Molecular epidemiological analysis of the clinically isolated bacteria for the measurement of nosocomial infections
| Project/Area Number |
18590539
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Laboratory medicine
|
|---|
| Research Institution | Showa University |
|---|
Principal Investigator |
GOMI Kunihide Showa University, 医学部, 教授 (60053980)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
CHEN Gelin 昭和大学, 医学部, 助教 (60266111)
FUKUCHI Kunihiko 昭和大学, 医学部, 教授 (70181287)
|
|---|
| Project Period (FY) |
2006 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,120,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
|
|---|
| Keywords | 臨床検査医学 / 院内感染 / メタロβラクタマーゼ / ESBL / 多剤耐性菌 / MRSA / エンテロバクター / ゲノム型 / 薬剤耐性菌 / 多剤耐性緑膿菌 / BLNAR / パルスフィールド電気泳動 / NICU / イミペネム耐性 |
|---|
| Research Abstract |
We analyzed the antibiotic resistant mechanism of bacteria responsible for nosocomial infection, such as MRSA, multidrug resistant Pseudomonas aeruginosa, ESBL producing E.coli, multidrug resistant Enterobacter cloacae. A variety of CTX-M genes or metallo-beta-lactamase genes were detected in highly resistant enterobacteriaceae. Various metallo-beta-lactamase genes were isolated from Multidrug resitant P. aeruginosa. Linezolid-resitant MRSA was isolated, and we detected the DNA mutation in rRNA region in its genome. Molecular epidemiology was performed by analyzing drug resistant gene along with genome analysis by Pulsed field gel electrophoresis.
|
Report
(6 results)
Research Products
(32 results)
