| Project/Area Number |
18590568
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Iwate Medical University |
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Principal Investigator |
OSAWA Masaki Iwate Medical University, School of Medicine, Lecturer (60295970)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIOKA Tomoaki Iwate Medical University, School of Medicine, Professor (80173409)
SAKATA Kiyomi Iwate Medical University, School of Medicine, Professor (50225794)
NAKAMURA Motoyuki Iwate Medical University, School of Medicine, Professor (40172449)
ITAI Kazuyoshi Iwate Medical University, School of Medicine, Associate Professor (10048572)
KONDA Ryuichirou Iwate Medical University, School of Medicine, Associate Professor (10225609)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥4,010,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | hemodialysis / cardiovascular disease / cohort stud / risk factors / 前向きコホート研究 / 循環器疾患 / リスク要因 / 衛生 / 循環器・高血圧 |
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| Research Abstract |
A population-based cohort study of hemodialysis patients (The KAREN Study) has been carried out in the northern part of the main island of Japan since 2003. Follow-up studies were completed on 1, 145 patients 2 years after initial registration. The total observation period was 2, 215 patient-years. There were 189 deaths, 214 cases of congestive heart failure, 29 cases of myocardial infarction, and 107 cases of stroke. Crude mortality was 85 (/1000 patient-years). Incident rates of myocardial infarction and stroke were 13.1 and 48.3, respectively. Cumulative mortality was 16.5%. The difference of mortality between men and women was not significant. The mortality rate in patients with diabetic nephropathy was significantly higher than those in patients with other causes of renal failure (log rank p < 0.01). Multivariate adjusted hazard ratios (HR)were determined by Cox regression analysis. Major risk factors for total mortality in hemodialysis patients were age (HR:(95%CI):1.047 (1.033-1.062)), diabetes mellitus (1.416 (1.045-1.919)), the presence of hepatitis C virus antibody (1.581 (1.043-2.395)), low levels of serum albumin (2.430 (1.785-3.308), and elevated serum CRP levels (1.944(1.442-2.621)). These factors independently contributed to increased mortality regardless of serious comorbid conditions such as myocardial infarction, stroke, and/or malignant disease.
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