The estab lishmentt of Hiroshima human hepatocyte bank
| Project/Area Number |
18590493
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical sociology
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| Research Institution | Hiroshima University |
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Principal Investigator |
AMANO Hironobu Hiroshima University, Hospital, Assistant Professor (30423370)
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| Co-Investigator(Kenkyū-buntansha) |
ASAHARA Toshimasa Hiroshima University, President (70175850)
ITAMOTO Toshiyuki Hiroshima University, Graduate School of Biomedical Sciences, Associate Professor (50294575)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,850,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2006: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | CRC / human hepatosyte / public resource bank / 肝細胞バンク / 公的資源化 / 肝細胞 |
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| Research Abstract |
Japanese hepatocytes are strongly required for research on development of a new medicine, because there are differences in drug metabolism among not only animal species but also human races. However there are many issues to be discussed such as protection of personal information and bioethics. In 1998, we started research on human hepatocytes isolated from a resected liver of patients with non-viral metastatic liver tumor aiming at regenerative medicine such as bioartificial liver support system and hepatocyte transplantation. We have established perfusion, cryopreservation, and cultivation system of human hepatocytes. On the basis of the background, we are strongly certain about the necessity of a public human hepatocyte bank for research use. We adopted three important plans. The first is the introduction of two step-informed consent which consists of the comprehensive consent for all patients when they first visit our hospital and the secondary consent for cell bank before the operation. The second is the participation of pathologists who judge if the liver tissue was adequately and safely donated or not. The third is the employment of CRC (clinical research coordinators) who can support mental care of patients (donors), assist researchers and return the research results to society. We provided 7 cases of Japanese human hepatocytes to the public resource bank for research use.
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Report
(3 results)
Research Products
(30 results)
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[Journal Article] 2007 Clinicopathologic features of poorly differentiated hepatocellular carcinoma2007
Author(s)
K. Oishi, T., Itamoto, H., Amano, S., Fukuda, H., Ohdan, H., Tashiro, F., Shimamoto, T., Asahara
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Journal Title
J Surg. Oncol 95(4)
Pages: 311-316
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] 2007 Repeat hepatectomy for recurrent hepatocellular carcinoma2007
Author(s)
T., Itamoto, H., Nakahara, H., Amano, T., Kohashi, H.,Ohdan, H.,Tashiro, T.,Asahara
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Journal Title
Surgery 141
Pages: 589-597
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Making a tissue donation system in research use of human liver in Hiroshima University2008
Author(s)
H., Amano, M., Tanimoto, T., Itamoto, Y., Igarashi, T., Tateno, K., Yoshizaato, T., Asahara
Organizer
The 7th Congress Society for Regenerative Medicine
Place of Presentation
Nagoya
Year and Date
2008-03-13
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Treatment of portal vein stenosis after living donor liver transplantation using interventional radiography2008
Author(s)
H., Amano, A., Oshita, H., Ohdan, H., Tashiro, T., Asahara, T., Itamoto
Organizer
8th Word Congress of the International Hepato Pancreato Hillary Assotiation
Place of Presentation
Mumbai (INDIA)
Year and Date
2008-02-28
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Significance of surgical treatment for patients with hepatocelluar carcinoma exceeding milan criteria2008
Author(s)
H., Amano, T., Itamoto, Y., Tanimoto, I., Ushitora, H., Ohdan, H., Tashiro, T., Asahara
Organizer
8th Word Congress of the International Hepato Pancreato Biliary Assotiation
Place of Presentation
Mumbai (INDIA)
Year and Date
2008-02-28
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Periopevative pitfall for the safety inpatients undergoing living donor transplantation2007
Author(s)
H., Amano, T., Itamoto, A., Ohshita, I., Ushitora, Y., Tanimoto, K., Ishiyama, H., Ohdan, H., Tashiro, T., Asahara
Organizer
The 43th Annual Congress of the Japan Society
Place of Presentation
Sendai
Year and Date
2007-11-23
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Surgical technic of hepatectomy for hepatocellular carcinoma toward "zero"morbidity2007
Author(s)
H., Amano, T., Itamoto, A., Oshita, K., Ishiyama, H., Ohdan, H., Tashiro, T., Asahara
Organizer
The 62th Japanese Society Gastroencological Surgery
Place of Presentation
Tokyo
Year and Date
2007-07-18
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Surgical treatment of cholangiocellular carcinoma2007
Author(s)
H., Amami., T., Itamoto, A., Oshita, I., Ushitora, J., Hashizume, H., Momisako, T., Matumoto, H., Ohdan, H., Tashiro, T., Asahara
Organizer
The 19th Meeting of Japanese Society of Hepato-Biliary-Pancreatic surgery
Place of Presentation
Yokohama
Year and Date
2007-06-06
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Risk factors of surgical site infection after heptectomy for hepatocellular carcinoma2007
Author(s)
H., Amano, R., Man, T., Itamoto, Y., Tanimoto, I., Ushitora, A., Oshita, H., Ohdan, H., Tashiro, T., Asahara
Organizer
The 69th Annual Congress of JSA
Place of Presentation
Tokyo
Year and Date
2007-01-30
Description
「研究成果報告書概要(欧文)」より
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