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Identification of transcription factors that control memory Th2 cell differentiation

Research Project

Project/Area Number 18590466
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionChiba University

Principal Investigator

YAMASHITA Masakatsu  Chiba University, Graduate School of Medicine, Associate Professor (00311605)

Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥4,020,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
KeywordsMemory Th2 cells / Transcription factors / Allergy / MLL / Bmi1 / Noxa / Gfi1 / GATA3 / ポリコーム / メモリーTh2 / IgE / 好酸球 / 気道炎症 / 免疫記憶
Research Abstract

One of the difficulties in memory Th2 cell study is limited numbers of antigen-specific memory Th2 cell in vivo. We developed an adoptive transfer technique for the generation of large number of antigen-specific memory Th2 cell in vivo. Using this technique, we tried to identify transcription factors, which are important for memory Th2 cell differentiation.
The following results could be achieved for this research on two years. (1) Mixed lineage leukemia (MLL) is required for the maintenance of Th2 cell identity in memory Th2 cells (Yamashita, et. Al. Immunity 24: 611, 2006). MLL appears to regulate stable Th2 identity through the epigenetic control of the GATA3 locus and the Th2 cytokine gene loci in memory Th2 cells. (2) Bmi1, a member of polycomb gene family, is required for proper generation of memory Th2 cells (Yamashita, et. Al., J. Exp. Med. 2008, in press). In the absence of Bmi1, the generation of Th2 memory cells was impaired as a consequence of increased Noxa expression. Our results indicate that Bmi1 controls memory Th2 cell survival and function through the direct repression of the Noxa gene. (3) Gfi1, a member of C2H2 type zinc finger transcription factors, is important for the stabilization of Th2 cell identity. Gfi1-mediated stabilization of GATA3 protein is required for the establishment of Th2 cell identity (Shinnakasu, et. Al., in preparation).

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (68 results)

All 2008 2007 2006

All Journal Article (28 results) (of which Peer Reviewed: 13 results) Presentation (40 results)

  • [Journal Article] Bmil regulates memory CD4 T cell survival via repression of the Noxa gene.2008

    • Author(s)
      Yamashita, M.
    • Journal Title

      J. Exp. Med. (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA32008

    • Author(s)
      Hosokawa, H.
    • Journal Title

      J. Immunol. 177

      Pages: 7656-7664

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Bmil regulates memory CD4 T cell survival via repression of the Noxa gene2008

    • Author(s)
      Yamashita, M.
    • Journal Title

      J. Exp. Med (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] Schurri-2 regulates Th2-dependent airway inflammation and airway hyperresponsiveness.2007

    • Author(s)
      Iwamura, C.
    • Journal Title

      Int. Immunol. 19

      Pages: 755-762

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Schunurri-2 controls memory Th1 and Th2 cell number in vivo.2007

    • Author(s)
      Kimura, Y
    • Journal Title

      J. Immunol. 178

      Pages: 4926-4936

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Chromatin remodeling at the Th2 cytokine gene loci in human type2 helper T cells.2007

    • Author(s)
      Kaneko, T.
    • Journal Title

      Mol. Immunol. 44

      Pages: 2249-2256

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Schurri-2 regulates Th2-dependent airway inflammation and airway hyperresponsiveness2007

    • Author(s)
      Iwamura, C.
    • Journal Title

      Int. Immunol 19

      Pages: 755-762

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Schunurri-2 controls memory Th1 and Th2 cell number in vivo2007

    • Author(s)
      Kimura, Y.
    • Journal Title

      J. Immunol 178

      Pages: 4926-4936

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Chromatin remodeling at the Th2 cytokine gene loci in human type 2 helper T cells2007

    • Author(s)
      Kaneko, T.
    • Journal Title

      Mol. Immunol 44

      Pages: 2249-2256

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Schurri-2 regulates Th2-dependent airway inflammation and airway herresonsiveness2007

    • Author(s)
      Yamashita, M
    • Journal Title

      Int. Immunol 19

      Pages: 755-762

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Schunurri-2 controls memory Thl and Th2 cell number in vivo2007

    • Author(s)
      Kimura, Y
    • Journal Title

      J. Immunol 178

      Pages: 4926-4936

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chromatin remodeling at the Th2 cytokine gene loci in human type 2 heler T cells2007

    • Author(s)
      Kaneko, T.
    • Journal Title

      Mol. Immunol 44

      Pages: 2249-2256

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical YxKxHxxxRP motif in the C-terminal region of GATA3 for its DNA binding and function.2006

    • Author(s)
      Shinnakasu, R.
    • Journal Title

      J. Immunol. 177

      Pages: 5801-5810

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Hyperresponsive Th2 cell with enhanced NF-kB activation induce apoptosis dermatitis-like lesions in NC/Nga mice.2006

    • Author(s)
      Tenda, Y.
    • Journal Title

      J. Allergy Clin. Immunol. 118

      Pages: 725-733

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Crucial role of MLL for the maintenance of memory T helper type2 cell responses.2006

    • Author(s)
      Yamashita, M.
    • Journal Title

      Immunity 24

      Pages: 611-622

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function.2006

    • Author(s)
      Nigo, I.
    • Journal Title

      Proc. Natl. Acad. Sci. USA 103

      Pages: 2286-2291

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Impaired GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuated allergic airway inflammation in aging mice.2006

    • Author(s)
      Hasegawa, A.
    • Journal Title

      J. Immunol. 176

      Pages: 2546-2554

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA32006

    • Author(s)
      Hosokawa, H.
    • Journal Title

      J. Immunol 177

      Pages: 7656-7664

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Critical YxKxHxxxRP motif in the C-terminal region of GATA3 for its DNA binding and function2006

    • Author(s)
      Shinnakasu, R.
    • Journal Title

      J. Immunol 177

      Pages: 5801-5810

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Hyperresponsive Th2 cell with enhanced NF-kB activation induce apoptosis dermatitis-like lesions in NC/Nga mice2006

    • Author(s)
      Tenda, Y.
    • Journal Title

      J. Allergy Clin. Immunol 118

      Pages: 725-733

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Crucial role of MLL for the maintenance of memory T helper type 2 cell responses2006

    • Author(s)
      Yamashita, M.
    • Journal Title

      Immunity 24

      Pages: 611-622

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function2006

    • Author(s)
      Nigo, I.
    • Journal Title

      Proc. Natl. Acad. Sci. USA 103

      Pages: 2286-2291

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Impaired GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuated allergic airway inflammation in aging mice2006

    • Author(s)
      Hasegawa, A.
    • Journal Title

      J. Immunol 176

      Pages: 2546-2554

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Chromatin remodeling at the Th2 cytokine gene loci in human type 2 helpe T cells.2006

    • Author(s)
      Kaneko, T.
    • Journal Title

      Mol. Immunol. (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Regulation of Th2 cell development by Polycomb group gene bmi-1 throug the stabilization of GATA3.2006

    • Author(s)
      Hosokawa, H.
    • Journal Title

      J. Immunol. 177

      Pages: 7656-7664

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Critical YxKxHxxxRP motif in the C-terminal region of GATA3 for its DN binding and function.2006

    • Author(s)
      Shinnakasu, R.
    • Journal Title

      J. Immunol. 177

      Pages: 5801-5810

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Hyperresponsive Th2 cell with enhanced NF-κB activation induce apoptosis dermatitis-like lesions in NC/Nga mice.2006

    • Author(s)
      Tenda, T.
    • Journal Title

      J. Allergy Clin. Immunol. 118

      Pages: 725-733

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Crucial role of MLL for the maintenance of memory T helper type 2 celresponses.2006

    • Author(s)
      Yamashita, M.
    • Journal Title

      Immunity. 24

      Pages: 611-622

    • Related Report
      2006 Annual Research Report
  • [Presentation] MLL-dependent maintenance of memory Th2 cell identity.2007

    • Author(s)
      Yamashita, M.
    • Organizer
      JSI-RCAIワークショップ2007
    • Place of Presentation
      横浜
    • Year and Date
      2007-03-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Schnurri-2によるメモリーTh1/Th2細胞形成調節/Schnurri-2 controls memory Th1 and Th2 cell numbers in vivo.2007

    • Author(s)
      鈴木茜
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      品川
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] BmilはNoxa遺伝子の発現抑制を介してメモリーTh細胞の生存を維持する/Bmil regulates memory Th cell survival via repression of the Noxagene.2007

    • Author(s)
      Yamashita, M.
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      品川
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] BmilはNoxa遺伝子の発現調節を介してメモリーCD4 T細胞の生存を制御する2007

    • Author(s)
      山下政克
    • Organizer
      第30回日本分子生物学会年会第80回日本生化学学会大会 合同大会 BMB2007
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ポリコーム群遺伝子BmilによるメモリーTh2細胞形成調節機構2007

    • Author(s)
      山下政克
    • Organizer
      第17回Kyoto T Cell Conference
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] MLL-dependent maintenance of memory Th2 cell identity2007

    • Author(s)
      Yamashita, M.
    • Organizer
      JSI-RCAI Workshop 2007 Transcriptional factors and T lymphocytes development
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Schnurri-2 controls memory Th1 and Th2 cell numbers in vivo2007

    • Author(s)
      Suzuki, A.
    • Organizer
      The 37th Annual meeting of the Japanese Society for Immunology
    • Place of Presentation
      Shinagawa
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Bmil regulates memory Th cell survival via repression of the Noxa gene2007

    • Author(s)
      Yamashita, M.
    • Organizer
      The 37th Annual meeting of the Japanese Society for Immunology
    • Place of Presentation
      Shinagawa
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Bmil regulates memory CD4T cell survival via repression of Noxa2007

    • Author(s)
      Yamashita, M.
    • Organizer
      Biochemistry and Molecular Biology
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of Th2 cell development by Polycomb group gene bmil2007

    • Author(s)
      Yamashita, M.
    • Organizer
      The 17th Kyoto T Cell Conference
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Schnurri-2によるメモリーTh1/Th2細胞形成調節/Schnuri-2 controls memory Th1 and Th2 cell numbers in vivo.2007

    • Author(s)
      鈴木 茜
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      品川
    • Related Report
      2007 Annual Research Report
  • [Presentation] Bmi1はNoxa遺伝子の発現抑制を介してメモリーTh細胞の生存を維持する/Bmi1 regulates memory Th cell survival via repression of the Noxa gene.2007

    • Author(s)
      Yamashita, M.
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      品川
    • Related Report
      2007 Annual Research Report
  • [Presentation] BmilはNoxa遺伝子の発現調節を介してメモリーCD4T細胞の生存を制御する2007

    • Author(s)
      山下 政克
    • Organizer
      第30回日本分子生物学会年会第80回日本生化学学会大会 合同大会BMB2007
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] ポリコーム群遺伝子Bmi1によるメモリL-Th2細胞形成調節機構2007

    • Author(s)
      山下 政克
    • Organizer
      第17回Kyoto T Cell Conference
    • Place of Presentation
      京都
    • Related Report
      2007 Annual Research Report
  • [Presentation] ヒストンメチル基転移酵素MLLによるメモリーTh2反応の維持機構2006

    • Author(s)
      山下政克
    • Organizer
      第16回Kyoto T Cell Conference
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ポリコ-ム群遺伝子産物Bmi-1によるTh2細胞分化の制御2006

    • Author(s)
      細川裕之
    • Organizer
      第16回Kyoto T Cell Conference
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Critical role for mast cell TLR4 in Lipopolysaccharide-mediated enhancement of allergic airway eosinophilic inflammation.2006

    • Author(s)
      Nakayama, T.
    • Organizer
      EAACI
    • Place of Presentation
      Vienna,Austria
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Crucial role of MLL for the maintenance of memory Th2 cell identity.2006

    • Author(s)
      Yamashita, M.
    • Organizer
      第36回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Hyperresponsive Th2 cells with enhanced NF-kB activation induce atopic dermatitis-like skin lesions in NC/Nga mice.2006

    • Author(s)
      Tenda, Y.
    • Organizer
      第36回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA3.2006

    • Author(s)
      Hosokawa, H.
    • Organizer
      第36回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Schnurri-2によるメモリーTh1/Th2細胞形成調節機構2006

    • Author(s)
      岩村千秋
    • Organizer
      第36回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Enhancement of Th1 cell differentiation by BCG cell wall components.2006

    • Author(s)
      Ito, T.
    • Organizer
      第36回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] メモリーTh2細胞形成のエピジェネティック制御2006

    • Author(s)
      山下政克
    • Organizer
      蛋白質研究所セミナー/ポリコーム超分子複合体を介した細胞記憶の制御メカニズム
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] TLR4を介した肥満細胞機能とアレルギー性気道炎症の制御2006

    • Author(s)
      山下政克
    • Organizer
      生体機能と創薬シンポジウム2006
    • Place of Presentation
      博多
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] TLR4を介した肥満細胞機能調節とアレルギー性気道炎症2006

    • Author(s)
      山下政克
    • Organizer
      第79回日本薬理学会シンポジウム
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Epigenetic regulation of memory Th2 cell generation.2006

    • Author(s)
      Yamashita, M.
    • Organizer
      第5回東アジア生物物理学会シンポジウム合同会議
    • Place of Presentation
      沖縄
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Crucial role of MLL for the maintenance of Th2 cell identity.2006

    • Author(s)
      Yamashita, M.
    • Organizer
      CAI-JSI International Symposium on Immunology.
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Crucial role of MLL for the maintenance of memory Th 2 cell responses2006

    • Author(s)
      Yamashita, M.
    • Organizer
      The 16th Kyoto T Cell Conference
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of Th2 cell development by Polycomb group gene Bmil through the stabilization of GATA32006

    • Author(s)
      Hosokawa, H.
    • Organizer
      The 16th Kyoto T Cell Conference
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Critical role for mast cell TLR4 in Lipopolysaccharide-mediated enhancement of allergic airway eosinophilic inflammation2006

    • Author(s)
      Nakayama, T.
    • Organizer
      EAACI
    • Place of Presentation
      Vienna, Austria
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Crucial role of MLL for the maintenance of memory Th2 cell identity2006

    • Author(s)
      Yamashita, M.
    • Organizer
      The 36th Annual meeting of the Japanese Society for Immunology
    • Place of Presentation
      Osaka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Hyperresponsive Th2 cells with enhanced NF-kB activation induce atopic dermatitis-like skin lesions in NC/Nga mice2006

    • Author(s)
      Tenda, Y.
    • Organizer
      The 36th Annual meeting of the Japanese Society for Immunology
    • Place of Presentation
      Osaka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA32006

    • Author(s)
      Hosokawa, H.
    • Organizer
      The 36th Annual meeting of the Japanese Society for Immunology
    • Place of Presentation
      Osaka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of memory Th1/Th2 cell generation bySchnurri-22006

    • Author(s)
      Iwamura, C.
    • Organizer
      The 36th Annual meeting of the Japanese Society for Immunology
    • Place of Presentation
      Osaka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Enhancement of Th 1 cell differentiation by BCG cell wall components2006

    • Author(s)
      Ito, T.
    • Organizer
      The 36th Annual meeting of the Japanese Society for Immunology
    • Place of Presentation
      Osaka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Epigenetic regulation of memory Th2 cell generation2006

    • Author(s)
      Yamashita, M.
    • Organizer
      Regulation of cellular memory by Polycomb super moleculer complexes
    • Place of Presentation
      Osaka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function2006

    • Author(s)
      Yamashita, M.
    • Organizer
      Biofunction and Drug Discovery Symposium 2006
    • Place of Presentation
      Hakata
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function2006

    • Author(s)
      Yamashita, M.
    • Organizer
      The 36th Annual meeting of the Japanese Phermacological Society
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Epigenetic regulation of memory Th2 cell generation2006

    • Author(s)
      Yamashita, M.
    • Organizer
      Fifth East Asian Biophysics Symposium & Forty-Fourth Annual meeting of the Biophysical Society of Japan
    • Place of Presentation
      Okinawa
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Crucial role of MLL for the maintenance of Th2 cell identity2006

    • Author(s)
      Yamashita, M.
    • Organizer
      CAI-JSI International Symposium on Immunology
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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