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Early diagnosis of myocardial ischemia using magnetocardiogram

Research Project

Project/Area Number 18590532
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionThe University of Tokushima

Principal Investigator

NOMURA Masahiro  The University of Tokushima, Faculty of Intergrated Arts and Sciences, Professor (00243684)

Co-Investigator(Kenkyū-buntansha) ITOZAKI Hideo  Osaka University, 基礎工学部, Professor (70354298)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,920,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2006: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywordsmagnetocardiogram / current density map / abnormal electrical current / isopotential map / early diagnosis / myocardial infarction / ischemic vector / myocardial ischemia
Research Abstract

We investigated the issue of whether the current density map method, in which cardiac current is estimated from the magnetic gradient, facilitates the visualization of cardiac current undetectable by ECG.
1) Evaluation of an infarction vector
Old inferior myocardial infarctions (MI group) and normal healthy subjects (Normal group) were recorded using magnetocardiometer. The electromotive force of the heart was estimated from a current density map. In the current density map of the ventricular depolarization phase, multiple current densities were deduced from magnetocardiograms of the ventricular depolarization phase in the MI group, unlike normal subjects. In 4 patients in the MI group, multiple current sources were suggested, which were not detected in a body surface electrocardiogram. Magnetocardiogram is capable of permitting infarct electromotive forces to be detected, which could not be deduced from electrocardiography data.
2) Detection of cardiac current undetectable by electrocard … More iography using magnetocardiography in various cardiac diseases
The subjects were 50 healthy adults (N group), 40 patients with left ventricular overloading (LVO group), 15 patients with right ventricular overloading (RVO group), 10 patients with an old inferior myocardial infarction (OMI group), and 30 patients with diabetes mellitus (DM group). MCGs were recorded with a second derivative superconducting quantum interference device (SQUID) gradiometer using liquid helium. Isopotential maps and current density maps from unipolar precordial ECG leads and MCGs, respectively, were prepared, and the cardiac electric current was examined. The current density map at the ventricular depolarization phase showed one peak of current density in the N group. However, in the OMI group, the current density map showed multiple peaks of current density areas. In the RVO group, two peaks of current densities were detected at the right superior region and left thoracic region and these two diploles appeared to be from the right and left ventricular derived cardiac currents, respectively. Moreover, there was a significant correlation between the magnitude of the current density from the right ventricle and the systolic pulmonary arterial pressure. The current density map at the ventricular repolarization phase in the N group showed only a single current source. However, abnormal current sources in the current density maps were frequently detected even in patients showing no abnormalities on isopotential maps in the LVO, DM, and OMI groups.
Our results suggest that MCG with a current density map is useful for detecting cardiac current undetectable by ECG in an early stage. Less

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (20 results)

All 2007 2006

All Journal Article (14 results) (of which Peer Reviewed: 4 results) Presentation (6 results)

  • [Journal Article] Visualization of cardiac dipole using a current density map: detection of cardiac current undetectable by electrocardiography using magnetocardiography2007

    • Author(s)
      Nomura M
    • Journal Title

      J Med Invest 54(1-2)

      Pages: 116-123

    • NAID

      110006215212

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 臨床医からみた不整脈診断の進歩と問題点2007

    • Author(s)
      野村昌弘
    • Journal Title

      日本生体磁気学会誌 20巻1号

      Pages: 88-89

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Evaluation of an infarction vector by magnetocardiogram: detection of electromotive forces that cannot be deduced from an electrocardiogram2007

    • Author(s)
      Nomura M
    • Journal Title

      International congress Series 1300

      Pages: 512-515

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Visualization of cardiac dipole using a current density map : detection of cardiac current undetectable by electrocardiography using magnetocardiography2007

    • Author(s)
      Nomura, M
    • Journal Title

      The Journal of Medical Investigation 54(1-2)

      Pages: 116-123

    • NAID

      110006215212

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Progress and problem of the arrhythmia diagnosis from a clinician2007

    • Author(s)
      Nomura, M
    • Journal Title

      The Journal of Japan Biomagnetism and Bioelectromagnetics Society 20(1)

      Pages: 88-89

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Evaluation of an infarction vector by magnetocardiogram : detection of electromotive forces that cannot be deduced from an electrocardiogram2007

    • Author(s)
      Nomura, M
    • Journal Title

      International congress Series 1300

      Pages: 512-515

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 臨床医からみた不整脈診断のシンポと問題点2007

    • Author(s)
      野村 昌弘, 他
    • Journal Title

      日本生体磁気学会誌 20巻1号

      Pages: 88-89

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Visualization of cardiac dipole using a current density map:detection of cardiac current undetectable by electrocardiography using magnetocardiography2007

    • Author(s)
      Ikefuji H, 他
    • Journal Title

      J Med Invest 54(1-2)

      Pages: 116-123

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of an infarction vector by magnetocardiogram: detection of electromotive forces that cannot be deduced from an electrocardiogram2007

    • Author(s)
      Nomura M, 他
    • Journal Title

      International congress Series 1300

      Pages: 512-515

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualization of cardiac dipole using a current density map : detection of cardiac current undetectable by electrocardiography using magnetocardiography.2007

    • Author(s)
      Ikefuji H, Nomura M, Nakaya Y, Mori T, Kondo N, Ieishi K, Fujimoto S, Ito S.
    • Journal Title

      J Med Invest 54(1-2)

      Pages: 140-145

    • NAID

      110006215212

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Evaluation of an infarction vector by magnetocardiogram : detection of electromotive forces that can not be deduced from an electrocardiogram2007

    • Author(s)
      Nomura M, Nakaya Y, Nakayasu K
    • Journal Title

      ICS 1300(Biomagnetism) (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 心磁図current density mapによる右室負荷疾患における肺動脈圧の推定2006

    • Author(s)
      野村昌弘
    • Journal Title

      日本生体磁気学会誌 19巻1号

      Pages: 66-67

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Evaluation of pulmonary arterial pressure using current density map in patients with right ventricular overloading2006

    • Author(s)
      Nomura, M
    • Journal Title

      The Journal of Japan Biomagnetism and Bioelectromagnetics Society 19(1)

      Pages: 66-67

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 心磁図current density mapによる右室負荷疾患における肺動脈圧の測定2006

    • Author(s)
      野村昌弘, 中屋 豊, 中安 紀美子
    • Journal Title

      日本生体磁気学会誌 特別号 19巻1号

      Pages: 66-67

    • Related Report
      2006 Annual Research Report
  • [Presentation] 臨床医からみた不整脈診断の進歩と問題点2007

    • Author(s)
      野村 昌弘
    • Organizer
      第22回日本生体磁気学会
    • Place of Presentation
      岡崎市
    • Year and Date
      2007-06-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Evaluation of an infarction vector by magnetocardiogram : detection of electromotive forces that cannot be deduced from an electrocardiogram2007

    • Author(s)
      Nomura, M
    • Organizer
      22th Conference of Japan Biomagnetism and Bioelectromagnetics Society
    • Place of Presentation
      Okazaki
    • Year and Date
      2007-06-21
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Evaluation of an infarction vector by magnetocardiogram: detection of electromotive forces that cannot be deduced from an electrocardiogram2006

    • Author(s)
      Nomura M,
    • Organizer
      Biomag2006
    • Place of Presentation
      Vancouver
    • Year and Date
      2006-08-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Progress and problem of the arrhythmia diagnosis from a clinician2006

    • Author(s)
      Nomura, M
    • Organizer
      Biomag2006
    • Place of Presentation
      Vancouver
    • Year and Date
      2006-08-20
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 心磁図current density mapによる右室負荷疾患における肺動脈圧の推定2006

    • Author(s)
      野村 昌弘
    • Organizer
      第21回日本生体磁気学会
    • Place of Presentation
      東京
    • Year and Date
      2006-06-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Evaluation of pulmonary arterial pressure using current density map in patients with right ventricular overloading2006

    • Author(s)
      Nomura, M
    • Organizer
      21th Conference of Japan Biomagnetism and Bioelectromagnetics Society
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-06-01
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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