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The Tailor Made Therapy of Anti-Cancer Drugs

Research Project

Project/Area Number 18590516
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied pharmacology
Research InstitutionSt.Marianna University School of Medicine

Principal Investigator

KOBAYASHI Shinichi  St.Marianna University School of Medicine, Department of Pharmacology, Professor (20129836)

Co-Investigator(Kenkyū-buntansha) KUMAI Toshio  St. Marianna University School of Medicine, Department of Pharmacology, Associate Professor (40139671)
TANAKA Masami  St. Marianna University School of Medicine, Institute of Experimental Animals, Associate Professor (00171801)
NAKANO Hiroshi  St. Marianna University School of Medicine, Department of Surgery, Associate Professor (10241035)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,950,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2006: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsTailor made therapy / Anti-cancer drugs / Gene polymorphism / Drug metabolizing enzymes / Transporter / DPD / Haplotype
Research Abstract

Anti-cancer drugs have a many serious side effects is well known. There are possible that the gene polymorphisms of drug metabolizing enzymes and drug transporter are affects on the anti-cancer drugs pharmacokinetics, pharmacodynamics and side effects. Further ethnic differences of gene polymorphisms of the several drug metabolizing enzymes and transporter have been reported. Therefore, we investigated that the gene polymorphisms of drug metabolizing enzymes and drug transporter, which are closely related anti-cancer drugs in the Japanese population. Genomic DNA obtained from the non cancer liver tissues by surgical resection for liver disease. Written informed consent was obtained from 34 patients with liver disease. This study was approved by the ethics committee of St. Marianna University School of Medicine. We can identified gene polymorphisms of CYP's (CYP1A2*1F, CYP2C19*2, *3, CYP2D6*4, *5, *6, *10, CYP3A4*4, *16) and MDR1 (-41A/G, -129T/C, 1236T/C, 2677G/A, T, 3435C/T, 4036A/G). The allele frequencies of CYP's were (CYP1A2*1F(69.4%), CYP2C19*2, *3(41.7%), CYP2D6*4, *5, *6, *10(42.6%), CYP3A4*4, *16(2.9%)), and MDR1 were (-41A/G(16.7%), -129T/C(9.4%), 1236T/C(24.2%), 2677G/A, T(64.6%), 3435C/T(40.9%), 4036A/G(27.3%)), respectively. The allele frequencies of CYP1A2, CYP2C19, CYP2D6, and 12677G/A, T, and 3435C/Tof MDR-1 were shown to be high compared to previously reports. These result indicated that the needs for attention on the using drugs for metabolism by these CYP's and for transport by MDR-1. These data suggested that the pharmacogenomic data is available on the tailor made therapeutic strategy of patients having above gene polymorphisms in Japanese.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (2 results)

All 2007

All Presentation (2 results)

  • [Presentation] 肝疾患におけるCYPsおよびMDR-1の遺伝子多型について2007

    • Author(s)
      熊井 俊夫
    • Organizer
      第28回日本臨床薬理学会
    • Place of Presentation
      宇都宮
    • Year and Date
      2007-11-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] The gene polymorphism of CYP's and MDR-1 in the several liver disease.2007

    • Organizer
      28th Annual Meeting of Japanese Clinical Pharmacology
    • Place of Presentation
      Utsunomiya
    • Year and Date
      2007-11-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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