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The estab lishmentt of Hiroshima human hepatocyte bank

Research Project

Project/Area Number 18590493
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical sociology
Research InstitutionHiroshima University

Principal Investigator

AMANO Hironobu  Hiroshima University, Hospital, Assistant Professor (30423370)

Co-Investigator(Kenkyū-buntansha) ASAHARA Toshimasa  Hiroshima University, President (70175850)
ITAMOTO Toshiyuki  Hiroshima University, Graduate School of Biomedical Sciences, Associate Professor (50294575)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,850,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2006: ¥1,900,000 (Direct Cost: ¥1,900,000)
KeywordsCRC / human hepatosyte / public resource bank / 肝細胞バンク / 公的資源化 / 肝細胞
Research Abstract

Japanese hepatocytes are strongly required for research on development of a new medicine, because there are differences in drug metabolism among not only animal species but also human races. However there are many issues to be discussed such as protection of personal information and bioethics. In 1998, we started research on human hepatocytes isolated from a resected liver of patients with non-viral metastatic liver tumor aiming at regenerative medicine such as bioartificial liver support system and hepatocyte transplantation. We have established perfusion, cryopreservation, and cultivation system of human hepatocytes. On the basis of the background, we are strongly certain about the necessity of a public human hepatocyte bank for research use. We adopted three important plans. The first is the introduction of two step-informed consent which consists of the comprehensive consent for all patients when they first visit our hospital and the secondary consent for cell bank before the operation. The second is the participation of pathologists who judge if the liver tissue was adequately and safely donated or not. The third is the employment of CRC (clinical research coordinators) who can support mental care of patients (donors), assist researchers and return the research results to society. We provided 7 cases of Japanese human hepatocytes to the public resource bank for research use.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (30 results)

All 2008 2007 2006

All Journal Article (9 results) (of which Peer Reviewed: 3 results) Presentation (18 results) Book (3 results)

  • [Journal Article] Clinicopathologic features of poorly differentiated hepatocellular carcinoma.2007

    • Author(s)
      K. Oishi
    • Journal Title

      J Surg Oncol. 95(4)

      Pages: 311-316

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Repeat hepatectomy for recurrent hepatocellular carcinoma.2007

    • Author(s)
      T.Itamoto
    • Journal Title

      Surgery. 141

      Pages: 589-597

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 肝炎、肝硬変2007

    • Author(s)
      板本敏行
    • Journal Title

      消化器外科NURSING 12

      Pages: 497-501

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 2007 Clinicopathologic features of poorly differentiated hepatocellular carcinoma2007

    • Author(s)
      K. Oishi, T., Itamoto, H., Amano, S., Fukuda, H., Ohdan, H., Tashiro, F., Shimamoto, T., Asahara
    • Journal Title

      J Surg. Oncol 95(4)

      Pages: 311-316

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 2007 Repeat hepatectomy for recurrent hepatocellular carcinoma2007

    • Author(s)
      T., Itamoto, H., Nakahara, H., Amano, T., Kohashi, H.,Ohdan, H.,Tashiro, T.,Asahara
    • Journal Title

      Surgery 141

      Pages: 589-597

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 2007 Hepatitis・Cirrhosis2007

    • Author(s)
      T.,Itamoto
    • Journal Title

      GASTROENTEROLOGICAL SURGERY NURSING 12

      Pages: 497-501

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Repeat hepatectomy for recurrent hepatocellular carcinoma2007

    • Author(s)
      Itamoto Toshiyuki
    • Journal Title

      Surgery 141

      Pages: 589-597

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肝炎、肝硬変2007

    • Author(s)
      板本 敏行
    • Journal Title

      消化器外科NURSING 12

      Pages: 497-501

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Clonicopathologic features of poorly differentiated hepatocellular carcinoma.2007

    • Author(s)
      K.Oishi
    • Journal Title

      Journal of Surgical Oncology 95(4)

      Pages: 311-316

    • Related Report
      2006 Annual Research Report
  • [Presentation] 広島大学におけるヒト肝組織バンク設立に向けた取り組み2008

    • Author(s)
      天野尋暢
    • Organizer
      第7回日本再生医療学会総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2008-03-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Making a tissue donation system in research use of human liver in Hiroshima University2008

    • Author(s)
      H., Amano, M., Tanimoto, T., Itamoto, Y., Igarashi, T., Tateno, K., Yoshizaato, T., Asahara
    • Organizer
      The 7th Congress Society for Regenerative Medicine
    • Place of Presentation
      Nagoya
    • Year and Date
      2008-03-13
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Treatment of portal vein stenosis after living donor liver Transplantation using interventional radiography2008

    • Author(s)
      Amano Hironobu
    • Organizer
      8th world Congress of the International Hepato Pancreato Association
    • Place of Presentation
      Mumbai(INDIA)
    • Year and Date
      2008-02-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Significance of surgical treatment for patients with hepatocelluar Hepatocellular carcinoma exceeding milan criteria2008

    • Author(s)
      Amano Hironobu
    • Organizer
      8th World Conggress of the Intemational Hepato Pancreato Biliary Association
    • Place of Presentation
      Mumbai(INDLA)
    • Year and Date
      2008-02-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Treatment of portal vein stenosis after living donor liver transplantation using interventional radiography2008

    • Author(s)
      H., Amano, A., Oshita, H., Ohdan, H., Tashiro, T., Asahara, T., Itamoto
    • Organizer
      8th Word Congress of the International Hepato Pancreato Hillary Assotiation
    • Place of Presentation
      Mumbai (INDIA)
    • Year and Date
      2008-02-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Significance of surgical treatment for patients with hepatocelluar carcinoma exceeding milan criteria2008

    • Author(s)
      H., Amano, T., Itamoto, Y., Tanimoto, I., Ushitora, H., Ohdan, H., Tashiro, T., Asahara
    • Organizer
      8th Word Congress of the International Hepato Pancreato Biliary Assotiation
    • Place of Presentation
      Mumbai (INDIA)
    • Year and Date
      2008-02-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Treatment of portal vein stenosis after living donor liver transplantation using interventional radiography2008

    • Author(s)
      Amano Hironobu
    • Organizer
      8th World Congress of the International Hepato Pancreato Biliary Association
    • Place of Presentation
      Mumbai(INDIA)
    • Year and Date
      2008-02-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] Significance of surgical treatment for patients with hepatocellular carcinoma exceeding milan criteria2008

    • Author(s)
      Amano Hironobu
    • Organizer
      8th World Congress of the International Hepato Pancreato Biliary Association
    • Place of Presentation
      Mumbai(INDIA)
    • Year and Date
      2008-02-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] 肝細胞癌切除後のSSI(手術部位感染)発症のリスクとその対策2007

    • Author(s)
      天野 尋暢
    • Organizer
      第69回日本臨床外科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] 生体肝移植ドナーの周術期安全性向上のための工夫2007

    • Author(s)
      天野尋暢
    • Organizer
      第43回日本移植学会総会
    • Place of Presentation
      仙台市
    • Year and Date
      2007-11-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Periopevative pitfall for the safety inpatients undergoing living donor transplantation2007

    • Author(s)
      H., Amano, T., Itamoto, A., Ohshita, I., Ushitora, Y., Tanimoto, K., Ishiyama, H., Ohdan, H., Tashiro, T., Asahara
    • Organizer
      The 43th Annual Congress of the Japan Society
    • Place of Presentation
      Sendai
    • Year and Date
      2007-11-23
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 生体肝移植ドナーの周術期安全性向上のための工夫.2007

    • Author(s)
      天野 尋暢
    • Organizer
      第43回日本移植学会総会
    • Place of Presentation
      仙台市
    • Year and Date
      2007-11-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] 合併症ゼロを目指した肝細胞癌切除の工夫2007

    • Author(s)
      天野尋暢
    • Organizer
      第62回日本消化器外科学会定期学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-07-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Surgical technic of hepatectomy for hepatocellular carcinoma toward "zero"morbidity2007

    • Author(s)
      H., Amano, T., Itamoto, A., Oshita, K., Ishiyama, H., Ohdan, H., Tashiro, T., Asahara
    • Organizer
      The 62th Japanese Society Gastroencological Surgery
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-07-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 肝内胆管癌に対する外科的治療成績と治療方針2007

    • Author(s)
      天野尋暢
    • Organizer
      第19回日本肝胆膵外科学会学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-06-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Surgical treatment of cholangiocellular carcinoma2007

    • Author(s)
      H., Amami., T., Itamoto, A., Oshita, I., Ushitora, J., Hashizume, H., Momisako, T., Matumoto, H., Ohdan, H., Tashiro, T., Asahara
    • Organizer
      The 19th Meeting of Japanese Society of Hepato-Biliary-Pancreatic surgery
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-06-06
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 肝細胞癌切除後SSI(手術部位感染)発症のリスクとその対策2007

    • Author(s)
      天野尋暢
    • Organizer
      第69回日本臨床外科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-01-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Risk factors of surgical site infection after heptectomy for hepatocellular carcinoma2007

    • Author(s)
      H., Amano, R., Man, T., Itamoto, Y., Tanimoto, I., Ushitora, A., Oshita, H., Ohdan, H., Tashiro, T., Asahara
    • Organizer
      The 69th Annual Congress of JSA
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-01-30
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 消化器外科学レビュー2007 (分担執筆「9.再生医療」)2007

    • Author(s)
      浅原利正
    • Publisher
      総合医学社,東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 消化器外科学レビュー2007 (分担執筆「9.再生医療」)2007

    • Author(s)
      浅原 利正
    • Publisher
      総合医学社,東京
    • Related Report
      2007 Annual Research Report
  • [Book] 消化器外科レビュー2006(「再生医療」分担執筆)2006

    • Author(s)
      浅原利正
    • Total Pages
      253
    • Publisher
      総合医学社
    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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