Regulation of T cell development mediated by BAF complex and Runx3
| Project/Area Number |
18590477
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Tokai University |
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Principal Investigator |
SATO Takehito Tokai University, School of Medicine, Associated Professor (50235363)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥4,010,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | epigenetics / thymus / Runx3 / Tcell / chromatin / BAF complex / 細胞系列決定 / DNA複製 / BAF / Runx / 分化 |
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| Research Abstract |
Developing thymocytes provide a useful tool to investigate the changes of the chromatin structure in the differentiation process. Based on the previous result that Runx3 plays pivotal roles in the development of CD8 thymocytes (Sato T., et. Al. Immunity 2005), this study has been designed to clarify the molecular basis for the lineage choice to CD8 thymocytes through the function of Runx3.
This study revealed that chromatin re-modeler BAF complex controls CD4 and 8 expression quite similarly to Runx3. This raised the possibility that Runx3 binds to BAF complex and coordinately regulate CD4 and 8 expressions. In the study, I found that the control of DNA replication play some important roles in the lineage determination process. Blockade of DNA replication inhibited CD8 thymocytes differentiation, whereas augmentation of DNA replication inhibited CD4 thymocytes differentiation. Since DNA replication is accompanied with dynamic change of chromatin structure, it is to be clarified how DNA replication control affect on the lineage determination process in near future.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Runx proteins are involved in regulation of CD122, Ly49 family and IFNg expression during NK cell differentiation2008
Author(s)
S., Ohno, * T., Sato, K., Kohu, K., Takeda, K., Okumura, M., Satake, S., Habu
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Journal Title
Internationl Immunology 20
Pages: 71-71
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Pleiotropic roles of Runx transcription Factors in the differentiation and function of T lymphocytes2008
Author(s)
K., Kohu, M., Kubo, H., Ichikawa, S., Ohno, S., Habu, T., Sato, M., Satake
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Journal Title
Current Immunology Review 4
Pages: 101-101
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Presentation] Molecular basis for the lineage choice of CD4/8 thymocytes2006
Author(s)
T., Sato, T., Chiba, S., Ohno, K., Kohu, M., Satake, S., Habu
Organizer
Proceedings of the Japanese Society for Immunology
Year and Date
2006-12-12
Description
「研究成果報告書概要(欧文)」より
Related Report
