• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Research for signal transduction factors in carcinogenesis by differential proteomics analysis

Research Project

Project/Area Number 18590506
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied pharmacology
Research InstitutionUniversity of Tsukuba

Principal Investigator

UCHIDA Kazuhiko  University of Tsukuba, Graduated School of Comprehensive Human Science, Associate Professor (90211078)

Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥4,020,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
KeywordsProteome / Drug-resistance / Protein / Mass spectrometry
Research Abstract

In this study, the low-molecular-weight proteome, peptidome, is a source of potential biomarkers for the disease. However, almost all detected peptides in previous reports are fragments originating from highly abundant plasma proteins, probably through the activities of disease-associated proteases and the ex vivo coagulation and complement degradation pathways in the collected blood. In addition, the major plasma proteins abundant in blood mask the presence of circulating peptide biomarkers indicative of the disease state, making the discovery of such biomarkers challenging. In present study, we established the methodology for differential and quantitative serum peptidome profiling that is efficient in the discovery of these peptides. Comprehensive fractionation by 2 dimensional LC-MALDI-TOF MS, non-labeling quantification and multi-sample comparison data analysis were performed. Numerous reports claim that the use of surface-enhanced laser desorption/ionization (SELDI)-TOF MS or MALD … More I-TOF MS has identified mass peaks or combinations of mass peaks that are capable of diagnosing disease with high sensitivity and specificity. However, most of these studies are pattern-based without identification of each of such mass peaks and, therefore, present analytical platform must be powerful tool for differential proteomics to reveal signaling pathways in carcinogenesis and cancer progression. We also analyzed signaling pathways involved in cancer progression and drug-resistance in clear cell carcinoma of kidney. To identify genomic alterations involved in progression of clear cell renal cell carcinoma (CRCC) and figure out the oncogenic pathways of renal cell. Twenty-three tumors and their corresponding normal tissues were collected and genomic DNA and RNA were isolated. The 50 K SNP mapping array U133 Plus 2.0 array was used. Individual copy numbers on chromosome and gene expression patterns at corresponding loci were analyzed. We have identified novel homozygous deletion at 4q24 including CXXC4 by using SNP array in renal cell carcinoma. The CXXC4 gene encodes the Idax protein that whose functions as is a negative regulator of the Wnt signaling by binding to the PDZ domain of Dvl Here we report a possible role of CXXC4 in development and progression of RCC. Present data suggest that the decrease of CXXC4 might play an important role for tumor progression in RCC. Its loss in RCC may result in constitutively activate Writ signaling, and induce the expression of genes that function downstream of beta-catenin. Less

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (83 results)

All 2008 2007 2006 Other

All Journal Article (28 results) (of which Peer Reviewed: 13 results) Presentation (52 results) Book (3 results)

  • [Journal Article] Use of Iaser microdissection in the analysis of renal-infiltrating T cells inMRL/lpr mice.2008

    • Author(s)
      Wang Y, Uchida K, et. al.
    • Journal Title

      Mod. Rheumatol (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Growth suppre ssion of thyroid cancer cells by adenylcyclaSe'activator.2007

    • Author(s)
      Yano, Y., Uchida K., et. al.
    • Journal Title

      Oneoogy Reports 18

      Pages: 441-445

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Prediction of in vitro response to interferon-alpha in renal cell carcinoma cell lines.2007

    • Author(s)
      Shimazui, T., Uchida, K. et.a1.
    • Journal Title

      98

      Pages: 529-534

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Comprehensive differential serum ptidome profiling by non-labeling quantitative 2D-LC MLAIDI-TOF MS reveals scriminating the chronic liver disease.2007

    • Author(s)
      Uchida, K , et. al.
    • Journal Title

      Mol. Cell. Proteomics HUPO 2007

      Pages: 393-393

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Prote omic analysis for sea rching of quantitative trait genes in B6 and C3H mice2007

    • Author(s)
      Ide, ML, Uchida, K. , et. al.
    • Journal Title

      Mol. Cell. Proteomies HUPO 2007

      Pages: 391-391

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Alpha-1-antitrypsin and complement component C7 are involved in asthma exacerbation2007

    • Author(s)
      Nishioka T, Uchida K, Meno K, Ishii T, Aoki T, Imada Y, Makino Y, Hirata K, Matsumoto Y, Arinami T and Noguchi E
    • Journal Title

      Proteomics 18

      Pages: 441-445

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Growth suppression of thyroid cancer cells by adenylcyclase activator2007

    • Author(s)
      Yano Y, Kamma H, Matsumoto H, Fujiwara M, Bando H, Hara H, Yashiro T, Ueno E, Ito K and Uchida K.
    • Journal Title

      Oncol. Rep. 18

      Pages: 441-445

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Prediction of in vitro response to interferon-alpha in renal cell carcinoma cell lines2007

    • Author(s)
      Shimazui T, Ami Y, Yoshikawa K, Uchida K, Kojima T, Oikawa T, Nakamura K, Honda N, Hinotsu S, Miyazaki J, Kunita N and Akaza H.
    • Journal Title

      Cancer. Sci. 98

      Pages: 529-534

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Comprehensive differential serum peptidome profiling by non-labeling quantitative 2D-LC MALDI-TOF MS reveals novel peptide biomarkers discriminating the chronic liver disease2007

    • Author(s)
      Uchida K, Suzuki H, Meno K, Ishii T, Fujimoto H, Yamaguchi E, Takeda Y, Takano J, Nagashima R and Shiraki K.
    • Journal Title

      Mol. Cell. Proteomics, HUPO 2007

      Pages: 393-393

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Proteomic analysis for searching of quantitative trait genes in B6 and C3H mice, HUPO 20072007

    • Author(s)
      Ide M, Ishii y Katagiri T, Iwayama Y, watanabe A, Hori T, Mizukami K, Yoshikawa T, Katagiri T, Uchida K and Asada T.
    • Journal Title

      Mol.Cell.Proteomics,HUPO 2007

      Pages: 391-391

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 「研究成果報告書概要(欧文)」より2007

    • Author(s)
      Wang Y, Ito S, Chino Y, Iwanami K, Yasukochi T, Goto D, Matsumoto I, Hayashi T, Uchida K, and Sumida T.
    • Journal Title

      Mod. Rheumatol. (in press)

    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Gene expression profiling for biomarker discovery. In BioArrays : From Basics to Diagnostics2007

    • Author(s)
      Uchida. K
    • Journal Title

      edited by Appasani, K. Humana Press, Totowa, NJ

      Pages: 95-106

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Growth suppression of thyroid cancer cells by adenylcyclase activator.2007

    • Author(s)
      Yano, Y., Uchida, K., et. al.
    • Journal Title

      Oncoogy. Reports 18

      Pages: 441-445

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prediction of in vitro response to interferon-alpha in renal cell carcinoma cell lines.2007

    • Author(s)
      Shimazui, T., Uchida, K., et. al.
    • Journal Title

      Cancer. Science 98

      Pages: 529-534

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive differential serum peptidome profiling by non-labeling quantitative 2D-LC MALDI-TOF MS reveals novel peptide biomarkers discriminating the chronic liver disease.2007

    • Author(s)
      Uchida, K., et. al.
    • Journal Title

      Mol. Cell. Proteomics HUPO 2007

      Pages: 391-391

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic analysis for searching of quantitative trait genes in B6 and C3H mice.2007

    • Author(s)
      Ide, M., Uchida, K., et. al.
    • Journal Title

      Mol. Cell. Proteomics HUPO 2007

      Pages: 391-391

    • NAID

      130006999192

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prediction of in vitro response to interferon-alpha in renal cell carcinoma cell lines.2007

    • Author(s)
      Shimazui, T., et al.
    • Journal Title

      Cancer Sci 98

      Pages: 529-34

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Quantitation of thyroid in peripheral blood for early detection of thyroid papillary carcinoma.2006

    • Author(s)
      Ishikawa T, Uchida K, et. al.
    • Journal Title

      Thyroid 16

      Pages: 435-442

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Gene expression profiling defined pathways corrted with fibroblast cell proljferation induced by Opisthorchis viverrmi excretory/secretory product2006

    • Author(s)
      Thuwajit C, Uchida K, et. al.
    • Journal Title

      World J Gastroenterol. 12

      Pages: 3585-3592

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Influence of chemotherapeutic agents and cytokines on the expression of 5-fluorouracil-associated enzymes in human colon cancer cell lines.2006

    • Author(s)
      Miyazaki K, Shibahara T, Sato D, Uchida K, Suzuki H, Matsui H, Yanaka A, Nakahara A, Matsuzaki Y
    • Journal Title

      J Gastroenterol. 41

      Pages: 140-150

    • NAID

      10017421164

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Gene expression profiling defined pathways correlated with fibroblast cell proliferation induced by Opisthorchis viverrini excretory/secretory product2006

    • Author(s)
      Thuwajit C, Thuwajit P, Uchida K, Daorueang D, Kaewkes S, Wongkham S, Miwa M.
    • Journal Title

      World J Gastroenterol. 12

      Pages: 3585-3592

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Quantitation of tissue-pecific mRNA of thyroid in peripheral blood for early detection of thyroid papillary carcinoma2006

    • Author(s)
      Ishikawa T, Miwa M, Uchida K.
    • Journal Title

      Thyroid 16

      Pages: 435-42

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Quantitation of tissue-specific mRNA of thyroid in peripheral blood for early detection of thyroid papillary carcinoma.2006

    • Author(s)
      Ishikawa, T., et al.
    • Journal Title

      Thyroid 16

      Pages: 435-42

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Gene expression profiling defined pathways correlated with fibroblast cellproliferation induced by Opisthorchis viverrini excretory/secretory product.2006

    • Author(s)
      Thuwajit, C., et al.
    • Journal Title

      World J. Gastroenterol. 12

      Pages: 3585-92

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Influence of chemotherapeutic agents and cytokines on the expression of 5-fluorouracil-associated enzymes in human colon cancer cell lines.2006

    • Author(s)
      Miyazaki, K. et al.
    • Journal Title

      J. Gastroenterol. 41

      Pages: 140-50

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Alpha-1-antitryp sin and-comp1ement component C7 are involved in asthma exacerbation.

    • Author(s)
      Nishioka, T., UchidaK., et. al.
    • Journal Title

      Proteoimics (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Influence of chemotherapeutic iagents and cytokines on the expression of 5-fluorouracil-associated enzymes human colon cancer cell lines

    • Author(s)
      Miyazaki K, Uchida K, et. al.
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Alpha-1-antitrypsin and complement component C7 are involved in asthma exacerbation.

    • Author(s)
      Nishioka, T., Uchida, K., et. al.
    • Journal Title

      Proteomics (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] CXXC4の発現低下は腎細胞癌の悪性度と進展に関与する2008

    • Author(s)
      小島崇宏・内田和彦, 他
    • Organizer
      第17回泌尿器分子細胞研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-02-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Decreased CXXC4 expression correlates metastasis and poor survival in renal cell carcinoma2008

    • Author(s)
      Kojima, T., Uchida, K, et. al.
    • Organizer
      17th Japanese Society for Molecular and Cellular Urology
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-02-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 非標識定量2D・LCMALDI-TOF MSによる低分子量プロテオミクス解析2007

    • Author(s)
      内田和彦
    • Organizer
      第4回千葉疾患プロテオミクス研究会
    • Place of Presentation
      千葉
    • Year and Date
      2007-10-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Comprehensive proteomic analysis reveals the disease-stage specific biomarkers for the HCV-related chronic liver diseases2007

    • Author(s)
      内田和彦, 他
    • Organizer
      第66回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Comprehensive genomic analysis of clear cell renal cell carcinoma by high-density SNP array and gene expression array2007

    • Author(s)
      小島崇宏・内田和彦, 他
    • Organizer
      第66回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Biological systems analysis of hepatocellular carcinoma by genomics using high-density SNP and gene expression arrays2007

    • Author(s)
      堀江亮・内田和彦, 他
    • Organizer
      日第66回本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Low molecular weight proteomics analysis by the non-mark fixed-quantity 2D-LC MALDI-TOF MS2007

    • Author(s)
      Uchida, K.
    • Organizer
      Chiba disease proteomics meeting for the study : special lecture
    • Place of Presentation
      Chiba
    • Year and Date
      2007-10-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Comprehensive proteomic analysis reveals the disease-stage specific biomarkers for the HCV-related chronic liver diseases2007

    • Author(s)
      Uchida, K, et. al.
    • Organizer
      Proc. 66th Ann. Meeting of Japanese Cancer Assciation
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-10-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Comprehensive genomic analysis of clear cell renal cell carcinoma by high-density SNP array and gene expression array2007

    • Author(s)
      Kojima, T., Uchida, K, et. al.
    • Organizer
      Proc. 66th Ann. Meeting of Japanese Cancer Assciation
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-10-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 非標識定量2D-LC MALDI-TOF MSによる低分子量プロテオミクス解析2007

    • Author(s)
      内田 和彦
    • Organizer
      第4回千葉疾患プロテオミクス研究会
    • Place of Presentation
      千葉
    • Year and Date
      2007-10-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Comprehensive proteomic analysis reveals the disease-stage specific biomarkers for the HCV-related chronic liver diseases2007

    • Author(s)
      内田 和彦, 他
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Comprehensive genomic analysis of clear cell renal cell carcinoma by high-density SNP array and gene expression array2007

    • Author(s)
      小島 崇宏, 他
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Quantitative 2D-μHPLC MALDI-TOF-MS reveals serum peptides related to the disease progression in patients with chronic hepatitis C2007

    • Author(s)
      Meno, K., Uchida, K, et. al.
    • Organizer
      20th International Congress of Biochemitry and Molecular Biology
    • Place of Presentation
      Kyoto
    • Year and Date
      2007-07-21
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] For base construction to support -clinical proteomics for base construction to support Omics medical care2007

    • Author(s)
      Uchida, K.
    • Organizer
      4th Symposium of Genome/Omics medical information
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-07-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] オミックス医療を文える基盤構築に同けて-臨床プロテオミクスを支える基盤構築に向けて2007

    • Author(s)
      内田和彦
    • Organizer
      第4何ゲノム・オミックス医療情報シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2007-06-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] オミックス医療を支える基盤構築に向けて-臨床プロテオミクスを支える基盤構築に向けて2007

    • Author(s)
      内田 和彦
    • Organizer
      第4回ゲノム・オミックス医療情報シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2007-06-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] Uniparental polysomy of 3q is possible metastatic marker in the patients of clear cell renal cell carcinoma2007

    • Author(s)
      Kojima, T・Uchida, K, et. al.
    • Organizer
      102nd American Urological Association Annual Meeting
    • Place of Presentation
      カリフォルニア州アナハイム
    • Year and Date
      2007-05-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Uniparental polysomy of 3q is possible metastatic marker in the patients of clear cell renal cell carcinoma2007

    • Author(s)
      Kojima, T., Uchida, K, et. al.
    • Organizer
      102nd American Urlogical Association Annual Meeting, California USA
    • Year and Date
      2007-05-20
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 高密度SNPアレイによる淡明腎細胞癌の網羅的ゲノム解析2007

    • Author(s)
      小島崇宏・内田和彦, 他
    • Organizer
      第95回日本泌尿器科学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2007-04-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Comprehensive genomic analysis of clear cell renal cell carcinoma by high-density SNP array2007

    • Author(s)
      Kojima, T., Uchida, K, et. al.
    • Organizer
      95th Japanese Urlogical Association Ann, Meeting
    • Place of Presentation
      Kobe
    • Year and Date
      2007-04-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 統合失調症の神経発達障害モデルラットにおける脳内プロテオミクス研究2007

    • Author(s)
      堀孝文・内田和彦, 他
    • Organizer
      第2回日本統合失調症学会
    • Place of Presentation
      富山
    • Year and Date
      2007-03-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Proteomic analysis of brain in a neurodevelopmental animal model of schizophrenia2007

    • Author(s)
      Hori, T., Uchida, K, et. al.
    • Organizer
      2nd Ann. Meeting of Japanese Soc. of Schizophrenia Research
    • Place of Presentation
      Toyama
    • Year and Date
      2007-03-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Biological systems analysis of hepatocellular carcinoma by genomics using high-density SNP and gene expression arrays2007

    • Author(s)
      Horie, R., Uchida, K, et. al.
    • Organizer
      Proc. 66th Ann. Meeting of Japanese Cancer Assciation
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 腎細胞がん株のインターフェロンα感受性や悪性度に関わるゲノム異常2006

    • Author(s)
      小島崇宏・内田和彦, 他
    • Organizer
      第65回日本癌学会学術総会
    • Place of Presentation
      神奈川
    • Year and Date
      2006-09-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Genomic alterations and gene expression profiling as a predictor of interferon alpha sensitivity in renal cell carcinoma cell lines2006

    • Author(s)
      Kojima, T., Uchida, K, et. al.
    • Organizer
      Proc. 65th Ann. Meeting of Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-09-30
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 二次元マイクロHPLCペプチドMSプロファイリ-ングによるバイオマーカー探索2006

    • Author(s)
      片桐拓也・内田和彦, 他
    • Organizer
      第65回日本癌学会学術総会
    • Place of Presentation
      神奈川
    • Year and Date
      2006-09-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 定量的2D-andmicro;HPLC MALDI-TOF-MSによるC型肝炎ウイルス性疾患マーカーペプチドの探索2006

    • Author(s)
      目野浩二・内田和彦, 他
    • Organizer
      第65回日本癌学会学術総会
    • Place of Presentation
      神奈川
    • Year and Date
      2006-09-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Gene ChipとアレイCGHによる肝細胞がん・肝硬変・正常肝のゲノム解析2006

    • Author(s)
      堀江亮・内田和彦, 他
    • Organizer
      第65回日本癌学会学術総会
    • Place of Presentation
      神奈川
    • Year and Date
      2006-09-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Clinical proteome analysis by 2D-HPLC peptide MS profiling2006

    • Author(s)
      Katagiri, K., Uchida, K, et. al.
    • Organizer
      Proc. 65th Ann. Meeting of Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-09-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Quantitative 2D-&micro ; HPLC MALDI-TOF MS reveals serum peptides related to the disease progression in patients with chronic hepatitis C2006

    • Author(s)
      Meno, K., Uchida, K, et. al.
    • Organizer
      Proc. 65th Ann. Meeting of Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-09-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Genomic analyses of hepatocellular carcinoma, liver chirrosis and normal liver by GeneChip and array-CGH2006

    • Author(s)
      Horie R., Uchida, K, et. al.
    • Organizer
      Proc. 65th Ann. Meeting of Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-09-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 放射線誘発アポトーシスおよび細胞周期停止にするシグナル伝達経路2006

    • Author(s)
      内田和彦, 他
    • Organizer
      第65回日本癌学会学術総会
    • Place of Presentation
      神奈川
    • Year and Date
      2006-09-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] マウスBBN膀胱発癌過程の遺伝子発現の変化2006

    • Author(s)
      阿弥良浩・内田和彦, 他
    • Organizer
      第65回日本癌学会学術総会
    • Place of Presentation
      神奈川
    • Year and Date
      2006-09-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Signal transduction cascades involved in g-irradiation induced apotosis and cell-cycle arrest2006

    • Author(s)
      Uchida, K, et. al.
    • Organizer
      Proc. 65th Ann. Meeting of Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-09-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Alteration of gene expression in bladder carcinogenesis induced by N-butyl-N-(4-hydroxybutyl) nitrosamine in mice2006

    • Author(s)
      Ami, Y., Uchida, K, et. al.
    • Organizer
      Proc. 65th Ann. Meeting of Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-09-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Development of an intact protein analytical platform for proteomics.2006

    • Author(s)
      Tanigawa, T・Uchida, K, et. al.
    • Organizer
      第20回国際生化学・分子生物学会
    • Place of Presentation
      京都
    • Year and Date
      2006-07-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Proteome analysis of choroid plexus in Alzheimer's disease2006

    • Author(s)
      Akatsu, H・Uchida, K, et. al.
    • Organizer
      第20回国際生化学・分子生物学会
    • Place of Presentation
      京都
    • Year and Date
      2006-07-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Development of an intact protein analytical platform for proteomics.2006

    • Author(s)
      Tanigawa T, Uchida, K, et. al.
    • Organizer
      20th International Congress of Biochemitry and Molecular Biology
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-07-22
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Identification of proteins contributing to prepulse inhibition by proteomic analyses of the brains and lymphocytes in mice with different prepulse inhibition phenotypes.2006

    • Author(s)
      Ide M, Uchida, K, et. al.
    • Organizer
      20th International Congress of Biochemitry and Molecular Biology
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-07-22
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Proteome analysis of choroid plexus in Alzheimer's disease.2006

    • Author(s)
      Akatsu H, Uchida, K, et. al.
    • Organizer
      20th International Congress of Biochemitry and Molecular Biology
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-07-22
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Quantitative 2D-uHPLC MALDI-TOF-MS reveals serum peptides related to the disease progression in patients with chronic hepatits C2006

    • Author(s)
      Meno, K・Uchida, K, et. al.
    • Organizer
      第20回国際生化学・分子生物学会
    • Place of Presentation
      京都
    • Year and Date
      2006-07-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Peptidomic analysisi of mouse brain by 2D-uHPLC-MALDI-TOF-MS2006

    • Author(s)
      Ishii, T・Uchida, K, et. al.
    • Organizer
      第20回国際生化学・分子生物学会
    • Place of Presentation
      京都
    • Year and Date
      2006-07-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Peptidomic analysis of mouse brain by 2D-μHPLC-MALDI-TOF-MS2006

    • Author(s)
      Ishii T, Uchida, K, et. al.
    • Organizer
      20th International Congress of Biochemitry and Molecular Biology
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-07-21
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Non-labeling quantitative 2D uLC-MALDI-TOF MS profiling system for biomarker discovery2006

    • Author(s)
      Fujimoto, T・Uchida, K, et. al.
    • Organizer
      第20回国際生化学・分子生物学会
    • Place of Presentation
      京都
    • Year and Date
      2006-07-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Non-labeling quantitative 2D μLC-MALDI-TOF MS profiling system for biomarker discovery2006

    • Author(s)
      Fujimoto T, Uchida, K, et. al.
    • Organizer
      20th International Congress of Biochemitry and Molecular Biology
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-07-20
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Identification of proteins contributing to prepulse inhibition by proteomic analyses of the brains and lymphocytes in mice with different prepulse inhibition phenotvpes2006

    • Author(s)
      Ide, M・Uchida, K, et. al.
    • Organizer
      第20回国際生化学・分子生物学会
    • Place of Presentation
      京都
    • Year and Date
      2006-07-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Quantitative 2D-uHPLC MALDI-TOF-MS reveals serum peptides related to the disease progression in patients with chronic hepatits C2006

    • Author(s)
      Fujimoto, H・Uchida, K, et. al.
    • Organizer
      日本ヒトプロテオーム機構(JHUPO)第4回大会・第2回日本臨床フロテオーム研究会連合大会
    • Place of Presentation
      東京
    • Year and Date
      2006-07-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Peptidomic analysis of mouse brain by 2D-uHPLC-MALDI-TOF-MS2006

    • Author(s)
      Ishii, T・Uchida, K, et. al.
    • Organizer
      日本ヒトプロテオーム機構(JHUPO)第4回大会・第2回日本臨床フロテオーム研究会連合大会
    • Place of Presentation
      東京
    • Year and Date
      2006-07-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] C型慢性肝炎から肝硬変への進行に伴って変化するタンパク質アイソフォームの同定2006

    • Author(s)
      片桐拓也・内田和彦, 他
    • Organizer
      日本ヒトプロテオーム機構(JHUPO)第4回大会・第2回日本臨床フロテオーム研究会連合大会
    • Place of Presentation
      東京
    • Year and Date
      2006-07-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Quantitative 2D-μHPLC MALDI-TOF-MS reveals serum peptides related to the disease progression in patients with chronic hepatitis C2006

    • Author(s)
      Fujimoto H., Uchida, K, et. al.
    • Organizer
      The 4th JHUPO and The 2th nd JSCP Joint Conference
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-07-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Peptidomic analysis of mouse brain by 2D-μHPLC-MALDI-TOF-MS2006

    • Author(s)
      Ishii T, Meno K., Uchida, K, et. al.
    • Organizer
      The 4th JHUPO and The 2th nd JSCP Joint Conference
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-07-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Serum biomarkers for hepatitis C type virus-induced liver disease ; a proteomic sudy2006

    • Author(s)
      Katagiri, K, Uchida, K, et. al.
    • Organizer
      The 4th JHUPO and The 2th nd JSCP Joint Conference
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-07-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Gene expression profiling for biomarker discovery. In BioArrays: From Basics to Diagnostics, edited by Appasani, K.2007

    • Author(s)
      Uchida K.
    • Total Pages
      12
    • Publisher
      Humana Press, Totowa, NJ.
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Gene expression profiling for biomarker discovery. In BioArrays:From Basics to Diagnostics, edited by Appasani, K.2007

    • Author(s)
      Uchida, K.,
    • Total Pages
      12
    • Publisher
      Humana Press, Totowa, NJ.
    • Related Report
      2007 Annual Research Report
  • [Book] In BioArrays : From Basics to Diagnostics, edited by Appaseni, K. Humana Press2007

    • Author(s)
      Uchida, K.
    • Publisher
      Gene expression profiling for biomarker discovery.(in press)
    • Related Report
      2006 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi