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A population-based cohort study of adult hemodialysis patients

Research Project

Project/Area Number 18590568
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionIwate Medical University

Principal Investigator

OSAWA Masaki  Iwate Medical University, School of Medicine, Lecturer (60295970)

Co-Investigator(Kenkyū-buntansha) FUJIOKA Tomoaki  Iwate Medical University, School of Medicine, Professor (80173409)
SAKATA Kiyomi  Iwate Medical University, School of Medicine, Professor (50225794)
NAKAMURA Motoyuki  Iwate Medical University, School of Medicine, Professor (40172449)
ITAI Kazuyoshi  Iwate Medical University, School of Medicine, Associate Professor (10048572)
KONDA Ryuichirou  Iwate Medical University, School of Medicine, Associate Professor (10225609)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥4,010,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordshemodialysis / cardiovascular disease / cohort stud / risk factors / 前向きコホート研究 / 循環器疾患 / リスク要因 / 衛生 / 循環器・高血圧
Research Abstract

A population-based cohort study of hemodialysis patients (The KAREN Study) has been carried out in the northern part of the main island of Japan since 2003. Follow-up studies were completed on 1, 145 patients 2 years after initial registration. The total observation period was 2, 215 patient-years. There were 189 deaths, 214 cases of congestive heart failure, 29 cases of myocardial infarction, and 107 cases of stroke. Crude mortality was 85 (/1000 patient-years). Incident rates of myocardial infarction and stroke were 13.1 and 48.3, respectively. Cumulative mortality was 16.5%. The difference of mortality between men and women was not significant. The mortality rate in patients with diabetic nephropathy was significantly higher than those in patients with other causes of renal failure (log rank p < 0.01). Multivariate adjusted hazard ratios (HR)were determined by Cox regression analysis. Major risk factors for total mortality in hemodialysis patients were age (HR:(95%CI):1.047 (1.033-1.062)), diabetes mellitus (1.416 (1.045-1.919)), the presence of hepatitis C virus antibody (1.581 (1.043-2.395)), low levels of serum albumin (2.430 (1.785-3.308), and elevated serum CRP levels (1.944(1.442-2.621)). These factors independently contributed to increased mortality regardless of serious comorbid conditions such as myocardial infarction, stroke, and/or malignant disease.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (34 results)

All 2009 2007 2006 2005 Other

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (30 results)

  • [Journal Article] 岩手県透析患者の悉皆的コホート研究:2年間の追跡調査結果報告2007

    • Author(s)
      大澤 正樹
    • Journal Title

      日本循環器病予防学会誌 第42巻第2号

      Pages: 86-96

    • NAID

      10029554298

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Mortality rate and cardiovascular incidence rate in hemodialysis patients. Results from 2-year follow-up data of the KAREN Study2007

    • Author(s)
      Ohsawa, M., Kato, K., Fujishima, Y., Itai, K., Tanno, K., Konda, R., Nakamura, M., Okayama, A., Onoda, T., Sakata, K., Fujioka, T
    • Journal Title

      Japanese Journal of Cardiovascular Disease Prevention 42

      Pages: 92-102

    • NAID

      10029554298

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 透析患者の血清リンと循環器疾患合併症の関連2006

    • Author(s)
      加藤 香廉
    • Journal Title

      日本腎泌尿器疾患予防医学研究会誌 14巻1号

      Pages: 106-107

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cardiovascular Risk Factors in Hemodialysis Patients : Results from Baseline Data of Kaleidoscopic Approaches to Patients with End-stage Renal Disease Study2005

    • Author(s)
      Ohsawa, M., Kato, K., Itai, K., Onoda, T., Konda, R., Fujioka, T., Nakamura, M., Okayama, A
    • Journal Title

      J Epidemiol 15(3)

      Pages: 96-105

    • NAID

      10015648862

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Serum Fluoride Levels Are Significantly Elevated in Hemodialysis Patients and Six Factors Are Associated with Fluoride Level2009

    • Author(s)
      Ohsawa M, Kato K, Fujishima Y, Itai K, Tanno K, Konda R, Nakamura, M Okayama A, Onoda T, Sakata K, Fujioka, T
    • Organizer
      American Society of Nephrology 39th Annual Meeting and Scientific Exposition
    • Place of Presentation
      San Diego
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Refractory hypertension contributes to increased risks for total and card iovascular mortalities in hemodialysis patients2007

    • Author(s)
      大澤 正樹
    • Organizer
      American Society of Nephrology(ASN) 40th Annual Meeting
    • Place of Presentation
      San Fransisco,CA
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Hepatitis C viral infection independently contributes to an increased mo rtality risk among hemodialysis patients2007

    • Author(s)
      大澤 正樹
    • Organizer
      ASN 40th Annual Meeting
    • Place of Presentation
      San Fransisco,CA
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Malnutrition state expressed as low BMI and hypoalbuminemia is the most important factor for predicting mortality in hemodialysis patients regardless of their comobid conditions2007

    • Author(s)
      藤島 洋介
    • Organizer
      ASN 40th Annual Meeting
    • Place of Presentation
      San Fransisco,CA
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Traditional risk factors remain significant risk factors in non-diabetic n ephropathy subjects, while hypoalbuminemia is only independent risk fa ctor for death in diabetic nephropathy subjects among hemodialysis pati ents2007

    • Author(s)
      藤島 洋介
    • Organizer
      ASN 40th Annual Meeting
    • Place of Presentation
      San Fransisco,CA
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Linearly increased mortality in non-diabetic and abruptly increased mor tality in diabetic subjects are observed in hemodialysis patients with re Bard to serum CRP level2007

    • Author(s)
      丹野 高三
    • Organizer
      ASN 40th Annual Meeting
    • Place of Presentation
      San Fransisco,CA
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Refractory hypertension contributes to increased risks for total and card iovascular mortalities in hemodialysis patients.2007

    • Author(s)
      大澤 正樹
    • Organizer
      American Society of Nephrology(ASN)40th Annual Meeting
    • Place of Presentation
      San Francisco, CA
    • Year and Date
      2007-11-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Hepatitis C viral infection independently contributes to an increased mortality risk among hemodialysis patients.2007

    • Author(s)
      大澤 正樹
    • Organizer
      ASN 40th Annual Meeting
    • Place of Presentation
      San Francisco, CA
    • Year and Date
      2007-11-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Malnutrition state expressed as low BMI and hypoalbuminemia is the most important factor for predicting mortality in hemodialysis patients regardless of their comobid conditions.2007

    • Author(s)
      藤島 洋介
    • Organizer
      ASN 40th Annual Meeting
    • Place of Presentation
      San Fransisco, CA
    • Year and Date
      2007-11-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Traditional risk factors remain significant risk factors in non-diabetic nephropathy subjects, while hypoalbuminemia is only independent risk factor for death in diabetic nephropathy subjects among hemodialysis patients.2007

    • Author(s)
      藤島 洋介
    • Organizer
      ASN 40th Annual Meeting
    • Place of Presentation
      San Fransisco, CA
    • Year and Date
      2007-11-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Linearly increased mortality in non-diabetic and abruptly increased mortality in diabetic subjects are observed in hemodialysis patients with regard to serum CRP level2007

    • Author(s)
      丹野 高三
    • Organizer
      ASN 40th Annual Meeting
    • Place of Presentation
      San Francisco, CA
    • Year and Date
      2007-11-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Low albumin level is a more powerful predictor for hemorrhagic stroke than elevated blood pressure in diabetic hemodialysis patients2007

    • Author(s)
      加藤 香廉
    • Organizer
      ASN 40th Annual Meeting
    • Place of Presentation
      San Fransisco,CA
    • Year and Date
      2007-11-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Elevated serum fluoride levels contribute to an increased mortality in hemodialysis patients2007

    • Author(s)
      板井 一好
    • Organizer
      ASN 40th Annual Meeting
    • Place of Presentation
      San Fransisco,CA
    • Year and Date
      2007-11-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Low albumin level is a more powerful predictor for hemorrhagic stroke than elevated blood pressure in diabetic hemodialysis patients2007

    • Author(s)
      加藤 香廉
    • Organizer
      ASN 40th Anllual Meeting
    • Place of Presentation
      San Francisco, CA
    • Year and Date
      2007-11-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Elevated serum fluoride levels contribute to an increased mortality in hemodialysis patients2007

    • Author(s)
      板井 一好
    • Organizer
      ASN 40th Annual Meeting
    • Place of Presentation
      San Fransisco, CA
    • Year and Date
      2007-11-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] C型肝炎感染が成人血液透祈患者の予後に与える影響についての検討2007

    • Author(s)
      大澤 正樹
    • Organizer
      第66回日本公衆衛生学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2007-10-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] C型肝炎感染が成人血液透析患者の予後に与える影響についての検討2007

    • Author(s)
      大澤 正樹
    • Organizer
      第66回日本公衆衛生学会総会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2007-10-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 岩手県透析患者の悉皆性コホート研究、2年間の追跡調査結果報告2007

    • Author(s)
      大澤 正樹
    • Organizer
      第66回日本公衆衛生学会総会
    • Place of Presentation
      滋賀県大津市
    • Year and Date
      2007-05-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 岩手県透析患者の悉皆性コホート研究、2年間の追跡調査結果報告2007

    • Author(s)
      大澤 正樹
    • Organizer
      第43回日本循環器病予防学会
    • Place of Presentation
      滋賀県大津市
    • Year and Date
      2007-05-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] Serum Fluoride Levels Are Significantly Elevated in Hemodialysis Patients and Six Factors Are Associated with Fluoride Level2006

    • Author(s)
      大澤 正樹
    • Organizer
      ASN 39th Annual Meeting
    • Place of Presentation
      San Diego,California
    • Year and Date
      2006-11-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Long-Term Hemodialysis Treatment Is Significantly Associated with High Prevalence of Hepatitis C Viral Infection in a Large Scale Cross-Sectional Study2006

    • Author(s)
      大澤 正樹
    • Organizer
      ASN 39th Annual Meeting
    • Place of Presentation
      San Diego,California
    • Year and Date
      2006-11-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 成人血液透析患者のC型肝炎抗体陽性率の検討、地域住民との比較検討2006

    • Author(s)
      大澤 正樹
    • Organizer
      第65回日本公衆衛生学会総会
    • Place of Presentation
      富山市
    • Year and Date
      2006-10-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Long- Term Hemodialysis Treatment Is Significantly Associated with High Prevalence of Hepatitis C Viral Infection in a Large Scale Cross-Sectional Study2006

    • Author(s)
      Ohsawa M, Kato K, Fujishima Y, Itai K, Tanno K, Konda R, Nakamura M, Okayama A, Onoda T, Sakata K, Abe K, Suzuki K, Fujioka T, Akiba, T
    • Organizer
      American Society of Nephrology 39th Annual Meeting and Scientific Exposition
    • Place of Presentation
      San Diego
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Hepatitis C viral infection independently contributes to an increased mortality risk among hemodialysis patients

    • Author(s)
      Ohsawa M, Kato K, Fujishima Y, Itai K, Tanno K, Konda R, Nakamura M, Okayama A, Onoda T, Sakata K, Abe K, Suiuki K, Fujioka T, Akiba, T
    • Organizer
      American Society of Nephrology 40th Annual Meeting and Scientific Exposition
    • Place of Presentation
      San Fransisco
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Refractory hypertension contributes to increased risks for total and cardiovascular mortalities in hemodialysis patients

    • Author(s)
      Ohsawa M, Fujioka, T
    • Organizer
      American Society of Nephrology 40th Annual Meeting and Scientific Exposition
    • Place of Presentation
      San Fransisco
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Malnutrition state expressed as low BMI and hypoalbuminemia is the most important factor for predicting mortality in h emodialysis patients regardless of their comobid conditions

    • Author(s)
      Fujishima Y, Ohsawa M, Fujioka, T
    • Organizer
      American Society of Nephrology 40th Annual Meeting and Scientific Exposition
    • Place of Presentation
      San Fransisco
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Traditional risk factors remain significant risk factors in non-diabetic nephropathy subjects, while hypoalbuminemia is only independent risk factor for death in diabetic nephropathy subjects among hemodialysis patients

    • Author(s)
      Fujishima M, Ohsawa M, Kato K, Fujioka, T
    • Organizer
      American Society of Nephrology 40th Annual Meeting and Scientific Exposition
    • Place of Presentation
      San Fransisco
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Low albumin level is a more powerful predictor for hemorrhagic stroke than elevated blood pressure in diabetic hemodialysis patients

    • Author(s)
      Kato K, Fujioka T, Ohsawa M, Itai K, Tanno K, Fujishima, Y
    • Organizer
      American Society of Nephrology 40th Annual Meeting and Scientific Exposition
    • Place of Presentation
      San Fransisco
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Linearly increased mortality in non-diabetic and abruptly increased mortality in diabetic subjects are observed in hemodialysis patients with regard to serum CRP levels

    • Author(s)
      Tanno K, Masaki, Ohsawa M, Karen, Kato K, Fujioka, T
    • Organizer
      American Society of Nephrology 40th Annual Meeting and Scientific Exposition
    • Place of Presentation
      San Fransisco
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Elevated serum fluoride levels contribute to an increased mortality in hemodialysis patients

    • Author(s)
      Itai K, Ohsawa M, Tannno K, Kato K, Konda R, Fujioka, T
    • Organizer
      American Society of Nephrology 40th Annual Meeting and Scientific Exposition
    • Place of Presentation
      San Fransisco
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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