Analysis of transcriptional regulation of RANK gene and osteoclastic differentiation in bone marrow microenvironment

• Project/Area Number: 18590372
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Kobe University
• Principal Investigator: KITAZAWA Riko Kobe University, 医学研究科, 講師 (00273780)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: 破骨細胞 / RAMK / RANKL / 骨芽細胞 / 遺伝子プロモータ / サイトカイン / RANK

Research Abstract

マウス破骨細胞分化因子受容体RANKの遺伝子プロモータ領域をクローニングして発現制御機構を検討した。RANK遺伝子の転写開始部位より1kb以内には、血球分化に重要なPU.1(-480)、MITF(-100)結合配列が存在した。ゲルシフトアッセイにて、結合配列の蛋白DNA結合を証明し、変異を導入したプロモータを用いた解析にて、PU.1、MITFは、これらの結合配列に作用して、RANK転写を促進することを明らかにした。

Research Products

• [Journal Article] Modulation of mouse RANKL gene expression by Runx2 and vitamin D3 pathway (2008)
  • Author(s): Kitazawa R, Mori K, Yamaguchi A, Kondo T, Kitazawa S
  • Journal Title: J Cell Biochem 105 Pages: 1289-1297
  • Peer Reviewed
• [Journal Article] Lipopolysaccharide suppresses RANK gene expression by macrophage through the down-regulation of PU.1 and MITF (2008)
  • Author(s): Ishii J, Kitazawa R, Mori K, McHugh KP, Kondo T, Kitazawa S
  • Journal Title: J Cell Biochem 105 Pages: 896-904
  • Peer Reviewed
• [Journal Article] Dexamethasone promotes osteoclastogenesis by inhibiting osteoprotegerin through multiple levels (2008)
  • Author(s): Kondo T, Kitazawa R, Yamaguchi A ,Kitazawa S
  • Journal Title: J Cell Biochem 103 Pages: 335-345
  • Peer Reviewed
• [Journal Article] Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes (2008)
  • Author(s): Takahashi M, Takahashi Y, Takahashi K, Zolotaryov FN, Hong KS, Kitazawa R, Iida K, Okimura Y, Kaji H, Kitazawa S, Kasuga M,Chihara K
  • Journal Title: FEBS Lett 582 Pages: 573-578
  • Peer Reviewed
• [Journal Article] Hepatic failure and enhanced oxidative stress in mitochondrial diabetes (2008)
  • Author(s): Takahashi Y, Iida K, Takeno R, Kitazawa R, Kitazawa S, Kitamura H, Fujioka Y, Yamada H, Kanda F, Ohta S, Nishimura K, Fujimoto M, Kondo T, Igucgi G, Takahashi K, Kaji H, Okimura Y, Chihara K
  • Journal Title: Endocr J 55 Pages: 509-514
  • NAID: 10021266426
  • Peer Reviewed
• [Journal Article] Taurin administration after appearance of proteinuria retards progression of diabetic nephropathy in rats (2008)
  • Author(s): Higo S, Miyata S, Jiang QY, Kitazawa R, Kitazawa S, Kasuga M
  • Journal Title: Kobe J Med Sci 54 Pages: 35-45
  • NAID: 110006648221
  • Peer Reviewed
• [Journal Article] Hypermethylation of epithelial-cadherin gene promoter is associated with Epstein-Barr virus in nasopharyngeal carcinoma (2008)
  • Author(s): Niemhom S, Kitazawa S, Kitazawa R, Maeda S, Leopairat J
  • Journal Title: Cancer Detect Prev 32 Pages: 127-134
  • Peer Reviewed
• [Journal Article] Identification of a major locus for islet inflammation and fibrosis in the Spontaneously Diabetic Torii rat (2008)
  • Author(s): Fuse M, Yokoi N, Shinohara M, Masuyama T, Kitazawa R, Kitazawa S,Seino S
  • Journal Title: Physiological Genomics 35 Pages: 96-105
  • Peer Reviewed
• [Journal Article] FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets (2008)
  • Author(s): Nishino N, Tamori Y, Tateya S, Kawaguchi T, Shibakusa T, Mizunoya W, Inoue K, Kitazawa R, Kitazawa S, Matsuki Y, Hiramatsu R, Masubuchi S, Omachi A, Kimura K, Saito M, Amo T, Ohta S, Yamaguchi T, Osumi T, Cheng J, Fujimoto T, Nakao H, NakaoK, Aiba A, Okamura H, Fushiki T, Kasuga M
  • Journal Title: J Clin Invest 118 Pages: 2808-2821
  • Peer Reviewed
• [Journal Article] MeCP2expression and promoter methylation of cyclin D1gene are associated with cyclin D1expression in developing rat epididymalduc (2008)
  • Author(s): Darwanto A, Kitazawa R, Mori K, KondoT, Kitazawa
  • Journal Title: Acta Histochem Cytochem 41 Pages: 135-142
  • Peer Reviewed
• [Journal Article] エピジェネティクスと病理 (2008)
  • Author(s): 北澤荘平, 近藤武史, 森清, 松田修一, 北澤理子
  • Journal Title: 臨床検査 52 Pages: 665-661
  • Peer Reviewed
• [Journal Article] 話題 : メタボリック症候群 (2008)
  • Author(s): 北澤理子
  • Journal Title: 病理と臨床 26 Pages: 518-519
  • Peer Reviewed
• [Journal Article] Modulation of mouse RANKL gene expression by Runx2 and vitamin D3 pathway. (2008)
  • Author(s): Kitazawa R., et al.
  • Journal Title: J Cell Biochem 105 Pages: 1289-1297
  • Peer Reviewed
• [Journal Article] Lipopolysaccharide suppresses RANK gene expression by macrophage through the down-regulation of PU. 1 and MITF. (2008)
  • Author(s): Ishii J., et al.
  • Journal Title: J Cell Biochem 105 Pages: 896-904
  • Peer Reviewed
• [Journal Article] MeCP2 expression and promoter mcthylalion of cyclin D1 gene are associated with cyclin D1 expression in developing rat epididymalduct. (2008)
  • Author(s): Darwanto A., et al.
  • Journal Title: Ada Histochcm Cylochem 41 Pages: 135-142
  • Peer Reviewed
• [Journal Article] Methylation status of a single CpG locus 3 bases upstream of TATA-box of RANKL gene promoter modulates cell- and tissue-specific RANKL expression and osteoclastogenesis (2007)
  • Author(s): Kitazawa R, Kitazawa S
  • Journal Title: Mol Endocrnol 20 Pages: 148-158
  • Peer Reviewed
• [Journal Article] Growth hormone reverses nonalcoholic steatohepatitis in a patient with adult growth hormone deficiency (2007)
  • Author(s): Takahashi Y, Iida K, Takahashi K, Yoshioka S, Fukuoka H, Takeno R, Imamura M, Nishizawa H, Takahashi M, Seo Y, Hayashi Y, Kondoh T, Okimura Y, Kaji H, Kitazawa R, Kitazawa S, Chihara K
  • Journal Title: Gastroenterology 132 Pages: 938-138
  • Peer Reviewed
• [Journal Article] Histomorphometric analysis of Diabetic Osteopenia in Streptozotocin-induced Diabetic Mice : a Possible Role of Oxidative Stress (2007)
  • Author(s): Hamada Y, Kitazawa S, Kitazawa R, Fujii H, Kasuga M, Fukagawa M
  • Journal Title: Bone 40 Pages: 1408-1414
  • Peer Reviewed
• [Journal Article] Overexpression of thioredoxin1in transgenic mice suppresses development of diabetic nephropathy (2007)
  • Author(s): Hamada Y, Miyata S, Nii-Kono T, Kitazawa R, Kitazawa S, Higo S, Fukunaga M, Ueyama S, Nakamura H, Yodoi J, Fukagawa M, Kasuga M
  • Journal Title: Nephrol Dial Transplant 22 Pages: 1547-1557
  • Peer Reviewed
• [Journal Article] Dexamethasone Promotes Osteoclastogenesis by Inhibiting Osteoprotegerin through Multiple Levels. (2007)
  • Author(s): Kondo T., et. al.
  • Journal Title: J Cell Biochem 103 Pages: 335-345
  • Peer Reviewed
• [Journal Article] Histomorphometric Analysis of Diabetic Osteopenia in Streptozotocin-induced Diabetic Mice: a Possible Role of Oxidative Stress (2007)
  • Author(s): Hamada Y., et. al.
  • Journal Title: Bone 40 Pages: 938-943
  • Peer Reviewed
• [Journal Article] Unsuspected Uterine Leiomyosarcoma: MR Imaging Findings before and after Focused Ultrasound Surgery(FUS) (2007)
  • Author(s): Fukunishi H., et. al.
  • Journal Title: Int J Gynecolog Cancer 17 Pages: 724-728
  • Peer Reviewed
• [Journal Article] Methylation status of a single CpG locus 3 bases upstream of TATA-box of RANKL gene promoter modulates cell- and tissue-specific RANKL expression and osteoclastogenesis (2007)
  • Author(s): Kitazawa R, et al.
  • Journal Title: Mol Endocrnol 21・1 Pages: 148-158
• [Journal Article] Growth hormone reverses nonalcoholic steatohepatitis in a patient with adult growth hormone deficiency. (2007)
  • Author(s): Takahashi Y, et al.
  • Journal Title: Gastroenterology (in press)
• [Journal Article] Expression profiles of genes related to osteoclastogenesis in mouse growth plate and articular cartilage (2006)
  • Author(s): Kishimoto K, Kitazawa R, Kurosaka M, Maeda S, Kitazawa S
  • Journal Title: Histochem Cell Biol 8 Pages: 1-10
  • Peer Reviewed
• [Journal Article] In situ detection of specific gene expression during and immediately after transcription at electron microscopic level (2006)
  • Author(s): Kitazawa S, Kitazawa R
  • Journal Title: J Structural Biol 153 Pages: 64-72
  • Peer Reviewed
• [Journal Article] Modulation of mouse RANKL gene expression by Runx2 and PKA pathway (2006)
  • Author(s): Mori K, Kitazawa R, Kondo T, Yamaguchi A, Maeda S, Kitazawa S
  • Journal Title: J Cell Biochem 98 Pages: 1629-1644
  • Peer Reviewed
• [Journal Article] insulin resistance, and hepatic steatosis in obesity (2006)
  • Author(s): MCP-1 contributes to macrophage infiltration into adipose tissue
  • Journal Title: J Clin Invest 166 Pages: 1494-1505
  • Peer Reviewed
• [Journal Article] Expression and functional analysis of menin in a multiple endocrine neoplasia type I(MENI)patient with somatic loss of heterozygosity in chromosome 11q13 and unidentified germline mutation of the MEN1 gene (2006)
  • Author(s): Naito J, Kaji H, Sowa H, Kitazawa R, Kitazawa S, Tsukada T, Hendy GN, Sugimoto T, Chihara K
  • Journal Title: Endocrine 29 Pages: 485-490
  • Peer Reviewed
• [Journal Article] Protruding disordered loop of gC1qR is specifically exposed and related to antiapoptotic property in germ cell lineage (2006)
  • Author(s): Kitazawa S, Takenaka A, Kondo T, Mizoguchi A, Kitazawa R
  • Journal Title: Histochem Cell Biol 126 Pages: 449-452
  • Peer Reviewed
• [Journal Article] 骨吸収、骨形成の相互作用 5. RANKL、OPGの転写制御 (2006)
  • Author(s): 北澤荘平,北澤理子,森清,近藤武史
  • Journal Title: THE BONE 20 Pages: 321-326
  • Peer Reviewed
• [Journal Article] Protruding disordered loop of gClqR is specifically exposed and related to antiapoptotic property in germ cell lineage. (2006)
  • Author(s): Kitazawa S, et al.
  • Journal Title: Histochem Cell Biol 126・6 Pages: 665-677
• [Journal Article] MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. (2006)
  • Author(s): Kanda H, et al.
  • Journal Title: J Clin Invest 116・6 Pages: 1494-1505
• [Journal Article] Modulation of mouse RANKL gene expression by Runx2 and PKA pathway. (2006)
  • Author(s): Mori K, et al.
  • Journal Title: J Cell Biochem 98・6 Pages: 1629-1644
• [Journal Article] Lung carcinosarcoma with liposarcoma element. an autopsy case. (2006)
  • Author(s): Kitazawa R, et al.
  • Journal Title: Pathol Int 56・8 Pages: 449-452
  • NAID: 10020332518
• [Presentation] Lipopolysaccharide Suppresses RANK Gene Thought the Down-Regulation of PU.1 and MITF (2008)
  • Author(s): Kitazawa R, Ishii J, Kondo T, Mori K, K.P.McHugh, Kitazawa S
  • Organizer: ASBMR 30th Annual Meeting
  • Place of Presentation: Motreal, Canada
• [Presentation] BAMBI Gene Is Epigenetically Silenced in a Subset of High-grade Bladder Cancer (2008)
  • Author(s): Kitazawa S, S.Sanda Khin, Mori K, Kondo T, Kitazawa R
  • Organizer: ASBMR 30th Annual Meeting
  • Place of Presentation: Motreal, Canada
• [Presentation] Lipopolysaccaharide(LPS)は転写因子PU.1、MITF抑制を介してRANKはつげんを抑制する (2008)
  • Author(s): 北澤理子, 石井淳子, 森清, 近藤武史,北澤荘平
  • Organizer: 第26回日本骨代謝学会総会
  • Place of Presentation: 大阪
• [Presentation] 破骨細胞分化の制御機構 (2008)
  • Author(s): 北澤理子, 近藤武史, 森清, 石井淳子, 北澤荘平
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
• [Presentation] マウスBAMBI遺伝子発現調節機構の解析 (2008)
  • Author(s): 近藤武史, 北澤理子, 森清, 北澤荘平
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
• [Presentation] 急性期酸化的ストレスを介する骨吸収亢進メカニズムとマウスsFRP-4遺伝子発現再活性化機構の解析 (2008)
  • Author(s): 森清, 北澤理子, 近藤武史, 濱田康弘, 北澤荘平
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
• [Presentation] Epigenetical alteration of BAMBI gene during bladder cancer progression (2008)
  • Author(s): Khin Sann Sanda, 北澤理子,Aye Than Than, Win Ne, 近藤武史, 森清, 北澤荘平
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
• [Presentation] マウスRANK 遺伝子プロモーターの解析 (2008)
  • Author(s): 石井淳子、北澤理子、近藤武史、森清ね北澤荘平
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
• [Presentation] 新生mRNAの動態解析(シンポジウム2) (2008)
  • Author(s): 北澤荘平, 北澤理子, 森清, 近藤武史
  • Organizer: 第113回日本解剖学会
  • Place of Presentation: 大分
• [Presentation] 破骨細胞分化の制御機構 (2008)
  • Author(s): 北洋埋子, 他
  • Organizer: 第97回日本病理学会総会ワークショップ
  • Place of Presentation: 金沢
• [Presentation] 破骨細胞分化を制御する分子機構の解析(A演説) (2007)
  • Author(s): 北澤 理子
  • Organizer: 第53回日本病理学会秋期特別総会
  • Place of Presentation: 東京
  • Year and Date: 2007-12-06
• [Presentation] 新規ケモカイン、メタボカイン1はインスリン感受性と脂質代謝を調節する (2007)
  • Author(s): 高橋路子, 高橋裕, 高橋健一, Zolotaryov Fyodor N, 洪卿秀, 飯田啓二, 高橋健太郎, 竹野亮子, 福岡秀規, 今中真理, 西澤衡, 加治秀介, 置村康彦, 清成寛, 大島尚子, 相澤慎一, 北澤理子, 北澤荘平, 千原和夫
  • Organizer: 第80回日本内分泌学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2007-06-15
• [Presentation] 破骨細胞分化を制御する分子機構の解析 (2007)
  • Author(s): 北澤理子
  • Organizer: 第53回日本病理学会秋期特別総会
  • Place of Presentation: 東京
• [Presentation] 多様化する骨粗鬆症研究 糖尿病性骨減少症における酸化ストレスの関与 チオレドキシン1トランスジェニックマウスを用いた検討 (2007)
  • Author(s): 濱田康弘, 藤井秀毅, 北澤理子, 北澤荘平, 深川雅史
  • Organizer: 第9回日本骨粗鬆症学会
  • Place of Presentation: 東京
• [Presentation] 日本とミャンマーにおける膀胱腫瘍進展過程におけるBAMBI遺伝子のエピジェネティクス制御の変化 (2007)
  • Author(s): サン サンダキン, 北澤理子, 近藤武史, 森清, タイタンエイ, ネウイン, 北澤荘平
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] 短期間酸化的ストレスによる骨代謝関連遺伝子発現の網羅的解析 (2007)
  • Author(s): 森清, 北澤理子, 近藤武史,濱田康弘, 北澤荘平
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] マウスBAMBI遺伝子発現調節機構 (2007)
  • Author(s): 近藤武史, 北澤理子, 森清, 北澤荘平
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] Modulation of Mouse RANKL Gene Expression by Runx2 and Vitamin D3 (2007)
  • Author(s): Kitazawa R, Mori K, Kondo T, Kitazawa S
  • Organizer: ASBMR 29th Annual Meeting
  • Place of Presentation: Honolulu, Hawaii, USA
• [Presentation] Kitazawa S. Molecular Cloning and Characterization of Mouse RANK Gene Promoter Region (2007)
  • Author(s): Ishii J, Kitazawa R, Kondo T, Mori K, McHugh K.P.
  • Organizer: ASBMR 29th Annual Meeting
  • Place of Presentation: Honolulu, Hawaii, USA
• [Presentation] Regulation of Mouse BAMBI Gene Expression (2007)
  • Author(s): Kondo T, Kitazawa R, Mori K, Kitazawa S
  • Organizer: ASBMR 29th Annual Meeting
  • Place of Presentation: Honolulu, Hawaii, USA
• [Presentation] Comprehensive Analysis of Bone-related Genes Expression Induced by Acute Oxidative Stress (2007)
  • Author(s): Mori K, Kitazawa R, Kondo T, Hamada Y, Kitazawa S
  • Organizer: ASBMR 29th Annual Meeting
  • Place of Presentation: Honolulu, Hawaii, USA
• [Presentation] Thioredoxin-1 Overexpression Attenuates Streptozotocin-induced Diabetic Osteopenia in Mice: A Novel Role of Oxidative Stress and Therapeutic Implications (2007)
  • Author(s): Hamada Y, Fujii H, Kitazawa R, Kitazawa S, Fukagawa M
  • Organizer: ASBMR 29th Annual Meeting
  • Place of Presentation: Honolulu, Hawaii, USA
• [Presentation] Runx2とvitaminn D3による破骨細胞分化因子(RANKL)発現制御 (2007)
  • Author(s): 北澤理子, 森清, 近藤武史, 北澤荘平
  • Organizer: 第25回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
• [Presentation] マウスRANK遺伝子プロモーター領域の解析 (2007)
  • Author(s): 石井淳子, 北澤理子, 近藤武史, 森清, 北澤荘平
  • Organizer: 第25回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
• [Presentation] マウスBAMBI遺伝子発現調節機構の解析 (2007)
  • Author(s): 近藤武史, 北澤理子, 森清, 北澤荘平
  • Organizer: 第25回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 抗酸化物質チオレドキシン1の糖尿病性骨減少に及ぼす影響 : チオレドキシン1トランスジェニックマウスを用いた検討 (2007)
  • Author(s): 濱田康弘, 藤井秀毅, 北澤理子, 北澤荘平, 深川雅史
  • Organizer: 第25回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 急性期酸化的ストレスによる骨代謝関連遺伝子発現の網羅的解析 (2007)
  • Author(s): 森清, 北澤理子, 近藤武史, 濱田康弘, 北澤荘平
  • Organizer: 第25回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
• [Presentation] マウスRANK 遺伝子プロモーターの解析 (2007)
  • Author(s): 石井淳子, 北澤理子, 近藤武史, 北澤荘平
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 大阪
• [Presentation] TATA-box近傍のCpGメチル化による破骨細胞分化因子(RANKL)転写抑制機構 (2007)
  • Author(s): 北澤理子, 森清, 近藤武史, 北澤荘平
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 大阪
• [Presentation] マウスBAMBI遺伝子発現調節機構の解析 (2007)
  • Author(s): 近藤武史, 北澤理子, 北澤荘平
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 大阪
• [Presentation] 急性期酸化的ストレス下における骨代謝関連遺伝子発現の網羅的解析 (2007)
  • Author(s): 森清, 北澤理子, 近藤武史, 濱田康弘, 北澤荘平
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 大阪
• [Presentation] 子宮平滑筋腫における集束超音波治療(FUS)抵抗性の機序 (2007)
  • Author(s): 北澤荘平, 福西秀信, 舟木馨, 北澤理子
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] SOD-1遺伝子異常の証明された家族性筋萎縮性側索硬化症の一例 (2007)
  • Author(s): 藤本昌代, 北澤理子, 近藤武史, 森清, 北澤荘平
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 大阪
• [Presentation] 日本、ミャンマー両国の膀胱腫瘍発生に関するエピジェネティクス解析 (2007)
  • Author(s): Sann Sanda Khin, 北澤理子, 近藤武史, 森清, 北澤荘平
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 大阪
• [Presentation] 肺癌剖検症例における肺内アスベスト小体濃度についての検討 (2007)
  • Author(s): 出射由香, 松本省司, 釜田里江, 大西一男, 北澤理子, 北澤荘平
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 大阪
• [Presentation] 悪性中皮腫剖検例の免疫組織化学による再検討 (2007)
  • Author(s): 兵頭香織, 北澤理子, 近藤武史, 森清, 北澤荘平
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 大阪
• [Presentation] Regulation of Mouse BAMBI Gene Expression (2006)
  • Author(s): Kondo T, Kitazawa R, Kitazawa S
  • Organizer: IOF+ANZBMS Combined Meeting
  • Place of Presentation: Mirage, Australia
• [Presentation] Regulation of Osteoclastogenesis by CpG Methylation of Mouse Receptor Activator of NF-kB Ligand(RANKL)Gene Promoter Region (2006)
  • Author(s): Kitazawa R, Mori K, Kondo T, Kitazawa S
  • Organizer: ASBMR 28th Annual Meeting
  • Place of Presentation: Philadeophia, Pennsylvania, USA
• [Presentation] Regulation of Mouse BAMBI Gene Expression (2006)
  • Author(s): Kondo T, Kitazawa R, Kitazawa S
  • Organizer: ASBMR 28th Annual Meeting
  • Place of Presentation: Philadeophia, Pennsylvania, USA
• [Presentation] Modulation of Mouse RANKL Gene Expression by Runx2 and the PKA Pathway (2006)
  • Author(s): Mori K, Kitazawa R, Kondo T, Yamaguchi A, Kitazawa S
  • Organizer: ASBMR 28th Annual Meeting
  • Place of Presentation: Philadeophia, Pennsylvania, USA
• [Presentation] In Situ of Specific Gene Expression During and Immediately After Transcription at Electron Microscopic Level (2006)
  • Author(s): Kitazawa S, Kitazawa R, Fujimoto M, Mori K, Sann Sanda Khin, Ishii J, Kondo T
  • Organizer: In Situ of Specific Gene Expression During and Immediately After Transcription at Electron Microscopic Level
  • Place of Presentation: Sapporo
• [Presentation] In Situ of Specific Gene Expression During and Immediately After Transcription at Electron Microscopic Level (2006)
  • Author(s): 北澤理子, 森清, 近藤武史, 北澤荘平
  • Organizer: 第24回日本骨代謝学会学術集会
  • Place of Presentation: 東京
• [Presentation] マウスBAMBI遺伝子発現調節機構の解析 (2006)
  • Author(s): 近藤武史, 北澤理子, 北澤荘平
  • Organizer: 第24回日本骨代謝学会学術集会
  • Place of Presentation: 東京
• [Presentation] ストレプトゾトシン誘発糖尿病マウスにおける骨病変は酸化ストレス亢進を伴った低回転骨である (2006)
  • Author(s): 濱田康弘, 河野(新居)智子, 北澤理子, 北澤荘平, 深川雅史
  • Organizer: 第24回日本骨代謝学会学術集会
  • Place of Presentation: 東京
• [Presentation] Regulation of Mouse Osteoprotegerin Gene Expression by Glucocorticoids (2006)
  • Author(s): Kondo T, Kitazawa R, Kitazawa S
  • Organizer: Ist International Conference on Osteoimmunology : Interactions of the Immune and Skeletal Systems
  • Place of Presentation: Crete, Greece
• [Book] DNA Methylation Research Trends, Epigenetic roles of CpG methylation at non-CpG-islands revealed (Editor ; Kobayashi TB)by morphology-oriented epigenetic research pp43-pp66 (2007)
  • Author(s): Kitazawa S, Mori K, Kondo T, Fujimoto M, Kitazawa R
  • Total Pages: 276
  • Publisher: Nova Science Publishers, New York
• [Book] DNA Methylation Research Trends (2007)
  • Author(s): T. B. Kobayashi
  • Total Pages: 200
  • Publisher: Nova Science Publishers Inc
• [Book] Epigenetic roles of CpG methylation at non-CpG-islands revealed by morphology-oriented epigenetic research. In ; DNA Methylation Research (2007)
  • Author(s): Kitazawa S, et al.
  • Total Pages: 240
  • Publisher: Nova Science Publishers, Inc. Hauppauge, New York