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Development of a in vivo screening method for evaluation prostate carcinogenic potential in chemicals

Research Project

Project/Area Number 18590377
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionNagoya City University

Principal Investigator

SHIRAI Tomoyuki  Nagoya City University, Graduate School of Medical Science, Professor (60080066)

Co-Investigator(Kenkyū-buntansha) ASAMOTO Makoto  Nagoya City University, Graduate School of Medical Science, Associate Professor (50212494)
鈴木 周五  名古屋市立大学, 大学院医学研究科, 研究員 (60363933)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥4,020,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
KeywordsProstate / Carcinogen / Screening method / PhIP / DMAB / Cadmium / マイクロアレイ / oncomoduline
Research Abstract

We obtained gene expressions profiles of rat ventral prostate tissue treated with three kinds of carcinogens, -amino-l-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP), 3, 2'-dimethyl-4-aminobiphenyl (DMAB)and cadmium. There were only three genes that was commonly up regulated in the 3 chemicals. Among the genes, we focused on oncomodulin and performed immunhistochemicl analysis for expression of oncomodulin in ventral prostates treated with the chemicals. Oncomodulin demonstrated sporadic positivity in cytoplasms of the prostate glands. However, there were no differences for expressions of oncomodulin between non-treated control group tissues and the 3 carcinogenic chemical groups, except for DMAB. There results indicated that the oncompdulin expression analysis may not be suitable for a in vivo screening method for prostate carcinogens.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (20 results)

All 2008 2007 2006

All Journal Article (18 results) (of which Peer Reviewed: 6 results) Presentation (2 results)

  • [Journal Article] Optimization of an animal test protocol for toxioogenomics studies(1);Requirement study of a protocol2007

    • Author(s)
      Sumida, K.
    • Journal Title

      Toxicol.Sci 32

      Pages: 19-32

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Optimization of an animal test protocol for toxioogenomics studies(2);A-cross-Laboratory gene expression analysis2007

    • Author(s)
      Sumida, K.
    • Journal Title

      Toxicol.Sci 32

      Pages: 33-45

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Protective effects of citrus nobiletin and auraptene in transgenicrats developing adenocarcinoma of the prostate(TRAP)and human prostate carcinomacells2007

    • Author(s)
      Tang, M.
    • Journal Title

      Cancer Sci 98

      Pages: 471-477

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Optimization of an animal test protocol for toxicogenomics studies (1); Requirement study of a protocol2007

    • Author(s)
      Sumida, K., Saito, K., Oeda, K., Otsuka, M., Tsujimura, K., Miyaura, H., Asamoto, M., Shirai, T
    • Journal Title

      Toxicol. Sci. 32

      Pages: 19-32

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Optimization ofan animal test protocol for toxicogenomics studies (2); A-cross-Laboratory gene expression analysis2007

    • Author(s)
      Sumida, K., Saito, K., Oeda, K., Otsuka, M., Tsujimura, K., Miyaura, H., Asamoto, M., Shirai, T
    • Journal Title

      Toxicol. Sci. 32

      Pages: 33-45

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Protective effects of citrus nobiletin and auraptene in transgenic rats developing adenocarcinoma of the prostate (TRAP) and human prostate carcinoma cells2007

    • Author(s)
      Tang, M., Ogawa, K., Asamoto, M., Hokaiwado, N., Azman, S., Suzuki, S., Takahashi, S., Tanaka, T., Ichikawa, K., Shirai, T
    • Journal Title

      Cancer Sci. 98

      Pages: 471-477

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Optimization of an animal test protocol for toxicogenomics studies(1);Requirement study of a protocol.2007

    • Author(s)
      Sumida, K.
    • Journal Title

      Toxicol.Sci. 32

      Pages: 19-32

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Optimization of an animal test protocol for toxicogenomics studies(2);A-cross-Laboratory gene expression analysis.2007

    • Author(s)
      Sumida, K.
    • Journal Title

      Toxicol.Sci. 32

      Pages: 33-45

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Protective effects of citrus nobiletin and auraptene in transgenic rats developing adenocarcinoma of the prostate(TRAP) and human prostate carcinoma cells.2007

    • Author(s)
      Tang, M.
    • Journal Title

      Cancer Sci. 98

      Pages: 471-477

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Pitfalls with MRI Evaluation of Prostate Cancer Detection2006

    • Author(s)
      Okamura, T.
    • Journal Title

      Urol.Int. 77

      Pages: 301-306

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Differences in gen expression profiles in the liver between carcinogenic and non-carcinogenic isomers of compounds given to ratina 28-day repeat-dose toxicity study2006

    • Author(s)
      Nakayama, K.
    • Journal Title

      Toxicol.Appl.Pharmacol 217

      Pages: 299-307

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Prediction of carcinogenic potential by a toxicogenomic approachusingrat hepatoma cells2006

    • Author(s)
      Tsujimura, K.
    • Journal Title

      Cancer Sci 97

      Pages: 1002-1010

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Pitfalls with MRI Evaluation of Prostate Cancer Detection2006

    • Author(s)
      Okamura, T., Uemoto, Y., Yamashita, K., Suzuki, S., Shirai, T., Hashimoto, Y., Kohri, K
    • Journal Title

      Urol. Int 77

      Pages: 301-306

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Differences in gene expression profiles in the liver between carcinogenic and non-carcinogenic isomers of compounds given to rat in a 28-day repeat-dose toxicity study2006

    • Author(s)
      Nakayama, K., Kawano, Y., Kawakami, Y., Moriwaki, N., Masaru, S., Otsuka, M., Yakabe, Y., Miyaura, H., Saito, K., Sumida, K., Shirai, T
    • Journal Title

      Toxicol. Appl. Pharmacol 217

      Pages: 299-307

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Prediction of carcinogenic potential by a toxicogenomic approach using rat hepatoma cells2006

    • Author(s)
      Tsujimura, K., Asamoto, M., Shugo, S., Hokaiwado, N., Ogawa, K., Shirai, T
    • Journal Title

      Cancer Sci. 97

      Pages: 1002-1010

    • NAID

      10019377814

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Pitfalls with MRI Evaluation of Prostate Cancer Detection.2006

    • Author(s)
      Okumura, T.
    • Journal Title

      Urol.Int. 77

      Pages: 301-306

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Differences in gene expression profiles in the liver between carcinogenic and non-carcinogenic isomers of compounds given to rat in a 28-day repeat-dose toxicity study.2006

    • Author(s)
      Nakayama, K.
    • Journal Title

      Toxicol. Appi. Pharmacol. 217

      Pages: 299-307

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Prediction of carcinogenic potential by a toxicogenomic approach using rat hepatoma cells.2006

    • Author(s)
      Tsujimura, K.
    • Journal Title

      Cancer Sci. 97

      Pages: 1002-1010

    • Related Report
      2006 Annual Research Report
  • [Presentation] cDNAアレイを用いた前立腺発がん物質に特異的な遺伝子の検索2008

    • Author(s)
      二口 充
    • Organizer
      第24回日本毒性病理学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-02-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] cDNA microarray analysis of genes which specifically alteredin the rat prostate after treatment with prostate carcinogens2008

    • Author(s)
      Futakuchi, M., Sato, S., Sumida, K., Saito, K., Takahashi, S., Asamoto, M., Shirai, T
    • Organizer
      The 24th Annual Meeting of the Japanese Society of Toxicologic Pathology
    • Place of Presentation
      Nagoya
    • Year and Date
      2008-02-07
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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