Interaction between genetic and environmental factors in metabolic syndrome
| Project/Area Number |
18590557
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Shimane University |
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Principal Investigator |
SHIWAKU Kuninori Shimane University, College of Medicine Environmental Medicine, Prof (10108384)
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| Co-Investigator(Kenkyū-buntansha) |
KAKAZU Naoki Shimane University, College of Medicine Environmental Medicine, Associate Prof (20264757)
YAMASAKI Masayuki Shimane University, College of Medicine Environmental Medicine, Assistant, Prof (60379683)
IWAMOTO Mamiko Shimane University, College of Medicine Environmental Medicine, Assistant, prof (90432616)
NOGI Akiko Yamaguchi Prefectural University, Faculty of Nursing and Human Nutrition, Clinical Nutrition, Associate Prof (90312305)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,930,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2006: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | Metabolic syndrome / Obesity / Genetic polymorphism / Fond / Carbohydrate / Exercise / Diabetes / 遺伝 / 生活習慣 / 日本 / 中国 / 疫学 |
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| Research Abstract |
A clustering of insulin resistance, hypertension and dyslipidemia has been labeled as metabolic syndrome. Asians have a lower frequency of obesity than do Caucasians, but have an increasing tendency toward metabolic syndrome. Most data on metabolic syndrome am based on studies from Western countries with only limited information derived from Asian populations.
To investigate the independent and combined effects of the Trp64Arg polymorphism of the beta3-adrenergic receptor (beta3AR) gene and the (-3826) A〓>G polymorphism of the uncoupling protein 1 (UCP1) gene are associated with weight-loss of Japanese. 300 subjects (72 men of 53.5±11.6 years and 228 women of 55.8±9.1 years) participated in a community-setting educational interventional trials for three months from 2000 to 2005. Participants were 28% overweight (23.0-24.9 BMI) and 48% obese (〓25 BMD. Each subject was completed the life-style modification program, and reduced 1.33±0.11 kg of weight, 385±24.05 kcal of energy balance. The
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beta3AR and UCP1 polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). General Linear Model (GLM-1) was fit to detect associations between body weight changes and the two gene polymorphisms. The body weight significantly reduced in women with beta3AR mutation but not in men, after controlling for potential confounding variables (p=0.007). The effect of UCP1 polymorphism on body weight change was not significant in both women and men. The synergistic effects of polymorphisms both beta3AR and UCP1 on body weight changes were not found to have additive effects (p=0.167). The synergistic effect of the beta3AR and the UCP1 gene polymorphism may be a weak contributing to body weight changes in Japanese with overweight and obese.
We also conducted a cross-sectional study of individuals aged 18-60 yr in workplace settings We examined and analyzed the health data of 1,564 Japanese, Chinese and Mongolians for metabolic syndrome based on the International Diabetes Federation (IDF) definition. The prevalence of visceral obesity using the Asian edition of waist circumference was 10% and 12% for Japanese, 39% and 24% for Chinese, and 51% and 54% for Mongolians, respectively The prevalence of metabolic syndrome was 7% and 7% for Japanese, 24% and 9% for Chinese, and 22% and 24% for Mongolians respectively Japanese has a lower frequency of visceral obesity than do Chinese and Mongolians, but have an increasing tendency toward obesity-related metabolic disorders. Obesity and metabolic syndrome are increasing in Asian workers with their social-economical development, but obesity-related metabolic disorders are remarkably different relative to ethnicity. Less
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Report
(3 results)
Research Products
(60 results)
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[Journal Article] Variation of interleukin 8 -251 A>T polymorphism in worldwide populations and intra-ethnic differences in Japanese populations2007
Author(s)
Fujihara, J., Shiwaku, K., Yasuda, T., Yuasa, I., Nishimukai, H., Iida, R., Takeshita, H
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Journal Title
Clin Chim Acta 377
Pages: 79-82
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Plasma n-3 polyunsaturated fatty acid and cardiovascular disease risk f actors in Japanese, Korean and Mongolian workers2007
Author(s)
Nogi, A., Yang, J., Li, L., Yamasaki, M., Watanabe, M., Hashimoto, M., Shiwaku, K
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Journal Title
J Occup Health 49
Pages: 205-216
NAID
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] CYP1A2 polymorphism (C> A at position -163) in Ovambos, Koreans and Mongolians2006
Author(s)
Fujihara, J., Shiwaku, K., Xue, Y., Kataoka, K., Hieda, Y., Takeshita, H
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Journal Title
Cell Biochem Funct 25
Pages: 491-494
Description
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[Journal Article] Effect of the G994T polymorphism in the lipoprotein-associated phospholipase A2 gene on the plasma oxidized low-density lipoprotein in Japanese-Shimane Study
Author(s)
Wang, T., Shibata, H., Yamasaki, M., Zhang, Y., Li, LM., Zhang, DF., Yamaguchi, S., Masuda, J., Shiwaku, K., Nabika, T
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Description
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[Presentation] 就業の有無と生活習慣改善との関係2008
Author(s)
井山ゆり, 岩本麻実子, 山崎雅之, 塩飽邦憲
Organizer
第18回日本医学看護学教育学会学術学会
Place of Presentation
出雲
Year and Date
2008-03-09
Description
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[Presentation] Prevalence of the metabolic syndrome using the International Diabetes Federation definition for workers in Japan, China and Mongolia2008
Author(s)
Shiwaku, K., Iwamoto, M., Ikenishi, R., Wang, Li., Yamasaki, M., Mutombo, BWB., Oyunsuren, T., Song, H
Organizer
XVIII World Congress on Safety and Health at Work, Soeul
Place of Presentation
Korea
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Influence of rice with different amylose contents on postprandial glycemic response2007
Author(s)
Yamasaki, M., Watanabe, M., Yoneyama, T., Yang, J., Li, L., Wang, L., Shiwaku, K
Organizer
4th Asia-Oceania Conference on Obesity, Soul
Place of Presentation
Korea
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Effects of beta3-adrenergic receptor gene and uncoupling protein 1 gene for weight-loss of Japanese2007
Author(s)
Yang, J., Yamasaki, M., Li, L., Wang, L., Watanabe, M., Yoneyama, T., Nogi, A., Shiwaku, K
Organizer
4th Asia-Oceania Conference on Obesity, Soul
Place of Presentation
Korea
Description
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[Presentation] Visceral obesity and insulin resistance in Japanese with metabolic syndrome or type 2 diabetes2007
Author(s)
Shiwaku, K., Yamasaki, M., Watanabe, M., Nogi, A., Yang, J., Li, L., Wang, L., Nabika, T., Masuda, J., Yamaguchi, S
Organizer
2nd International Congress on "Prediabetes" and the Metabolic Syndrome, Barcelona
Place of Presentation
Spain
Description
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[Presentation] 健康教育介入による体重と体組成の変化2006
Author(s)
渡部麻実子, 乃木章子, 山崎雅之, 米山敏美, 塩飽邦憲
Organizer
第55回日本農村医学会学術総会
Place of Presentation
名古屋
Year and Date
2006-10-13
Description
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[Presentation] Lifestyle and obesity-related metabolic disorders in Northeast Asia2006
Author(s)
Shiwaku, K., Nogi, A., Watanabe, M., Yamasaki, M., Yoneyama, T
Organizer
10th International Congress on Obesity, Sydney
Place of Presentation
Australia
Description
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