Protection mechanism of thrombotic formation though heme oxygenase-1 in stress response

• Project/Area Number: 18590523
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Kanazawa University
• Principal Investigator: MORISHITA Eriko Kanazawa University, Graduate School of Medicine, Associate altar (50251921)
• Co-Investigator(Kenkyū-buntansha): YACHIE Akihiro Kanazawa University, Graduate School of Medicine, Professor (40210281)
• Project Period (FY): 2006 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥3,990,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2006: ¥2,300,000 (Direct Cost: ¥2,300,000)
• Keywords: Heme oxygenase-1 / thrombosis / inflammation / tissue factor / plasminogen activator inhibitor 1 / TNF-α / thrombomodulin / endothelial cell / ヘムオキシゲナーゼ / TFPI / リポポリサッカライド / ヘムオキシゲナーゼー1 / 酸化ストレス

Research Abstract

Heme oxygenase (HO) plays a central role heme metabolism. At the same time, it protects cells from injury evoked by various oxidative stresses. A detailed analysis of the first case of HO-1 deficiency revealed that HO-1 is involved in the protection of multiple tissue and organs. Laboratory data in the patient were remarkable with hypercoagulable and heperfibrinolytic state. To see if the hypercoagulable state is directly caused by HO-1 deficiency, we examined the effect of HO-1 in endothelial cells in vitro.
In the first experiment, HUVEC was stimulated with hemin and mRNA and antigens for HO-1 and some of the parameters of coagulation/fibrinolysis were examined. Hemin stimulation induced significant levels of HO-1 production. Tissue factor (TF) production was minimum even after 8hrs of stimulation. Importantly, hemin stimulation reduced PAI-1 production more than half after 4hrs. In the second experiment, HO-1 production was induced by hemin prior to stimulation of HUVEC with TNF-a. Prior exposure to hemin induced significantly HO-1 production, but TNF-cc alone could not induce HO-1 in HUVEC. Although stimulation with TNF-α enhanced productions of both TF and PAI-1, they were significantly inhibited by prior treatment with hemin. These results indicate that hemin exert inhibitory effect on TF and PAI-1 through HO-1 production.

Research Products

• [Journal Article] A case of factor X(FX)deficiency due to novel mutation V196M, FX Hofu. (2008)
  • Author(s): Shinohara K, et. al.
  • Journal Title: Int J Hematol 87(3) Pages: 256-9
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Clonal relationship between infiltrating immunoglobulin G4(IgG4)-positive plasma cells in lacrimal glands and circulating IgG4-positive lymphocytes in Mikulicz's disease. (2008)
  • Author(s): Yamada K, et. al.
  • Journal Title: Clin Exp Immunol 152(3) Pages: 432-9
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 血液凝固異常症の臨床と血液検査. (2008)
  • Author(s): 森下英理子
  • Journal Title: 日本検査血液学会誌 9(1) Pages: 91-8
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 先天性血栓性素因が疑われたときに行う検査. (2008)
  • Author(s): 森下英理子
  • Journal Title: 検査と技術 36(1) Pages: 52-5
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Expression of annexin II in human atherosclerotic abdominal aortic aneurysms. (2008)
  • Author(s): Hayashi T, et. al.
  • Journal Title: Thromb Res (in press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Changes in molecular markers of hemostatic and fibrinolytic activation under various sampling conditions using vacum tube samples from healthy volunteers. (2008)
  • Author(s): Omote M, T, et. al.
  • Journal Title: Thromb Res (in press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] case of factor X (FX) deficiency due to novel mutation V196M, FX Hofu (2008)
  • Author(s): Shinohara, K., Adachi, M., Matsui, K., Matsuda, K., Nagaya, S., Morishita, E., A
  • Journal Title: Int J Hematol 87(3) Pages: 256-9
  • NAID: 10021255959
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Clonal relationship between infiltrating immunoglobulin G4 (IgG4)-positive plasma cells in lacrimal glands and circulating IgG4-positive lymphocytes in Mikulicz's disease (2008)
  • Author(s): Yamada, K., Kawano, M., Inoue, R., Hamano, R., Kakuchi, Y., Fujii, H., Matsumura, M., Zen, Y., Takahira, M., Yachie, A., Yamagishi, M
  • Journal Title: Clin Exp Immunol 152(3) Pages: 432-9
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A case of factor X(FX) deficiency due to novel mutation V196M, FXHofu (2008)
  • Author(s): Shinohara K, et. al.
  • Journal Title: Int J Hematol 87 Pages: 256-9
  • Peer Reviewed
• [Journal Article] Heme, heme oxygenase, and ferritin: how the vascular endothelium survives(and dies)in an iron-rich environment. (2007)
  • Author(s): Balla J, et. al.
  • Journal Title: Antioxid Redox Signal 9(12)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Skin infiltration of CD56(bright)CD16(-)natural killer cells in a case of X-SCID with Omenn syndrome-like manifestations. (2007)
  • Author(s): Shibata F, et. al.
  • Journal Title: Eur J Haematol 79(1) Pages: 81-5
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Immunophenotypic analysis of Epstein-Barr virus(EBV)-infected CD8(+)T cells in a patient with EBV-associated hemophagocytic lymphohistiocytosis. (2007)
  • Author(s): Wada T, et. al.
  • Journal Title: Eur J Haematol 79(1) Pages: 72-5
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Corticosteroid enhances home oxygenase-1 production by circulating monocytes by up-regulating hemoglobin scavenger receptor and amplifying the receptor-mediated uptake of hemoglobin-haptoglobin complex. (2007)
  • Author(s): Yamazaki H, et. al.
  • Journal Title: Biochem Biophys Res Commun 358(2) Pages: 506-12
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Reactive peripheral blood plasmacytosis in a patient with acute hepatitis A. (2007)
  • Author(s): Wada T, et. al.
  • Journal Title: Int J Hematol 85(3) Pages: 191-4
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Role of T cells in the pathogenesis of type I diabetes mellitus: structure analysis of complementarity determining region 3 of circulating T cells. (2007)
  • Author(s): Sakumai M, et. al.
  • Journal Title: Rinsho Byori 55(2) Pages: 112-9
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Clonotypic analysis of T cell reconstitution after haematopoietic stem cell transplantation(HSCT)in patients with severe combined immunodeficiency. (2007)
  • Author(s): Okamoto H, et. al.
  • Journal Title: Clin Exp Immunol 148(3) Pages: 450-60
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] ヘムオキシゲナーゼと生体防御機構;抗炎症治療のパラダイムシフト (2007)
  • Author(s): 谷内江昭宏
  • Journal Title: 日本臨床免疫学会会誌 30(1) Pages: 11-21
  • NAID: 10018857951
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Sequential measurement of fecal parameters in a case of non-immunoglobulin E-mediated milk allergy. (2007)
  • Author(s): Wada T, et. al.
  • Journal Title: Pediatr Int 49(1) Pages: 109-11
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Somatic revertant mosaicism in a patient with leukocyte adhesion deficiency type 1. (2007)
  • Author(s): Tone Y, et. al.
  • Journal Title: Blood 109(3) Pages: 1182-4
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] プロトロンビン時間正常活トロンボテスト低値の症例とループスアンチコアグラント (2007)
  • Author(s): 高道小百合、その他
  • Journal Title: 日本検査血液学会誌 8(1) Pages: 28-35
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 東海・北陸地域におけるフローサイトメーターを用いたCD4陽性Tリンパ球測定に関するアンケート調査および模擬精度管理調査. (2007)
  • Author(s): 正兼亜季、その他
  • Journal Title: 日本検査血液学会誌 8(2) Pages: 192-7
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 先天性凝固異常症の臨床と病態解析 (2007)
  • Author(s): 森下英理子
  • Journal Title: 臨床血液 48(5) Pages: 363-370
  • NAID: 130004501098
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 特発性深部静脈血栓症における経口抗凝固薬3ヶ月投与群と1年間投与群の比較試験.特集データブック-血栓症の大規模臨床試験PART2. (2007)
  • Author(s): 森下英理子
  • Journal Title: 血栓と循環 15(4) Pages: 171-2
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Analysis of MPO-ANCA subtypes in a patient with propylthiouracil-induced vasculitis with multiple (2007)
  • Author(s): Ohta, K., Shimizu, M., Yokoyama, T., Ohta, K., Nakai, A., Seno, A., Kasahara, Y., Yachie, A., Fujieda, M., Koizumi, S
  • Journal Title: Clin Nephrol 68(5) Pages: 315-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] heme oxygenase, and ferritin : how the vascular endothelium survives (and dies) in an iron-rich environment. Antioxid Redox Signal (2007)
  • Author(s): Balla, J., Vercellotti, GM., Jeney, V., Yachie, A., Varga, Z., Jacob, HS., Eaton, JW., Balla, G. Heme
  • Journal Title: Antioxid Redox Signal 9(12) Pages: 2119-37
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Skin infiltration of CD56(bright) CD16(-) natural killer cells in a case of X-SCID with Omenn syndrome-like manifestations (2007)
  • Author(s): Shibata, F., Toma, T., Wada, T., Inoue, M., Tone, Y., Ohta, K., Kasahara, Y., Sano, F., Kimura, M., Ikeno, M., Koizumi, S., Yachie, A
  • Journal Title: Eur J Haematol 79(1) Pages: 81-5
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Immunophenotypic analysis of Epstein-Barr virus (EBV)-infected CD8(÷) T cells in a patient with EBV-associated hemophagocytic lymphohistiocytosis (2007)
  • Author(s): Wada, T., Kurokawa, T., Toma, T., Shibata, F., Tone, Y., Hashida, Y., Kaya, H., Yoshida, T., Yachie, A
  • Journal Title: Eur J Haematol 79(1) Pages: 72-5
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Corticosteroid enhances heme oxygenase-1 production by circulating monocytes by up-regulating hemoglobin scavenger receptor and amplifying the receptor-mediated uptake of hemoglobin-haptoglobin complex (2007)
  • Author(s): Yamazaki, H., Ohta, K., Tsukiji, H., Tema, T., Hashida, Y., Ishizaki, A., Saito, T., Arai, S., Koizumi, S., Yachie, A
  • Journal Title: Biochem Biophys Res Commun 358(2) Pages: 506-12
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Reactive peripheral blood plasmacytosis in a patient with acute hepatitis A (2007)
  • Author(s): Wada, T., Maeba, H., Ikawa, Y., Hashida, Y., Okumura, A., Shibata, F., Tone,. Y, Inoue, M., Koizumi, S, Takatori H, Sakai Y ; Kaneko S, Yachie, A
  • Journal Title: Int J Hematol 85(3) Pages: 191-4
  • NAID: 10019488769
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role Of T cells in the pathogenesis of type I diabetes mellitus : structure analysis of complementarity determining region 3 of circulating T cells (2007)
  • Author(s): Sakumai, M., Yachie, A., Kasahara, Y
  • Journal Title: Rinsho Byori 55(2) Pages: 112-9
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Clonotypic analysis of T cell reconstitution after haematopoietic stem cell transplantation (HSCT) in patients with severe combined immunodeficiency (2007)
  • Author(s): Okamoto, H., Arii, C., Shibata, F., Toma, T., Wada, T., Inoue, M., Tone, Y., Kasahara, Y., Koizumi, S., Kamachi, Y., Ishida, Y., Inagaki, J., Kato, M., Morio, T., Yachie, A
  • Journal Title: Clin Exp Immunol 148(3) Pages: 450-60
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Heme oxygenase and its role in defense system ; paradigm shift of anti-inflammatory therapy (2007)
  • Author(s): Yachie, A
  • Journal Title: Nihon Rinsho Meneki Gakkai Kaishi 30(1) Pages: 11-21
  • NAID: 10018857951
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Sequential measurement of fecal parameters in a case of non- immunoglobulin E-mediated milk allergy (2007)
  • Author(s): Wada, H., Horisawa, T., Inoue, M., Yoshida, T., Toma, T., Yachie, A
  • Journal Title: Pediatr Int 49(1) Pages: 109-11
  • NAID: 10018837878
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Somatic revertant mosaicism in a patient with leukocyte adhesion deficiency type 1 (2007)
  • Author(s): Tone, Y., Wada, T., Shibata, F., Toma, T., Hashida, Y., Kasahara, Y., Koizumi, S., Yachie, A
  • Journal Title: Blood 109(3) Pages: 1182-4
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Corticosteroid enhances heme oxygenase-1 production by circulating monocytes by up-regulating hemoglobin scavenger receptor and amplifying the receptor-mediated uptake of hemoglobin-haptoglobin complex (2007)
  • Author(s): Yamazaki H, et. al.
  • Journal Title: Biochem Biophys Res Commun 358 Pages: 506-12
  • Peer Reviewed
• [Journal Article] Skin infiltration of CD56(bright) CD16(-)natural killer cells in a case of X-SCID with Omenn syndrome-like manifestations (2007)
  • Author(s): Shibata F, et. al.
  • Journal Title: Eur J Haematol 79 Pages: 81-5
  • Peer Reviewed
• [Journal Article] Clonotypic analysls ot T cell reconstitution after haematopoietic stem cell transplantation (HSCT) in patients with severe combined immunodeficiency. (2007)
  • Author(s): Okamoto H
  • Journal Title: Clin Exp Imunol (印刷中)
• [Journal Article] Somatic revertant mosaicism in a patient with leukocyte adhesion deficiency type 1 (2007)
  • Author(s): Tone Y
  • Journal Title: Blood 109・3 Pages: 1182-1184
• [Journal Article] ヘムオキシゲナーゼと生体防御機構 : 抗炎症治療のパラダイムシフト (2007)
  • Author(s): 谷内江昭宏
  • Journal Title: 日本臨床免疫学会会誌 30・1 Pages: 11-21
  • NAID: 10018857951
• [Journal Article] No interplay between the pathways mediating coagulation and inflammation in tissue factor-induced disseminated intravascular coagulation in rats. (2006)
  • Author(s): Ontachi Y, et. al.
  • Journal Title: Crit Care Med 34(10) Pages: 2646-50
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Immunoglobulin preparations attenuate organ dysfunction and hemostatic abnormality by suppressing the production of cytokines in lipopolysaccharide-induced disseminated intravascular coagulation in rats. (2006)
  • Author(s): Asakura, et. al.
  • Journal Title: Crit Care Med 34(9) Pages: 2421-5
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Effects of sarpogrelate hydrochloride in a patient with chronic graft-versus-host disease: a case report. (2006)
  • Author(s): Hayashi T, et. al.
  • Journal Title: Am J Hematol 81(2) Pages: 121-3
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Rituximab therapy for Epstein-Barr virus-related chronic hepatitis following living donor kidney transplantation. (2006)
  • Author(s): Ohta K, et. al.
  • Journal Title: Am J Kidney Dis 48(6) Pages: 986-9
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. Immunity. (2006)
  • Author(s): Minegishi Y, et. al.
  • Journal Title: Immunity 25(5) Pages: 745-55
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Omenn syndrome-review of several phenotypes of Omenn syndrome and RAG1/RAG2 mutations in Japan. Allergol Int. (2006)
  • Author(s): Kato M, et. al.
  • Journal Title: Allergol Int 55(2) Pages: 115-9
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Somatic revertant mosaicism in a patient with leukocyte adhe sion deficiency type 1. (2006)
  • Author(s): Tone Y, et. al.
  • Journal Title: Blood Sep 21(Epub ahead of print)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Neuromyelitis optica associated with myasthenia gravis: characteristic phenotype in Japanese population. (2006)
  • Author(s): Furukawa Y, et. al.
  • Journal Title: Eur J Neurol 13(6) Pages: 655-8
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cytomegalovirus-associated protracted diarrhea in an immunocompetent boy. (2006)
  • Author(s): Shimizu M, et. al.
  • Journal Title: J Paediatr Child Health 42(5) Pages: 259-62
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A second-site mutation in the initiation codon of WAS(WASP)results in expansion of subsets of lymphocytes in an Wiskott-Aldrich syndrome patient. (2006)
  • Author(s): Du W, et. al.
  • Journal Title: Hum Mutat 27(4) Pages: 370-5
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 血管内皮細胞における凝固線溶制御因子の発現に与えるHMG-CoA還元酵素阻害剤の影響. (2006)
  • Author(s): 山崎和美、その他
  • Journal Title: 日本血栓止血学会誌 17(4) Pages: 454-61
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 基礎疾患別にみたループスアンチコアグラント陽性率の検討-当院における依頼検体の現状-. (2006)
  • Author(s): 表美香、その他
  • Journal Title: 臨床病理 54(9) Pages: 903-9
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Analysis of MPO-ANCA subtypes in a patient with propylthiour acil-induced vasculitis with multiple complications. (2006)
  • Author(s): Ohta K, et. al.
  • Journal Title: Clin. Nephrol 68(5) Pages: 315-21
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] No interplay between the pathways mediating coagulation and inflammation in tissue factor-induced disseminated intravascular coagulation in rats (2006)
  • Author(s): Ontachi, Y., Asakura, H., Takahashi, Y., Hayashi, T., Arahata, M., Kadohira, Y.,. Maekawa, M., Omote, M., Yoshida, T., Yamazaki, M., Morishita, E., Miyamoto, K., Nakao, S
  • Journal Title: Crit Care Med 34(10) Pages: 2646-50
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Immunoglobulin preparations attenuate organ dysfunction and hemostatic abnormality by suppressing the production of cytokines in lipopolysaccharide- induced disseminated intravascular coagulation in rats (2006)
  • Author(s): Asakura, H., Takahashi, Y., Kubo, A., Ontachi, Y., Hayashi, T., Omote, M., Arahata, M., Kadohira, Y., Maekawa, M., Yamazaki, M., Morishita, E., Takami, A., Yoshida, T., Miyamoto, K., Nakao, S
  • Journal Title: Crit Care Med 34(9) Pages: 2421-5
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of sarpogrelate hydrochloride in a patient with chronic graft-versus-host disease : a case report (2006)
  • Author(s): Hayashi, T., Morishita, E., Ontachi, Y., Yamazaki, M., Asakura, H., Yoshida, T., Nakao, S
  • Journal Title: Ant J Hematol 81(2) Pages: 121-3
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Rituximab therapy for Epstein-Barr virus-related chronic hepatitis following living donor kidney transplantation (2006)
  • Author(s): Ohta, K., ShiMizu, M., Nakai, A., Toma, T., KaSahare, Y., Arii, C., Yachie, A., Kawamura, T., Aikawa, A., Hasegawa, A., Sato, K., Yokoyama, H., Ishikawa, I., Koizumi, S
  • Journal Title: Am J Kidney Dis 48(6) Pages: 986-9
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity (2006)
  • Author(s): Minegishi, Y., Saito, M., Mario, T ; Watanabe, K., Agematsu, K., Tsuchiya, S., Takada, H., Hara, T., Kawamura, N., Ariga, T, Kaneko, H., Kondo, N., Tsuge, L., Yachie, A. Sakiyama, Y., Iwata, T., Bessho, F., Ohishi, T., Joh, K., Imai, K., Kogawa, K., Shinohara, M., Fujieda, M., Wakiguchi, H., Paste, S., Abinun, M., Ochs, HD., Renner, ED., Janssen, A., Belohradsky, BH., Metin, A., Shimizu, N., Mizutani, S., Miyawaki, T., Nonoyama, S., Karasuyama, H
  • Journal Title: Immunity 25(5) Pages: 745-55
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Omenn syndrome-review of several phenotypes of Omenn syndrome and RAG1/RAG2 mutations in Japan (2006)
  • Author(s): Kato, M., Kimura, H., Seki, M., Shimada, A., Hayashi, Y., Morio, T., Kumaki, S., Ishida, Y., Kamachi, Y., Yachie, A
  • Journal Title: Allergol Int. Review 55(2) Pages: 115-9
  • NAID: 10019169596
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Somatic revertant mosaicism in a patient with leukocyte adhesion deficiency type 1 (2006)
  • Author(s): Tone, Y., Wada, T., Shibata, F., Toma, T., Hashida, Y., Kasahara, Y., Koizumi, S., Yachie, A
  • Journal Title: Blood (Epub ahead of print)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Neuromyelitis optica associated with myasthenia gravis : characteristic phenotype in Japanese population (2006)
  • Author(s): Furukawa, Y., Yoshikawa, H., Yachie, A., Yamada, M
  • Journal Title: Eur J Neurol 13(6) Pages: 655-8
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cytomegalovirus-associated protracted diarrhoea in an immunocompetent boy (2006)
  • Author(s): Shimizu, M., Ohta, K., Wada, H., Sumita, R., Yachie, A., Koizumi, S
  • Journal Title: J Paediatr Child Health 42(5) Pages: 259-62
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] second-site mutation in the initiation codon of WAS (WASP) results in expansion.of subsets of lyphocytes in an Wiskott-Aldrich syndrome patient (2006)
  • Author(s): Du, W., Kumaki, S., Uchiyama, T.,Yachie, A., Yeng Looi, C., Kawai, S., Minegishi, M., Ramesh, N., Geha, RS., Sasahara, Y., Tsuchiya, S.,A
  • Journal Title: Hum Mutat 27(4) Pages: 370-5
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Immunoglobulin preparations attenuate organ dysfunction and hemostatic abnormality by suppressing the production of cytokines in lipopolysaccharide-induced disseminated intravascular coagulation in rats (2006)
  • Author(s): Asakura H
  • Journal Title: Crit Care Med 34・9 Pages: 2421-2425
• [Journal Article] No interplay between the pathways mediating coagulation and inflammation in tissue factor-induced disseminated intravascular coagulation in rats (2006)
  • Author(s): Ontachi Y
  • Journal Title: Crit Care Med 34・10 Pages: 2646-2650
• [Journal Article] A second-site mutation in the initiation codon of WAS (WASP) results in expansion of subsets of lymphocytes in an Wiskott-Aldrich syndrome patient (2006)
  • Author(s): Du W
  • Journal Title: Hum Mutat 27・4 Pages: 370-376
• [Journal Article] Expression of annexin II in human atherosclerotic abdominal aortic aneurysms
  • Author(s): Hayashi, T., Morishita, E., Ohtake, H., Oda, Y., Ohta, K., Arahata, M., Kadohira, Y., Maekawa, M., Ontachi, Y., Yamazaki, M., Asakura, H., Takami, A., Nakao, S
  • Journal Title: Thromb Res (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Changes in molecular markers of hemostatic and fibrinolytic activation under various sampling conditions using vacuum tube samples from healthy volunteers
  • Author(s): Omote, M., Asakura, H., Takamichi, S., Shibayama, M., Yoshida, T., Kadohira, Y., Maekawa, M., Yamazaki, M., Morishita, E., Nakao, S., Wada, T
  • Journal Title: Thromb Res (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] スタチン製剤の多面的作用-凝固線溶系に及ぼす影響-. (2007)
  • Author(s): 森下英理子、その他
  • Organizer: 第5回北陸循環障害研究会
  • Place of Presentation: 金沢
  • Year and Date: 2007-11-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Clinical significance of platelet-derived microparticle(PDMP)in APS: plasma levels of PDMP were significantly elevated in APS patients with arterial thrombosis. (2007)
  • Author(s): Yamazaki M, et. al.
  • Organizer: XXIst Congeress of the International Society on Thrombosis and Haemostasis
  • Place of Presentation: Switzerland
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Pathophysiological mechanisms of vasculopathy in systemic scleroderma(SSc): Platelet activation induced by antiphospholipid antibody(aPL)is associated with arterial thromboses and digital pitting scar in SSc patients. (2007)
  • Author(s): Yamazaki M, et. al.
  • Organizer: XXIst Congeress of the International Society on Thrombosis and Haemostasis
  • Place of Presentation: Switzerland
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 血液凝固異常症の臨床と血液検査 (2007)
  • Author(s): 森下英理子
  • Organizer: 第8回日本検査血液学会学術集会
  • Place of Presentation: 福井
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The first case of human HO-1 deficiency; its clinical profiles as a disease of immune dysregulation. (2007)
  • Author(s): Yachie A
  • Organizer: The 5th International Congress Heme Oxygenase 2007
  • Place of Presentation: Krakow, Poland
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 先天性複合ヘテロ接合体プロトロンビン欠乏症(Prothrombin Kawaguchi)の一例. (2007)
  • Author(s): 森下英理子、その他
  • Organizer: 第69回日本血液学会・第49回日本臨床血液学会
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 先天性第X因子欠損症の遺伝子解析. (2007)
  • Author(s): 森下英理子、その他
  • Organizer: 第30回日本血栓止血学会
  • Place of Presentation: 三重
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Clinical significance of platelet- derived microparticle (PDMP) in APS : plasma levels of PDMP were significantly elevated in APS patients with arterial thrombosis. (2007)
  • Author(s): Yamazaki, M., Kadohira, Y., Maekawa, M., Arahata, M., Ontachi, Y., Morishita, E., Asakura, H., Nakao, S
  • Organizer: XXIst Congeress of the International Society on Thrombosis and Haemostasis
  • Place of Presentation: Switzerland
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Pathophysiological mechanisms of vasculopathy in systemic scleroderma (SSc) : Platelet activation induced by antiphospholipid antibody (aPL) is associated with arterial thromboses and digital pitting scar in SSc patients (2007)
  • Author(s): Yamazaki, M., Kadohira, Y., Maekawa, M., Arahata, M., Ontachi, Y., Morishita, E., Asakura, H., Nakao, S
  • Organizer: XXIst Congeress of the International Society on Thrombosis and Haemostasis
  • Place of Presentation: Switzerland
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The first case of human HO-1 deficiency ; its clinical profiles as a disease of immune dysregulation (2007)
  • Author(s): Yachie, A
  • Organizer: The 5th International Congress Heme Oxygenase
  • Place of Presentation: Krakow, Poland
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 先天性複合ヘテロ接合体プロトロンビン欠乏症(ProthrombinKawaguchi)の一 (2007)
  • Author(s): 森下英理子ほか
  • Organizer: 第69回目本血液学会・第49回日本臨床血液学会
  • Place of Presentation: 横浜
• [Presentation] HMG-CoA還元酵素阻害剤内服が高脂血症患者の凝固線溶系に及ぼす影響. (2006)
  • Author(s): 森下英理子、その他
  • Organizer: 第38回日本動脈硬化学会総会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 家族性地中海熱(Familial Mediterranean Fever; FMF)が疑われた周期熱症候群の一例. (2006)
  • Author(s): 森下英理子、その他
  • Organizer: 第7回日本検査血液学会学術集会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Roles of adhesion molecules in the development of antiphosph olipid syndrome: Key roles of E-selection in the induction of antiphospholipid antibodies. (2006)
  • Author(s): Yamazaki M, et. al.
  • Organizer: The Fourth Asian-Pacific Congress on Thrombosis and Hemostasis
  • Place of Presentation: Soshu, China
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Inherited thrombotic and hemorrhagic disorders:Clinical manifestation and molecular mechanism(シンポジウム) (2006)
  • Author(s): 森下英理子、その他
  • Organizer: 第68回日本血液学会・第48回日本臨床血液学会
  • Place of Presentation: 福岡
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Roles of adhesion molecules in the development of antiphospholipid syndrome : key roles of E-selection in the induction of antiphospholipid antibodies (2006)
  • Author(s): Yamazaki, M., Kawashima, Y., Kadohira, Y., Arahata, M., Maekawa, M., Ontachi, Y., Hayashi, T., Asakura, H., Morishita, E., Nakao, S
  • Organizer: The Fourth Asian-Pacific Congress on Thrombosis and Hemostasis
  • Place of Presentation: Soshu,China
  • Description: 「研究成果報告書概要(欧文)」より