Research Project
Grant-in-Aid for Scientific Research (C)
We have done the studies on anti ate immunity by the APOBEC family proteins and obtained the results as described below.1. Analysis on antiviral activity of APOBEC3 proteins1) Antiviral activity against other viruses : We demonstrate that APOBEC3G has antiviral activity against HBV.2) Antiviral activity of other APOBEC3 proteins : We demonstrate that APOBEC3B and 3F also have anti-HIV-1 activity and that their antiviral activity and Vif-sensitivity vary.3) Antiviral activity against murine Ieukemia virus : We demonstrate that murine retrovirus escapes form murine APOBEC3 via two distinct novel mechanisms.2. Regulation of APOBEC3G function by phosphorylation by PKA : We demonstrate that PKA phosphorylates APOBEC3G and that its phosphorylation render APOBEC3G resistant to Vif-induced degradation.3. Regulation of APOBEC3G expression : We demonstrate that IFN-a induces APOBEC3G expression in hepatoeytes.
All 2008 2007 2006 Other
All Journal Article (18 results) (of which Peer Reviewed: 6 results) Presentation (31 results) Book (1 results) Remarks (1 results)
Mini-Reviews in Medical Chemistry 8
Pages: 231-238
日本エイズ学会誌 10
Pages: 19-24
10017102577
Mini-Reviews in Medical Chemistry 8(3)
J Gen Virol 88
Pages: 432-440
J Gen Virol 88(Pt2)
Virology 344
Pages: 263-266
Biochem Biophys Res Commun 341
Pages: 314-319
Int J Hematol 83
Pages: 213-216
Curr Biol 16
Pages: 1565-1570
Virolagy 344
Pages: 314-9
Curr Biol 16(15)
Virology 344・2
Biochem Biophys Res Commun 341・2
Int J Hematol 83・3
Curr Biol 16・15
J Gen Virol 88・2
http://www.kuhp.kyoto-u.ac.jp/~hemonc/hematolindex.html
