kaji H, Kitazawa S, Kasuga M,Chihara K
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Journal Title
FEBS Lett 582
Pages: 573-578
Related Report
Peer Reviewed
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[Journal Article] Hepatic failure and enhanced oxidative stress in mitochondrial diabetes2008
Author(s)
Takahashi Y, Iida K, Takeno R, Kitazawa R, Kitazawa S, Kitamura H, Fujioka Y, Yamada H, Kanda F, Ohta S, Nishimura K, Fujimoto M, Kondo T, Igucgi G, Takahashi K, Kaji H, Okimura Y, Chihara K
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Journal Title
Endocr J 55
Pages: 509-514
NAID
Related Report
Peer Reviewed
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[Journal Article] FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets2008
Author(s)
Nishino N, Tamori Y, Tateya S, Kawaguchi T, Shibakusa T, Mizunoya W, Inoue K, Kitazawa R, Kitazawa S, Matsuki Y, Hiramatsu R, Masubuchi S, Omachi A, Kimura K, Saito M, Amo T, Ohta S, Yamaguchi T, Osumi T, Cheng J, Fujimoto T, Nakao H, NakaoK, Aiba A, Okamura H, Fushiki T, Kasuga M
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Journal Title
J Clin Invest 118
Pages: 2808-2821
Related Report
Peer Reviewed
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[Journal Article] Growth hormone reverses nonalcoholic steatohepatitis in a patient with adult growth hormone deficiency2007
Author(s)
Takahashi Y, Iida K, Takahashi K, Yoshioka S, Fukuoka H, Takeno R, Imamura M, Nishizawa H, Takahashi M, Seo Y, Hayashi Y, Kondoh T, Okimura Y, Kaji H, Kitazawa R, Kitazawa S, Chihara K
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Journal Title
Gastroenterology 132
Pages: 938-138
Related Report
Peer Reviewed
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[Journal Article] Overexpression of thioredoxin1in transgenic mice suppresses development of diabetic nephropathy2007
Author(s)
Hamada Y, Miyata S, Nii-Kono T, Kitazawa R, Kitazawa S, Higo S, Fukunaga M, Ueyama S, Nakamura H, Yodoi J, Fukagawa M, Kasuga M
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Journal Title
Nephrol Dial Transplant 22
Pages: 1547-1557
Related Report
Peer Reviewed
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[Presentation] 新規ケモカイン、メタボカイン1はインスリン感受性と脂質代謝を調節する2007
Author(s)
高橋路子, 高橋裕, 高橋健一, Zolotaryov Fyodor N, 洪卿秀, 飯田啓二, 高橋健太郎, 竹野亮子, 福岡秀規, 今中真理, 西澤衡, 加治秀介, 置村康彦, 清成寛, 大島尚子, 相澤慎一, 北澤理子, 北澤荘平, 千原和夫
Organizer
第80回日本内分泌学会学術総会
Place of Presentation
東京
Year and Date
2007-06-15
Related Report
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