Establishment of an experimental therapy for aggressive renal cell carcinoma by knock-down of SPARC gene expression.

• Project/Area Number: 18590376
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Yokohama City University
• Principal Investigator: NAGASHIMA Yoji Yokohama City University, GRADUATE SCHOOL OF MEDICINE, DEPARTMENT OF MOLECULAR PATHOLOGY AND ONCOLOGY, ASSOCIATE PROFESSOR (10217995)
• Co-Investigator(Kenkyū-buntansha): YAO Masahiro YOKOHAMA CITY UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, DEPARTMENT OF UROLOGIC MOLECULAR GENETICS, ASSOCIATE PROFESSOR (00260787)
• Project Period (FY): 2006 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥3,960,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥360,000); Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2006: ¥2,400,000 (Direct Cost: ¥2,400,000)
• Keywords: SPARC / siRNA / renal cell carcinoma / Experimental therapy / 浸潤転移

Research Abstract

Renal cell carcinoma (RCC) involves heterogenous subtypes of tumors with different pathology and molecular biological abnormalities. Although most of RCCs is successfully treated with surgery after detection in the early stages, several histological types, i.e. sarcomatoid and collecting duct carcinoma are aggressive and resistant to adjuvant treatment. This research aimed to establish a novel therapy for aggressive RCCs by knock down the SPARC gene expression by siRNA. For suppress the SPARC gene expression, we synthesized 21base pair dsRNAs and introduced them into RCC cell lines by the Lipofectamine method. Only one cell line DRY showed decreased expression of SPARC, but not other three lines (ACHN, CAM-1, YCR) .DRY failed to show growth suppression, colony formation on agar plates or tumorigenicity in nude mice.
The value of SPARC as the molecular target of RCC treatment should be carefully reevaluated. In future, we should examine the other molecules in the HIF-VEGF-SAPRC pathway as the target.

Research Products

• [Journal Article] Prostaglandin E(1) improves survival rate after 95% hepatectomy in rat s (2008)
  • Author(s): Togo, S, et. al.
  • Journal Title: Journal of Surgical Research 146(1) Pages: 66-72
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Carcinoid tumor of the renal pelvis:Consideration on the histogenesis (2008)
  • Author(s): Kuroda, N, et. al.
  • Journal Title: Pathol lnt 58(1) Pages: 51-54
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Mutations of c-kit gene in bilateral testicular germ cell tumours in Japan (2008)
  • Author(s): Sakuma, Y, et. al.
  • Journal Title: Cancer Lett 259(2) Pages: 119-126
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Chromophobe rrenal cell carcinoma and "capsuloma" with acquired cystic disease of the kidney in a long-term hemodialysis patient:a case report (2008)
  • Author(s): Nishihara, K, et. al.
  • Journal Title: Int J Urol 15(6) Pages: 543-545
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Ethmoidal lipid-rich carcinoma with focal glandular structures (2008)
  • Author(s): Oshiro, H, et. al.
  • Journal Title: Archives of Otolaryngology-Head & Neck Surgery (In Press)(掲載確定)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The overexpression and altered localization of the atypical Protein Kinase C λ/t in breast cancer correlates with the pathological type of these tumors (2008)
  • Author(s): Kojima, Y, Nagashima, Y(Correspondence), et. al.
  • Journal Title: Human Pathology (In press)(掲載確定)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Collecting duct carcinoma of the kidney:an immunohistochemical evaluation of the use of antibodies for differential diagnosis (2008)
  • Author(s): Kobayashi, N, Nagashima, Y(Correspondence), et. al.
  • Journal Title: Human Pathology (In press)(掲載確定)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 5-Aza-2'-deoxycytidine suppresses human renal carcinoma cell growth in axenograft model via up-regulation of the connexin 32 gene (2008)
  • Author(s): Hagiwara, H, et. al.
  • Journal Title: British Journal of Pharmacology (In press)(掲載確定)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Renal collecting duct carcinoma in a dog (2008)
  • Author(s): Kobayashi, N, et. al.
  • Journal Title: Vet Pathol (In press)(掲載確定)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A three-gene expression signature model to predict clinical outcome of clear cell renal carcinoma (2008)
  • Author(s): Yao, M, et. al.
  • Journal Title: Int J Cancer (In press)(掲載確定)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Role of nitric oxide synthesized by nitric oxide synthase 2 in liver regeneration (2008)
  • Author(s): Kumamoto, T, Nagashima, Y(Correspondence), et. al.
  • Journal Title: Liver International (In press)(掲載確定)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Effectiveness of antiplatelet drugs against experimental non-alcoholic fatty liver disease (2008)
  • Author(s): Fujita, K, et. al.
  • Journal Title: Gut (In press)(掲載確定)
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• [Journal Article] Antitumour effctofelectrochemotherapy with bleomycin on human prostatic cancer xenograft (2008)
  • Author(s): Ueki, T, et. al.
  • Journal Title: Brit J Urol (In press)(掲載確定)
  • Description: 「研究成果報告書概要(和文)」より
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• [Journal Article] Heme oxygenase 1 attenuates the development of atopic dermatitis-like lesions in mice:imphcations for human disease (2008)
  • Author(s): Kirino, M, et. al.
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• [Journal Article] Makignant Mullerian tumor(carcinosarcoma)in mixed epithelial and stromal tumor of the kiduey:A morphological and molecular genetic study (2008)
  • Author(s): Kuroda, N, et. al.
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• [Journal Article] Semaphorin3A alleviates skin lesions and scratching behavior in NC/Nga mice,an atopic dermatitis model (2008)
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  • Description: 「研究成果報告書概要(和文)」より
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• [Journal Article] 稀な低悪性度腎癌Mucinous tubular and spindle cell carcinomaの病理学的検討 (2008)
  • Author(s): 黒田 陽子, 他
  • Journal Title: 同愛医学雑誌 24(1) Pages: 115-120
  • Description: 「研究成果報告書概要(和文)」より
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• [Journal Article] 後腎性腺腫metanephric adenomaの2例 (2008)
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  • Description: 「研究成果報告書概要(和文)」より
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• [Journal Article] 症例解説2005 通常の腎細胞癌と区別されるべき腎腫瘍の2例:後腎性腺腫・mucinous tubular spindle cell carcinoma (2008)
  • Author(s): 長嶋 洋治, 他
  • Journal Title: 病理と臨床 24(10) Pages: 1120-1121
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 第二部 腎臓(手術) (2008)
  • Author(s): 長嶋 洋治, 他
  • Journal Title: 病理と臨床26『外科病理マニュアル』 26(臨時増刊号) Pages: 277-282
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Prostaglandin E(1)improves survival rate after 95% hepatectomy in rats (2008)
  • Author(s): Togo, S, Chen, H, Takahashi, T, Kubota, T, Matsuo, K, Morioka, D, Watanabe, K, Yamamoto, H, Nagashima, Y, Shimada, H
  • Journal Title: J Surg Res 146(1) Pages: 66-72
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Carcinoid tumor of the renal pelvis: Consideration on the histogenesis (2008)
  • Author(s): Kuroda, N, Katto, K, Tamura, M, Shiotsu, T, Hes, O, Michal, M, Nagashima, Y, Ohara, M, Hirouchi, T, Mizuno, K, Hayashi, Y, Lee, G-H
  • Journal Title: Pathol Int 58(1) Pages: 51-54
  • NAID: 10027375514
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mutations of c-kit gene in bilateral testicular germ cell tumours(in Japan) (2008)
  • Author(s): Sakuma, Y, Matsukuma, S, Yoshihara, M, Sakurai, S, Nishii, M, Kishida, T, Kubota, Y, Nagashima, Y, Inayama, Y, Sasaki, T, Nakamura, Y, Miura, T, Kameda, Y, Tsuchiya, E, Miyagi, Y
  • Journal Title: Cancer Lett 259(2) Pages: 119-126
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Chromophobe rrenal cell carcinoma and "capsuloma" with acquired cystic disease of the kidney in a long-term hemodialysis patient: a case report (2008)
  • Author(s): Nishihara, K, Shomori, K, Nagashima, Y, Kuroda, N, Nagamatsu, H, Ito, H
  • Journal Title: Int J Urol 15(6) Pages: 543-545
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 5-Aza-2'-deoxycytidine suppresses human renal carcinoma cell growth in a xenograft model via up-regulation of the connexin 32 gene (2008)
  • Author(s): Hagiwara, H, Sato, H, Ohde, Y, Takano, Y, Seki, T, Ariga, T, Hokaiwado, N, Asamoto, M, Shirai, T, Nagashima, Y, Yano, T
  • Journal Title: Br J Pharmacol
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Collecting duct carcinoma of the kidney: an immunohistochemical evaluation of the use of antibodies for differential diagnosis (2008)
  • Author(s): Kobayashi, N Nagashima, Y(Correspondence), et. al.
  • Journal Title: Human Pathology (In press)(掲載確定)
  • Peer Reviewed
• [Journal Article] The overexpression and altered localization of the atypical Protein Kinase C λ/ι in breast cancer correlates with the pathological type of these tumors. (2008)
  • Author(s): Kojima, Y Nagashima, Y(Correspondence), et. al.
  • Journal Title: Human Pathology (In press)(掲載確定)
  • Peer Reviewed
• [Journal Article] Role of nitric oxide synthesized by nitric oxide synthase 2 in liver regeneration. (2008)
  • Author(s): Kumamoto, T Nagashima, Y(Correspondence), et. al.
  • Journal Title: Liver International (In press)(掲載確定)
  • Peer Reviewed
• [Journal Article] 5-Aza-2'-deoxycytidine suppresses human renal carcinoma cell growth in a xenograft model via up-regulation of the connexin 32 gene. (2008)
  • Author(s): Hagiwara, H, et. al.
  • Journal Title: British Journal of Pharmacology (In press)(掲載確定)
  • Peer Reviewed
• [Journal Article] Production of functional spermatids from mouse germline stem cells in ectopically reconstituted seminiferous tubules (2007)
  • Author(s): Kita, K, et. al.
  • Journal Title: Biology of Reproduction 76(2) Pages: 211-217
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Prognostic value of integrin beta1-ILK-pAkt signaling pathway in non-small cell lung cancer (2007)
  • Author(s): Okamura, M, et. al.
  • Journal Title: Human Pathology 38(4) Pages: 1081-1091
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Expression of adipose differentiation-related protein:a predictor of cancer-specific survival in clear cell renal carcinoma (2007)
  • Author(s): Yao, M, et. al.
  • Journal Title: Clinical Cancer Research 13(1) Pages: 152-160
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Identification and characterization of the Birt-Hogg-Dube associated renal carcinoma (2007)
  • Author(s): Murakami T, et. al.
  • Journal Title: American Journal of Pathology 211(5) Pages: 524-531
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] ARPP protein is selectively expressed in renaloncocytoma,but rarely in renal cell carcinomas (2007)
  • Author(s): Shomori K, et. al.
  • Journal Title: Modern Pathology 20(2) Pages: 199-207
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Androgen receptor signals promote bladder cancer development and progression (2007)
  • Author(s): Miyanloto H, et. al.
  • Journal Title: Journal of The National Cancer Institute 99(7) Pages: 558-568
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Interleukin-15 inhibits smooth muscle cell proliferation and hyaluronan production in rat ductus arteriosus (2007)
  • Author(s): Iwasaki, S, et. al.
  • Journal Title: Pediatric Research 62(4) Pages: 392-398
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] PAI-1 plays an important role in liver fhilure after excessive hepatectomy in the rat (2007)
  • Author(s): Watanabe, K, et. al.
  • Journal Title: Journal of Surgical Research 143(1) Pages: 13-19
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 5-Aminosalicylic acid given in the remission stage of colitis suppresses colitis-associated caocer in a mouse colitis model (2007)
  • Author(s): Ikeda, I, et. al.
  • Journal Title: Clinical Cancer Research 13(21) Pages: 6527-6531
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The inhibitory effect of Connexin 32 gene on metastasis in renal cell carcinoma (2007)
  • Author(s): Sato, H, et. al.
  • Journal Title: Molecular carcinogenesis (Epub ahead of print)(掲載確定)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 4回の外科的切除後にMedroxyprogesterone acetateの投与で約2年間生存した再発性腎癌の1例 (2007)
  • Author(s): 泉 浩司, 他
  • Journal Title: 泌尿紀要 53(9) Pages: 623-626
  • Description: 「研究成果報告書概要(和文)」より
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• [Journal Article] 下血のみを初発症状とした虫垂出血の1手術例 (2007)
  • Author(s): 藤嵜 秀博, 他
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• [Journal Article] 神奈川県病理医会・学生のためのセミナー (2007)
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  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 第2部9b 腎腫瘍 (2007)
  • Author(s): 長嶋 洋治, 他
  • Journal Title: 病理と臨床『診断に役立っ免疫組織化学』 25(臨時増刊号) Pages: 107-110
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Production of functional spermatids from mouse germline stem cells in ectopically reconstituted seminiferous tubules (2007)
  • Author(s): Kita, K, Watanabe, T, Ohsaka, K, Hayashi, H, Kubota, Y, Nagashima, Y, Aoki, I, Noce, T, Inoue, K, Miki, H, Ogonuki, N, Tanaka, H, Ogura, A, Ogawa, T
  • Journal Title: Biol Reproduction 76(2) Pages: 211-217
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Prognostic value of integrin betal-ILK-pAkt signaling pathway in non-small cell lung cancer (2007)
  • Author(s): Okamura, M, Yamaji, S, Nagashima, Y, Nishikawa, M, Yoshimoto, N, Kido, Y, Iemoto, Y, Aoki, I, Ishigatsubo, Y
  • Journal Title: Hum Pathol 38(4) Pages: 1081-1091
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Expression of adipose differentiation-related protein: a predictor of cancer-specific survival in clear cell renal carcinoma (2007)
  • Author(s): Yao, M, Huang, Y, Shioi, K, Hattori, K, Murakami, T, Nakaigawa, N, Kishida, T, Nagashima, Y, Kubota, Y
  • Journal Title: Clin Cancer Res 13(1) Pages: 152-160
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification and characterization of the Birt-Hogg-Dube associated renal carcinoma (2007)
  • Author(s): Murakami, T, Sano, F, Huang, Y, Komiya, A, Baba, M, Osada, Y, Nagashima, Y, Kondo, K-i, Nakaigawa, N, Miura, T, Kubota, Y, Yao, M, Kishida, T
  • Journal Title: J Pathol 211(5) Pages: 524-531
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] ARPP protein is selectively expressed in renal oncocytoma. but rarely in renal cell carcinomas (2007)
  • Author(s): Shomori, K, Nagashima, Y, Kuroda, N, Honjo, A, Tsukamoto, Y, Tokuyasu, N, Maeta, N, Matsuura, K, Hijiya, N, Yano, S, Yokoyama, S, Ito, H, Moriyama, M
  • Journal Title: Mod Pathol 20(2) Pages: 199-207
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Androgen receptor signals promote bladder cancer development and progression (2007)
  • Author(s): Miyamoto, H, Yang, Z, Chen, Y-T, Ishiguro, H, Uemura, H, Kubota, Y, Nagashima, Y, Chang, Y-J, Hu, Y-C, Tsai, M-Y, Yeh, S, Messing, EM, Chang, C
  • Journal Title: J Natl Cancer Inst 99(7) Pages: 558-568
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Interleukin-15 inhibits smooth muscle cell proliferation and hyaluronan production in rat ductus arteriosus (2007)
  • Author(s): Iwasaki, S, Minamisawa, S, Yokoyama, U, Akaike, T, Nagashima, Y, Nishimaki, S, Ishikawa, Y, Yokota, S
  • Journal Title: Pediatr Res 62(4) Pages: 392-398
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] PM-1 plays an important role in liver failure after excessive hepatectomy in the rat (2007)
  • Author(s): Watanabe, K, Togo, S, Takahashi, T, Matsuyama, R, Yamamoto, H, Shimizu, T, Makino, H, Matsuo, K, Morioka, D, Kubota, T, Nagashima, Y, Shimada, H
  • Journal Title: J Surg Res 143(1) Pages: 13-19
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 5-Aminosalicylic acid given in the remission stage of colitis suppresses colitis-associated cancer in a mouse colitis model (2007)
  • Author(s): Ikeda, I, Tomimoto, A, Wada, K, Fujisawa, T, Fujita, K, Yonemitsu, K, Nozaki, Y, Endo, H, Takahashi, H, Yoneda, M, Inamori, M, Kubota, K, Saito, S, Nagashima, Y, Nakagama, H, Nakajima, A
  • Journal Title: Clin Cancer Res 13(21) Pages: 6527-6531
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The inhibitory effect of Connexin 32 gene on metastasis in renal cell carcinoma (2007)
  • Author(s): Sato, H, Hagiwara, H, Senba, H, Fukumoto, K , Nagashima, Y, Yamasaki, H, Ueno, K, Yano, T
  • Journal Title: Mol Carcinogenesis 30
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The inhibitory effect of Connexin 32 gene on metastasis in renal cell carcinoma. (2007)
  • Author(s): Sato, H, et. al.
  • Journal Title: Molecular carcinogenesis (Epub ahead of print)(掲載確定)
  • Peer Reviewed
• [Journal Article] Production of functional spermatids from mouse germline stem cells in ectopically reconstituted seminiferous tubules. (2007)
  • Author(s): Kita, K, et. al.
  • Journal Title: Biolgy of Reproduction 76(2) Pages: 211-217
  • Peer Reviewed
• [Journal Article] Prognostic value of integrin betal-ILK-pAkt signaling pathway in non-small cell lung cancer. (2007)
  • Author(s): Okamura, M, et. al.
  • Journal Title: Human Pathology 38(4) Pages: 1081-1091
  • Peer Reviewed
• [Journal Article] Expression of adipose differentiation-related protein: a predictor of cancer-specific survival in clear cell renal carcinoma. (2007)
  • Author(s): Yao, M, et. al.
  • Journal Title: Clinical Cancer Research 13(1) Pages: 152-160
  • Peer Reviewed
• [Journal Article] Identification and characterization of the Birt-Hogg-Dube associated renal carcinoma. (2007)
  • Author(s): Murakami T, et. al.
  • Journal Title: American Journal of Pathology 211(5) Pages: 524-531
  • Peer Reviewed
• [Journal Article] ARPP protein is selectively expressed in renal oncocytoma, but rarely in renal cell carcinomas. (2007)
  • Author(s): Shomori K, et. al.
  • Journal Title: Modern Pathology 20(2) Pages: 199-207
  • Peer Reviewed
• [Journal Article] Androgen receptor signals promote bladder cancer development and progression. (2007)
  • Author(s): Miyamoto H, et. al.
  • Journal Title: Journal of The National Cancer Institute 99(7) Pages: 558-568
  • Peer Reviewed
• [Journal Article] Interleukin-15 inhibits smooth muscle cell proliferation and hyaluronan production in rat ductus arteriosus. (2007)
  • Author(s): Iwasaki, S, et. al.
  • Journal Title: Pediatric Research 62(4) Pages: 392-398
  • Peer Reviewed
• [Journal Article] PAI-1 plays an important role in liver failure after excessive hepatectomy in the rat. (2007)
  • Author(s): Watanabe, K, et. al.
  • Journal Title: Journal of Surgical Research 143(1) Pages: 13-19
  • Peer Reviewed
• [Journal Article] 5-Aminosalicylic acid given in the remission stage of colitis suppresses colitis-associated cancer in a mouse colitis model. (2007)
  • Author(s): Ikeda, I, et. al.
  • Journal Title: Clinical Cancer Research 13(21) Pages: 6527-6531
  • Peer Reviewed
• [Journal Article] Prostaglandin E(1)improves survival rate after 95% hepatectomy in rats. (2007)
  • Author(s): Togo, S, et. al.
  • Journal Title: Journal of Surgical Research 146(1) Pages: 66-72
  • Peer Reviewed
• [Journal Article] Prognostic value of integrin betal-ILK-pAkt signaling pathway in non-small cell lung cancer. (2007)
  • Author(s): Okamura M et al.
  • Journal Title: Human Pathology Apr 17(Epub ahead of print)
• [Journal Article] Androgen receptor signals promote bladder cancer development and progressin. (2007)
  • Author(s): Miyamoto H et al.
  • Journal Title: Journal of National cancer Institute 99・7 Pages: 558-568
• [Journal Article] Identifivation and characterization of the Birt-Hogg-Dube associated renal carcinoma. (2007)
  • Author(s): Murakami T et al.
  • Journal Title: Journal of pathology 211・5 Pages: 524-531
• [Journal Article] Expression of adipose differentiation-related protein : a predictor of cancer-specific surval in clear cell renal carcinoma. (2007)
  • Author(s): Yao M et al.
  • Journal Title: Clinical Cancer Research 13・1 Pages: 152-160
• [Journal Article] ARPP protein is selectively expressed in renal oncocytoma,but not in other renal carcinomas. (2007)
  • Author(s): Shomori K et al.
  • Journal Title: Modern Pathology 20・2 Pages: 199-207
• [Journal Article] Mutinous tubular and spindle cell carcinoma of the kidney:Report of acase with imprint cytologic features (2006)
  • Author(s): Otani, M, et. al.
  • Journal Title: Acta Cytol 50(6) Pages: 680-682
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Inactivation of VHL gene induces constitutive phosphorylation of MET protein in clear cell renal carcinoma (2006)
  • Author(s): Nakaigawa, N, et. al.
  • Journal Title: Cancer Res 66(7) Pages: 3699-3075
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Inhibition of Src activity enhances the tumor-suppressive effect of the connexin 32 gene in Caki-1 renal cancer cells (2006)
  • Author(s): Fujimoto, E, et. al.
  • Journal Title: Oncol Rep 15(5) Pages: 1359-1365
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Paradoxical discrepancy between the serum level and the placental intensity of PP5/TFPI-2 in preeclampsia and/or intrauterine growth restrictson:probable interaction and correlation with gylpican-3 hold the key (2006)
  • Author(s): Ogawa, M, et. al.
  • Journal Title: Placenta 28(2-3) Pages: 224-232
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Collecting duct (Bellini duct) renal cell carcinoma:a nation-wide survey in Japan (2006)
  • Author(s): Tokuda, N, et. al.
  • Journal Title: J Urol 176(1) Pages: 43-46
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A rat model of arepeat 70% major hepatectomy (2006)
  • Author(s): Saito, S, et. al.
  • Journal Title: J Surg Res 134(2) Pages: 322-326
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Heme oxygenase-1,a potential biomarker of chronic silicosis,attenuates silica-induced lung injury (2006)
  • Author(s): Sato, T, et. al.
  • Journal Title: Am J Respir Crit Care Med 174(8) Pages: 906-914
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Development of an orthotopic transplantation model in nude mice that simulates the clinical features of human lung cancer (2006)
  • Author(s): Kang, Y, et. al.
  • Journal Title: Cancer Sci 97(10) Pages: 996-1001
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Vascular cell adhesion molecule 1 predicts cancer-free survival in clear cell renal carcinoma patients (2006)
  • Author(s): Shioi, Kl, et. al.
  • Journal Title: Clin Cancer Res 12(24) Pages: 7339-7346
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] An immunohistochemical scoring system of prolyl isomerase Pinl for predicting relapse of prostate carcinoma after radical prostatectomy (2006)
  • Author(s): Sasaki, T, et. al.
  • Journal Title: Pathol Res Pract 202(5) Pages: 357-364
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 色素嫌性腎細胞癌 16例の臨床病理学的検討 (2006)
  • Author(s): 中井 川昇, 他
  • Journal Title: 泌尿紀要 52(1) Pages: 1-6
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 米国における医療(患者)安全教育の現状 (2006)
  • Author(s): 井尻 理恵子, 他
  • Journal Title: 医学教育 37(3) Pages: 153-162
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 学生諸君,いま病理が面白いぞ!7.病理学的知識を深める(2) CPCの抄読会 (2006)
  • Author(s): 長嶋 洋治, 他
  • Journal Title: 病理と臨床 24(12) Pages: 1321-1325
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 横浜市立大学医学部における実践的医療安全教育 (2006)
  • Author(s): 青木 昭子, 他
  • Journal Title: 医学教育 37(6) Pages: 389-395
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 21.腎,「良性と間違えやすい悪性腫瘍,悪性と間違えやすい良性腫瘍」 (2006)
  • Author(s): 長嶋 洋治, 他
  • Journal Title: 病理と臨床 24(増刊号) Pages: 139-145
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Mucinous tubular and spindle cell carcinoma of the kidney: Report of a case with imprint cytologic features (2006)
  • Author(s): Otani, M, Shimizu, T, Serizawa, H, Nagashima, Y
  • Journal Title: Acta Cytol 50(6) Pages: 680-682
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Inactivation of VHL gene induces constitutive phosphorylation of MET protein in clear cell renal carcinoma (2006)
  • Author(s): Nakaigawa, N, Yao, M, Baba, M, Kato, S, Kishida, T, Hattori, K, Nagashima, Y, Kubota, Y
  • Journal Title: Cancer Res 66(7) Pages: 3699-3705
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Inhibition of Src activity enhances the tumor-suppressive effect of the connexin 32 gene in Caki-1 renal cancer cells (2006)
  • Author(s): Fujimoto, E, Sato, H, Shirai, S, Nagashima, Y, Virgona, N, Hagiwara, K, Yamasaki, H, Negishi, E, Ueno, K, Yano, T
  • Journal Title: Oncol Rep 15(5) Pages: 1359-1365
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Paradoxical discrepancy between the serum level and the placental intensity of PP5/TFPI-2 in preeclampsia and/or intrauterine growth restriction: probable interaction and correlation with gylpican-3 hold the key (2006)
  • Author(s): Ogawa, M, Yanoma, S, Nagashima, Y, Okamoto, N, Ishikawa, H, Haruki, A, Miyagi, E, Takahashi, T, Hirahara, F
  • Journal Title: Placenta 28(2-3) Pages: 224-232
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Collecting duct (Bellini duct) renal cell carcinoma: a nation-wide survey(in Japan) (2006)
  • Author(s): Tokuda, N, Naito, S, Matsuzaki, O, Nagashima, Y, Ozono, S, Igarashi, T
  • Journal Title: J Urol 176(1) Pages: 43-46
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A rat model of a repeat 70% major hepatectomy (2006)
  • Author(s): Saito, S, Togo, S, Morioka, D, Matsuo, KI, Yoshimoto, N, Nagano, Y, Tanaka, K, Kubota, T, Nagashima, Y, Shimada, H
  • Journal Title: J Surg Res 134(2) Pages: 322-326
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Heme oxygenase-1, a potential biomarker of chronic silicosis, attenuates silica-induced lung injury (2006)
  • Author(s): Sato, T, Takeno, M, Honma, K, Yamauchi, H, Saito, Y, Sasaki, T, Morikubo, H, Nagashima, Y, Takagi, S, Yamanaka, K, Kaneko, T, Ishigatsubo, Y
  • Journal Title: Am J Respir Crit Care Med 174(8) Pages: 906-914
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Development of an orthotopic transplantation model in nude mice that simulates the clinical features of human lung cancer (2006)
  • Author(s): Kang, Y, Omura, M, Suzuki, A, Oka, T, Nakagami, Y, Cheng, C, Nagashima, Y, Inoue, T
  • Journal Title: Cancer Sci 97(10) Pages: 996-1001
  • NAID: 10019377776
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Vascular cell adhesion molecule 1 predicts cancer-free survival in clear cell renal carcinoma patients (2006)
  • Author(s): Shioi, KI, Komiya, A, Hattori, K, Huang, Y, Sano, T, Murakami, T, Nakaigawa, N, Kishida, T, Kubota, Y, Nagashima, Y, Yao, M
  • Journal Title: Clin Cancer Res 12(24) Pages: 7339-7346
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] An im munohistochemical scoring system of prolyl isomerase Pin1 for predicting relapse of prostate carcinoma after radical prostatectomy (2006)
  • Author(s): Sasaki, T, Ryo, A, Uemura, H, Ishiguro, H, Inayama, Y, Yamanaka, S, Kubota, Y, Nagashima, Y, Harada, M, Aoki, I
  • Journal Title: Pathol Res Pract 202(5) Pages: 357-64
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Vascular cell adhesion molecule 1 predicts cancer-free survival in clear cell renal carcinoma patients. (2006)
  • Author(s): Shioi KI et al.
  • Journal Title: Clinical Cancer Research 12・24 Pages: 7339-7346
• [Journal Article] An immunohistochemical scoring system of prolyl isomerase Pinl for predicting relapse of prostate carcinoma after radical prostatectomy. (2006)
  • Author(s): Sasaki T et al.
  • Journal Title: Pathology Research Practice 202・5 Pages: 357-364
• [Journal Article] Collecting duct(Bellini duct)renal cell carcinoma : a nation-wide survey in Japan. (2006)
  • Author(s): Tokuda N et al.
  • Journal Title: Journal of Urology 176・1 Pages: 40-43
• [Journal Article] Inactivation of VHL gene induces constitutive phosphorylation of MET protein in clear cell renal carcinoma. (2006)
  • Author(s): Nakaigawa N et al.
  • Journal Title: Cancer research 66・7 Pages: 3699-3705
• [Journal Article] Ethmoidal lipid-rich carcinoma with focal glandular structures
  • Author(s): Oshiro, H, Nagao, J, Nagashima, Y, Taguchi, T, Yamanaka, S, Inayama, Y
  • Journal Title: Archives of Otolaryngology - Head & Neck Surgery (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The overexpression and altered localization of the atypical protein kinase C A / in breast correlates with the pathological type of these tumors
  • Author(s): Kojima Y, Akimoto K, Nagashima Y*, Ishiguro H, Shirai S, Chishima T, Ichikawa Y, T. Ishikawa, T. Sasaki, Y. Kubota, Y. Inayama, I. Aoki, S. Ohno, H. Shimada
  • Journal Title: Hum Pathol (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Collecting duct carcinoma of the kidney: an immunohistochemical evaluation of the use of antibodies for differential diagnosis
  • Author(s): Kobayashi, N, Matsuzaki, O, Shirai, S, Aoki, I, Yao, M, Nagashima, Y
  • Journal Title: Hum Pathol (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Renal collecting duct carcinoma in a dog
  • Author(s): Kobayashi, N, Suzuki, K, Shibuya, H, Sato, T, Aoki, I, Nagashima, Y
  • Journal Title: Vet Pathol (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A three-gene expression signature model to predict clinical outcome of clear cell renal carcinoma
  • Author(s): Yao, M, Huang, Y, Shioi, K, Hattori, K, Murakami, T, Sano, F, Baba, M, Kondo, K, Nakaigawa, N, Kishida, T, Nagashima, Y, Yamada-Okabe, H, Kubota, Y
  • Journal Title: Int J Cancer (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hayashizaki Y, Shimada H. Role of nitric oxide synthesized by nitric oxide synthase 2 in liver regeneration
  • Author(s): Kumamoto, T, Togo, S, Ishibe, A, Morioka, D, Watanabe, K, Takahashi, T, Shimizu, T, Matsuo, KI, Kubota, T, Tanaka, K, Nagashima, Y, Kawai, J, Hayashizaki, Y, Shimada, H
  • Journal Title: Liver Int 2008 Apr1 (Epub ahead of print)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effectiveness of antiplatelet drugs against experimental non-alcoholic fatty liver disease
  • Author(s): Fujita, K, Nozaki, Y, Wada, K, Yoneda, M, Endo, H, Takahashi, H, Iwasaki, T, Inamori, M, Abe, Y, Kobayashi, N, Kirikoshi, H, Kubota, K, Saito, S, Nagashima, Y, Nakajima, A
  • Journal Title: Gut (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Antitumour effect of electrochemotherapy with bleomycin on human prostatic cancer xenograft
  • Author(s): Ueki, T, Uemura, H, Nagashima, Y, Ohta, S, Ishiguro, H, Kubota, Y
  • Journal Title: Brit J Urol (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Heme oxygenase 1 attenuates the development of atopic dermatitis-like lesions in mice: implications for human disease
  • Author(s): Kirino, M, Kirino, Y, Takeno, M, Nagashima, Y, Takahashi, K, Kobayashi, M, Murakami, S, Hirasawa, T, Ueda, A, Aihara, M, Ikezawa, Z, Ishigatsubo, Y
  • Journal Title: J Allergy Clin Immunol (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Makignant Mullerian tumor(carcinosarcoma)in mixed epithelial and stroma] tumor of the kidney: A morphological and molecular genetic study
  • Author(s): Kuroda, N, Sakaida, N, Oe, C, Uemura, Y, Matsuda, T, Kinoshita, H, Watanabe, M, Hes, O, M. Michael, S. Okamoto, Y. Nagashima, Y. Tanaka, T. Takeuchi, Y. Hayashi, GH. Lee
  • Journal Title: APMIS (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Semaphorin3A alleviates skin lesions and scratching behavior in NC/Nga mice, an atopic dermatitis model
  • Author(s): Yamaguchi, J, Nakamura, F, Aihara, M, Yamashita, N, Usui, H, Hida, T, Takei, K, Nagashima, Y, Ikezawa, Z, Goshima, Y
  • Journal Title: J Invest Dermatol (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 特別講演「おとなから見た小児腎腫瘍の病理と分子生物学」 (2008)
  • Author(s): 長嶋 洋治
  • Organizer: 第53回東海小児がん研究会
  • Place of Presentation: 名古屋
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 教育講演「医学部で学ぶこと」 (2008)
  • Author(s): 長嶋 洋治
  • Organizer: 医学連第25回定期全国大会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 淡明細胞腎癌の3遺伝子発現による予後判定モデルの作成 (2008)
  • Author(s): 矢尾 正祐, 他
  • Organizer: 第96回泌尿器科学会総会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The status of aPKCλ/t in breast cancer correlates with the pathologic types (2008)
  • Author(s): 長嶋 洋治, 他
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Epithelioid angiomyolipoma.A report of three cases (2008)
  • Author(s): 長嶋 洋治, 他
  • Organizer: 第97回目本病理学会総会
  • Place of Presentation: 金沢
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 腎上皮性腫瘍の新組織分類-病理学と分子生物学的側面から (2008)
  • Author(s): 長嶋 洋治, 他
  • Organizer: 第49回日本臨床細胞学会(春季大会)教育講演
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 反応性尿細管上皮細胞と悪性腫瘍細胞の鑑別 (2008)
  • Author(s): 大崎 博之, 他
  • Organizer: 第49回日本臨床細胞学会(春季大会)教育講演
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Epithelioid angiomyolipoma. A report of three cases (2008)
  • Author(s): Nagashima, Y, Inayama, K, Sasaki, T, Oshiro, H, Murakami, A, Yamanaka, S, kawachi, K, Nozawa, A, Aoki, I
  • Organizer: 97th Annual Meeting of Japanese Association of Pathology
  • Place of Presentation: Kanazawa
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The inhibitory effect of comexin32 gene on metastasis in renal cell carcinoma (2007)
  • Author(s): Sato, H, et. al.
  • Organizer: Am Assoc Cancer Res Annual Meeting 2007
  • Place of Presentation: Los Angels(CA)
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] aPKC role in prostatic cancer progression (2007)
  • Author(s): Ishiguro, H, et. al.
  • Organizer: Yokohama City Univercity 21st Century COE Program Cell Polarity International Symposium on Cell Polarity System and Future Medicine
  • Place of Presentation: Hayama(Japan)
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Expression and locahzation of atypical protein kinase C λ/ι in breast cancer (2007)
  • Author(s): Kojima, Y, et. al.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Identification and characterization of Birt-Hogg-Dube associated renal carcinoma (2007)
  • Author(s): Murakami, T, et. al.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Gene expression outcome predictor score model for clear cell renal carcinoma (2007)
  • Author(s): Yao, M, et. al.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Gene expression analysis of renal carcinoma:AQP1 and BIRC5 as predictive indictors for prognosis of clear cell RCC (2007)
  • Author(s): Huang, Y, et. al.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Androgen receptor expression in human bladder tumor (2007)
  • Author(s): Ishiguro, H, et. al.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Mutations of c-kit gene in bilateral testicular germ cell tumors in Japan (2007)
  • Author(s): Sakuma, Y, et. al.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Epithelioid angiomyolipoma of the kidney.A report of three cases (2007)
  • Author(s): Nagashima, Y, et. al.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Effects of restoration of connexin32 gene in human metastatic renal cell carcinoma xenografts in mice (2007)
  • Author(s): Sato, H, et. al.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 上大静脈症候群で発症し右房内に腫瘤を形成した浸潤型胸腺腫の1剖検例 (2007)
  • Author(s): 野口 彩子, 他
  • Organizer: 第173回日本呼吸器学会関東地方会兼第151回日本結核病学会関東支部学会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 腎細胞がんの最新の診断基準-WHO2004の病理診断基準を中心に (2007)
  • Author(s): 長嶋 洋治
  • Organizer: 第7回泌尿器がん治療フォーラム
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 腎腫瘍の病理(腎孟癌,非上皮性腫瘍の病理,腎腫瘍の分子生物学) (2007)
  • Author(s): 長嶋 洋治
  • Organizer: 第96回日本病理学会総会 系統的病理診断講習会「腎.腎孟, 尿管, 尿道の腫瘍」
  • Place of Presentation: 大阪
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Neurofiもmmatosis type1に発症したMPNSTの2症例 (2007)
  • Author(s): 五味 淳, 他
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 大阪
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 腎オンコサイトーマおよび遠位尿細管におけるARPPの発現 (2007)
  • Author(s): 庄盛 浩平, 他
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 大阪
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] わが国のトロトラスト血管内注入者の晩発障害に関する全生涯研究 (2007)
  • Author(s): 森 武三郎, 他
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 大阪
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 胃壁に発生した限局性悪性中皮腫の一例 (2007)
  • Author(s): 長嶋 洋治, 他
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 大阪
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 腎epithehoid angiomyohpomaの二例 (2007)
  • Author(s): 加藤 生真, 他
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 大阪
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 腎腫瘍における細胞極性規定因子aPKCλの局在 (2007)
  • Author(s): 白井 澄子, 他
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 大阪
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 腎乳頭癌とその周辺 (2007)
  • Author(s): 長嶋 洋治
  • Organizer: 第33回腎癌研究会「乳頭状腎細胞癌:診断から治療まで」(基調講演)
  • Place of Presentation: 神戸
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 当院におけるBellini管癌(集合管癌:CDC)の治療経験 (2007)
  • Author(s): 北原 克教, 他
  • Organizer: 第72回日本泌尿器科学会東部総会
  • Place of Presentation: 札幌
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 当院における紡錘細胞型腎癌の経験 (2007)
  • Author(s): 中井 川昇, 他
  • Organizer: 第72回日本泌尿器科学会東部総会
  • Place of Presentation: 札幌
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 後腎性腺腫metallephric adenomaの2例 (2007)
  • Author(s): 寺尾 秀行, 他
  • Organizer: 第72回日本泌尿器科学会東部総会
  • Place of Presentation: 札幌
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 腎腫瘍性疾患の病理と分子生物学 (2007)
  • Author(s): 長嶋 洋治
  • Organizer: 第37回高知腎疾患懇話会
  • Place of Presentation: 高知
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Epithelioid angiomyolipoma of the kidney.A report of three cases (2007)
  • Author(s): 長嶋 洋治, 他
  • Organizer: 第54回日本臨床検査医学会学術総会
  • Place of Presentation: 大阪
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Xp11転座腎癌の一例 (2007)
  • Author(s): 長嶋 洋治, 他
  • Organizer: 46回日本臨床細胞学会秋期特別総会
  • Place of Presentation: 仙台
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The inhibitory effect of connexin32 gene on metastasis in renal cell carcinoma (2007)
  • Author(s): Sato, H, Nagashima, Y, Senba, H, Hagiwara, H, Negishi, E, Ueno, K, Yano, T
  • Organizer: Am Assoc Cancer Res Annual Meeting 2007, Los Angels(CA)
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Expression and localization of atypical protein kinase C L / c in breast cancer (2007)
  • Author(s): Kojima, Y, Chishima, T, Nagashima, Y, Akimoto, K, Ishigura, H, Ishikawa, T, Shimada, H, Ohno, S
  • Organizer: 66th Annual Meeting of Japanese Association of the Japanese Cancer Association
  • Place of Presentation: Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Identification and characterization of Birt-Hogg-Dube associated renal carcinoma (2007)
  • Author(s): Murakami, T, Sano, F, Huang, Y, Komiya, A, Baba, M, Osada, Y, Nagashima, Y, Kondo, K, Nakaigawa, N, Miura, T, Kubota, Y, Yao, M, Kishida, T
  • Organizer: 36th Annual Meeting of Japanese Association of the [apanese Cancer Association
  • Place of Presentation: Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Gene expression outcome predictor score model for clear cell renal carcinoma (2007)
  • Author(s): Yao, M, Huang, Y, Shioi, K, Hattori, K, Murakami, T, Nakaigawa, N, Kishida, T, Kubota, Y, Nagashima, Y
  • Organizer: 66th Annual Meeting of Japanese Association of the Japanese Cancer Association
  • Place of Presentation: Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Gene expression analysis of renal carcinoma: AQP1 and BIRC5 as predictive indictors for prognosis of clear cell RCC (2007)
  • Author(s): Huang, Y, Sano, F, Murakami, T, Nakaigawa, N, Kishida, T, Kubota, Y, Nagashima, Y, Yao, M
  • Organizer: 66th Annual Meeting of Japanese Association of the Japanese Cancer Association
  • Place of Presentation: Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Androgen receptor expression in human bladder tumor (2007)
  • Author(s): Ishiguro, H, Funahashi, M, Miyamoto, H, Nagashima, Y, Nakaigawa, N, Miyoshi, Y, Uemura, H, Kubota, Y
  • Organizer: 66th Annual Meeting of Japanese Association of the Japanese Cancer Association
  • Place of Presentation: Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Mutations of c-kit gene in bilateral testicular germ cell tumors(in Japan) (2007)
  • Author(s): Sakuma, Y., Matsukuma, S., Yoshihara, M., Sakurai, S., Kishida, T., Nagashima, Y., Inayama, Y., Miura, T., Kameda, Y., Nakamura, Y., Tsuchiya, E., Miyagi, Y
  • Organizer: 66th Annual Meeting of Japanese Association of the Japanese Cancer Association
  • Place of Presentation: Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Epithelioid angiomyolipoma of the kidney. A report of three cases (2007)
  • Author(s): Nagashima, Y, Inayama, Y, Aoki, I, Shirai, S, Yao, M
  • Organizer: 66th Annual Meeting of Japanese Association of the Japanese Cancer Association
  • Place of Presentation: Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Effects of restoration of connexin 32 gene in human metastatic renal cell carcinoma xenografts in mice (2007)
  • Author(s): Sato, H, Hagiwara, H, Nagashima, Y, Yano, T
  • Organizer: 66th Annual Meeting of Japanese Association of the Japanese Cancer Association
  • Place of Presentation: Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Symposium on Cell Polarity System and Future Medicine(Hayama, Japan) (2007)
  • Author(s): Ishiguro, H, Akimoto, K, Nagashima, Y, Kojima, Y, Ishiguro, Y, Sasaki, T, Uemura, H, Ohono, S, Kubota, Y
  • Organizer: Yokohama City Univercity 21st Century COE Program Cell Polarity International Symposium on Cell Polarity System and Future Medicine
  • Place of Presentation: Hayama, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Epithelioid angiomyolipoma of the kidney. A report of three cases (2007)
  • Author(s): Nagashima, Y, Yamanaka, S, Oshiro, H, Gomi, J, Aoki, I, Inayama, K
  • Organizer: 54th Annual Meeting of Japan Society of Laboratory Medicine
  • Place of Presentation: Osaka
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The inhibitory effect of connexin32 gene on metastasis in renal cell carcinoma. (2007)
  • Author(s): Sato, H, et. al.
  • Organizer: Am Assoc Cancer Res Annual Meeting 2007
  • Place of Presentation: Los Angels(CA)
• [Presentation] aPKC role in prostatic cancer progression. (2007)
  • Author(s): Ishiguro, H, et. al.
  • Organizer: Yokohama City Univercity 21st Century COE Program Cell Polarity International Symposium on Cell Polarity System and Future Medicine
  • Place of Presentation: Hayama, Japan
• [Presentation] 多彩な病理像を示したACDK:合併RCCの一例 (2006)
  • Author(s): 小貫 竜昭, 他
  • Organizer: 第33回日本泌尿器科学会神奈川地方会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] NF κ B Decoyを用いた拡大肝切除後肝不全の制御 (2006)
  • Author(s): 高橋 車嗣, 他
  • Organizer: 第42回腹部救急医学会総会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 遺伝子発現解析に基づく淡明細胞腎癌の転移関連遺伝子群の探索と予後予測モデルの構築 (2006)
  • Author(s): 矢尾 正祐, 他
  • Organizer: 第94回日本泌尿器科学会総会
  • Place of Presentation: 福岡
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Composite collecting duct-derived renal cell carcinoma with chromophobe and collecting duct carcinomatous elements (2006)
  • Author(s): 長嶋 洋治, 他
  • Organizer: 第94回日本泌尿器科学会総会
  • Place of Presentation: 福岡
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Renal oncocytosis.Acase report (2006)
  • Author(s): 長嶋 洋治, 他
  • Organizer: 第94回日本泌尿器科学会総会
  • Place of Presentation: 福岡
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] SPARC発現は,舌癌 stage II症例における予後因子として有用である (2006)
  • Author(s): 加藤 靖正, 他
  • Organizer: 第94回日本病理学会総会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 癌性胸水の発症における癌の肺靭帯転移の意義 (2006)
  • Author(s): 大城 久, 他
  • Organizer: 第94回日本病理学会総会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 成人小脳に発生した髄芽腫(medulloblastoma)の1症例 (2006)
  • Author(s): 五味 淳, 他
  • Organizer: 第94回目本病理学会総会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 精巣原発カルチノイドの一例 (2006)
  • Author(s): 宇高 阿依, 他
  • Organizer: 第94回日本病理学会総会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 腎集合管癌24例の臨床病理学的検討 (2006)
  • Author(s): 古林 直人, 他
  • Organizer: 第94回日本病理学会総会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 腎腫瘍における細胞外基質蛋白SPARCの発現と局在 (2006)
  • Author(s): 長嶋 洋治, 他
  • Organizer: 第94回日本病理学会総会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 淡明細胞腎癌、予後不良群に特異的な発現遺伝子の同定 (2006)
  • Author(s): 近藤 慶一, 他
  • Organizer: 第95回日本泌尿器科学会総会
  • Place of Presentation: 神戸
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 腎Mucinous tubular and spindle cell carcinomaの1例 (2006)
  • Author(s): 介川 雅之, 他
  • Organizer: 第47回日本臨床細胞学会春期総会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 癌性胸水の発症における癌の肺靭帯転移の意義 (2006)
  • Author(s): 大城 久, 他
  • Organizer: 第47回目本臨床細胞学会春期総会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 稀な低悪性度腎癌(Mucinous tubular and spindle cell carcinma)の一例 (2006)
  • Author(s): 黒田 陽子, 他
  • Organizer: 第31回日本病理学会関東支部学術集会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 知っておきたい腎腫瘍の病理学-WHO分類(2004年)を中心に-.腎癌治療最前線 (2006)
  • Author(s): 長嶋 洋治
  • Organizer: 腎癌治療最前線2006
  • Place of Presentation: 山形
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 病理と私とサッカーと (2006)
  • Author(s): 長嶋 洋治
  • Organizer: 第1回神奈川県病理医会 医学生のための病理学セミナー
  • Place of Presentation: 伊勢原
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 高校生のための病理学入門 (2006)
  • Author(s): 長嶋 洋治
  • Organizer: 平成17年度スーパーサイエンスハイスクール生徒研究発表会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] プロラクチンによる卵巣癌のアポトーシス抑制作用に関する研究 (2006)
  • Author(s): 佐藤 美紀子, 他
  • Organizer: 第5回日本婦人科がん分子標的研究会学術集会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ヒト腎細胞癌における細胞極性規定因子aPKCλの局在 (2006)
  • Author(s): 白井 澄子, 他
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 転移性腎細胞癌におけるコネキシン32遺伝子の転移抑制能に関する研究 (2006)
  • Author(s): 佐藤 洋美, 他
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 腎癌におけるaquaporin1の発現解析:臨床病理因子および予後の関係 (2006)
  • Author(s): 黄 栄, 他
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 遺伝子発現解析にもとつく淡明細胞腎癌の予後予測モデルの作成 (2006)
  • Author(s): 矢尾 正祐, 他
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 腎集合管癌17例の臨床病理学的検討 (2006)
  • Author(s): 長嶋 洋治, 他
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 知っておきたい腎腫瘍の病理学-WHO新分類を中心に (2006)
  • Author(s): 長嶋 洋治
  • Organizer: 第114回尿路生殖研究会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 腎腫瘍の病理と分子生物学 (2006)
  • Author(s): 長嶋 洋治
  • Organizer: 第3回静岡腎癌セミナー
  • Place of Presentation: 静岡
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 腎腫瘍の病理と分子生物学 (2006)
  • Author(s): 長嶋 洋治
  • Organizer: 第51回日本病理学会秋期特別総会
  • Place of Presentation: 和歌山
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Composite collecting duct-derived renal cell carcinoma with chromophobe and collecting duct carcinomatous elements (2006)
  • Author(s): Nagashima, Y, Nakaigawa, N, Yao, M, Kubota, Y, Kouno, N, Inayama, Y, Aoki, I
  • Organizer: 94th Annual Meeting of Japan Urological Association
  • Place of Presentation: Fukuoka
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Renal oncocytosis. A case report (2006)
  • Author(s): Nagashima, Y, Noguchi, S, Shioi, K, Hamano, A, Oko, M, Kishida, K, Yao, M, Kubota, Y, Aoki, I
  • Organizer: 94th Annual Meeting of Japan Urological Association
  • Place of Presentation: Fukuoka
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] WAGR syndrome.Encyclopedic reference of molecular mechanism of disease (2008)
  • Author(s): Nagashima, Y, et. al.
  • Publisher: Springer-Verlag(In press)
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 機能的狭窄, 神経原性腫, 多形(性)腺腫, 低分化腺癌, 亜急性炎症, 異物反応, 壊疽性炎, 炎症細胞浸潤, 炎症反応, 増生, 粘膜関連リンパ腫, 看護学大事典(第2版) (2008)
  • Author(s): 長嶋 洋治
  • Publisher: 医学書院(東京)(印刷中)
  • Description: 「研究成果報告書概要(和文)」より
• [Book] ショープ乳頭腫, 看護学大事典(第2版) (2008)
  • Author(s): 長嶋 洋治, 他
  • Publisher: 医学書院(東京)(印刷中)
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 【各論】泌尿器系, NEW エッセンシャル病理学(第6版), 長村 義之, 笹野 公伸, 澤井 高志, 高松 哲郎, 内滕 真, 八木橋 操六(編) (2008)
  • Author(s): 長嶋 洋治
  • Publisher: 医歯薬出版(東京)(印刷中)
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 正常画像と並べてわかる鯉アトラス(下正宗 編)第14章 腎臓 (2008)
  • Author(s): 長嶋 洋治, 他
  • Publisher: 羊土社(東京)
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 正常画像と並べてわかる離アトラス(下正宗 編)第15章 尿路臓 (2008)
  • Author(s): 長嶋 洋治, 他
  • Publisher: 羊土社(東京)
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 腎臓10-58-62, 64-67, 69-82, 84-89, 94-96, 98-107, 鷹橋 浩幸, 白石 泰三, 福田 国彦, 羽野 寛(監訳) 「ロビンス病理学アトラス」 (2008)
  • Author(s): 長嶋 洋治(分担訳)
  • Publisher: エルゼビア・ジャパン社(東京)(印刷中)
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 各論 3.腎臓.梅澤 明弘, 黒田 雅彦, 大喜 多肇(監修), 研修医のための病理マニュアルーこれ一冊で CPC レポートが書ける (2008)
  • Author(s): 長嶋 洋治(分担)
  • Publisher: 診断と治療社(東京)
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 小児病理、青笹 克之(編)、明解病理学 (2008)
  • Author(s): 長嶋 洋治(分担)
  • Publisher: 医歯薬出版(印刷中)
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 正常画像と並べてわかる病理アトラス(下正宗 編)第14章 腎臓 (2008)
  • Author(s): 長嶋 洋治, 他
  • Publisher: 羊土社
• [Book] 正常画像と並べてわかる病理アトラス(下正宗 編)第15章 尿路 (2008)
  • Author(s): 長嶋 洋治, 他
  • Publisher: 羊土社
• [Book] 第1章 腎癌.2.病因・病理(2)病理, 木原和徳(編):最新医学別冊 新しい診断と治療のABC 45腎癌・膀胱癌 26-31 (2007)
  • Author(s): 長嶋 洋治
  • Publisher: 最新医学社(大阪)
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 第1章 腎癌.2.病因・病理 (2)病理, 木原和徳(編):最新医学別冊 新しい診断と治療のABC45腎癌・膀胱癌 26-31, (2007)
  • Author(s): 長嶋 洋治
  • Publisher: 最新医学社(大阪)
• [Book] 第8章 腎臓.12.腎腫.石倉 浩, 佐藤 昇志・笠原 正典(編)「器官病理学」
  • Author(s): 長嶋 洋治
  • Publisher: 南山堂(東京)(印刷中)
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 器管病理学 第2部 第8章 12.「腎腫瘍」
  • Author(s): 長嶋洋治
  • Publisher: 南山堂(印刷中)